iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090484

UUCD1 version

UUC-PaT-00701

Ensembl Protein ID

ENSPTRP00000034889.3

UniProt Accession

H2QWD9; H2QWD9_PANTR

Genbank Protein ID

JAA21904.1; JAA32483.1; JAA40419.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AACZ03065185; GABD01000617; GABE01004320

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000020395.5	ENSPTRT00000037746.3	ENSPTRP00000034889.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.00e-135	449.9	589	921

Active Site

Position(s)	Description	Evidence
890	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 589  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 676
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 677  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 762
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 763  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 850
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 851  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 921
           *********************************************************************96 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGEI TKTAKSSSSS 60
NPKWDEQLTV NVTPQTTLEF QVWSHRTLKA DALLGKATID LKQALLIHNR KLERVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATAGGTTT TAGCTGAATT TTGGGACATG GCCACTGCTT CACCAAGGTC TGATACTAGT 60
AATAACCACA GTGGAAGGTT GCAGTTACAG GTAACTGGTA AGTTATTTTT ATATTTAATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

ptr:464269

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	94.47	0.00e+00	1778.00
IUUC-Apl-003310	Anas platyrhynchos	83.10	0.00e+00	1554.00
IUUC-Aca-005388	Anolis carolinensis	80.34	0.00e+00	1467.00
IUUC-Ame-010992	Astyanax mexicanus	90.38	0.00e+00	804.00
IUUC-Bta-012857	Bos taurus	93.38	0.00e+00	1724.00
IUUC-Cel-018299	Caenorhabditis elegans	67.01	0.00e+00	815.00
IUUC-Cja-019448	Callithrix jacchus	97.72	0.00e+00	1848.00
IUUC-Cfa-020728	Canis familiaris	95.12	0.00e+00	1776.00
IUUC-Cpo-021635	Cavia porcellus	89.31	0.00e+00	1686.00
IUUC-Csa-023805	Chlorocebus sabaeus	98.83	0.00e+00	1393.00
IUUC-Cho-024943	Choloepus hoffmanni	84.37	0.00e+00	1221.00
IUUC-Cin-025212	Ciona intestinalis	73.70	0.00e+00	884.00
IUUC-Csv-026256	Ciona savignyi	72.66	0.00e+00	879.00
IUUC-Dre-028245	Danio rerio	70.77	0.00e+00	1182.00
IUUC-Dno-029618	Dasypus novemcinctus	94.79	0.00e+00	1779.00
IUUC-Dor-030665	Dipodomys ordii	78.70	0.00e+00	1188.00
IUUC-Dme-032041	Drosophila melanogaster	71.02	0.00e+00	876.00
IUUC-Ete-032779	Echinops telfairi	94.89	0.00e+00	1120.00
IUUC-Eca-033313	Equus caballus	92.19	0.00e+00	1695.00
IUUC-Eeu-035259	Erinaceus europaeus	85.03	0.00e+00	1573.00
IUUC-Fca-035420	Felis catus	93.82	0.00e+00	1768.00
IUUC-Fal-037335	Ficedula albicollis	82.47	0.00e+00	1535.00
IUUC-Gmo-039172	Gadus morhua	86.44	0.00e+00	1020.00
IUUC-Gga-040246	Gallus gallus	82.90	0.00e+00	1541.00
IUUC-Gac-042211	Gasterosteus aculeatus	91.11	0.00e+00	1129.00
IUUC-Ggo-045001	Gorilla gorilla	99.51	0.00e+00	1667.00
IUUC-Hsa-046544	Homo sapiens	99.89	0.00e+00	1896.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	92.68	0.00e+00	1718.00
IUUC-Lch-050398	Latimeria chalumnae	77.32	0.00e+00	1392.00
IUUC-Loc-052116	Lepisosteus oculatus	75.70	0.00e+00	1361.00
IUUC-Laf-053551	Loxodonta africana	92.85	0.00e+00	1709.00
IUUC-Meu-056455	Macropus eugenii	67.30	0.00e+00	823.00
IUUC-Mga-059986	Meleagris gallopavo	82.65	0.00e+00	1543.00
IUUC-Mmr-060945	Microcebus murinus	93.17	0.00e+00	1748.00
IUUC-Mdo-063024	Monodelphis domestica	82.44	0.00e+00	1491.00
IUUC-Mmu-063202	Mus musculus	90.46	0.00e+00	1647.00
IUUC-Mpu-065773	Mustela putorius furo	94.37	0.00e+00	1759.00
IUUC-Mlu-067373	Myotis lucifugus	68.70	0.00e+00	1131.00
IUUC-Nle-069188	Nomascus leucogenys	98.92	0.00e+00	1869.00
IUUC-Opr-070965	Ochotona princeps	88.50	0.00e+00	1642.00
IUUC-Ont-072226	Oreochromis niloticus	91.62	0.00e+00	1135.00
IUUC-Oan-073497	Ornithorhynchus anatinus	85.48	0.00e+00	1550.00
IUUC-Ocu-073891	Oryctolagus cuniculus	89.71	0.00e+00	1647.00
IUUC-Ola-087438	Oryzias latipes	89.11	0.00e+00	1134.00
IUUC-Oga-087922	Otolemur garnettii	94.26	0.00e+00	1760.00
IUUC-Oar-089317	Ovis aries	92.32	0.00e+00	1691.00
IUUC-Pan-092117	Papio anubis	98.37	0.00e+00	1862.00
IUUC-Psi-093338	Pelodiscus sinensis	83.53	0.00e+00	1557.00
IUUC-Pma-094279	Petromyzon marinus	74.91	0.00e+00	847.00
IUUC-Pfo-096171	Poecilia formosa	92.47	0.00e+00	1137.00
IUUC-Pab-098654	Pongo abelii	96.62	0.00e+00	1352.00
IUUC-Pca-100501	Procavia capensis	74.17	0.00e+00	932.00
IUUC-Pva-102811	Pteropus vampyrus	80.26	0.00e+00	1435.00
IUUC-Rno-106125	Rattus norvegicus	90.35	0.00e+00	1662.00
IUUC-Sha-107243	Sarcophilus harrisii	85.02	0.00e+00	1563.00
IUUC-Ssc-115368	Sus scrofa	93.30	0.00e+00	1729.00
IUUC-Tgu-117079	Taeniopygia guttata	82.33	0.00e+00	1519.00
IUUC-Tru-118062	Takifugu rubripes	70.69	0.00e+00	1314.00
IUUC-Tsy-119507	Tarsius syrichta	90.56	0.00e+00	1684.00
IUUC-Tni-120151	Tetraodon nigroviridis	91.31	0.00e+00	1121.00
IUUC-Ttr-129260	Tursiops truncatus	84.27	0.00e+00	1519.00
IUUC-Uma-129332	Ustilago maydis	45.93	6.00e-145	508.00
IUUC-Vpa-130390	Vicugna pacos	82.71	0.00e+00	941.00
IUUC-Xtr-132877	Xenopus tropicalis	69.33	0.00e+00	1207.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence