iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	25.86	2.00e-03	38.90	IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	94.96	1.00e-74	276.00	IUUC-Hsa-046547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity).

Protein Sequence
(Fasta)

MPRKAASPEE AAGEPGPEEM EAGRPRPVLR SVNSREPSQV IFCNRSPRVV LPLWLNFDGE 60
PQPYPILPPG TGRRIHSYRG HLWLFRDAGT HDGLLVNQTE LFVPSLNVDG QPIFANITLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGCGGCCC CTGGCTCCGT GCCGCCCCGC CCCCCAGTTT GAGGGCTCCC GGCGGCCATT 60
TCCGCCTTCA AGTTGCCCGG AGCGCGTCTG GGACCGGCAG ACCTGTCCCG GAGCGCGTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0833--Ubl conjugation pathway

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005929--C:cilium
GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030891--C:VCB complex
GO:0019899--F:enzyme binding
GO:0032403--F:protein complex binding
GO:0008134--F:transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0001525--P:angiogenesis
GO:0043534--P:blood vessel endothelial cell migration
GO:0048593--P:camera-type eye morphogenesis
GO:0061073--P:ciliary body morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0048069--P:eye pigmentation
GO:0048877--P:homeostasis of number of retina cells
GO:0061072--P:iris morphogenesis
GO:0006582--P:melanin metabolic process
GO:0045602--P:negative regulation of endothelial cell differentiation
GO:0010629--P:negative regulation of gene expression
GO:1902072--P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:0070244--P:negative regulation of thymocyte apoptotic process
GO:0061428--P:negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0030182--P:neuron differentiation
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0003310--P:pancreatic A cell differentiation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010498--P:proteasomal protein catabolic process
GO:0030163--P:protein catabolic process
GO:0051291--P:protein heterooligomerization
GO:0015031--P:protein transport
GO:0016567--P:protein ubiquitination
GO:2001233--P:regulation of apoptotic signaling pathway
GO:0042069--P:regulation of catecholamine metabolic process
GO:1903827--P:regulation of cellular protein localization
GO:0010468--P:regulation of gene expression
GO:0070243--P:regulation of thymocyte apoptotic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0045471--P:response to ethanol
GO:0003309--P:type B pancreatic cell differentiation

KEGG

mmu:22346

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	80.00	5.00e-68	250.00
IUUC-Apl-003580	Anas platyrhynchos	69.62	3.00e-25	106.00
IUUC-Aca-004492	Anolis carolinensis	77.17	2.00e-55	207.00
IUUC-Ang-009806	Aspergillus niger	58.82	2.40e-01	26.60
IUUC-Ame-011818	Astyanax mexicanus	52.63	7.00e-43	166.00
IUUC-Bta-013459	Bos taurus	89.51	2.00e-83	300.00
IUUC-Cel-018173	Caenorhabditis elegans	30.77	3.00e-04	38.10
IUUC-Cja-019826	Callithrix jacchus	89.38	3.00e-82	297.00
IUUC-Cfa-021280	Canis familiaris	89.81	5.00e-81	293.00
IUUC-Cpo-022544	Cavia porcellus	89.63	6.00e-84	302.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	41.67	8.00e-08	51.60
IUUC-Csa-023644	Chlorocebus sabaeus	90.51	1.00e-82	298.00
IUUC-Cho-024479	Choloepus hoffmanni	59.23	2.00e-37	147.00
IUUC-Cin-025505	Ciona intestinalis	27.05	1.00e-05	42.40
IUUC-Cgl-026420	Colletotrichum gloeosporioides	26.09	2.60e-01	30.40
IUUC-Cme-027232	Cyanidioschyzon merolae	32.43	2.00e-05	42.70
IUUC-Dre-028350	Danio rerio	51.97	4.00e-33	134.00
IUUC-Dno-029207	Dasypus novemcinctus	82.14	5.00e-51	193.00
IUUC-Dor-030912	Dipodomys ordii	62.50	4.00e-47	181.00
IUUC-Dme-031988	Drosophila melanogaster	25.86	8.00e-05	40.00
IUUC-Eca-034007	Equus caballus	97.50	2.00e-19	86.70
IUUC-Fca-036350	Felis catus	89.81	7.00e-80	289.00
IUUC-Fal-037192	Ficedula albicollis	66.67	6.00e-55	206.00
IUUC-Gmo-038921	Gadus morhua	57.06	3.00e-45	174.00
IUUC-Gga-041016	Gallus gallus	67.76	2.00e-55	208.00
IUUC-Gac-042560	Gasterosteus aculeatus	49.39	4.00e-37	147.00
IUUC-Ggo-045419	Gorilla gorilla	90.91	1.00e-80	291.00
IUUC-Hsa-046547	Homo sapiens	90.91	2.00e-80	291.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	92.55	5.00e-86	309.00
IUUC-Lch-050463	Latimeria chalumnae	62.34	6.00e-53	200.00
IUUC-Loc-052053	Lepisosteus oculatus	58.74	2.00e-48	184.00
IUUC-Laf-053893	Loxodonta africana	88.20	1.00e-82	298.00
IUUC-Mcc-055347	Macaca mulatta	57.79	2.00e-53	201.00
IUUC-Mtr-058490	Medicago truncatula	45.45	4.40e-02	31.60
IUUC-Mdo-062169	Monodelphis domestica	75.53	1.00e-38	150.00
IUUC-Mpu-066593	Mustela putorius furo	90.80	1.00e-84	305.00
IUUC-Mlu-066926	Myotis lucifugus	77.55	6.00e-83	299.00
IUUC-Nle-069724	Nomascus leucogenys	91.56	2.00e-81	294.00
IUUC-Opr-070679	Ochotona princeps	80.81	1.00e-76	278.00
IUUC-Ont-071332	Oreochromis niloticus	52.44	3.00e-43	167.00
IUUC-Ola-086869	Oryzias latipes	47.02	7.00e-41	159.00
IUUC-Oga-089124	Otolemur garnettii	88.34	5.00e-82	296.00
IUUC-Oar-089799	Ovis aries	87.76	4.00e-48	182.00
IUUC-Ptr-091186	Pan troglodytes	86.87	4.00e-47	179.00
IUUC-Pan-092150	Papio anubis	90.91	2.00e-80	291.00
IUUC-Psi-094039	Pelodiscus sinensis	67.14	1.00e-51	195.00
IUUC-Pma-094129	Petromyzon marinus	45.45	1.00e-28	119.00
IUUC-Pfo-096892	Poecilia formosa	48.70	3.00e-36	144.00
IUUC-Pab-097822	Pongo abelii	91.56	2.00e-81	295.00
IUUC-Pca-101058	Procavia capensis	86.79	1.00e-76	279.00
IUUC-Pva-102932	Pteropus vampyrus	92.41	1.00e-84	305.00
IUUC-Rno-105050	Rattus norvegicus	93.37	4.00e-96	343.00
IUUC-Sha-106738	Sarcophilus harrisii	79.17	3.00e-42	162.00
IUUC-Ssc-115973	Sus scrofa	86.39	5.00e-84	303.00
IUUC-Tgu-116663	Taeniopygia guttata	69.47	8.00e-33	131.00
IUUC-Tru-118654	Takifugu rubripes	51.88	2.00e-42	164.00
IUUC-Tca-121306	Theobroma cacao	38.89	1.00e-01	28.10
IUUC-Ttr-128418	Tursiops truncatus	88.75	5.00e-83	300.00
IUUC-Vpa-130268	Vicugna pacos	91.09	4.00e-49	187.00
IUUC-Xtr-132506	Xenopus tropicalis	64.79	1.00e-53	202.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence