iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-64	211.6	741	779
UBD/Beta-Prp	2.00e-116	388.7	610	784

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt+svt ++f +d  ll+s+s Dgt+k+WD+r+ +  k
   Q: 741  GHTNSVTHCRFsPDdELLASCSADGTLKLWDVRSANEKK 779
           8***********777*****************9987665 PP

UBD/Beta-Prp

   S: 89   tlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           +++ h+d v+   fs++g++++s ++d+t++v++ etg++l ++++ +d+v +c+ +++d+++++++s D++v++Wd+ tgkl++t ++
   Q: 610  VVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCA-FSSDDSYIATCSVDKKVKIWDSGTGKLVHTYEE 697
           4557888888888888888888888888888888888888887777666655554.555588888888888888888888888888887 PP
   S: 178  ghtdsvyslsfdsngke..lvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlh 263
            h ++v++  f+ ++++  l++gs+d+ +klwdl ++ec +t+ ght+ v+  rfsp+de+l+s+s+Dg++++Wd+rs +  k+++ +
   Q: 698  -HSEQVNCCHFTNKSNHllLATGSNDSFLKLWDLNQKECRNTMFGHTNSVTHCRFSPDDELLASCSADGTLKLWDVRSANEKKSINVK 784
           .888888888888885511568888888888888888888888888888888888888888888888888888888888888887765 PP

Organism

Rattus norvegicus

Functional Description
(View)

Regulates progammed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity).

Protein Sequence
(Fasta)

MDAKARNCLL QHKEALEKDI KTSYIMDHMI SNGVLTVVEE EKVKSQATQY QRAAALIKMI 60
LNKDNYAYIS FYNALLHEGY KDLAGLLHSG LPLVSSSSGK DTDGGNTSFV RTVLCEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGACGGGG CGGGCCCAGC TGTGTTTGAG TGCTCCGCGG TCCTGGGAGC CAGAGACCTG 60
GAGGAAGCGA GCTGGGTAGA CGGCTTTCTC CGCTCGCGGA AGGGTGTGAG AGGAGTGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0106--Calcium
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0031072--F:heat shock protein binding
GO:0042802--F:identical protein binding
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0007568--P:aging
GO:0007420--P:brain development
GO:0010659--P:cardiac muscle cell apoptotic process
GO:0030154--P:cell differentiation
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0030900--P:forebrain development
GO:0034349--P:glial cell apoptotic process
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:0051260--P:protein homooligomerization
GO:1902510--P:regulation of apoptotic DNA fragmentation
GO:0001666--P:response to hypoxia
GO:0007584--P:response to nutrient

KEGG

rno:78963

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	86.90	0.00e+00	2261.00
IUUC-Apl-004201	Anas platyrhynchos	70.02	0.00e+00	1818.00
IUUC-Aca-004638	Anolis carolinensis	67.76	0.00e+00	1805.00
IUUC-Ani-009285	Aspergillus nidulans	26.59	3.00e-70	261.00
IUUC-Ame-011062	Astyanax mexicanus	54.75	0.00e+00	1378.00
IUUC-Bta-012865	Bos taurus	86.87	0.00e+00	2299.00
IUUC-Cel-018376	Caenorhabditis elegans	21.78	1.00e-24	109.00
IUUC-Cja-018815	Callithrix jacchus	77.61	0.00e+00	1986.00
IUUC-Cfa-020222	Canis familiaris	82.49	0.00e+00	2119.00
IUUC-Cpo-021524	Cavia porcellus	86.07	0.00e+00	2249.00
IUUC-Csa-023861	Chlorocebus sabaeus	87.75	0.00e+00	2273.00
IUUC-Cho-024484	Choloepus hoffmanni	77.06	0.00e+00	1197.00
IUUC-Dre-028006	Danio rerio	53.66	0.00e+00	1269.00
IUUC-Dno-029591	Dasypus novemcinctus	87.99	0.00e+00	2318.00
IUUC-Dor-030237	Dipodomys ordii	73.83	0.00e+00	1075.00
IUUC-Ete-032620	Echinops telfairi	82.74	0.00e+00	1075.00
IUUC-Eca-033569	Equus caballus	87.51	0.00e+00	2281.00
IUUC-Eeu-035354	Erinaceus europaeus	63.62	2.00e-176	613.00
IUUC-Fca-036337	Felis catus	87.28	0.00e+00	2302.00
IUUC-Fal-037077	Ficedula albicollis	69.50	0.00e+00	1818.00
IUUC-Gmo-039687	Gadus morhua	50.82	0.00e+00	934.00
IUUC-Gga-040299	Gallus gallus	68.75	0.00e+00	1831.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.37	0.00e+00	1285.00
IUUC-Ggo-045563	Gorilla gorilla	87.83	0.00e+00	2285.00
IUUC-Hsa-046771	Homo sapiens	87.35	0.00e+00	2275.00
IUUC-Lch-050200	Latimeria chalumnae	64.09	0.00e+00	1634.00
IUUC-Loc-052090	Lepisosteus oculatus	59.71	0.00e+00	1523.00
IUUC-Laf-053861	Loxodonta africana	86.72	0.00e+00	2268.00
IUUC-Mcc-055543	Macaca mulatta	88.07	0.00e+00	2284.00
IUUC-Meu-056688	Macropus eugenii	78.43	0.00e+00	2024.00
IUUC-Mga-059243	Meleagris gallopavo	69.35	0.00e+00	1846.00
IUUC-Mmr-061134	Microcebus murinus	83.48	0.00e+00	1965.00
IUUC-Mdo-062913	Monodelphis domestica	77.80	0.00e+00	2038.00
IUUC-Mmu-063811	Mus musculus	96.08	0.00e+00	2504.00
IUUC-Mpu-066780	Mustela putorius furo	86.88	0.00e+00	2243.00
IUUC-Mlu-067276	Myotis lucifugus	87.04	0.00e+00	2286.00
IUUC-Nle-069129	Nomascus leucogenys	87.19	0.00e+00	2272.00
IUUC-Opr-071007	Ochotona princeps	65.22	0.00e+00	1105.00
IUUC-Ont-071348	Oreochromis niloticus	55.09	0.00e+00	1409.00
IUUC-Oan-072717	Ornithorhynchus anatinus	79.47	0.00e+00	2097.00
IUUC-Ocu-074286	Oryctolagus cuniculus	87.75	0.00e+00	1961.00
IUUC-Ola-086895	Oryzias latipes	50.58	0.00e+00	1206.00
IUUC-Oga-088678	Otolemur garnettii	88.63	0.00e+00	2309.00
IUUC-Oar-089359	Ovis aries	86.47	0.00e+00	2273.00
IUUC-Ptr-091062	Pan troglodytes	87.59	0.00e+00	2281.00
IUUC-Pan-092528	Papio anubis	89.68	0.00e+00	1339.00
IUUC-Psi-093430	Pelodiscus sinensis	72.73	0.00e+00	1924.00
IUUC-Pma-094690	Petromyzon marinus	38.77	2.00e-152	533.00
IUUC-Pfo-097204	Poecilia formosa	54.96	0.00e+00	1388.00
IUUC-Pab-097690	Pongo abelii	87.75	0.00e+00	2284.00
IUUC-Pca-100778	Procavia capensis	69.56	0.00e+00	1179.00
IUUC-Pva-102870	Pteropus vampyrus	84.99	0.00e+00	2053.00
IUUC-Pyt-104620	Pyrenophora triticirepentis	28.07	3.00e-62	234.00
IUUC-Sha-107465	Sarcophilus harrisii	77.53	0.00e+00	2068.00
IUUC-Sar-113268	Sorex araneus	85.47	0.00e+00	644.00
IUUC-Ssc-115654	Sus scrofa	86.47	0.00e+00	2279.00
IUUC-Tgu-117302	Taeniopygia guttata	70.06	0.00e+00	1837.00
IUUC-Tru-118363	Takifugu rubripes	54.77	0.00e+00	1391.00
IUUC-Tsy-119007	Tarsius syrichta	83.75	0.00e+00	2175.00
IUUC-Tni-120910	Tetraodon nigroviridis	53.60	0.00e+00	1336.00
IUUC-Tbe-127413	Tupaia belangeri	75.47	0.00e+00	1398.00
IUUC-Ttr-129213	Tursiops truncatus	80.46	0.00e+00	2076.00
IUUC-Vpa-130146	Vicugna pacos	81.72	0.00e+00	1579.00
IUUC-Xtr-132559	Xenopus tropicalis	59.90	0.00e+00	1538.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence