iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000061194.7	ENSDART00000086984.7	ENSDARP00000081418.4
ENSDARG00000061194.7	ENSDART00000168105.1	ENSDARP00000135476.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-100	338.4	418	756

Active Site

Position(s)	Description	Evidence
724	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+v+fvgE+gld+gG+t+e++ ll+++++++d+g+f+y +++++ ++ + +      ++ + F+++G l+g+a++++  ld+
   Q: 418  RADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHTDYGMFTYVKESQCYWFSSWKC-----DNYSEFRLVGALMGLAVYNSITLDI 501
           589*************************************************9976655.....789********************** PP
   S: 91   plsksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           ++++++yk+ll+                l+l+dl++++p+l++ l e++++ e ++ee  +  tf+v +e+lg +k+++LkpgG++ipV
   Q: 502  RFPPCVYKKLLTPpivpcdldtpvgmaTLTLDDLQQIMPDLAHGLGELLSY-EGNVEED-FYTTFQVFQEELGVVKAYNLKPGGDKIPV 588
           **********999555555555555555**********************9.6788885.***************************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevle 254
           tn N++eYv+l++++ l+++i +q++af+ Gf++v+  + l l+++ee+e+l+cG++++d+ +l++  +y+ gy++++p+i+ Fw+v+ 
   Q: 589  TNLNRKEYVQLYIDFLLNKSIYRQFAAFYHGFHSVCASNALMLLRPEEVEILVCGSPNLDMGSLQRVVQYE-GYSKTDPTIRAFWDVVL 676
           **********************************************************************5.5**************** PP
   S: 255  efsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +f  e +k++L+F+Tgs+r+P+gG+a+l+   f i+k d s+d+lP s+TCfn+++LP+Y+sk++l++kL++Ai++++gF+l+
   Q: 677  AFPLELQKKLLHFTTGSDRVPVGGMADLN---FKISKiDVSTDWLPVSHTCFNQICLPPYKSKKELRQKLTIAISNAEGFGLE 756
           *****************************...89999899****************************************985 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MHLNMSENNC PLEERDRDRL PPIINHQNLE RGPKLPFPSY GSFISTLNHK RESGSHSFSS 60
PLFLPAVKQV RELPPIYPDV RQKHRISIDV LPPEVKARFV SEPIIPIRTK TAKEFQDDVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCCATGAGG GAAAAGCTGA GAATGTAATA CAGTACACGC AACATCTTAT GTAGGCTAGT 60
TATTAGCAAA ACATGCATAA ACTAGTCTGT GTTCACATTT AATCCAATTC TTAATCGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

dre:562999

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	76.87	0.00e+00	1186.00
IUUC-Apl-003589	Anas platyrhynchos	76.99	0.00e+00	1158.00
IUUC-Aca-004350	Anolis carolinensis	72.88	0.00e+00	1111.00
IUUC-Ago-007908	Ashbya gossypii	36.80	2.00e-86	313.00
IUUC-Acl-008288	Aspergillus clavatus	33.38	2.00e-98	354.00
IUUC-Afl-008402	Aspergillus flavus	34.33	1.00e-91	331.00
IUUC-Afu-008762	Aspergillus fumigatus	34.32	7.00e-97	349.00
IUUC-Ani-009176	Aspergillus nidulans	35.05	3.00e-92	333.00
IUUC-Ang-009791	Aspergillus niger	34.58	3.00e-93	337.00
IUUC-Aor-009921	Aspergillus oryzae	34.16	3.00e-91	330.00
IUUC-Ate-010295	Aspergillus terreus	35.71	4.00e-100	360.00
IUUC-Ame-010660	Astyanax mexicanus	94.98	1.00e-173	602.00
IUUC-Bgr-011981	Blumeria graminis	33.39	7.00e-91	329.00
IUUC-Bta-012945	Bos taurus	76.74	0.00e+00	1156.00
IUUC-Bci-013697	Botrytis cinerea	33.39	7.00e-81	296.00
IUUC-Cja-019263	Callithrix jacchus	75.51	0.00e+00	1140.00
IUUC-Cfa-020486	Canis familiaris	81.06	0.00e+00	1114.00
IUUC-Cpo-021755	Cavia porcellus	75.24	0.00e+00	1165.00
IUUC-Csa-023814	Chlorocebus sabaeus	75.72	0.00e+00	1080.00
IUUC-Cho-024980	Choloepus hoffmanni	63.61	0.00e+00	912.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	40.88	2.00e-95	344.00
IUUC-Dno-029497	Dasypus novemcinctus	77.39	0.00e+00	1080.00
IUUC-Dor-030867	Dipodomys ordii	67.17	0.00e+00	974.00
IUUC-Dse-031239	Dothistroma septosporum	29.39	1.00e-88	322.00
IUUC-Ete-032902	Echinops telfairi	76.39	0.00e+00	940.00
IUUC-Eca-033678	Equus caballus	76.74	0.00e+00	1171.00
IUUC-Eeu-035262	Erinaceus europaeus	65.31	0.00e+00	899.00
IUUC-Fca-035590	Felis catus	77.02	0.00e+00	1188.00
IUUC-Fal-037123	Ficedula albicollis	72.58	0.00e+00	1105.00
IUUC-Fox-037941	Fusarium oxysporum	40.04	6.00e-102	365.00
IUUC-Fso-038388	Fusarium solani	40.67	2.00e-103	370.00
IUUC-Gmo-039553	Gadus morhua	70.51	0.00e+00	894.00
IUUC-Ggr-040110	Gaeumannomyces graminis	39.60	5.00e-95	343.00
IUUC-Gga-040406	Gallus gallus	77.26	0.00e+00	1195.00
IUUC-Gac-042141	Gasterosteus aculeatus	81.88	0.00e+00	1192.00
IUUC-Ggo-045504	Gorilla gorilla	74.73	0.00e+00	1143.00
IUUC-Hsa-045786	Homo sapiens	75.27	0.00e+00	1149.00
IUUC-Itr-048050	Ictidomys tridecemlineatus	74.27	0.00e+00	1043.00
IUUC-Kpa-049152	Komagataella pastoris	32.63	2.00e-76	280.00
IUUC-Lch-049824	Latimeria chalumnae	76.67	0.00e+00	1049.00
IUUC-Loc-052173	Lepisosteus oculatus	80.24	0.00e+00	1212.00
IUUC-Laf-054017	Loxodonta africana	79.77	0.00e+00	1150.00
IUUC-Mcc-055713	Macaca mulatta	75.65	0.00e+00	1130.00
IUUC-Meu-056212	Macropus eugenii	62.04	2.00e-100	360.00
IUUC-Mor-057045	Magnaporthe oryzae	35.46	2.00e-89	325.00
IUUC-Mla-059187	Melampsora laricipopulina	42.55	3.00e-83	302.00
IUUC-Mga-059884	Meleagris gallopavo	71.04	0.00e+00	1051.00
IUUC-Mmr-061344	Microcebus murinus	77.04	0.00e+00	1157.00
IUUC-Mdo-062653	Monodelphis domestica	74.63	0.00e+00	1144.00
IUUC-Mmu-063775	Mus musculus	74.73	0.00e+00	1076.00
IUUC-Mpu-066069	Mustela putorius furo	79.46	0.00e+00	1122.00
IUUC-Mlu-067925	Myotis lucifugus	76.61	0.00e+00	1152.00
IUUC-Nfi-068439	Neosartorya fischeri	34.48	7.00e-97	348.00
IUUC-Ncr-068903	Neurospora crassa	37.27	2.00e-92	334.00
IUUC-Nle-070046	Nomascus leucogenys	74.87	0.00e+00	1152.00
IUUC-Opr-071085	Ochotona princeps	67.11	3.00e-117	416.00
IUUC-Ont-072126	Oreochromis niloticus	79.09	0.00e+00	1260.00
IUUC-Oan-072933	Ornithorhynchus anatinus	79.32	0.00e+00	1068.00
IUUC-Ocu-073800	Oryctolagus cuniculus	79.61	0.00e+00	1110.00
IUUC-Ola-086988	Oryzias latipes	81.22	0.00e+00	1191.00
IUUC-Oga-088117	Otolemur garnettii	80.34	0.00e+00	974.00
IUUC-Oar-089371	Ovis aries	76.88	0.00e+00	1141.00
IUUC-Ptr-090551	Pan troglodytes	75.94	0.00e+00	1126.00
IUUC-Pan-092067	Papio anubis	76.06	0.00e+00	1137.00
IUUC-Psi-092963	Pelodiscus sinensis	76.21	0.00e+00	1140.00
IUUC-Pfo-096562	Poecilia formosa	77.76	0.00e+00	1208.00
IUUC-Pab-098680	Pongo abelii	75.13	0.00e+00	1146.00
IUUC-Pca-100986	Procavia capensis	63.67	0.00e+00	764.00
IUUC-Pva-102219	Pteropus vampyrus	71.00	0.00e+00	876.00
IUUC-Pgr-103315	Puccinia graminis	35.70	1.00e-93	338.00
IUUC-Ptt-103736	Puccinia triticina	38.19	4.00e-92	333.00
IUUC-Rno-105270	Rattus norvegicus	75.00	0.00e+00	1084.00
IUUC-Sce-106306	Saccharomyces cerevisiae	35.24	8.00e-74	272.00
IUUC-Sha-106819	Sarcophilus harrisii	77.12	0.00e+00	1187.00
IUUC-Spo-108271	Schizosaccharomyces pombe	34.71	2.00e-91	330.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	33.55	2.00e-84	308.00
IUUC-Sar-113134	Sorex araneus	68.54	0.00e+00	1013.00
IUUC-Ssc-115441	Sus scrofa	77.02	0.00e+00	1159.00
IUUC-Tgu-117166	Taeniopygia guttata	74.56	0.00e+00	1120.00
IUUC-Tsy-118898	Tarsius syrichta	64.67	0.00e+00	897.00
IUUC-Tre-122108	Trichoderma reesei	38.22	3.00e-90	327.00
IUUC-Tvi-122644	Trichoderma virens	38.10	8.00e-95	342.00
IUUC-Tme-127004	Tuber melanosporum	37.01	2.00e-104	374.00
IUUC-Tbe-127292	Tupaia belangeri	62.52	0.00e+00	875.00
IUUC-Ttr-128352	Tursiops truncatus	73.87	0.00e+00	1103.00
IUUC-Vda-129969	Verticillium dahliae	40.88	3.00e-95	343.00
IUUC-Vpa-130218	Vicugna pacos	74.07	0.00e+00	823.00
IUUC-Xtr-132594	Xenopus tropicalis	70.12	0.00e+00	1068.00
IUUC-Xma-134157	Xiphophorus maculatus	80.40	0.00e+00	1102.00
IUUC-Yli-134470	Yarrowia lipolytica	31.50	9.00e-81	295.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence