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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045836
UUCD1 version UUC-HoS-00255
Ensembl Protein ID ENSP00000304051.3
UniProt Accession Q8WU17; B3KMD5; O75485; Q7LDL3; RN139_HUMAN
Genbank Protein ID AAC39931.1; AAC39930.1; BAG50947.1; EAW92064.1; AAH21571.1; AAH64636.1
Protein Name E3 ubiquitin-protein ligase RNF139; RING finger protein 139; RING-type E3 ubiquitin transferase RNF139; Translocation in renal carcinoma on chromosome 8 protein
Genbank Nucleotide ID AF064800; AF064801; AK001602; CH471060; BC021571; BC064636
Gene Name RNF139; TRC8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000170881.4 ENST00000303545.3 ENSP00000304051.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19720873; 20068067
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.20e-08 37.0 547 585
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+ +f +  +++pC+H fha Cl kw       + +++CP C
   Q: 547  CAICYHEFTTSARITPCNHYFHALCLRKW------LYIQDTCPMC 585
           ********999******************......********** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.
 E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.
Protein Sequence
(Fasta)
MAAVGPPQQQ VRMAHQQVWA ALEVALRVPC LYIIDAIFNS YPDSSQSRFC IVLQIFLRLF 60
GVFASSIVLI LSQRSLFKFY TYSSAFLLAA TSVLVNYYAS LHIDFYGAYN TSAFGIELLP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045836|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GACTGACGGC GCAGCCTCCG GGCCTAGCCA CAGCAGCAAC GGCAGAGGCC AGCGGGCGAG 60
GTCAAGATGG TGGCTCCGCG GGCGGGGGAG GCAGTGGAGG GAGGAGGAGT CAGACCTTAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045836|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13705--TRC8_N
PF13639--zf-RING_2
SMART

SM00184--RING
SM00744--RINGv
Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0016021--C:integral component of membrane
GO:0016874--F:ligase activity
GO:0002020--F:protease binding
GO:0004872--F:receptor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0019787--F:ubiquitin-like protein transferase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:1904380--P:endoplasmic reticulum mannose trimming
GO:0036503--P:ERAD pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0017148--P:negative regulation of translation
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0070613--P:regulation of protein processing
GO:0031396--P:regulation of protein ubiquitination
KEGG hsa:11236
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002401 Ailuropoda melanoleuca 96.82 0.00e+00 1206.00
IUUC-Apl-004214 Anas platyrhynchos 85.50 0.00e+00 958.00
IUUC-Aca-005326 Anolis carolinensis 78.14 0.00e+00 972.00
IUUC-Ame-011687 Astyanax mexicanus 73.87 0.00e+00 870.00
IUUC-Bta-013394 Bos taurus 95.79 0.00e+00 1238.00
IUUC-Bci-013813 Botrytis cinerea 41.38 6.00e-08 52.00
IUUC-Bdi-014010 Brachypodium distachyon 32.43 5.00e-11 60.50
IUUC-Cja-019499 Callithrix jacchus 96.39 0.00e+00 1278.00
IUUC-Cfa-020357 Canis familiaris 96.39 0.00e+00 1214.00
IUUC-Cpo-021924 Cavia porcellus 94.76 0.00e+00 1159.00
IUUC-Csa-023513 Chlorocebus sabaeus 98.95 0.00e+00 1278.00
IUUC-Cho-024285 Choloepus hoffmanni 89.32 0.00e+00 1077.00
IUUC-Cin-025223 Ciona intestinalis 53.93 8.00e-75 273.00
IUUC-Csv-026018 Ciona savignyi 47.92 1.00e-64 240.00
IUUC-Dre-028660 Danio rerio 72.80 0.00e+00 787.00
IUUC-Dno-029463 Dasypus novemcinctus 94.63 2.00e-164 572.00
IUUC-Dor-030728 Dipodomys ordii 93.94 0.00e+00 1103.00
IUUC-Dse-031284 Dothistroma septosporum 43.40 5.00e-09 55.10
IUUC-Dme-032186 Drosophila melanogaster 48.05 3.00e-97 349.00
IUUC-Ete-032368 Echinops telfairi 87.26 0.00e+00 1155.00
IUUC-Eca-034325 Equus caballus 95.49 0.00e+00 1182.00
IUUC-Fca-035537 Felis catus 94.64 0.00e+00 1163.00
IUUC-Fal-037459 Ficedula albicollis 85.05 0.00e+00 932.00
IUUC-Gmo-039442 Gadus morhua 78.65 3.00e-97 349.00
IUUC-Ggr-039921 Gaeumannomyces graminis 31.91 1.00e-07 52.80
IUUC-Gga-041071 Gallus gallus 82.17 0.00e+00 991.00
IUUC-Gac-042483 Gasterosteus aculeatus 66.57 0.00e+00 891.00
IUUC-Ggo-044672 Gorilla gorilla 99.25 0.00e+00 1281.00
IUUC-Itr-048588 Ictidomys tridecemlineatus 95.28 0.00e+00 1240.00
IUUC-Lch-050073 Latimeria chalumnae 72.90 0.00e+00 968.00
IUUC-Loc-052908 Lepisosteus oculatus 70.08 0.00e+00 932.00
IUUC-Laf-053519 Loxodonta africana 92.78 0.00e+00 1239.00
IUUC-Mcc-054674 Macaca mulatta 95.48 1.00e-106 379.00
IUUC-Mor-057262 Magnaporthe oryzae 32.93 4.00e-08 53.90
IUUC-Mga-059922 Meleagris gallopavo 85.56 0.00e+00 953.00
IUUC-Mmr-061452 Microcebus murinus 94.59 0.00e+00 1192.00
IUUC-Mdo-062412 Monodelphis domestica 88.69 0.00e+00 1159.00
IUUC-Mmu-063147 Mus musculus 93.11 0.00e+00 1198.00
IUUC-Mpu-065929 Mustela putorius furo 96.23 0.00e+00 1214.00
IUUC-Mlu-067899 Myotis lucifugus 92.63 0.00e+00 1197.00
IUUC-Nle-070083 Nomascus leucogenys 98.95 0.00e+00 1277.00
IUUC-Opr-070461 Ochotona princeps 90.85 0.00e+00 1207.00
IUUC-Ont-072256 Oreochromis niloticus 70.49 0.00e+00 907.00
IUUC-Oan-073150 Ornithorhynchus anatinus 84.84 0.00e+00 932.00
IUUC-Ocu-073748 Oryctolagus cuniculus 92.95 0.00e+00 1196.00
IUUC-Oga-088565 Otolemur garnettii 95.89 0.00e+00 1219.00
IUUC-Oar-089432 Ovis aries 96.03 0.00e+00 1154.00
IUUC-Ptr-091422 Pan troglodytes 99.40 0.00e+00 1283.00
IUUC-Pan-092331 Papio anubis 98.80 0.00e+00 1276.00
IUUC-Psi-092933 Pelodiscus sinensis 83.22 0.00e+00 932.00
IUUC-Pfo-097466 Poecilia formosa 70.02 0.00e+00 904.00
IUUC-Pab-098702 Pongo abelii 99.10 0.00e+00 1279.00
IUUC-Pca-100125 Procavia capensis 90.48 0.00e+00 1181.00
IUUC-Pva-102628 Pteropus vampyrus 96.23 0.00e+00 1204.00
IUUC-Rno-104886 Rattus norvegicus 93.29 0.00e+00 1209.00
IUUC-Sha-106702 Sarcophilus harrisii 85.97 0.00e+00 1133.00
IUUC-Ssc-116164 Sus scrofa 95.04 0.00e+00 1253.00
IUUC-Tgu-116829 Taeniopygia guttata 82.86 0.00e+00 970.00
IUUC-Tru-118557 Takifugu rubripes 70.05 0.00e+00 868.00
IUUC-Tsy-119399 Tarsius syrichta 91.00 0.00e+00 670.00
IUUC-Tni-120006 Tetraodon nigroviridis 61.09 0.00e+00 756.00
IUUC-Tbe-127664 Tupaia belangeri 94.42 0.00e+00 1210.00
IUUC-Ttr-129144 Tursiops truncatus 94.74 0.00e+00 1257.00
IUUC-Vpa-130226 Vicugna pacos 95.94 0.00e+00 1238.00
IUUC-Xtr-132461 Xenopus tropicalis 71.41 0.00e+00 903.00
Created Date 25-Jun-2017

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