iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-087936

Ensembl Protein ID

ENSOGAP00000006711.2

UniProt Accession

H0WWF3; H0WWF3_OTOGA

Genbank Protein ID

ENSOGAP00000006711

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03002572

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000007506.2	ENSOGAT00000007507.2	ENSOGAP00000006711.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.10e-08	33.2	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+Pv +p+G+ + +++I k +++ g++cP++++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREPVQTPCGHRFCKACIIKSIRDAGHKCPIDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MSLLNCENSC GGSQSESDCC AAMASSCSAA AKDDSVSGTA STGNLSSSFM EEIQGFDVEF 60
DPPLESKYEC PICLMALREP VQTPCGHRFC KACIIKSIRD AGHKCPIDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTCTGC TAAACTGTGA AAACAGCTGT GGAGGCAGCC AGTCTGAAAG CGACTGCTGT 60
GCCGCCATGG CCAGCTCCTG TAGTGCCGCT GCGAAGGATG ACAGCGTGAG TGGGACTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	90.39	0.00e+00	954.00
IUUC-Apl-004062	Anas platyrhynchos	71.69	0.00e+00	804.00
IUUC-Aca-004636	Anolis carolinensis	70.26	0.00e+00	761.00
IUUC-Acl-008349	Aspergillus clavatus	28.70	7.00e-15	75.10
IUUC-Ame-011682	Astyanax mexicanus	54.88	4.00e-160	557.00
IUUC-Bta-012692	Bos taurus	86.53	0.00e+00	953.00
IUUC-Bci-013998	Botrytis cinerea	26.32	7.00e-13	68.60
IUUC-Bra-017948	Brassica rapa	29.79	1.00e-09	58.20
IUUC-Cja-019426	Callithrix jacchus	89.35	0.00e+00	959.00
IUUC-Cfa-020948	Canis familiaris	89.00	0.00e+00	845.00
IUUC-Cpo-021378	Cavia porcellus	87.66	0.00e+00	947.00
IUUC-Csa-024045	Chlorocebus sabaeus	89.53	0.00e+00	967.00
IUUC-Cho-024973	Choloepus hoffmanni	72.62	8.00e-98	350.00
IUUC-Csv-026300	Ciona savignyi	39.82	1.00e-45	176.00
IUUC-Dre-027557	Danio rerio	58.22	2.00e-171	595.00
IUUC-Dno-030032	Dasypus novemcinctus	84.97	5.00e-143	500.00
IUUC-Dor-030790	Dipodomys ordii	88.97	0.00e+00	950.00
IUUC-Dse-031478	Dothistroma septosporum	24.89	1.00e-11	64.70
IUUC-Dme-031921	Drosophila melanogaster	26.71	1.00e-40	160.00
IUUC-Ete-032952	Echinops telfairi	84.08	7.00e-164	570.00
IUUC-Eca-033924	Equus caballus	85.82	0.00e+00	870.00
IUUC-Eeu-034734	Erinaceus europaeus	82.46	0.00e+00	857.00
IUUC-Fca-036222	Felis catus	83.09	0.00e+00	833.00
IUUC-Fal-036834	Ficedula albicollis	73.04	0.00e+00	727.00
IUUC-Fox-037935	Fusarium oxysporum	32.34	1.00e-21	97.80
IUUC-Gmo-039061	Gadus morhua	59.68	7.00e-86	311.00
IUUC-Ggr-040084	Gaeumannomyces graminis	28.86	1.00e-13	71.60
IUUC-Gga-040599	Gallus gallus	73.03	0.00e+00	812.00
IUUC-Gac-041977	Gasterosteus aculeatus	55.47	4.00e-165	574.00
IUUC-Ggo-044508	Gorilla gorilla	84.04	0.00e+00	885.00
IUUC-Hsa-046349	Homo sapiens	89.91	0.00e+00	976.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	88.48	0.00e+00	945.00
IUUC-Lch-049821	Latimeria chalumnae	67.08	0.00e+00	736.00
IUUC-Lpe-051025	Leersia perrieri	26.37	5.00e-06	45.40
IUUC-Loc-051995	Lepisosteus oculatus	60.15	8.00e-179	620.00
IUUC-Laf-054115	Loxodonta africana	84.84	0.00e+00	938.00
IUUC-Mcc-055298	Macaca mulatta	89.53	0.00e+00	966.00
IUUC-Mor-057263	Magnaporthe oryzae	29.63	8.00e-18	85.10
IUUC-Mpo-057517	Magnaporthe poae	29.30	3.00e-16	79.70
IUUC-Mga-059340	Meleagris gallopavo	72.66	0.00e+00	808.00
IUUC-Mvi-060553	Microbotryum violaceum	30.48	6.00e-16	79.00
IUUC-Mmr-061063	Microcebus murinus	91.31	0.00e+00	968.00
IUUC-Mdo-062075	Monodelphis domestica	80.37	0.00e+00	888.00
IUUC-Mmu-063780	Mus musculus	86.36	0.00e+00	899.00
IUUC-Mpu-065748	Mustela putorius furo	88.95	0.00e+00	955.00
IUUC-Mlu-067888	Myotis lucifugus	87.80	0.00e+00	944.00
IUUC-Ncr-068632	Neurospora crassa	29.50	8.00e-18	85.50
IUUC-Nle-069234	Nomascus leucogenys	89.91	0.00e+00	973.00
IUUC-Opr-070393	Ochotona princeps	96.24	6.00e-123	434.00
IUUC-Ont-072459	Oreochromis niloticus	56.35	3.00e-173	601.00
IUUC-Oan-073578	Ornithorhynchus anatinus	80.88	0.00e+00	902.00
IUUC-Ocu-074201	Oryctolagus cuniculus	91.30	0.00e+00	978.00
IUUC-Ogl-077406	Oryza glaberrima	27.96	3.00e-08	52.40
IUUC-Ogu-078803	Oryza glumaepatula	27.41	2.00e-08	53.50
IUUC-Olo-080508	Oryza longistaminata	28.49	1.00e-08	53.90
IUUC-Ome-081315	Oryza meridionalis	26.13	6.00e-09	55.10
IUUC-Oni-082966	Oryza nivara	27.49	1.00e-08	54.30
IUUC-Osa-085780	Oryza sativa	27.96	3.00e-08	52.80
IUUC-Ola-087319	Oryzias latipes	60.85	6.00e-87	314.00
IUUC-Olu-087748	Ostreococcus lucimarinus	21.99	9.00e-10	57.80
IUUC-Oar-089379	Ovis aries	86.53	0.00e+00	956.00
IUUC-Ptr-090758	Pan troglodytes	90.28	0.00e+00	971.00
IUUC-Pan-092590	Papio anubis	89.72	0.00e+00	967.00
IUUC-Psi-093948	Pelodiscus sinensis	70.93	0.00e+00	794.00
IUUC-Pma-094434	Petromyzon marinus	44.24	9.00e-126	444.00
IUUC-Pfo-096912	Poecilia formosa	54.98	4.00e-166	578.00
IUUC-Pab-097651	Pongo abelii	90.28	0.00e+00	974.00
IUUC-Pop-099898	Populus trichocarpa	26.80	3.00e-10	59.70
IUUC-Pca-100958	Procavia capensis	84.72	0.00e+00	689.00
IUUC-Pva-103247	Pteropus vampyrus	90.08	2.00e-127	449.00
IUUC-Pte-104279	Pyrenophora teres	26.48	9.00e-13	68.90
IUUC-Rno-104994	Rattus norvegicus	85.23	0.00e+00	917.00
IUUC-Sha-106494	Sarcophilus harrisii	80.41	0.00e+00	889.00
IUUC-Ssl-108580	Sclerotinia sclerotiorum	25.71	4.00e-13	69.30
IUUC-Sar-113375	Sorex araneus	85.26	0.00e+00	908.00
IUUC-Sre-115218	Sporisorium reilianum	27.23	3.00e-15	77.00
IUUC-Ssc-115417	Sus scrofa	89.09	0.00e+00	983.00
IUUC-Tgu-117232	Taeniopygia guttata	72.11	0.00e+00	781.00
IUUC-Tru-118321	Takifugu rubripes	55.07	4.00e-165	574.00
IUUC-Tni-120475	Tetraodon nigroviridis	56.25	8.00e-165	573.00
IUUC-Tbe-127719	Tupaia belangeri	79.14	0.00e+00	819.00
IUUC-Ttr-129264	Tursiops truncatus	86.96	1.00e-122	433.00
IUUC-Uma-129620	Ustilago maydis	28.40	2.00e-19	90.90
IUUC-Vpa-130244	Vicugna pacos	87.75	2.00e-126	446.00
IUUC-Xtr-131948	Xenopus tropicalis	65.77	0.00e+00	726.00
IUUC-Xma-133132	Xiphophorus maculatus	55.66	2.00e-167	582.00
IUUC-Yli-134356	Yarrowia lipolytica	27.00	6.00e-13	68.60

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence