iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067925

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02020206

Gene Name

HECTD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000015375.2	ENSMLUT00000015387.2	ENSMLUP00000014020.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.60e-104	349.3	392	730

Active Site

Position(s)	Description	Evidence
698	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+v+fvgE+gld+gG+t+e++ ll++++++pd+g+f+y+++++++++ + +      ++ + F+++G+l+g+a++++  ld+
   Q: 392  RADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKC-----DNYSEFRLVGILMGLAVYNSITLDI 475
           589***************************************************87766.....789********************** PP
   S: 91   plsksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           ++++++yk+ll+               +++ +dl++++pel++ l e++++ e ++ee  +  tf+v +e++g +k+++LkpgGe+ipV
   Q: 476  RFPPCCYKKLLSPpivpsdqntpvgicSVTTDDLSQIMPELAHGLSELLSY-EGNVEED-FYSTFQVFQEEFGIIKSYNLKPGGEKIPV 562
           ************9666666666665555**********************9.6788885.***************************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevle 254
           tn+N++eYv+l++++ l+++i +q++af+ Gf++v+  + l l+++ee+e+l+cG++e+d+++l++ t+y+g y +++++i++Fw+v+ 
   Q: 563  TNQNRKEYVQLYIDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQRSTQYDG-YAKTDSTIRYFWDVVL 650
           **********************************************************************76.**************** PP
   S: 255  efsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +f  + +k++L+F+Tgs+r+P+gG+a+l+   f i+k ++s+++lP ++TCfn+L+LP+Y+sk+ lk+kL++ i++++gF+l+
   Q: 651  GFPLDLQKKLLHFTTGSDRVPVGGMADLN---FKISKnETSTNWLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 730
           *****************************...9999967777**************************************985 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

GLDRGSKGQI STFSSSVSTV SQKQEAAENR SSPTHPAFPN IKNVRDLPPI SLDVRQKQRV 60
STDASSSEIK AAVPPESTLP IQPKTMKDFQ EDVEKAKSSG DWKAVHDFYL TTFDSFPELN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTTGGACA GAGGATCCAA AGGCCAAATT TCGACTTTCA GCAGTTCTGT TTCAACTGTC 60
AGCCAGAAGC AAGAAGCCGC TGAAAACAGA AGTTCACCCA CACACCCTGC TTTCCCTAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	95.37	0.00e+00	1415.00
IUUC-Apl-003589	Anas platyrhynchos	85.64	0.00e+00	1265.00
IUUC-Aca-004350	Anolis carolinensis	80.96	0.00e+00	1201.00
IUUC-Ago-007908	Ashbya gossypii	34.86	3.00e-80	293.00
IUUC-Acl-008288	Aspergillus clavatus	35.53	6.00e-97	349.00
IUUC-Afl-008402	Aspergillus flavus	33.83	5.00e-89	322.00
IUUC-Afu-008762	Aspergillus fumigatus	34.48	1.00e-93	338.00
IUUC-Ani-009176	Aspergillus nidulans	36.38	4.00e-93	336.00
IUUC-Ang-009791	Aspergillus niger	36.20	9.00e-93	335.00
IUUC-Aor-009921	Aspergillus oryzae	33.67	1.00e-88	320.00
IUUC-Ate-010295	Aspergillus terreus	36.29	4.00e-100	359.00
IUUC-Ame-010660	Astyanax mexicanus	82.61	1.00e-154	538.00
IUUC-Bgr-011981	Blumeria graminis	32.29	6.00e-93	335.00
IUUC-Bta-012945	Bos taurus	95.21	0.00e+00	1383.00
IUUC-Bci-013697	Botrytis cinerea	32.69	1.00e-79	291.00
IUUC-Cja-019263	Callithrix jacchus	93.73	0.00e+00	1368.00
IUUC-Cfa-020486	Canis familiaris	97.67	0.00e+00	1302.00
IUUC-Cpo-021755	Cavia porcellus	93.56	0.00e+00	1390.00
IUUC-Csa-023814	Chlorocebus sabaeus	94.50	0.00e+00	1295.00
IUUC-Cho-024980	Choloepus hoffmanni	77.81	0.00e+00	1090.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	42.48	5.00e-97	349.00
IUUC-Dre-028551	Danio rerio	76.61	0.00e+00	1129.00
IUUC-Dno-029497	Dasypus novemcinctus	93.62	0.00e+00	1264.00
IUUC-Dor-030867	Dipodomys ordii	82.44	0.00e+00	1170.00
IUUC-Dse-031239	Dothistroma septosporum	29.51	5.00e-89	323.00
IUUC-Ete-032902	Echinops telfairi	79.04	0.00e+00	1137.00
IUUC-Eca-033678	Equus caballus	95.21	0.00e+00	1397.00
IUUC-Eeu-035262	Erinaceus europaeus	78.13	0.00e+00	1041.00
IUUC-Fca-035590	Felis catus	96.58	0.00e+00	1431.00
IUUC-Fal-037123	Ficedula albicollis	82.04	0.00e+00	1195.00
IUUC-Fox-037941	Fusarium oxysporum	41.48	4.00e-101	363.00
IUUC-Fso-038388	Fusarium solani	42.26	8.00e-104	372.00
IUUC-Gmo-039553	Gadus morhua	66.46	0.00e+00	852.00
IUUC-Ggr-040110	Gaeumannomyces graminis	31.84	1.00e-98	355.00
IUUC-Gga-040406	Gallus gallus	86.16	0.00e+00	1300.00
IUUC-Gac-042141	Gasterosteus aculeatus	76.38	0.00e+00	1109.00
IUUC-Ggo-045504	Gorilla gorilla	93.05	0.00e+00	1360.00
IUUC-Hsa-045786	Homo sapiens	93.84	0.00e+00	1364.00
IUUC-Itr-048050	Ictidomys tridecemlineatus	89.24	0.00e+00	1213.00
IUUC-Kpa-049152	Komagataella pastoris	33.78	6.00e-74	272.00
IUUC-Lch-049824	Latimeria chalumnae	81.04	0.00e+00	1089.00
IUUC-Loc-052173	Lepisosteus oculatus	79.34	0.00e+00	1177.00
IUUC-Laf-054017	Loxodonta africana	95.63	0.00e+00	1333.00
IUUC-Mcc-055713	Macaca mulatta	94.14	0.00e+00	1366.00
IUUC-Meu-056212	Macropus eugenii	69.72	4.00e-117	415.00
IUUC-Mor-057045	Magnaporthe oryzae	36.77	2.00e-90	327.00
IUUC-Mla-059187	Melampsora laricipopulina	43.74	1.00e-86	313.00
IUUC-Mga-059884	Meleagris gallopavo	79.64	0.00e+00	1146.00
IUUC-Mmr-061344	Microcebus murinus	93.69	0.00e+00	1385.00
IUUC-Mdo-062653	Monodelphis domestica	88.84	0.00e+00	1308.00
IUUC-Mmu-063775	Mus musculus	91.52	0.00e+00	1290.00
IUUC-Mpu-066069	Mustela putorius furo	96.98	0.00e+00	1321.00
IUUC-Nfi-068439	Neosartorya fischeri	34.48	2.00e-93	337.00
IUUC-Ncr-068903	Neurospora crassa	38.08	6.00e-93	336.00
IUUC-Nle-070046	Nomascus leucogenys	93.60	0.00e+00	1384.00
IUUC-Opr-071085	Ochotona princeps	79.19	8.00e-137	481.00
IUUC-Ont-072126	Oreochromis niloticus	76.73	0.00e+00	1135.00
IUUC-Oan-072933	Ornithorhynchus anatinus	89.34	0.00e+00	1177.00
IUUC-Ocu-073800	Oryctolagus cuniculus	96.22	0.00e+00	1289.00
IUUC-Ola-086988	Oryzias latipes	76.42	0.00e+00	1114.00
IUUC-Oga-088117	Otolemur garnettii	96.38	0.00e+00	1124.00
IUUC-Oar-089371	Ovis aries	95.21	0.00e+00	1365.00
IUUC-Ptr-090551	Pan troglodytes	93.68	0.00e+00	1337.00
IUUC-Pan-092067	Papio anubis	94.66	0.00e+00	1371.00
IUUC-Psi-092963	Pelodiscus sinensis	86.16	0.00e+00	1251.00
IUUC-Pfo-096562	Poecilia formosa	75.29	0.00e+00	1113.00
IUUC-Pab-098680	Pongo abelii	94.25	0.00e+00	1367.00
IUUC-Pca-100986	Procavia capensis	77.00	0.00e+00	900.00
IUUC-Pva-102219	Pteropus vampyrus	80.00	0.00e+00	1061.00
IUUC-Pgr-103315	Puccinia graminis	36.72	6.00e-96	345.00
IUUC-Ptt-103736	Puccinia triticina	41.91	1.00e-94	341.00
IUUC-Rno-105270	Rattus norvegicus	91.92	0.00e+00	1295.00
IUUC-Sce-106306	Saccharomyces cerevisiae	35.24	2.00e-69	257.00
IUUC-Sha-106819	Sarcophilus harrisii	90.41	0.00e+00	1345.00
IUUC-Spo-108271	Schizosaccharomyces pombe	31.21	1.00e-84	308.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	31.37	2.00e-84	307.00
IUUC-Sar-113134	Sorex araneus	85.89	0.00e+00	1221.00
IUUC-Ssc-115441	Sus scrofa	95.48	0.00e+00	1373.00
IUUC-Tgu-117166	Taeniopygia guttata	84.66	0.00e+00	1226.00
IUUC-Tsy-118898	Tarsius syrichta	81.99	0.00e+00	1107.00
IUUC-Tre-122108	Trichoderma reesei	39.34	2.00e-90	327.00
IUUC-Tvi-122644	Trichoderma virens	39.92	6.00e-96	345.00
IUUC-Tme-127004	Tuber melanosporum	34.86	1.00e-102	368.00
IUUC-Tbe-127292	Tupaia belangeri	78.22	0.00e+00	1056.00
IUUC-Ttr-128352	Tursiops truncatus	91.51	0.00e+00	1315.00
IUUC-Vda-129969	Verticillium dahliae	40.66	4.00e-93	336.00
IUUC-Vpa-130218	Vicugna pacos	92.95	0.00e+00	984.00
IUUC-Xtr-132594	Xenopus tropicalis	78.77	0.00e+00	1130.00
IUUC-Xma-134157	Xiphophorus maculatus	75.46	0.00e+00	1040.00
IUUC-Yli-134470	Yarrowia lipolytica	34.55	1.00e-75	278.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence