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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063636
UUCD1 version UUC-MuM-00976
Ensembl Protein ID ENSMUSP00000073652.5
UniProt Accession Q9ES34; Q8K068; UBE3B_MOUSE
Genbank Protein ID AAG16783.3; AAH23956.1; AAH34059.1; AAH96743.1
Protein Name Ubiquitin-protein ligase E3B; HECT-type ubiquitin transferase E3B
Genbank Nucleotide ID AF244362; BC023956; BC034059; BC096743
Gene Name Ube3b
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029577.13 ENSMUST00000074002.11 ENSMUSP00000073652.5
ENSMUSG00000029577.13 ENSMUST00000130169.7 ENSMUSP00000138723.1
ENSMUSG00000029577.13 ENSMUST00000151809.2 ENSMUSP00000142943.1
ENSMUSG00000029577.13 ENSMUST00000196651.4 ENSMUSP00000143455.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusPHOSIDA
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.50e-112 377.5 705 1070
Active Site
Position(s) Description Evidence
1038 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           ++++k +++v+fv+     E+g+d++Gv++efl++++k++++p l+lf+++++d++ l+p+p+s++++ ++l+lFef+G++lgka++
   Q: 705  QHAMKGVIRVKFVNdlgvdEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHE-NYLQLFEFVGKMLGKAVY 789
           7899********************************************99987665.59*******76.****************** PP
   S: 84   dgrlldlplsksfyklllgk.....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           +g ++d+p++++f++++lg+       s+++l+++d+e+yk+l++ik++ + di +lgl+l++  +e+++g+  ++eL+pgG++ipV
   Q: 790  EGIVVDVPFASFFLSQMLGHhhsvfYSSVDELPSLDSEFYKNLTSIKRY-DGDIADLGLTLSY--DEDVMGQLVCHELVPGGKTIPV 873
           ********************777777999********************.6788887777766..6999****************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwe 251
           t eNk +Y++l++++r++++ik+q++a+ +Gf+++i++e++++F++ el+ li+G+ +eid+edlkk+t y gg++ ++++i+w+w+
   Q: 874  TDENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDnAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD 960
           ********************************************************9****************************** PP
   S: 252  vl.eefsseerkafLqFvTgssrlPlgGfaelk........................prlfvirkdasddrlPssnTCfnyLkLPeY 313
           +l ++f+ eer++fL+FvT++sr Pl Gfa+lk                        + +f+irk +   rlP+s+TCfn+LkLP+Y
   Q: 961  ILaSDFTPEERAMFLKFVTSCSRPPLLGFAYLKppfsircvevsddqdtgdtlgsvlRGFFTIRKREPGGRLPTSSTCFNLLKLPNY 1047
           **99*************************************************************8888****************** PP
   S: 314  sskeilkekLlyAieetkgFels 336
           s+k++l+ekL+yAi++++gFels
   Q: 1048 SKKSVLREKLRYAISMNTGFELS 1070
           ********************985 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MFTVSQTSRA WFIDRARQAR EERLVQKERE RSAVTIQALV RSFLCRRRLH RDIRKEIDEF 60
FSADESGSSK RSALCIFKIA RRLLFICKTT EDSERLEKLC RSILNSMDAE NEPKVWYVSL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063636|E3,HECT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTAAGCCCTA GATGGGGGGA ACTCTTTTTA TCAACCGTTC CCGCCTCCCC TTGGCCGAGT 60
CAGGCGTTTA GTCCCACTTC TGGATGTTTG TTTCTCCTTT CCGTCTGCTA AAGAAGATGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063636|E3,HECT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS
PROSITE

PS50237--HECT
PS50096--IQ
Pfam

PF00632--HECT
PF00612--IQ
SMART

SM00119--HECTc
Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
KEGG mmu:117146
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000128 Aegilops tauschii 39.29 1.00e-105 378.00
IUUC-Aml-002107 Ailuropoda melanoleuca 92.24 0.00e+00 2008.00
IUUC-Atr-003017 Amborella trichopoda 38.10 1.00e-109 391.00
IUUC-Apl-003328 Anas platyrhynchos 86.06 0.00e+00 1818.00
IUUC-Aly-005794 Arabidopsis lyrata 38.97 8.00e-109 389.00
IUUC-Ath-007269 Arabidopsis thaliana 39.50 2.00e-111 397.00
IUUC-Bta-013547 Bos taurus 92.24 0.00e+00 2029.00
IUUC-Bdi-014502 Brachypodium distachyon 38.76 2.00e-109 390.00
IUUC-Bol-015093 Brassica oleracea 40.21 6.00e-113 402.00
IUUC-Bra-016722 Brassica rapa 40.04 3.00e-113 403.00
IUUC-Cel-018447 Caenorhabditis elegans 38.80 0.00e+00 696.00
IUUC-Cja-019855 Callithrix jacchus 92.34 0.00e+00 2011.00
IUUC-Cfa-020066 Canis familiaris 91.78 0.00e+00 1982.00
IUUC-Cpo-021504 Cavia porcellus 91.40 0.00e+00 2014.00
IUUC-Csa-023579 Chlorocebus sabaeus 92.62 0.00e+00 2018.00
IUUC-Cho-024430 Choloepus hoffmanni 81.66 0.00e+00 1474.00
IUUC-Cin-025750 Ciona intestinalis 46.42 0.00e+00 959.00
IUUC-Csv-026016 Ciona savignyi 47.35 0.00e+00 1009.00
IUUC-Dre-028271 Danio rerio 79.53 0.00e+00 1730.00
IUUC-Dno-029054 Dasypus novemcinctus 92.99 0.00e+00 2021.00
IUUC-Dor-030938 Dipodomys ordii 92.81 0.00e+00 1177.00
IUUC-Dme-031602 Drosophila melanogaster 47.79 0.00e+00 962.00
IUUC-Ete-033041 Echinops telfairi 73.99 0.00e+00 1324.00
IUUC-Eca-034411 Equus caballus 93.18 0.00e+00 1998.00
IUUC-Eeu-035201 Erinaceus europaeus 84.48 0.00e+00 806.00
IUUC-Fca-036594 Felis catus 91.50 0.00e+00 1967.00
IUUC-Fal-037317 Ficedula albicollis 82.87 0.00e+00 1830.00
IUUC-Gmo-039412 Gadus morhua 77.02 0.00e+00 1706.00
IUUC-Gga-040149 Gallus gallus 86.17 0.00e+00 1853.00
IUUC-Gac-042088 Gasterosteus aculeatus 78.64 0.00e+00 1783.00
IUUC-Gma-042728 Glycine max 39.75 6.00e-111 395.00
IUUC-Ggo-045279 Gorilla gorilla 92.43 0.00e+00 2014.00
IUUC-Hsa-045660 Homo sapiens 92.15 0.00e+00 2009.00
IUUC-Hvu-047102 Hordeum vulgare 39.12 3.00e-105 376.00
IUUC-Itr-048021 Ictidomys tridecemlineatus 89.69 0.00e+00 1008.00
IUUC-Lch-050664 Latimeria chalumnae 81.05 0.00e+00 1800.00
IUUC-Lpe-050755 Leersia perrieri 37.10 2.00e-98 353.00
IUUC-Loc-052791 Lepisosteus oculatus 80.91 0.00e+00 1752.00
IUUC-Laf-053902 Loxodonta africana 92.43 0.00e+00 2018.00
IUUC-Mcc-054730 Macaca mulatta 92.52 0.00e+00 2017.00
IUUC-Meu-056527 Macropus eugenii 78.26 0.00e+00 1652.00
IUUC-Mtr-057671 Medicago truncatula 39.40 2.00e-111 397.00
IUUC-Mga-059260 Meleagris gallopavo 85.91 0.00e+00 1848.00
IUUC-Mmr-060804 Microcebus murinus 92.43 0.00e+00 1964.00
IUUC-Mdo-062575 Monodelphis domestica 82.82 0.00e+00 1774.00
IUUC-Mac-064989 Musa acuminata 38.69 2.00e-106 380.00
IUUC-Mpu-066677 Mustela putorius furo 92.25 0.00e+00 1885.00
IUUC-Mlu-067952 Myotis lucifugus 92.15 0.00e+00 1939.00
IUUC-Nle-069153 Nomascus leucogenys 92.15 0.00e+00 2008.00
IUUC-Opr-070554 Ochotona princeps 91.93 0.00e+00 1835.00
IUUC-Ont-071372 Oreochromis niloticus 79.83 0.00e+00 1764.00
IUUC-Oan-073327 Ornithorhynchus anatinus 69.51 0.00e+00 716.00
IUUC-Ocu-074183 Oryctolagus cuniculus 92.15 0.00e+00 1991.00
IUUC-Oba-075213 Oryza barthii 38.65 2.00e-106 380.00
IUUC-Obr-076320 Oryza brachyantha 39.15 3.00e-109 390.00
IUUC-Ogl-077093 Oryza glaberrima 38.82 4.00e-109 389.00
IUUC-Ogu-078947 Oryza glumaepatula 36.65 3.00e-109 390.00
IUUC-Oin-080058 Oryza indica 38.82 1.00e-108 388.00
IUUC-Olo-080742 Oryza longistaminata 38.65 6.00e-108 386.00
IUUC-Ome-081741 Oryza meridionalis 38.10 7.00e-101 362.00
IUUC-Oni-082385 Oryza nivara 36.65 3.00e-109 390.00
IUUC-Opu-083529 Oryza punctata 38.82 5.00e-109 389.00
IUUC-Oru-085128 Oryza rufipogon 36.43 4.00e-95 343.00
IUUC-Osa-085557 Oryza sativa 39.08 3.00e-108 385.00
IUUC-Ola-087337 Oryzias latipes 79.18 0.00e+00 1701.00
IUUC-Oga-088342 Otolemur garnettii 92.25 0.00e+00 1914.00
IUUC-Oar-090234 Ovis aries 91.60 0.00e+00 1994.00
IUUC-Ptr-091661 Pan troglodytes 92.52 0.00e+00 2017.00
IUUC-Pan-092728 Papio anubis 92.34 0.00e+00 2012.00
IUUC-Psi-093251 Pelodiscus sinensis 84.61 0.00e+00 1698.00
IUUC-Pma-094195 Petromyzon marinus 69.55 0.00e+00 1438.00
IUUC-Ppa-095544 Physcomitrella patens 37.70 2.00e-109 390.00
IUUC-Pfo-097472 Poecilia formosa 79.44 0.00e+00 1767.00
IUUC-Pab-098570 Pongo abelii 92.15 0.00e+00 2011.00
IUUC-Pca-100110 Procavia capensis 81.21 0.00e+00 1693.00
IUUC-Ppe-101281 Prunus persica 38.34 1.00e-106 381.00
IUUC-Pva-102887 Pteropus vampyrus 87.68 0.00e+00 1873.00
IUUC-Rno-106028 Rattus norvegicus 92.34 0.00e+00 1917.00
IUUC-Sha-107331 Sarcophilus harrisii 83.86 0.00e+00 1789.00
IUUC-Smo-109488 Selaginella moellendorffii 37.14 1.00e-105 378.00
IUUC-Sit-109811 Setaria italica 38.87 9.00e-109 388.00
IUUC-Sly-111362 Solanum lycopersicum 35.32 1.00e-100 361.00
IUUC-Sar-113287 Sorex araneus 81.35 0.00e+00 690.00
IUUC-Sbi-114433 Sorghum bicolor 39.22 3.00e-109 390.00
IUUC-Ssc-116103 Sus scrofa 92.71 0.00e+00 1991.00
IUUC-Tgu-117275 Taeniopygia guttata 85.89 0.00e+00 1837.00
IUUC-Tru-118681 Takifugu rubripes 78.50 0.00e+00 1778.00
IUUC-Tsy-118985 Tarsius syrichta 86.60 0.00e+00 986.00
IUUC-Tni-120850 Tetraodon nigroviridis 91.23 0.00e+00 775.00
IUUC-Tca-121770 Theobroma cacao 39.22 9.00e-112 398.00
IUUC-Tae-125466 Triticum aestivum 36.04 7.00e-106 379.00
IUUC-Tur-126086 Triticum urartu 39.29 3.00e-105 377.00
IUUC-Tbe-127461 Tupaia belangeri 87.94 0.00e+00 1832.00
IUUC-Ttr-129269 Tursiops truncatus 91.78 0.00e+00 1965.00
IUUC-Vpa-130523 Vicugna pacos 79.47 3.00e-121 429.00
IUUC-Vvi-131524 Vitis vinifera 38.72 1.00e-108 388.00
IUUC-Xtr-132146 Xenopus tropicalis 82.00 0.00e+00 1801.00
IUUC-Xma-133526 Xiphophorus maculatus 79.07 0.00e+00 1760.00
Created Date 25-Jun-2017

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