iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-036957

Ensembl Protein ID

ENSFALP00000005260.1

UniProt Accession

U3JR56; U3JR56_FICAL

Genbank Protein ID

ENSFALP00000005260

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01011216

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000005053.1	ENSFALT00000005286.1	ENSFALP00000005260.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-122	408.9	1278	1610

Active Site

Position(s)	Description	Evidence
1578	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1278 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1363
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n+ Vt++Nk+eY+++
   Q: 1364 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTAVTEKNKKEYIER 1446
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1447 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWAAVERFNNEQRLR 1533
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1534 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1610
           ************************999***********************************************985 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ NRRRCKEPLR YSYNPDQFHN TDIRNSPHEM 60
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIYW DIKEEVDAGD WIGMYLIDEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTTAAAAT GTCGCTTATG TTGGTTATGG GATACATGCT GAGTTAACCT CATTGAACTT 60
TTCCCCAGGA ATTGATGCGC TTACAATTGG CGGGTCATTA TGCTGCTCCA CCTGTGTAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	81.99	0.00e+00	1687.00
IUUC-Apl-003299	Anas platyrhynchos	95.41	0.00e+00	2919.00
IUUC-Aca-005024	Anolis carolinensis	88.90	0.00e+00	2723.00
IUUC-Bta-012604	Bos taurus	78.50	0.00e+00	2392.00
IUUC-Cja-019880	Callithrix jacchus	75.39	0.00e+00	2020.00
IUUC-Cfa-021216	Canis familiaris	83.70	0.00e+00	1715.00
IUUC-Cpo-021466	Cavia porcellus	92.31	0.00e+00	1648.00
IUUC-Csa-023080	Chlorocebus sabaeus	81.51	0.00e+00	2438.00
IUUC-Cho-024740	Choloepus hoffmanni	90.87	0.00e+00	1124.00
IUUC-Dre-028750	Danio rerio	73.98	0.00e+00	1571.00
IUUC-Dno-030019	Dasypus novemcinctus	80.54	0.00e+00	2400.00
IUUC-Dor-031030	Dipodomys ordii	71.84	0.00e+00	1113.00
IUUC-Ete-032352	Echinops telfairi	92.53	0.00e+00	1244.00
IUUC-Eca-033948	Equus caballus	82.89	0.00e+00	1714.00
IUUC-Eeu-034474	Erinaceus europaeus	68.35	0.00e+00	818.00
IUUC-Fca-036148	Felis catus	84.80	0.00e+00	1725.00
IUUC-Gmo-038714	Gadus morhua	69.13	0.00e+00	1021.00
IUUC-Gga-041194	Gallus gallus	95.57	0.00e+00	2960.00
IUUC-Gac-041366	Gasterosteus aculeatus	76.88	0.00e+00	1367.00
IUUC-Ggo-045442	Gorilla gorilla	76.44	0.00e+00	1524.00
IUUC-Hsa-045730	Homo sapiens	81.58	0.00e+00	2440.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	81.58	0.00e+00	2462.00
IUUC-Lch-050185	Latimeria chalumnae	73.81	0.00e+00	2056.00
IUUC-Loc-052744	Lepisosteus oculatus	82.81	0.00e+00	1631.00
IUUC-Laf-054368	Loxodonta africana	94.33	0.00e+00	1453.00
IUUC-Mcc-055487	Macaca mulatta	81.77	0.00e+00	2445.00
IUUC-Meu-056751	Macropus eugenii	91.34	0.00e+00	728.00
IUUC-Mga-059545	Meleagris gallopavo	94.90	0.00e+00	2919.00
IUUC-Mmr-061078	Microcebus murinus	83.62	0.00e+00	1688.00
IUUC-Mdo-062176	Monodelphis domestica	84.42	0.00e+00	1714.00
IUUC-Mmu-063513	Mus musculus	79.47	0.00e+00	2349.00
IUUC-Mpu-065786	Mustela putorius furo	85.08	0.00e+00	1753.00
IUUC-Mlu-067780	Myotis lucifugus	79.05	0.00e+00	1544.00
IUUC-Nle-069213	Nomascus leucogenys	81.27	0.00e+00	2404.00
IUUC-Opr-070208	Ochotona princeps	93.82	0.00e+00	1450.00
IUUC-Ont-072132	Oreochromis niloticus	76.59	0.00e+00	1364.00
IUUC-Oan-072807	Ornithorhynchus anatinus	87.92	0.00e+00	1784.00
IUUC-Ocu-074745	Oryctolagus cuniculus	84.87	0.00e+00	1727.00
IUUC-Ola-086981	Oryzias latipes	73.61	0.00e+00	1491.00
IUUC-Oga-087965	Otolemur garnettii	86.11	0.00e+00	1716.00
IUUC-Oar-089749	Ovis aries	82.45	0.00e+00	1727.00
IUUC-Ptr-091243	Pan troglodytes	81.58	0.00e+00	2438.00
IUUC-Pan-092201	Papio anubis	80.79	0.00e+00	2412.00
IUUC-Psi-093511	Pelodiscus sinensis	88.18	0.00e+00	2657.00
IUUC-Pfo-097001	Poecilia formosa	65.57	0.00e+00	1592.00
IUUC-Pab-098728	Pongo abelii	78.00	0.00e+00	2327.00
IUUC-Pca-100129	Procavia capensis	77.90	0.00e+00	1205.00
IUUC-Pva-102250	Pteropus vampyrus	70.78	0.00e+00	1943.00
IUUC-Rno-105031	Rattus norvegicus	79.08	0.00e+00	2338.00
IUUC-Tgu-117515	Taeniopygia guttata	97.39	0.00e+00	2970.00
IUUC-Tru-117914	Takifugu rubripes	76.28	0.00e+00	1386.00
IUUC-Tsy-119379	Tarsius syrichta	78.03	0.00e+00	781.00
IUUC-Tni-120178	Tetraodon nigroviridis	76.40	0.00e+00	1405.00
IUUC-Tbe-127762	Tupaia belangeri	81.07	0.00e+00	1619.00
IUUC-Ttr-128806	Tursiops truncatus	88.18	0.00e+00	1635.00
IUUC-Xtr-132903	Xenopus tropicalis	78.75	0.00e+00	1983.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence