iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000167977.8	ENST00000301738.8	ENSP00000301738.4
ENSG00000167977.8	ENST00000564195.1	ENSP00000456844.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other	BTB_Other	18573101

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	8.30e-11	43.8	44	114

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaas.SsvFyalf..lmele.esksklmveikdvqpevfrallkFlYtgklden 68
           ++v l+vgg++f +++ +L++   s++y+l+  + +l+ ++++++ + i+ ++p++f  +l++l++gkl +n
   Q: 44   KWVRLNVGGTYFLTTRQTLCRDpKSFLYRLCqaDPDLDsDKDETGAYLID-RDPTYFGPVLNYLRHGKLVIN 114
           59*****************************7777777788999999**9.******************887 PP

Organism

Homo sapiens

Functional Description
(View)

Homopentamer. Interacts (via C-terminus) with GRASP55/GORASP2. Interacts with CUL3 and with ubiquitinated proteins. Interacts with adeno-associated virus 2 (AAV-2) REP proteins.

Protein Sequence
(Fasta)

MAENHCELLS PARGGIGAGL GGGLCRRCSA GLGALAQRPG SVSKWVRLNV GGTYFLTTRQ 60
TLCRDPKSFL YRLCQADPDL DSDKDETGAY LIDRDPTYFG PVLNYLRHGK LVINKDLAEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGAACTCA GAGGACGCTA TTAAAAGCCG GACGCTTCCG GTGGAAGGGA GCTGTTGCGG 60
GGCTTGCTGG GATCATGGCG GAGAATCACT GCGAGCTCCT GTCGCCGGCC CGGGGCGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB

Pfam

PF02214--BTB_2

SMART

SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0097602--F:cullin family protein binding
GO:0042802--F:identical protein binding
GO:0032403--F:protein complex binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization
GO:0016032--P:viral process

KEGG

hsa:54442

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005071	Anolis carolinensis	97.91	3.00e-110	390.00
IUUC-Ame-011953	Astyanax mexicanus	66.38	4.00e-86	310.00
IUUC-Bta-013238	Bos taurus	96.58	1.00e-117	415.00
IUUC-Cfa-020368	Canis familiaris	97.01	5.00e-126	443.00
IUUC-Cpo-022539	Cavia porcellus	96.58	8.00e-125	439.00
IUUC-Csa-023074	Chlorocebus sabaeus	84.52	2.00e-96	345.00
IUUC-Cho-024408	Choloepus hoffmanni	75.68	1.00e-62	231.00
IUUC-Csv-026375	Ciona savignyi	72.92	9.00e-84	302.00
IUUC-Dre-027599	Danio rerio	90.05	5.00e-101	360.00
IUUC-Dno-029324	Dasypus novemcinctus	94.02	9.00e-114	402.00
IUUC-Dor-030398	Dipodomys ordii	83.76	9.00e-106	375.00
IUUC-Dme-031661	Drosophila melanogaster	64.40	2.00e-65	241.00
IUUC-Eca-033240	Equus caballus	86.75	9.00e-115	405.00
IUUC-Fal-037455	Ficedula albicollis	91.22	2.00e-107	381.00
IUUC-Gmo-039650	Gadus morhua	78.67	1.00e-99	355.00
IUUC-Gga-040799	Gallus gallus	75.00	1.00e-92	332.00
IUUC-Gac-042357	Gasterosteus aculeatus	81.62	2.00e-107	381.00
IUUC-Ggo-044563	Gorilla gorilla	100.00	2.00e-123	434.00
IUUC-Laf-053631	Loxodonta africana	93.59	5.00e-123	433.00
IUUC-Mcc-055489	Macaca mulatta	99.09	6.00e-112	396.00
IUUC-Mga-059269	Meleagris gallopavo	92.50	2.00e-83	301.00
IUUC-Mmr-061170	Microcebus murinus	97.79	8.00e-116	409.00
IUUC-Mdo-063068	Monodelphis domestica	87.29	2.00e-112	398.00
IUUC-Mmu-064160	Mus musculus	96.15	1.00e-119	422.00
IUUC-Mpu-066707	Mustela putorius furo	94.44	1.00e-124	438.00
IUUC-Mlu-067096	Myotis lucifugus	97.01	4.00e-119	420.00
IUUC-Ont-072315	Oreochromis niloticus	89.47	2.00e-109	388.00
IUUC-Oan-072751	Ornithorhynchus anatinus	96.03	3.00e-85	306.00
IUUC-Ocu-074090	Oryctolagus cuniculus	97.44	2.00e-118	417.00
IUUC-Ola-087038	Oryzias latipes	87.86	1.00e-105	375.00
IUUC-Oga-088148	Otolemur garnettii	97.86	1.00e-119	421.00
IUUC-Oar-089499	Ovis aries	97.40	5.00e-94	336.00
IUUC-Pan-092829	Papio anubis	99.15	2.00e-120	424.00
IUUC-Ppa-095886	Physcomitrella patens	34.82	2.00e-11	62.00
IUUC-Pfo-097467	Poecilia formosa	70.63	6.00e-95	340.00
IUUC-Pab-098083	Pongo abelii	83.33	1.00e-91	328.00
IUUC-Rno-104834	Rattus norvegicus	95.73	3.00e-119	421.00
IUUC-Smo-109623	Selaginella moellendorffii	37.40	6.00e-14	72.00
IUUC-Tgu-116616	Taeniopygia guttata	96.24	4.00e-105	373.00
IUUC-Tru-118495	Takifugu rubripes	90.43	2.00e-110	391.00
IUUC-Tni-120558	Tetraodon nigroviridis	89.47	6.00e-110	389.00
IUUC-Ttr-129255	Tursiops truncatus	96.15	8.00e-126	442.00
IUUC-Xtr-132856	Xenopus tropicalis	84.21	1.00e-107	382.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence