iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132100

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Tripartite motif containing 13

Genbank Nucleotide ID

AAMC01049541

Gene Name

trim13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000015691.3	ENSXETT00000034221.3	ENSXETP00000034221.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.90e-09	35.9	10	58

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw....pglknssskefrCPlCr 46
           C+iC++ f+d p+vlpC H f+++Cl  +       ++    +f+CP+Cr
   Q: 10   CPICCSLFDD-PRVLPCSHNFCKKCLDGVleenSRTMQWRPSSFKCPTCR 58
           ********99.**************95555555566677999999****8 PP

Organism

Xenopus tropicalis

Functional Description
(View)

E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins (By similarity).

Protein Sequence
(Fasta)

MEVLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLDGVLEE NSRTMQWRPS SFKCPTCRKE 60
TPTMGVNGLQ VNYLLKGIVE KYNKIKVSPK MPVCKEHSDQ PLNIFCSTDL KLICGSCATT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGTGC TGGAGGAAGA TCTAACGTGC CCAATCTGCT GTAGCCTTTT TGATGACCCA 60
AGAGTCTTAC CTTGTTCACA CAACTTCTGC AAGAAATGTT TGGATGGTGT TCTGGAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0436--Ligase
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016874--F:ligase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002269	Ailuropoda melanoleuca	58.58	6.00e-130	457.00
IUUC-Apl-004168	Anas platyrhynchos	59.02	2.00e-139	488.00
IUUC-Aca-004395	Anolis carolinensis	58.94	4.00e-136	477.00
IUUC-Ame-011325	Astyanax mexicanus	45.00	1.00e-65	243.00
IUUC-Bta-012613	Bos taurus	59.80	2.00e-135	475.00
IUUC-Cja-018856	Callithrix jacchus	59.76	6.00e-139	486.00
IUUC-Cfa-021019	Canis familiaris	57.60	9.00e-129	453.00
IUUC-Cpo-021845	Cavia porcellus	58.82	4.00e-131	461.00
IUUC-Csa-023380	Chlorocebus sabaeus	57.84	2.00e-131	461.00
IUUC-Cho-024733	Choloepus hoffmanni	81.44	2.00e-46	179.00
IUUC-Dre-028675	Danio rerio	59.53	4.00e-106	377.00
IUUC-Dno-030018	Dasypus novemcinctus	59.31	4.00e-139	487.00
IUUC-Dor-030599	Dipodomys ordii	49.26	4.00e-64	237.00
IUUC-Ete-033134	Echinops telfairi	59.76	2.00e-136	478.00
IUUC-Eca-033931	Equus caballus	59.07	1.00e-131	462.00
IUUC-Eeu-034903	Erinaceus europaeus	59.02	4.00e-131	461.00
IUUC-Fca-035642	Felis catus	58.15	3.00e-129	454.00
IUUC-Fal-037108	Ficedula albicollis	60.19	6.00e-144	503.00
IUUC-Gga-040903	Gallus gallus	58.97	1.00e-138	485.00
IUUC-Ggo-044635	Gorilla gorilla	59.07	7.00e-133	466.00
IUUC-Hsa-046345	Homo sapiens	59.07	5.00e-133	467.00
IUUC-Itr-048220	Ictidomys tridecemlineatus	59.12	9.00e-128	449.00
IUUC-Lch-050599	Latimeria chalumnae	53.48	4.00e-121	427.00
IUUC-Loc-052378	Lepisosteus oculatus	61.11	3.00e-112	397.00
IUUC-Laf-053332	Loxodonta africana	58.33	1.00e-131	462.00
IUUC-Mcc-054705	Macaca mulatta	58.54	1.00e-131	462.00
IUUC-Meu-056825	Macropus eugenii	59.95	7.00e-140	489.00
IUUC-Mga-059528	Meleagris gallopavo	58.55	1.00e-141	495.00
IUUC-Mmr-060688	Microcebus murinus	59.31	5.00e-134	470.00
IUUC-Mdo-061882	Monodelphis domestica	60.68	5.00e-141	493.00
IUUC-Mmu-064352	Mus musculus	59.80	1.00e-136	479.00
IUUC-Mpu-066712	Mustela putorius furo	68.95	4.00e-121	427.00
IUUC-Mlu-068093	Myotis lucifugus	57.80	9.00e-130	456.00
IUUC-Nle-069310	Nomascus leucogenys	59.07	1.00e-133	469.00
IUUC-Ont-071759	Oreochromis niloticus	58.44	2.00e-105	375.00
IUUC-Oan-073673	Ornithorhynchus anatinus	58.74	5.00e-139	487.00
IUUC-Ocu-074192	Oryctolagus cuniculus	59.07	3.00e-133	468.00
IUUC-Ola-087424	Oryzias latipes	56.27	1.00e-105	376.00
IUUC-Oga-088808	Otolemur garnettii	58.82	6.00e-134	470.00
IUUC-Oar-089553	Ovis aries	59.07	1.00e-133	469.00
IUUC-Ptr-090518	Pan troglodytes	59.07	6.00e-133	467.00
IUUC-Pan-092781	Papio anubis	58.29	3.00e-131	461.00
IUUC-Psi-093914	Pelodiscus sinensis	59.76	3.00e-141	494.00
IUUC-Pma-094162	Petromyzon marinus	32.51	1.00e-41	163.00
IUUC-Pfo-096346	Poecilia formosa	46.93	2.00e-102	365.00
IUUC-Pca-100914	Procavia capensis	58.29	5.00e-135	473.00
IUUC-Pva-102728	Pteropus vampyrus	57.11	1.00e-129	456.00
IUUC-Rno-105922	Rattus norvegicus	58.82	1.00e-131	462.00
IUUC-Sha-107124	Sarcophilus harrisii	61.17	2.00e-143	501.00
IUUC-Sar-113607	Sorex araneus	58.58	4.00e-129	454.00
IUUC-Ssc-116355	Sus scrofa	59.31	6.00e-133	466.00
IUUC-Tgu-116476	Taeniopygia guttata	59.71	3.00e-143	501.00
IUUC-Tru-118737	Takifugu rubripes	56.59	1.00e-102	366.00
IUUC-Tsy-118908	Tarsius syrichta	58.54	9.00e-134	469.00
IUUC-Tbe-127258	Tupaia belangeri	59.07	1.00e-133	469.00
IUUC-Vpa-130138	Vicugna pacos	59.07	1.00e-132	466.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence