iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-097580

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01346426

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000010936.2	ENSPPYT00000012692.2	ENSPPYP00000012212.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-135	452.5	516	848

Active Site

Position(s)	Description	Evidence
817	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 516  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 603
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ v+e
   Q: 604  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE 689
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ +t++s++i wFw++++e+++e+r ++LqFv
   Q: 690  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-FTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 777
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 778  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 848
           *********************************************************************96 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MSDSGSQLGS MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCNNT 60
NSPKWKQSLT VIVTPVSKLH FRVWSHQTLK SDVLLGTAAL DIYETLKSNN MKLEEVVVTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAATAAGCTC TCTAGGTGAT TCTGATGCAC ACCATAGTTT AAGAATCACA GTCCTTATAG 60
GCTCTGGTGG GCGGGGTGTT AAAAAAAAAA AAAAAAAAAA AAAAAAAGCC TGGAGGTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	85.15	0.00e+00	1443.00
IUUC-Apl-003752	Anas platyrhynchos	72.14	0.00e+00	1265.00
IUUC-Aca-005338	Anolis carolinensis	71.06	0.00e+00	1246.00
IUUC-Ame-010601	Astyanax mexicanus	84.04	0.00e+00	982.00
IUUC-Bta-012782	Bos taurus	84.94	0.00e+00	1412.00
IUUC-Cja-018899	Callithrix jacchus	89.64	0.00e+00	1498.00
IUUC-Cfa-020648	Canis familiaris	83.97	0.00e+00	1407.00
IUUC-Cpo-022073	Cavia porcellus	85.83	0.00e+00	1456.00
IUUC-Csa-023252	Chlorocebus sabaeus	86.16	0.00e+00	1467.00
IUUC-Cho-024695	Choloepus hoffmanni	82.72	0.00e+00	1456.00
IUUC-Dre-028451	Danio rerio	61.37	0.00e+00	1043.00
IUUC-Dno-029884	Dasypus novemcinctus	84.94	0.00e+00	1480.00
IUUC-Eca-033793	Equus caballus	85.71	0.00e+00	1468.00
IUUC-Eeu-034716	Erinaceus europaeus	92.79	0.00e+00	890.00
IUUC-Fca-035605	Felis catus	84.93	0.00e+00	1459.00
IUUC-Fal-037126	Ficedula albicollis	65.61	0.00e+00	1160.00
IUUC-Gmo-038596	Gadus morhua	75.82	0.00e+00	873.00
IUUC-Gga-040832	Gallus gallus	72.05	0.00e+00	1279.00
IUUC-Gac-041520	Gasterosteus aculeatus	83.97	0.00e+00	982.00
IUUC-Ggo-044535	Gorilla gorilla	83.61	0.00e+00	1434.00
IUUC-Hsa-046564	Homo sapiens	91.25	0.00e+00	1572.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	84.83	0.00e+00	1389.00
IUUC-Lch-050454	Latimeria chalumnae	62.41	0.00e+00	1129.00
IUUC-Loc-052647	Lepisosteus oculatus	68.78	0.00e+00	1222.00
IUUC-Laf-054383	Loxodonta africana	85.94	0.00e+00	1462.00
IUUC-Mcc-055532	Macaca mulatta	86.38	0.00e+00	1469.00
IUUC-Mga-059661	Meleagris gallopavo	71.83	0.00e+00	1271.00
IUUC-Mmr-061135	Microcebus murinus	85.83	0.00e+00	1483.00
IUUC-Mdo-062505	Monodelphis domestica	76.16	0.00e+00	1314.00
IUUC-Mmu-063375	Mus musculus	83.65	0.00e+00	1406.00
IUUC-Mpu-066203	Mustela putorius furo	85.49	0.00e+00	1446.00
IUUC-Mlu-067837	Myotis lucifugus	85.16	0.00e+00	1464.00
IUUC-Nle-069244	Nomascus leucogenys	85.64	0.00e+00	1449.00
IUUC-Opr-070585	Ochotona princeps	84.05	0.00e+00	1427.00
IUUC-Ont-071822	Oreochromis niloticus	67.40	0.00e+00	1187.00
IUUC-Oan-073679	Ornithorhynchus anatinus	67.32	0.00e+00	987.00
IUUC-Ocu-074298	Oryctolagus cuniculus	85.64	0.00e+00	1443.00
IUUC-Ola-086526	Oryzias latipes	58.19	0.00e+00	1046.00
IUUC-Oga-088167	Otolemur garnettii	85.63	0.00e+00	1470.00
IUUC-Oar-090316	Ovis aries	69.17	0.00e+00	1018.00
IUUC-Ptr-090819	Pan troglodytes	90.03	0.00e+00	1520.00
IUUC-Pan-092454	Papio anubis	86.38	0.00e+00	1469.00
IUUC-Psi-093319	Pelodiscus sinensis	71.44	0.00e+00	1245.00
IUUC-Pfo-096937	Poecilia formosa	84.40	0.00e+00	989.00
IUUC-Pca-100923	Procavia capensis	68.22	0.00e+00	1176.00
IUUC-Pva-103209	Pteropus vampyrus	84.27	0.00e+00	1415.00
IUUC-Rno-104924	Rattus norvegicus	83.43	0.00e+00	1414.00
IUUC-Sha-107175	Sarcophilus harrisii	77.72	0.00e+00	1322.00
IUUC-Sar-113761	Sorex araneus	79.18	0.00e+00	1339.00
IUUC-Tgu-116632	Taeniopygia guttata	66.01	0.00e+00	1121.00
IUUC-Tru-118442	Takifugu rubripes	83.67	0.00e+00	986.00
IUUC-Tsy-119198	Tarsius syrichta	79.29	0.00e+00	1342.00
IUUC-Tni-120168	Tetraodon nigroviridis	83.20	0.00e+00	919.00
IUUC-Tbe-127756	Tupaia belangeri	87.97	0.00e+00	879.00
IUUC-Ttr-128504	Tursiops truncatus	76.96	0.00e+00	1010.00
IUUC-Vpa-130103	Vicugna pacos	75.55	0.00e+00	1242.00
IUUC-Xtr-132885	Xenopus tropicalis	70.29	0.00e+00	1246.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence