iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093319

Ensembl Protein ID

ENSPSIP00000007810.1

UniProt Accession

K7FIF0; K7FIF0_PELSI

Genbank Protein ID

ENSPSIP00000007810

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AGCU01143587

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000006924.1	ENSPSIT00000007851.1	ENSPSIP00000007810.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.00e-136	452.8	512	844

Active Site

Position(s)	Description	Evidence
813	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++ r++d+
   Q: 512  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHVRFIDT 599
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k+  l+dle+vdpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G+n+ Vt+eNkeeY++lv++
   Q: 600  GFSLPFYKRMLNKPTGLKDLESVDPEFYNSLIWVKEN---NIEECGLEMYFSVDNEILGEIKSHDLKPNGSNVLVTEENKEEYIRLVAD 685
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 686  WRISRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 773
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 774  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 844
           *********************************************************************96 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MKSQLQITVI SAKLKENKNK WFGPSPYVEV SVDGQSKKTE KCNNTNSPKW KQHLTVIVTP 60
VSKLNFRVWS HQTLKSDVLL GSATLDVRET LKSNNMKLEQ VIVTLQLVSD REPAEVIGDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCAAGGCC CAGTTCGTAA TATGGCTGGC ACTGGGCCAA GATCAGGAAT GAAATCACAG 60
CTTCAGATTA CTGGTAAGTC TTTCAAAAGA TTAAATGTTT TCTCCCCATT CCTGGAAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

KEGG

pss:102444318

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	82.22	0.00e+00	1400.00
IUUC-Apl-003752	Anas platyrhynchos	87.73	0.00e+00	1493.00
IUUC-Aca-005338	Anolis carolinensis	85.76	0.00e+00	1443.00
IUUC-Ame-010601	Astyanax mexicanus	83.08	0.00e+00	1055.00
IUUC-Bta-012782	Bos taurus	82.24	0.00e+00	1375.00
IUUC-Cja-018899	Callithrix jacchus	78.72	0.00e+00	1355.00
IUUC-Cfa-020648	Canis familiaris	80.90	0.00e+00	1366.00
IUUC-Cpo-022073	Cavia porcellus	81.18	0.00e+00	1404.00
IUUC-Csa-023252	Chlorocebus sabaeus	80.60	0.00e+00	1395.00
IUUC-Cho-024695	Choloepus hoffmanni	76.41	0.00e+00	1355.00
IUUC-Dre-028451	Danio rerio	73.59	0.00e+00	1249.00
IUUC-Dno-029884	Dasypus novemcinctus	80.60	0.00e+00	1410.00
IUUC-Eca-033793	Equus caballus	82.45	0.00e+00	1392.00
IUUC-Fca-035605	Felis catus	81.52	0.00e+00	1424.00
IUUC-Fal-037126	Ficedula albicollis	88.66	0.00e+00	1486.00
IUUC-Gmo-038596	Gadus morhua	77.36	0.00e+00	954.00
IUUC-Gga-040832	Gallus gallus	88.54	0.00e+00	1503.00
IUUC-Gac-041658	Gasterosteus aculeatus	81.19	0.00e+00	1066.00
IUUC-Ggo-044535	Gorilla gorilla	77.71	0.00e+00	1355.00
IUUC-Hsa-046564	Homo sapiens	78.17	0.00e+00	1367.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	88.49	0.00e+00	1148.00
IUUC-Lch-050454	Latimeria chalumnae	78.47	0.00e+00	1349.00
IUUC-Loc-052647	Lepisosteus oculatus	72.26	0.00e+00	1294.00
IUUC-Laf-054383	Loxodonta africana	81.89	0.00e+00	1410.00
IUUC-Mcc-055532	Macaca mulatta	80.37	0.00e+00	1392.00
IUUC-Mga-059661	Meleagris gallopavo	88.43	0.00e+00	1483.00
IUUC-Mmr-061135	Microcebus murinus	81.41	0.00e+00	1420.00
IUUC-Mdo-062505	Monodelphis domestica	84.97	0.00e+00	1438.00
IUUC-Mmu-063375	Mus musculus	80.60	0.00e+00	1377.00
IUUC-Mpu-066203	Mustela putorius furo	82.45	0.00e+00	1405.00
IUUC-Mlu-067837	Myotis lucifugus	81.99	0.00e+00	1398.00
IUUC-Nle-069244	Nomascus leucogenys	81.64	0.00e+00	1375.00
IUUC-Opr-070585	Ochotona princeps	78.08	0.00e+00	1359.00
IUUC-Ont-071822	Oreochromis niloticus	69.96	0.00e+00	1255.00
IUUC-Ocu-074298	Oryctolagus cuniculus	82.79	0.00e+00	1405.00
IUUC-Oga-088167	Otolemur garnettii	75.06	0.00e+00	1295.00
IUUC-Oar-090316	Ovis aries	67.47	0.00e+00	1031.00
IUUC-Ptr-090819	Pan troglodytes	78.41	0.00e+00	1361.00
IUUC-Pan-092454	Papio anubis	80.37	0.00e+00	1392.00
IUUC-Pfo-096937	Poecilia formosa	85.20	0.00e+00	1065.00
IUUC-Pab-097580	Pongo abelii	72.00	0.00e+00	1224.00
IUUC-Pca-100923	Procavia capensis	71.60	0.00e+00	1150.00
IUUC-Pva-103209	Pteropus vampyrus	80.58	0.00e+00	1344.00
IUUC-Rno-104924	Rattus norvegicus	81.99	0.00e+00	1390.00
IUUC-Sha-107175	Sarcophilus harrisii	84.16	0.00e+00	1439.00
IUUC-Sar-113761	Sorex araneus	92.67	0.00e+00	1127.00
IUUC-Tgu-116632	Taeniopygia guttata	80.00	0.00e+00	1338.00
IUUC-Tru-118442	Takifugu rubripes	79.21	0.00e+00	1070.00
IUUC-Tsy-119198	Tarsius syrichta	76.30	0.00e+00	1280.00
IUUC-Tni-120168	Tetraodon nigroviridis	83.18	0.00e+00	1000.00
IUUC-Tbe-127756	Tupaia belangeri	64.39	0.00e+00	1058.00
IUUC-Ttr-128504	Tursiops truncatus	73.04	0.00e+00	951.00
IUUC-Vpa-130103	Vicugna pacos	70.70	0.00e+00	1201.00
IUUC-Xtr-132885	Xenopus tropicalis	74.12	0.00e+00	1325.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence