iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020754

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03000197

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000000267.2	ENSCAFT00000000421.2	ENSCAFP00000000383.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.50e-39	135.8	93	262
UBD/ZnF/ZnF_A20	9.80e-23	80.1	757	789

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepe... 74
           ++lkt+gDGnCL++A+sq+++gv+d+d+ l++al+++L+e+ ++++    q es + +ef+e++         de++ + k++++e   
   Q: 93   VALKTNGDGNCLMHAASQYMWGVQDTDLvLRKALFSTLKETDTRNFkfrwQLESLKSQEFVETGlcydtrnwTDEWDSLVKMASTEtpv 181
           789**********************************************9*******************9999**********999777 PP
   S: 75   akg.......eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
           a+g       eeihif+L++iL+rpiiv+++++l+s          kvggi+lpl++p+++ +++pi+L+Y+s H+ +Lv+
   Q: 182  ARGglqynslEEIHIFVLCNILRRPIIVISDKMLRSlesgsnfaplKVGGIYLPLHWPAQEcYRYPIILGYDSQHFVPLVT 262
           774699*************************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrr 33
           p+k++C++ +C+++Gn+++ gyC++C+++++ +
   Q: 757  PPKQRCRApACDHFGNAKCSGYCNECFQFKQLY 789
           9*****************************977 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MAEQLLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KSMHRYTLEM FRTCQFCPQF 60
REIIHKALID RSIQASLESQ KKLNWCREVR KLVALKTNGD GNCLMHAASQ YMWGVQDTDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGATTTTCT GCAGAAAAAC GGCTGAGAAA AAAGAACCTA TTTCATTTCC AGTTCCCATC 60
ACCGCGATTT CCACATGGAT GTGACGTTGG GCCAGCTTCC GAAATGCCCA GGTGACTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0006955--P:immune response
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	96.20	0.00e+00	1565.00
IUUC-Apl-003501	Anas platyrhynchos	66.08	0.00e+00	1048.00
IUUC-Aca-004245	Anolis carolinensis	64.80	0.00e+00	1071.00
IUUC-Ame-011789	Astyanax mexicanus	46.67	0.00e+00	699.00
IUUC-Bta-012664	Bos taurus	88.35	0.00e+00	1405.00
IUUC-Cja-019895	Callithrix jacchus	90.00	0.00e+00	1484.00
IUUC-Cpo-021780	Cavia porcellus	87.88	0.00e+00	1442.00
IUUC-Csa-023568	Chlorocebus sabaeus	90.51	0.00e+00	1503.00
IUUC-Cho-024300	Choloepus hoffmanni	89.80	0.00e+00	654.00
IUUC-Dre-028577	Danio rerio	49.50	0.00e+00	694.00
IUUC-Dno-029382	Dasypus novemcinctus	83.80	0.00e+00	1360.00
IUUC-Dor-030874	Dipodomys ordii	85.95	0.00e+00	1398.00
IUUC-Ete-032721	Echinops telfairi	92.33	0.00e+00	807.00
IUUC-Eca-033596	Equus caballus	87.59	0.00e+00	1437.00
IUUC-Eeu-035159	Erinaceus europaeus	88.06	0.00e+00	1140.00
IUUC-Fca-035847	Felis catus	95.57	0.00e+00	1558.00
IUUC-Fal-036681	Ficedula albicollis	65.01	0.00e+00	1062.00
IUUC-Gmo-038521	Gadus morhua	59.56	3.00e-148	519.00
IUUC-Gga-040975	Gallus gallus	64.69	0.00e+00	1071.00
IUUC-Gac-042216	Gasterosteus aculeatus	59.72	3.00e-154	538.00
IUUC-Ggo-045258	Gorilla gorilla	90.00	0.00e+00	1494.00
IUUC-Hsa-046071	Homo sapiens	90.25	0.00e+00	1498.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	90.89	0.00e+00	1489.00
IUUC-Lch-050326	Latimeria chalumnae	57.09	0.00e+00	923.00
IUUC-Loc-051945	Lepisosteus oculatus	46.45	1.00e-177	617.00
IUUC-Laf-053722	Loxodonta africana	88.48	0.00e+00	1451.00
IUUC-Mcc-055503	Macaca mulatta	90.25	0.00e+00	1496.00
IUUC-Meu-056481	Macropus eugenii	75.19	0.00e+00	1180.00
IUUC-Mga-059690	Meleagris gallopavo	62.85	0.00e+00	988.00
IUUC-Mmr-061233	Microcebus murinus	89.27	0.00e+00	1454.00
IUUC-Mdo-062446	Monodelphis domestica	80.68	0.00e+00	1310.00
IUUC-Mmu-063436	Mus musculus	88.23	0.00e+00	1408.00
IUUC-Mpu-066808	Mustela putorius furo	96.71	0.00e+00	1573.00
IUUC-Mlu-067339	Myotis lucifugus	90.51	0.00e+00	1479.00
IUUC-Nle-069888	Nomascus leucogenys	90.13	0.00e+00	1496.00
IUUC-Opr-070303	Ochotona princeps	88.27	0.00e+00	1449.00
IUUC-Ont-072283	Oreochromis niloticus	58.63	4.00e-150	525.00
IUUC-Oan-072925	Ornithorhynchus anatinus	77.07	0.00e+00	1246.00
IUUC-Ocu-073889	Oryctolagus cuniculus	89.25	0.00e+00	1436.00
IUUC-Oni-082742	Oryza nivara	27.27	2.60e+00	28.90
IUUC-Oru-085223	Oryza rufipogon	27.27	2.50e+00	28.90
IUUC-Ola-087417	Oryzias latipes	58.87	3.00e-150	525.00
IUUC-Oga-088708	Otolemur garnettii	86.08	0.00e+00	1365.00
IUUC-Oar-089271	Ovis aries	88.23	0.00e+00	1413.00
IUUC-Ptr-091296	Pan troglodytes	90.25	0.00e+00	1497.00
IUUC-Pan-092474	Papio anubis	90.38	0.00e+00	1500.00
IUUC-Psi-093447	Pelodiscus sinensis	68.98	0.00e+00	1119.00
IUUC-Pfo-096511	Poecilia formosa	59.10	9.00e-152	530.00
IUUC-Pab-098700	Pongo abelii	90.13	0.00e+00	1494.00
IUUC-Pca-100246	Procavia capensis	75.95	0.00e+00	1204.00
IUUC-Pva-102606	Pteropus vampyrus	78.43	2.00e-179	622.00
IUUC-Rno-105818	Rattus norvegicus	87.74	0.00e+00	1432.00
IUUC-Sha-106559	Sarcophilus harrisii	79.42	0.00e+00	1284.00
IUUC-Sit-110516	Setaria italica	47.62	1.90e-02	35.40
IUUC-Sar-113454	Sorex araneus	93.90	0.00e+00	649.00
IUUC-Ssc-116064	Sus scrofa	89.62	0.00e+00	1448.00
IUUC-Tgu-117212	Taeniopygia guttata	64.94	0.00e+00	1054.00
IUUC-Tru-118230	Takifugu rubripes	60.14	2.00e-152	533.00
IUUC-Tsy-119066	Tarsius syrichta	88.10	0.00e+00	1446.00
IUUC-Tni-119825	Tetraodon nigroviridis	47.01	0.00e+00	682.00
IUUC-Tvi-122358	Trichoderma virens	43.24	2.50e-01	29.60
IUUC-Tur-126383	Triticum urartu	46.43	6.90e-02	28.50
IUUC-Tbe-127601	Tupaia belangeri	96.34	0.00e+00	674.00
IUUC-Ttr-128930	Tursiops truncatus	89.49	0.00e+00	1435.00
IUUC-Vpa-130450	Vicugna pacos	95.76	0.00e+00	806.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence