iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Acl-008239

Ensembl Protein ID

CADACLAP00004413

UniProt Accession

A1CIL1; CREB_ASPCL

Genbank Protein ID

EAW10716.1

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase creB; Carbon catabolite repression protein B; Deubiquitinating enzyme creB; Ubiquitin thioesterase creB; Ubiquitin-hydrolyzing enzyme creB; Ubiquitin-specific-processing protease creB

Genbank Nucleotide ID

DS027054

Gene Name

ACLA_051880; creB

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADACLAG00004514	CADACLAT00004514	CADACLAP00004413

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-94	315.9	68	480

Active Site

Position(s)	Description	Evidence
64	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
420	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.................................................... 42
           G++N gNtCY+NS+LQcL+   ++re++ + ++ +++ e+                                                     
   Q: 68   GMENYGNTCYCNSILQCLYYSVPFREAVIN-YPTRTPIESLeaalakslrypnpnahleaeaqaekqraanaqrpgmppaqpqkpedkdspdy 159
           9*****************************.5555544443556666666777778888888899999999999*************999999 PP
   S: 43   ....................kepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknk 113
                                +++++l +sl+++fe+++  +s+ + v p+++l++l++ +e+f++ ++qDa+Efl+ ll+++  +++ e++k
   Q: 160  kkkmalqtlplleaqnnatsYGMSESLFTSLKDIFESVVgsQSRIGIVRPQQFLDVLRRDHEMFRTAMHQDAHEFLNLLLNEVVANVEAEASK 252
           9999999999999999999999999*************99999999*****************************************775555 PP
   S: 114  pkeeeeeedkselsde........aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkee 198
           +    e++    ++d+        ++ +k+  ++ ++++lF+g+l+s+++cl+c++vs+r+e fldls+++++++     s+++cL++f++ee
   Q: 253  QPAAIEKSL--PAPDHaetvdqsaSSGSKTPNTTRWVHELFEGTLTSETQCLTCEKVSQRDEIFLDLSVDLEQHS-----SVTSCLRKFSAEE 338
           544443333..44444455555657777777888*****************************************.....9************ PP
   S: 199  elegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.sl 290
           +l+++nk++c++c ++qeaek++k+k+lP++L lhLkRf+++e+ ++ +k++ +v +p +L l  f+t+++ ++  ++ YeL+avvvH G ++
   Q: 339  MLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRL--FNTTDDAED-PDRLYELYAVVVHIGgGP 428
           **********************************************************88887..566645544.49**************** PP
   S: 291  ssGHYvayvknekgkWllfdDskVtevkeeevleetg.....staYvlfYkr 337
            +GHYva++k e+++WllfdD+ V++v+++ v ++ g     + aYvlfY++
   Q: 429  YHGHYVAIIKTEDRGWLLFDDELVEPVDKNYVRNFFGdkpglACAYVLFYQE 480
           **********************************999*************97 PP

Organism

Aspergillus clavatus

Functional Description
(View)

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).

Protein Sequence
(Fasta)

MRYDFPRQLL CLPVLPSAWK TFFFGSTTPS VGAVPAKKEV PIPPMTPLEK RLLDMGSIRG 60
DGSDKFYGME NYGNTCYCNS ILQCLYYSVP FREAVINYPT RTPIESLEAA LAKSLRYPNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGGTATG ATTTCCCCCG GCAGTTGCTG TGCTTGCCTG TCCTGCCCTC CGCATGGAAG 60
ACGTTTTTCT TTGTGTGTTC GCAAACCGAT ATCACGACGA CACCAATATC CTTTTTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0045013--P:carbon catabolite repression of transcription
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

act:ACLA_051880

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000193	Aegilops tauschii	45.19	6.00e-82	295.00
IUUC-Aml-001964	Ailuropoda melanoleuca	50.00	1.00e-84	304.00
IUUC-Atr-002650	Amborella trichopoda	47.25	4.00e-82	296.00
IUUC-Apl-003411	Anas platyrhynchos	49.67	8.00e-84	301.00
IUUC-Aca-005212	Anolis carolinensis	50.33	3.00e-84	303.00
IUUC-Aly-005830	Arabidopsis lyrata	46.62	6.00e-77	278.00
IUUC-Ath-006663	Arabidopsis thaliana	47.00	5.00e-80	289.00
IUUC-Ago-007871	Ashbya gossypii	40.91	4.00e-63	234.00
IUUC-Afl-008602	Aspergillus flavus	73.78	0.00e+00	937.00
IUUC-Afu-008816	Aspergillus fumigatus	90.43	0.00e+00	925.00
IUUC-Ani-009137	Aspergillus nidulans	79.73	0.00e+00	786.00
IUUC-Ang-009703	Aspergillus niger	73.90	0.00e+00	863.00
IUUC-Aor-009901	Aspergillus oryzae	70.69	0.00e+00	838.00
IUUC-Ate-010431	Aspergillus terreus	73.39	0.00e+00	883.00
IUUC-Ame-011015	Astyanax mexicanus	50.67	4.00e-86	309.00
IUUC-Bgr-012071	Blumeria graminis	47.14	9.00e-161	558.00
IUUC-Bta-012981	Bos taurus	50.67	4.00e-85	306.00
IUUC-Bci-013837	Botrytis cinerea	56.42	7.00e-173	598.00
IUUC-Bdi-014008	Brachypodium distachyon	45.86	1.00e-80	291.00
IUUC-Bol-015409	Brassica oleracea	47.37	2.00e-77	281.00
IUUC-Bra-016956	Brassica rapa	47.70	2.00e-78	284.00
IUUC-Cel-018379	Caenorhabditis elegans	41.07	1.00e-73	268.00
IUUC-Cja-018831	Callithrix jacchus	50.33	8.00e-85	305.00
IUUC-Cfa-020534	Canis familiaris	49.67	5.00e-84	302.00
IUUC-Cpo-021703	Cavia porcellus	50.00	2.00e-84	303.00
IUUC-Cre-022711	Chlamydomonas reinhardtii	45.75	9.00e-66	241.00
IUUC-Csa-023841	Chlorocebus sabaeus	47.67	2.00e-79	286.00
IUUC-Cho-024902	Choloepus hoffmanni	39.67	6.00e-57	212.00
IUUC-Cin-025659	Ciona intestinalis	39.83	6.00e-70	256.00
IUUC-Csv-025828	Ciona savignyi	50.22	1.00e-63	234.00
IUUC-Cgl-026611	Colletotrichum gloeosporioides	55.58	5.00e-174	602.00
IUUC-Cne-026900	Cryptococcus neoformans	42.35	1.00e-64	239.00
IUUC-Cme-027339	Cyanidioschyzon merolae	31.60	4.00e-36	144.00
IUUC-Dre-027845	Danio rerio	50.33	6.00e-86	308.00
IUUC-Dno-029460	Dasypus novemcinctus	49.33	4.00e-84	303.00
IUUC-Dor-030972	Dipodomys ordii	52.29	6.00e-75	272.00
IUUC-Dse-031470	Dothistroma septosporum	53.50	4.00e-175	606.00
IUUC-Dme-032038	Drosophila melanogaster	56.06	2.00e-67	248.00
IUUC-Ete-032659	Echinops telfairi	54.24	1.00e-54	204.00
IUUC-Eca-033439	Equus caballus	50.00	1.00e-84	304.00
IUUC-Eeu-034916	Erinaceus europaeus	50.41	1.00e-64	238.00
IUUC-Fca-035524	Felis catus	49.67	3.00e-84	303.00
IUUC-Fal-036833	Ficedula albicollis	50.67	3.00e-84	303.00
IUUC-Fox-037682	Fusarium oxysporum	60.50	4.00e-167	579.00
IUUC-Fso-038299	Fusarium solani	58.76	6.00e-157	546.00
IUUC-Gmo-038763	Gadus morhua	49.83	1.00e-84	305.00
IUUC-Ggr-039806	Gaeumannomyces graminis	58.87	1.00e-174	604.00
IUUC-Gga-041151	Gallus gallus	49.67	6.00e-84	302.00
IUUC-Gac-041967	Gasterosteus aculeatus	50.00	2.00e-85	307.00
IUUC-Gma-043101	Glycine max	47.57	4.00e-83	299.00
IUUC-Ggo-044659	Gorilla gorilla	47.67	3.00e-79	286.00
IUUC-Hsa-045700	Homo sapiens	50.33	8.00e-85	305.00
IUUC-Hvu-047692	Hordeum vulgare	45.95	3.00e-81	293.00
IUUC-Itr-049082	Ictidomys tridecemlineatus	50.00	2.00e-84	304.00
IUUC-Kpa-049250	Komagataella pastoris	48.02	7.00e-94	336.00
IUUC-Lch-050435	Latimeria chalumnae	50.33	7.00e-84	302.00
IUUC-Lpe-051368	Leersia perrieri	44.98	2.00e-78	283.00
IUUC-Loc-051968	Lepisosteus oculatus	49.67	2.00e-83	300.00
IUUC-Lma-053300	Leptosphaeria maculans	58.26	0.00e+00	637.00
IUUC-Laf-053887	Loxodonta africana	50.00	1.00e-84	304.00
IUUC-Mcc-055701	Macaca mulatta	50.33	8.00e-85	305.00
IUUC-Mor-057072	Magnaporthe oryzae	62.11	1.00e-172	598.00
IUUC-Mpo-057424	Magnaporthe poae	58.91	3.00e-176	610.00
IUUC-Mtr-057715	Medicago truncatula	47.63	4.00e-82	296.00
IUUC-Mla-059142	Melampsora laricipopulina	54.67	2.00e-100	358.00
IUUC-Mga-059195	Meleagris gallopavo	49.67	1.00e-83	301.00
IUUC-Mvi-060357	Microbotryum violaceum	55.79	1.00e-85	309.00
IUUC-Mmr-060751	Microcebus murinus	50.00	1.00e-84	304.00
IUUC-Mdo-062735	Monodelphis domestica	50.00	1.00e-84	304.00
IUUC-Mmu-063263	Mus musculus	50.00	3.00e-84	303.00
IUUC-Mac-065323	Musa acuminata	47.25	8.00e-78	281.00
IUUC-Mpu-066038	Mustela putorius furo	48.00	2.00e-79	287.00
IUUC-Mlu-068128	Myotis lucifugus	50.00	1.00e-84	304.00
IUUC-Nfi-068611	Neosartorya fischeri	80.35	0.00e+00	1009.00
IUUC-Ncr-068699	Neurospora crassa	58.54	1.00e-173	602.00
IUUC-Nle-069767	Nomascus leucogenys	50.33	9.00e-85	305.00
IUUC-Opr-070980	Ochotona princeps	47.67	3.00e-79	286.00
IUUC-Ont-072658	Oreochromis niloticus	50.67	1.00e-85	308.00
IUUC-Oan-073372	Ornithorhynchus anatinus	49.67	3.00e-83	300.00
IUUC-Ocu-074322	Oryctolagus cuniculus	50.33	2.00e-84	304.00
IUUC-Oba-075220	Oryza barthii	44.98	2.00e-78	284.00
IUUC-Obr-076208	Oryza brachyantha	47.57	6.00e-75	272.00
IUUC-Ogl-077216	Oryza glaberrima	44.98	2.00e-78	284.00
IUUC-Ogu-078836	Oryza glumaepatula	44.98	2.00e-78	284.00
IUUC-Oin-079522	Oryza indica	44.98	2.00e-78	284.00
IUUC-Olo-080882	Oryza longistaminata	44.98	2.00e-78	284.00
IUUC-Ome-081549	Oryza meridionalis	44.98	2.00e-78	284.00
IUUC-Oni-082982	Oryza nivara	44.98	2.00e-78	284.00
IUUC-Opu-083532	Oryza punctata	45.31	6.00e-79	285.00
IUUC-Oru-084568	Oryza rufipogon	44.98	2.00e-78	284.00
IUUC-Osa-085299	Oryza sativa	44.98	2.00e-78	284.00
IUUC-Ola-087418	Oryzias latipes	50.67	9.00e-86	308.00
IUUC-Olu-087809	Ostreococcus lucimarinus	45.67	5.00e-65	239.00
IUUC-Oga-088298	Otolemur garnettii	50.00	2.00e-84	303.00
IUUC-Oar-090269	Ovis aries	50.67	1.00e-84	305.00
IUUC-Ptr-090467	Pan troglodytes	50.33	8.00e-85	305.00
IUUC-Pan-092437	Papio anubis	50.17	2.00e-83	300.00
IUUC-Psi-092993	Pelodiscus sinensis	49.67	4.00e-84	303.00
IUUC-Pma-094388	Petromyzon marinus	48.68	1.00e-80	291.00
IUUC-Pno-095044	Phaeosphaeria nodorum	58.54	1.00e-179	621.00
IUUC-Ppa-095415	Physcomitrella patens	49.34	2.00e-82	297.00
IUUC-Pfo-097052	Poecilia formosa	51.00	5.00e-86	309.00
IUUC-Pab-097797	Pongo abelii	50.33	8.00e-85	305.00
IUUC-Pop-099798	Populus trichocarpa	48.29	3.00e-83	300.00
IUUC-Pca-100835	Procavia capensis	51.65	2.00e-68	250.00
IUUC-Ppe-101474	Prunus persica	47.30	3.00e-82	296.00
IUUC-Pva-102878	Pteropus vampyrus	50.00	2.00e-84	303.00
IUUC-Pgr-103306	Puccinia graminis	54.72	2.00e-104	372.00
IUUC-Pte-104356	Pyrenophora teres	58.47	0.00e+00	632.00
IUUC-Pyt-104709	Pyrenophora triticirepentis	58.47	7.00e-158	548.00
IUUC-Rno-106060	Rattus norvegicus	50.33	6.00e-85	305.00
IUUC-Sce-106367	Saccharomyces cerevisiae	40.94	3.00e-73	268.00
IUUC-Sha-107087	Sarcophilus harrisii	50.00	1.00e-84	304.00
IUUC-Sja-107684	Schizosaccharomyces japonicus	43.40	1.00e-97	348.00
IUUC-Spo-108095	Schizosaccharomyces pombe	45.67	3.00e-110	390.00
IUUC-Smo-108674	Selaginella moellendorffii	50.33	1.00e-85	308.00
IUUC-Sit-110819	Setaria italica	45.37	5.00e-80	289.00
IUUC-Sly-111210	Solanum lycopersicum	48.22	8.00e-83	298.00
IUUC-Stu-112398	Solanum tuberosum	48.00	2.00e-79	287.00
IUUC-Sar-113216	Sorex araneus	49.33	4.00e-82	296.00
IUUC-Sbi-114724	Sorghum bicolor	46.30	2.00e-81	294.00
IUUC-Sre-115197	Sporisorium reilianum	55.32	2.00e-93	335.00
IUUC-Ssc-116321	Sus scrofa	50.33	8.00e-85	305.00
IUUC-Tgu-117482	Taeniopygia guttata	50.33	1.00e-82	298.00
IUUC-Tru-118613	Takifugu rubripes	50.67	8.00e-86	308.00
IUUC-Tsy-119520	Tarsius syrichta	54.90	2.00e-59	220.00
IUUC-Tni-120293	Tetraodon nigroviridis	50.67	8.00e-86	308.00
IUUC-Tca-121329	Theobroma cacao	48.33	2.00e-81	294.00
IUUC-Tre-122226	Trichoderma reesei	52.61	8.00e-163	565.00
IUUC-Tvi-122330	Trichoderma virens	59.26	7.00e-161	558.00
IUUC-Tae-125280	Triticum aestivum	45.63	8.00e-82	295.00
IUUC-Tur-126563	Triticum urartu	46.18	4.00e-82	296.00
IUUC-Tme-126890	Tuber melanosporum	66.86	3.00e-136	476.00
IUUC-Tbe-127783	Tupaia belangeri	50.00	1.00e-84	304.00
IUUC-Ttr-129083	Tursiops truncatus	50.33	6.00e-85	305.00
IUUC-Uma-129409	Ustilago maydis	55.09	1.00e-92	333.00
IUUC-Vda-129736	Verticillium dahliae	50.00	2.00e-146	511.00
IUUC-Vpa-130391	Vicugna pacos	47.00	3.00e-75	273.00
IUUC-Vvi-131371	Vitis vinifera	47.90	9.00e-83	298.00
IUUC-Xtr-132082	Xenopus tropicalis	48.68	7.00e-82	295.00
IUUC-Xma-133475	Xiphophorus maculatus	51.00	5.00e-86	309.00
IUUC-Yli-134632	Yarrowia lipolytica	60.11	5.00e-125	440.00
IUUC-Zma-134951	Zea mays	45.86	2.00e-80	290.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence