iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-055298

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6; RING-type E3 ubiquitin transferase TRAF6

Genbank Nucleotide ID

EU204929

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000018266.3	ENSMMUT00000025667.3	ENSMMUP00000024012.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	8.20e-07	30.1	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Macaca mulatta

Functional Description
(View)

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Protein Sequence
(Fasta)

MSLLNCENSC GSSQSESDCC VAMASSCSAA TKDDSVGGTA STGNLSSSFM EDIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 120

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Nucleotide Sequence
(Fasta)

CAGCAGAGAA GGCGGAAGCA GTGGCGTCCG CAGCTAGCGT TTGGCCTGCG GACGGTTCCC 60
GGAGATGGCG ACGGAGCCCA TTGGACCCAG AGTTTGACGT CCAAGCAGCC ACGTCTCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0391--Immunity
KW-1017--Isopeptide bond
KW-0551--Lipid droplet
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0987--Osteopetrosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0005938--C:cell cortex
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006955--P:immune response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0007165--P:signal transduction

KEGG

mcc:716907

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	90.57	0.00e+00	949.00
IUUC-Apl-004062	Anas platyrhynchos	72.05	0.00e+00	825.00
IUUC-Aca-004636	Anolis carolinensis	70.44	0.00e+00	769.00
IUUC-Ame-011682	Astyanax mexicanus	53.41	1.00e-162	566.00
IUUC-Bta-012692	Bos taurus	88.38	0.00e+00	967.00
IUUC-Bci-013998	Botrytis cinerea	25.24	4.00e-14	72.80
IUUC-Bra-017948	Brassica rapa	28.08	5.00e-09	56.60
IUUC-Cja-019426	Callithrix jacchus	93.88	0.00e+00	994.00
IUUC-Cfa-020948	Canis familiaris	88.96	0.00e+00	834.00
IUUC-Cpo-021378	Cavia porcellus	88.40	0.00e+00	942.00
IUUC-Csa-024045	Chlorocebus sabaeus	99.62	0.00e+00	1057.00
IUUC-Cho-024973	Choloepus hoffmanni	74.60	7.00e-105	374.00
IUUC-Csv-026300	Ciona savignyi	39.13	4.00e-46	177.00
IUUC-Dre-027557	Danio rerio	56.91	5.00e-177	613.00
IUUC-Dno-030032	Dasypus novemcinctus	83.49	3.00e-141	494.00
IUUC-Dor-030790	Dipodomys ordii	91.06	0.00e+00	969.00
IUUC-Dme-031921	Drosophila melanogaster	26.97	2.00e-38	153.00
IUUC-Ete-032952	Echinops telfairi	88.44	9.00e-170	590.00
IUUC-Eca-033924	Equus caballus	84.35	0.00e+00	862.00
IUUC-Eeu-034734	Erinaceus europaeus	86.04	0.00e+00	887.00
IUUC-Fca-036222	Felis catus	82.66	0.00e+00	836.00
IUUC-Fal-036834	Ficedula albicollis	73.46	0.00e+00	732.00
IUUC-Fox-037935	Fusarium oxysporum	29.44	7.00e-21	95.50
IUUC-Gmo-039061	Gadus morhua	57.30	2.00e-88	320.00
IUUC-Ggr-040084	Gaeumannomyces graminis	28.38	4.00e-13	69.70
IUUC-Gga-040599	Gallus gallus	72.66	0.00e+00	833.00
IUUC-Gac-041977	Gasterosteus aculeatus	55.66	8.00e-167	580.00
IUUC-Ggo-044508	Gorilla gorilla	90.65	0.00e+00	939.00
IUUC-Hsa-046349	Homo sapiens	98.08	0.00e+00	1078.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	90.94	0.00e+00	979.00
IUUC-Lch-049821	Latimeria chalumnae	66.91	0.00e+00	752.00
IUUC-Lpe-051025	Leersia perrieri	25.29	2.00e-06	47.00
IUUC-Loc-051995	Lepisosteus oculatus	60.34	0.00e+00	630.00
IUUC-Laf-054115	Loxodonta africana	85.03	0.00e+00	930.00
IUUC-Mor-057263	Magnaporthe oryzae	31.02	8.00e-19	88.60
IUUC-Mpo-057517	Magnaporthe poae	28.96	5.00e-15	75.90
IUUC-Mga-059340	Meleagris gallopavo	72.48	0.00e+00	811.00
IUUC-Mvi-060553	Microbotryum violaceum	28.12	9.00e-15	74.70
IUUC-Mmr-061063	Microcebus murinus	91.18	0.00e+00	957.00
IUUC-Mdo-062075	Monodelphis domestica	79.67	0.00e+00	904.00
IUUC-Mmu-063780	Mus musculus	87.36	0.00e+00	900.00
IUUC-Mpu-065748	Mustela putorius furo	88.72	0.00e+00	954.00
IUUC-Mlu-067888	Myotis lucifugus	88.08	0.00e+00	939.00
IUUC-Ncr-068632	Neurospora crassa	26.15	7.00e-17	82.40
IUUC-Nle-069234	Nomascus leucogenys	98.08	0.00e+00	1047.00
IUUC-Opr-070393	Ochotona princeps	95.77	3.00e-122	431.00
IUUC-Ont-072459	Oreochromis niloticus	54.24	2.00e-175	608.00
IUUC-Oan-073578	Ornithorhynchus anatinus	80.88	0.00e+00	895.00
IUUC-Ocu-074201	Oryctolagus cuniculus	90.76	0.00e+00	963.00
IUUC-Oba-075457	Oryza barthii	27.01	2.00e-08	53.50
IUUC-Obr-076500	Oryza brachyantha	26.40	4.00e-10	58.50
IUUC-Ogl-077406	Oryza glaberrima	27.01	1.00e-08	53.90
IUUC-Ogu-078803	Oryza glumaepatula	26.49	9.00e-09	54.70
IUUC-Oin-079307	Oryza indica	27.01	1.00e-08	53.90
IUUC-Olo-080508	Oryza longistaminata	27.59	7.00e-09	54.70
IUUC-Ome-081315	Oryza meridionalis	27.01	8.00e-09	55.10
IUUC-Oni-082966	Oryza nivara	26.49	1.00e-08	54.30
IUUC-Oru-085055	Oryza rufipogon	26.49	1.00e-08	54.30
IUUC-Osa-085780	Oryza sativa	27.01	1.00e-08	53.90
IUUC-Ola-087319	Oryzias latipes	59.32	1.00e-91	330.00
IUUC-Olu-087748	Ostreococcus lucimarinus	23.14	1.00e-10	60.50
IUUC-Oga-087936	Otolemur garnettii	89.53	0.00e+00	956.00
IUUC-Oar-089379	Ovis aries	88.19	0.00e+00	972.00
IUUC-Ptr-090758	Pan troglodytes	98.47	0.00e+00	1047.00
IUUC-Pan-092590	Papio anubis	99.81	0.00e+00	1057.00
IUUC-Psi-093948	Pelodiscus sinensis	70.93	0.00e+00	800.00
IUUC-Pma-094434	Petromyzon marinus	50.36	2.00e-75	276.00
IUUC-Pfo-096912	Poecilia formosa	52.56	1.00e-168	586.00
IUUC-Pab-097651	Pongo abelii	98.47	0.00e+00	1050.00
IUUC-Pca-100958	Procavia capensis	89.54	0.00e+00	715.00
IUUC-Pva-103247	Pteropus vampyrus	92.06	7.00e-130	457.00
IUUC-Rno-104994	Rattus norvegicus	86.04	0.00e+00	912.00
IUUC-Sha-106494	Sarcophilus harrisii	82.86	0.00e+00	921.00
IUUC-Sar-113375	Sorex araneus	87.10	0.00e+00	923.00
IUUC-Sre-115218	Sporisorium reilianum	27.63	3.00e-15	77.00
IUUC-Ssc-115417	Sus scrofa	88.17	0.00e+00	959.00
IUUC-Tgu-117232	Taeniopygia guttata	72.29	0.00e+00	787.00
IUUC-Tru-118321	Takifugu rubripes	53.42	5.00e-167	580.00
IUUC-Tni-120475	Tetraodon nigroviridis	54.60	3.00e-166	578.00
IUUC-Tbe-127719	Tupaia belangeri	80.49	0.00e+00	824.00
IUUC-Ttr-129264	Tursiops truncatus	88.14	4.00e-124	438.00
IUUC-Uma-129620	Ustilago maydis	28.06	9.00e-17	82.00
IUUC-Vpa-130244	Vicugna pacos	87.75	2.00e-126	445.00
IUUC-Xtr-131948	Xenopus tropicalis	65.05	0.00e+00	749.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence