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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-032193
Ensembl Protein ID FBpp0084636
UniProt Accession Q8MT36; Q1LZ05; Q9VAY5; MES4_DROME
Genbank Protein ID AAF56762.2; AAM48433.1; ABF17912.1
Protein Name Probable histone-lysine N-methyltransferase Mes-4; Maternal-effect sterile 4 homolog
Genbank Nucleotide ID AE014297; AY118404; BT025221
Gene Name Mes-4; CG4976
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0039559 FBtr0335014 FBpp0307022
FBgn0039559 FBtr0085267 FBpp0084636
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.70e-11 44.2 779 810
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCek.CrewfHpaClklsv 36
           +C+ C ++g+d   lv+C++ C++w+H++Cl+++v
   Q: 779  ICKYCYQAGSD---LVRCSRtCSSWLHADCLERKV 810
           68888888884...******************984 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity).
 Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity).
Protein Sequence
(Fasta)
MKLSTDAHSE IEGDAAHGNV LCNSASDSLT ATDEVAAGND ESVATEGDDV EIPRDTNNST 60
PVRLLDKPGQ NPVQNGAQPA AEESELESQR QTPVQKQQQQ RVSMVNRKRD LINLQSALSP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032193|E3,PHD|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTGCAGTCGA AGTTTTGGCG CAAGCGAAGC CTCTGTGTTC TTAGAAATTG TCGAATTAAC 60
GGTAGTGTTT AATTGACGAG AGCGCGATTA AACTGGACCG CAGAATGAAG CTGAGCACGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032193|E3,PHD|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00855--PWWP
PF00856--SET
SMART

SM00570--AWS
SM00249--PHD
SM00293--PWWP
SM00317--SET
Gene Ontology

GO:0000228--C:nuclear chromosome
GO:0005721--C:pericentric heterochromatin
GO:0005700--C:polytene chromosome
GO:0031490--F:chromatin DNA binding
GO:0042054--F:histone methyltransferase activity
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0008270--F:zinc ion binding
GO:0016458--P:gene silencing
GO:0018992--P:germ-line sex determination
GO:0010452--P:histone H3-K36 methylation
KEGG dme:Dmel_CG4976
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001795 Ailuropoda melanoleuca 36.70 1.00e-122 434.00
IUUC-Apl-003953 Anas platyrhynchos 37.02 2.00e-116 414.00
IUUC-Aca-005339 Anolis carolinensis 35.78 5.00e-121 429.00
IUUC-Ame-011932 Astyanax mexicanus 36.01 8.00e-113 401.00
IUUC-Bta-012966 Bos taurus 36.87 3.00e-123 437.00
IUUC-Cja-018780 Callithrix jacchus 36.87 6.00e-123 436.00
IUUC-Cfa-020975 Canis familiaris 36.70 1.00e-122 435.00
IUUC-Cpo-021331 Cavia porcellus 35.76 3.00e-118 420.00
IUUC-Csa-024226 Chlorocebus sabaeus 36.87 1.00e-122 435.00
IUUC-Cho-025058 Choloepus hoffmanni 38.06 3.00e-52 200.00
IUUC-Csv-026298 Ciona savignyi 28.79 3.00e-33 135.00
IUUC-Dre-028152 Danio rerio 36.45 1.00e-119 424.00
IUUC-Dno-029230 Dasypus novemcinctus 41.72 6.00e-122 432.00
IUUC-Dor-031103 Dipodomys ordii 37.30 2.00e-95 343.00
IUUC-Ete-032488 Echinops telfairi 38.70 9.00e-103 367.00
IUUC-Eca-033591 Equus caballus 35.88 2.00e-122 434.00
IUUC-Eeu-035199 Erinaceus europaeus 37.10 8.00e-46 179.00
IUUC-Fca-035791 Felis catus 36.70 1.00e-122 435.00
IUUC-Fal-037378 Ficedula albicollis 36.69 3.00e-117 416.00
IUUC-Gmo-039686 Gadus morhua 36.82 5.00e-115 408.00
IUUC-Gga-040881 Gallus gallus 36.22 1.00e-118 421.00
IUUC-Gac-042123 Gasterosteus aculeatus 37.09 3.00e-121 429.00
IUUC-Ggo-044643 Gorilla gorilla 42.18 1.00e-118 421.00
IUUC-Hsa-046436 Homo sapiens 36.87 4.00e-123 436.00
IUUC-Itr-048194 Ictidomys tridecemlineatus 36.87 5.00e-123 436.00
IUUC-Lch-050217 Latimeria chalumnae 36.19 3.00e-121 429.00
IUUC-Loc-052766 Lepisosteus oculatus 40.15 3.00e-118 419.00
IUUC-Laf-054046 Loxodonta africana 36.87 1.00e-122 434.00
IUUC-Mcc-055593 Macaca mulatta 36.87 4.00e-123 436.00
IUUC-Meu-056051 Macropus eugenii 42.94 1.00e-85 311.00
IUUC-Mga-059756 Meleagris gallopavo 36.22 4.00e-118 419.00
IUUC-Mmr-061182 Microcebus murinus 36.70 6.00e-123 436.00
IUUC-Mdo-062576 Monodelphis domestica 36.13 2.00e-118 419.00
IUUC-Mmu-063605 Mus musculus 36.80 9.00e-126 445.00
IUUC-Mpu-066446 Mustela putorius furo 36.70 7.00e-123 436.00
IUUC-Mlu-067261 Myotis lucifugus 36.70 8.00e-123 435.00
IUUC-Nle-069818 Nomascus leucogenys 36.87 8.00e-123 435.00
IUUC-Opr-070842 Ochotona princeps 39.84 2.00e-113 404.00
IUUC-Ont-072197 Oreochromis niloticus 36.76 7.00e-117 414.00
IUUC-Oan-073496 Ornithorhynchus anatinus 40.80 3.00e-120 426.00
IUUC-Ocu-074918 Oryctolagus cuniculus 36.87 4.00e-123 436.00
IUUC-Obr-076178 Oryza brachyantha 29.74 2.00e-13 70.50
IUUC-Olo-080702 Oryza longistaminata 38.18 5.00e-37 149.00
IUUC-Opu-083371 Oryza punctata 39.45 4.00e-39 155.00
IUUC-Ola-087518 Oryzias latipes 40.20 3.00e-111 394.00
IUUC-Oga-088743 Otolemur garnettii 36.70 2.00e-123 437.00
IUUC-Oar-090265 Ovis aries 36.87 4.00e-123 436.00
IUUC-Ptr-090521 Pan troglodytes 36.87 4.00e-123 436.00
IUUC-Pan-092752 Papio anubis 42.07 5.00e-116 411.00
IUUC-Psi-093620 Pelodiscus sinensis 35.35 3.00e-118 419.00
IUUC-Pma-094747 Petromyzon marinus 43.37 5.00e-87 315.00
IUUC-Pfo-096416 Poecilia formosa 35.57 6.00e-117 415.00
IUUC-Pab-098644 Pongo abelii 36.87 2.00e-122 434.00
IUUC-Pop-099927 Populus trichocarpa 27.03 8.00e-13 68.60
IUUC-Pca-100273 Procavia capensis 36.25 4.00e-116 412.00
IUUC-Pva-103094 Pteropus vampyrus 43.12 1.00e-113 405.00
IUUC-Rno-105803 Rattus norvegicus 36.70 2.00e-124 440.00
IUUC-Sha-107278 Sarcophilus harrisii 36.39 1.00e-120 428.00
IUUC-Sit-110333 Setaria italica 30.65 3.00e-13 69.30
IUUC-Sar-113310 Sorex araneus 35.34 5.00e-118 418.00
IUUC-Sbi-114254 Sorghum bicolor 28.43 6.00e-14 72.00
IUUC-Ssc-116193 Sus scrofa 36.87 2.00e-122 434.00
IUUC-Tgu-116786 Taeniopygia guttata 36.50 3.00e-119 422.00
IUUC-Tru-117638 Takifugu rubripes 36.89 5.00e-120 425.00
IUUC-Tsy-118830 Tarsius syrichta 36.87 1.00e-122 435.00
IUUC-Tni-120452 Tetraodon nigroviridis 36.54 3.00e-115 409.00
IUUC-Tca-121456 Theobroma cacao 33.69 3.00e-22 99.80
IUUC-Tbe-127291 Tupaia belangeri 39.23 1.00e-106 380.00
IUUC-Ttr-128240 Tursiops truncatus 33.92 3.00e-110 393.00
IUUC-Vpa-130666 Vicugna pacos 33.04 3.00e-103 369.00
IUUC-Xtr-132673 Xenopus tropicalis 31.09 2.00e-134 473.00
IUUC-Xma-133695 Xiphophorus maculatus 36.93 4.00e-116 412.00
Created Date 25-Jun-2017

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