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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046400
UUCD1 version UUC-HoS-00046
Ensembl Protein ID ENSP00000376785.3
UniProt Accession O94972; A8K0V9; A8K8U4; A8MZ79; B4DGZ3; F8WEE6; Q7Z3E6; Q8IYF7; Q8WYF7; TRI37_HUMAN
Genbank Protein ID AAL36460.1; BAA74921.1; BAF82363.1; BAG57954.1; BAF85148.1; CAD97922.1; EAW94425.1; EAW94426.1; AAH36012.1
Protein Name E3 ubiquitin-protein ligase TRIM37; Mulibrey nanism protein; RING-type E3 ubiquitin transferase TRIM37; Tripartite motif-containing protein 37
Genbank Nucleotide ID AF213365; AB020705; AK289674; AK294850; AK292459; BX537955; AC005207; CH471109; BC036012
Gene Name TRIM37; KIAA0898; MUL; POB1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000108395.13 ENST00000585287.5 ENSP00000464666.1
ENSG00000108395.13 ENST00000583945.5 ENSP00000462778.1
ENSG00000108395.13 ENST00000393066.7 ENSP00000376785.3
ENSG00000108395.13 ENST00000577554.5 ENSP00000462340.1
ENSG00000108395.13 ENST00000393065.6 ENSP00000376784.2
ENSG00000108395.13 ENST00000581468.1 ENSP00000462863.1
ENSG00000108395.13 ENST00000580973.5 ENSP00000464590.1
ENSG00000108395.13 ENST00000580122.5 ENSP00000464688.1
ENSG00000108395.13 ENST00000584889.3 ENSP00000464263.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16306379
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 92.44 0.00e+00 1579.00 IUUC-Mmu-064161
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).
 E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).
Protein Sequence
(Fasta)
MDEQSVESIA EVFRCFICME KLRDARLCPH CSKLCCFSCI RRWLTEQRAQ CPHCRAPLQL 60
RELVNCRWAE EVTQQLDTLQ LCSLTKHEEN EKDKCENHHE KLSVFCWTCK KCICHQCALW 120
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Protein Fasta Sequence


>IUUC-Hsa-046400|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
CCTCCTTTCC CCTCCCACAG CGTCCTGCGC GCATGCGCTT CGCAGCTTCT CTCGCCGCCG 60
CGCCCCCAGC TGCTCTGGTT ACGGTTGGTG TTTGCGAATT CTCTGCGGCA CCTTCTTCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046400|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0242--Dwarfism
KW-0479--Metal-binding
KW-0576--Peroxisome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003649--Bbox_C
IPR002083--MATH/TRAF_dom
IPR008974--TRAF-like
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50144--MATH
PS50119--ZF_BBOX
PS50089--ZF_RING_2
Pfam

PF00917--MATH
PF00643--zf-B_box
SMART

SM00502--BBC
SM00336--BBOX
SM00061--MATH
Gene Ontology

GO:0016235--C:aggresome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0005777--C:peroxisome
GO:0003682--F:chromatin binding
GO:0042803--F:protein homodimerization activity
GO:0005164--F:tumor necrosis factor receptor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0070842--P:aggresome assembly
GO:0035518--P:histone H2A monoubiquitination
GO:0036353--P:histone H2A-K119 monoubiquitination
GO:0046600--P:negative regulation of centriole replication
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051865--P:protein autoubiquitination
GO:0006351--P:transcription, DNA-templated
KEGG hsa:4591
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002402 Ailuropoda melanoleuca 95.54 0.00e+00 1635.00
IUUC-Apl-003421 Anas platyrhynchos 79.12 0.00e+00 1283.00
IUUC-Aca-004895 Anolis carolinensis 76.03 0.00e+00 1233.00
IUUC-Aly-005536 Arabidopsis lyrata 30.00 4.00e-08 52.80
IUUC-Ath-007082 Arabidopsis thaliana 29.46 1.00e-08 54.30
IUUC-Ame-011010 Astyanax mexicanus 70.78 0.00e+00 993.00
IUUC-Bta-012395 Bos taurus 92.95 0.00e+00 1486.00
IUUC-Bol-016312 Brassica oleracea 31.01 5.00e-08 52.80
IUUC-Cja-019077 Callithrix jacchus 97.41 0.00e+00 1678.00
IUUC-Cfa-020944 Canis familiaris 94.72 0.00e+00 1575.00
IUUC-Cpo-021701 Cavia porcellus 90.06 0.00e+00 1540.00
IUUC-Csa-023468 Chlorocebus sabaeus 98.76 0.00e+00 1700.00
IUUC-Cho-024941 Choloepus hoffmanni 84.93 0.00e+00 788.00
IUUC-Cin-025184 Ciona intestinalis 71.73 9.00e-172 596.00
IUUC-Csv-026304 Ciona savignyi 64.94 9.00e-60 222.00
IUUC-Dre-027580 Danio rerio 61.95 0.00e+00 993.00
IUUC-Dno-029665 Dasypus novemcinctus 92.40 0.00e+00 1439.00
IUUC-Dor-030509 Dipodomys ordii 67.84 0.00e+00 668.00
IUUC-Ete-032665 Echinops telfairi 73.97 2.00e-164 573.00
IUUC-Eca-034388 Equus caballus 95.03 0.00e+00 1594.00
IUUC-Eeu-034530 Erinaceus europaeus 68.72 4.00e-49 190.00
IUUC-Fca-035842 Felis catus 94.82 0.00e+00 1630.00
IUUC-Fal-037490 Ficedula albicollis 91.67 0.00e+00 936.00
IUUC-Gmo-039700 Gadus morhua 97.47 4.00e-94 338.00
IUUC-Gga-040199 Gallus gallus 77.81 0.00e+00 1270.00
IUUC-Gac-041724 Gasterosteus aculeatus 73.74 0.00e+00 923.00
IUUC-Gma-043466 Glycine max 30.43 6.00e-08 51.20
IUUC-Ggo-045389 Gorilla gorilla 97.26 0.00e+00 1539.00
IUUC-Itr-048382 Ictidomys tridecemlineatus 92.04 0.00e+00 1566.00
IUUC-Lch-049653 Latimeria chalumnae 70.21 0.00e+00 1075.00
IUUC-Loc-051900 Lepisosteus oculatus 62.45 0.00e+00 1002.00
IUUC-Laf-053606 Loxodonta africana 95.45 0.00e+00 1620.00
IUUC-Mcc-054607 Macaca mulatta 98.86 0.00e+00 1702.00
IUUC-Meu-056746 Macropus eugenii 91.19 0.00e+00 787.00
IUUC-Mga-060028 Meleagris gallopavo 78.64 0.00e+00 1271.00
IUUC-Mmr-061345 Microcebus murinus 95.64 0.00e+00 1615.00
IUUC-Mdo-062615 Monodelphis domestica 83.50 0.00e+00 1394.00
IUUC-Mmu-064161 Mus musculus 92.44 0.00e+00 1572.00
IUUC-Mac-065602 Musa acuminata 28.26 3.00e-07 49.30
IUUC-Mpu-066437 Mustela putorius furo 94.31 0.00e+00 1594.00
IUUC-Mlu-068208 Myotis lucifugus 92.24 0.00e+00 1603.00
IUUC-Nle-069104 Nomascus leucogenys 98.64 0.00e+00 1682.00
IUUC-Opr-070233 Ochotona princeps 97.35 1.00e-87 318.00
IUUC-Ont-071969 Oreochromis niloticus 84.40 0.00e+00 874.00
IUUC-Oan-072914 Ornithorhynchus anatinus 71.90 0.00e+00 706.00
IUUC-Ocu-074943 Oryctolagus cuniculus 92.44 0.00e+00 1541.00
IUUC-Oga-088371 Otolemur garnettii 94.40 0.00e+00 1631.00
IUUC-Oar-090383 Ovis aries 93.16 0.00e+00 1527.00
IUUC-Ptr-091450 Pan troglodytes 99.69 0.00e+00 1726.00
IUUC-Pan-091800 Papio anubis 96.93 0.00e+00 1043.00
IUUC-Psi-093665 Pelodiscus sinensis 91.68 0.00e+00 902.00
IUUC-Pma-094559 Petromyzon marinus 83.19 0.00e+00 795.00
IUUC-Ppa-095483 Physcomitrella patens 42.34 6.00e-92 332.00
IUUC-Pfo-097163 Poecilia formosa 61.30 6.00e-136 478.00
IUUC-Pab-098742 Pongo abelii 99.58 0.00e+00 1683.00
IUUC-Pop-099648 Populus trichocarpa 31.39 1.00e-06 47.40
IUUC-Pca-100656 Procavia capensis 77.14 0.00e+00 741.00
IUUC-Ppe-101374 Prunus persica 31.82 1.00e-09 57.40
IUUC-Pva-103231 Pteropus vampyrus 83.87 0.00e+00 806.00
IUUC-Rno-105564 Rattus norvegicus 92.33 0.00e+00 1597.00
IUUC-Smo-109220 Selaginella moellendorffii 36.60 1.00e-87 317.00
IUUC-Sar-112934 Sorex araneus 86.37 0.00e+00 719.00
IUUC-Ssc-116278 Sus scrofa 91.20 0.00e+00 944.00
IUUC-Tgu-117396 Taeniopygia guttata 91.64 0.00e+00 944.00
IUUC-Tru-118296 Takifugu rubripes 75.61 0.00e+00 943.00
IUUC-Tsy-119188 Tarsius syrichta 87.67 0.00e+00 723.00
IUUC-Tni-120147 Tetraodon nigroviridis 73.88 0.00e+00 924.00
IUUC-Tbe-127682 Tupaia belangeri 87.62 0.00e+00 713.00
IUUC-Ttr-129176 Tursiops truncatus 99.09 0.00e+00 854.00
IUUC-Vpa-130336 Vicugna pacos 86.69 0.00e+00 1325.00
IUUC-Vvi-131514 Vitis vinifera 34.88 1.00e-07 50.80
IUUC-Xtr-132646 Xenopus tropicalis 66.80 0.00e+00 1070.00
Created Date 25-Jun-2017

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