iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046107

UUCD1 version

UUC-HoS-01129

Ensembl Protein ID

ENSP00000300896.3

UniProt Accession

Q8NFA0; Q7Z5T3; Q9BX85; Q9Y591; UBP32_HUMAN

Genbank Protein ID

AAM97922.1; AAK30207.1; AAH54344.1; AAD42882.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 32; Deubiquitinating enzyme 32; Renal carcinoma antigen NY-REN-60; Ubiquitin thioesterase 32; Ubiquitin-specific-processing protease 32

Genbank Nucleotide ID

AF533230; AF350251; AC003962; AF155116

Gene Name

USP32; USP10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000170832.12	ENST00000300896.8	ENSP00000300896.3
ENSG00000170832.12	ENST00000593071.1	ENSP00000466740.1
ENSG00000170832.12	ENST00000590133.5	ENSP00000465844.1
ENSG00000170832.12	ENST00000591768.1	ENSP00000464762.1
ENSG00000170832.12	ENST00000589552.1	ENSP00000465922.1
ENSG00000170832.12	ENST00000589335.5	ENSP00000465659.1
ENSG00000170832.12	ENST00000393003.7	ENSP00000376727.2
ENSG00000170832.12	ENST00000588898.1	ENSP00000467098.1
ENSG00000170832.12	ENST00000590297.1	ENSP00000467435.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	19615732

Classification

Family	E-value	Score	Start	End
DUB/USP	2.10e-106	357.6	734	1567

Active Site

Position(s)	Description	Evidence
743	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
1526	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           tGl+NlgNtC+mNS +Qc sn+++l++++ + ++  +ln++np ++kg+++k++ +l++elw++++k+v+p +l  +++k+a++f+g++q
   Q: 734  TGLSNLGNTCFMNSSIQCVSNTQPLTQYFISgRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQ 823
           7******************************9********************************************************** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           qD+qE+laflld+l+e+l++ ++kp+ e++++d   ++d+     a++++ ++n+s+++dlF+gql+sq+kc++c+++s+r++pf+ lsl
   Q: 824  QDSQELLAFLLDGLHEDLNRVHEKPYVELKDSD--GRPDWevaaeAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSL 911
           *****************************9999..6666666777********************************************* PP
   S: 175  pvpgkeetkke............................................................................... 185
           p+p+++ +++e                                                                               
   Q: 912  PLPMDSYMHLEitvikldgttpvryglrlnmdekytglkkqlsdlcglnseqillaevhgsniknfpqdnqkvrlsvsgflcafeipvpv 1001
           *******9999******************************************************************************* PP
   S: 186  .......................................................................................... 185
                                                                                                     
   Q: 1002 spisassptqtdfssspstnemftlttngdlprpifipngmpntvvpcgteknftngmvnghmpslpdspftgyiiavhrkmmrtelyfl 1091
           ****************************************************************************************** PP
   S: 186  .......................................................................................... 185
                                                                                                     
   Q: 1092 ssqknrpslfgmplivpctvhtrkkdlydavwiqvsrlasplppqeasnhaqdcddsmgyqypftlrvvqkdgnscawcpwyrfcrgcki 1181
           ****************************************************************************************** PP
   S: 186  ....................................................slqdcLesftkeeelegenkyycekckkkqeaekklkl 223
                                                               +l++cL++ft+eeel ++++yyc+kck ++ a+kkl+l
   Q: 1182 dcgedrafignayiavdwdptalhlryqtsqervvdehesveqsrraqaepiNLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDL 1271
           ****************************************************************************************** PP
   S: 224  kklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfcts............................................. 267
           ++lP++Li+hLkRf+f +   + +k +k v+fp+e +d s f++                                              
   Q: 1272 WRLPPILIIHLKRFQFVNG--RWIKSQKIVKFPREsFDPSAFLVPrdpalcqhkpltpqgdelseprilarevkkvdaqssageedvlls 1359
           **************99775..5569******************99999999999999999999999999999999999988888888888 PP
   S: 268  ...................................................................peekqke................ 274
                                                                                    +                
   Q: 1360 kspsslsaniisspkgspsssrksgtscpssknsspnssprtlgrskgrlrlpqigsknklssskenL-----Daskengagqicelada 1444
           88888888888888888888888777777777666666666666666666666666665555555550.....05555555555666666 PP
   S: 275  ..............................................................kkkYeLiavvvHsGslssGHYvayvkne 302
                                                                         k +Y+L+a+ +HsG l++GHYv+y+kn 
   Q: 1445 lsrghvlggsqpelvtpqdhevalangflyeheacgngysngqlgnhseedstddqredtriKPIYNLYAISCHSGILGGGHYVTYAKNP 1534
           66666666666666666666666666666666666666666666666666677777788888**************************** PP
   S: 303  kgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           + kW++++Ds+++e++ +e+ +   ++aY+lfY+++
   Q: 1535 NCKWYCYNDSSCKELHPDEIDT---DSAYILFYEQQ 1567
           **********************...********985 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MGAKESRIGF LSYEEALRRV TDVELKRLKD AFKRTCGLSY YMGQHCFIRE VLGDGVPPKV 60
AEVIYCSFGG TSKGLHFNNL IVGLVLLTRG KDEEKAKYIF SLFSSESGNY VIREEMERML 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGCCACGG CAACCGCCAA CACAGAACCC AGCCCCCCAC CCCGCTCCCA TTTCCTCATT 60
CTTAGGGGTG GCTGCAGCTG GCCCCTCCAG CTGGGATCTG GACTAGGGAA CGGAGCAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0106--Calcium
KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0636--Prenylation
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF13202--EF-hand_5
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP
SM00054--EFh

Gene Ontology

GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0016020--C:membrane
GO:0005509--F:calcium ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:84669

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001611	Ailuropoda melanoleuca	96.64	0.00e+00	2619.00
IUUC-Apl-003272	Anas platyrhynchos	83.49	0.00e+00	2653.00
IUUC-Aca-005057	Anolis carolinensis	83.53	0.00e+00	2301.00
IUUC-Ame-010781	Astyanax mexicanus	74.88	0.00e+00	2401.00
IUUC-Bta-013502	Bos taurus	92.61	0.00e+00	2816.00
IUUC-Cja-018754	Callithrix jacchus	98.50	0.00e+00	3138.00
IUUC-Cfa-020526	Canis familiaris	96.91	0.00e+00	3046.00
IUUC-Cpo-021568	Cavia porcellus	91.53	0.00e+00	2772.00
IUUC-Csa-023143	Chlorocebus sabaeus	98.75	0.00e+00	3110.00
IUUC-Cho-024603	Choloepus hoffmanni	62.92	0.00e+00	700.00
IUUC-Cin-025583	Ciona intestinalis	50.60	0.00e+00	1281.00
IUUC-Csv-026344	Ciona savignyi	47.08	0.00e+00	1172.00
IUUC-Dre-028121	Danio rerio	82.69	0.00e+00	2176.00
IUUC-Dno-029911	Dasypus novemcinctus	95.41	0.00e+00	2979.00
IUUC-Dor-030608	Dipodomys ordii	59.86	0.00e+00	1100.00
IUUC-Dme-032094	Drosophila melanogaster	45.02	4.00e-123	437.00
IUUC-Ete-032639	Echinops telfairi	93.38	0.00e+00	1575.00
IUUC-Eca-034253	Equus caballus	96.68	0.00e+00	3019.00
IUUC-Eeu-035084	Erinaceus europaeus	80.24	0.00e+00	1580.00
IUUC-Fca-035474	Felis catus	96.42	0.00e+00	2509.00
IUUC-Fal-036985	Ficedula albicollis	84.43	0.00e+00	2608.00
IUUC-Gmo-039568	Gadus morhua	80.61	0.00e+00	2138.00
IUUC-Gga-040509	Gallus gallus	83.37	0.00e+00	2739.00
IUUC-Gac-041757	Gasterosteus aculeatus	78.55	0.00e+00	2187.00
IUUC-Ggo-044956	Gorilla gorilla	90.37	0.00e+00	1877.00
IUUC-Itr-048865	Ictidomys tridecemlineatus	95.78	0.00e+00	1192.00
IUUC-Lch-050681	Latimeria chalumnae	78.07	0.00e+00	2406.00
IUUC-Loc-052474	Lepisosteus oculatus	77.75	0.00e+00	2474.00
IUUC-Laf-054273	Loxodonta africana	95.95	0.00e+00	3054.00
IUUC-Mcc-054718	Macaca mulatta	98.82	0.00e+00	3139.00
IUUC-Meu-056558	Macropus eugenii	71.82	0.00e+00	1407.00
IUUC-Mga-059892	Meleagris gallopavo	84.86	0.00e+00	2655.00
IUUC-Mmr-060866	Microcebus murinus	96.84	0.00e+00	3133.00
IUUC-Mdo-062607	Monodelphis domestica	92.28	0.00e+00	2975.00
IUUC-Mmu-063797	Mus musculus	95.76	0.00e+00	3112.00
IUUC-Mpu-066121	Mustela putorius furo	97.20	0.00e+00	3106.00
IUUC-Mlu-067581	Myotis lucifugus	95.04	0.00e+00	3042.00
IUUC-Nle-069916	Nomascus leucogenys	96.78	0.00e+00	3007.00
IUUC-Opr-071073	Ochotona princeps	85.55	0.00e+00	1209.00
IUUC-Ont-071310	Oreochromis niloticus	81.21	0.00e+00	2156.00
IUUC-Oan-073356	Ornithorhynchus anatinus	89.73	0.00e+00	2870.00
IUUC-Ocu-074216	Oryctolagus cuniculus	96.51	0.00e+00	3076.00
IUUC-Ola-087434	Oryzias latipes	78.91	0.00e+00	2090.00
IUUC-Oga-089034	Otolemur garnettii	95.91	0.00e+00	2993.00
IUUC-Oar-090369	Ovis aries	96.74	0.00e+00	3041.00
IUUC-Ptr-090605	Pan troglodytes	99.81	0.00e+00	3162.00
IUUC-Pan-092381	Papio anubis	98.79	0.00e+00	3058.00
IUUC-Psi-093819	Pelodiscus sinensis	87.07	0.00e+00	2752.00
IUUC-Pma-094480	Petromyzon marinus	64.11	0.00e+00	1477.00
IUUC-Pfo-096561	Poecilia formosa	80.00	0.00e+00	2122.00
IUUC-Pab-097643	Pongo abelii	96.51	0.00e+00	3024.00
IUUC-Pca-100944	Procavia capensis	78.14	0.00e+00	1027.00
IUUC-Pva-102732	Pteropus vampyrus	86.67	0.00e+00	2681.00
IUUC-Rno-105113	Rattus norvegicus	95.71	0.00e+00	3045.00
IUUC-Sha-107608	Sarcophilus harrisii	84.14	2.00e-171	595.00
IUUC-Sar-113201	Sorex araneus	83.90	0.00e+00	1691.00
IUUC-Ssc-115469	Sus scrofa	94.34	0.00e+00	656.00
IUUC-Tgu-117322	Taeniopygia guttata	85.81	0.00e+00	2756.00
IUUC-Tru-118705	Takifugu rubripes	68.79	0.00e+00	676.00
IUUC-Tsy-119433	Tarsius syrichta	81.68	0.00e+00	2122.00
IUUC-Tni-120631	Tetraodon nigroviridis	79.69	0.00e+00	2099.00
IUUC-Tbe-127553	Tupaia belangeri	88.24	0.00e+00	707.00
IUUC-Ttr-128260	Tursiops truncatus	95.84	0.00e+00	3046.00
IUUC-Vpa-130479	Vicugna pacos	91.74	0.00e+00	2847.00
IUUC-Xtr-132686	Xenopus tropicalis	82.65	0.00e+00	2603.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence