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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-136748
Ensembl Protein ID ENSP00000265299.6
UniProt Accession Q4G0A6; Q71AZ7; Q9H6D2; MINY4_HUMAN
Genbank Protein ID AF538962; AC004691; BC098569; AK026027
Protein Name Probable ubiquitin carboxyl-terminal hydrolase MINDY-4;Probable deubiquitinating enzyme MINDY-4
Genbank Nucleotide ID AAQ10898.1; EAW93970.1; AAH98569.1; BAB15327.1
Gene Name MINDY4;C7orf67;FAM188B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000106125.14 ENST00000265299.6 ENSP00000265299.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
circRNADbCircNetmiRTarBasemicroRNA
TRANSFACmiRcodeRAID2
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
UniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPM
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/MINDY MINDY 27292798; 27392144
UBD/Alpha-Helix/MIU MIU 27292798; 27392144
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
 Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Protein Sequence
(Fasta)
MDSLFVEEVA ASLVREFLSR KGLKKTCVTM DQERPRSDLS INNRNDLRKV LHLEFLYKEN 60
KAKENPLKTS LELITRYFLD HFGNTANNFT QDTPIPALSV PKKNNKVPSR CSETTLVNIY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-136748|DUB,MINDY;UBD,MIU|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATACTGCGCC GGACAGACCC AGTTGCCTGG TGCTGCGGCC CGGCGTGGGC CTCGTGGGCA 60
GAGCCAGAGC CAGAGCCATG GACAGCCTCT TCGTGGAGGA GGTGGCCGCC TCCTTGGTCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-136748|DUB,MINDY;UBD,MIU|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR025257--DUF4205
Pfam

PF13898--DUF4205
SMART

SM01174--DUF4205
Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
KEGG hsa:84182
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-136380 Ailuropoda melanoleuca 81.41 0.00e+00 1252.00
IUUC-Apl-136386 Anas platyrhynchos 52.71 4.00e-178 618.00
IUUC-Aca-136390 Anolis carolinensis 69.86 1.00e-146 514.00
IUUC-Ame-136408 Astyanax mexicanus 44.33 1.00e-152 533.00
IUUC-Bta-136412 Bos taurus 78.27 0.00e+00 1098.00
IUUC-Cel-018268 Caenorhabditis elegans 40.00 5.70e+00 27.30
IUUC-Cja-136425 Callithrix jacchus 89.04 0.00e+00 1007.00
IUUC-Cfa-136429 Canis familiaris 80.89 0.00e+00 1217.00
IUUC-Cpo-136433 Cavia porcellus 75.69 0.00e+00 1110.00
IUUC-Cre-136436 Chlamydomonas reinhardtii 46.39 3.00e-44 171.00
IUUC-Csa-136439 Chlorocebus sabaeus 95.64 0.00e+00 1370.00
IUUC-Cho-136443 Choloepus hoffmanni 35.28 4.00e-42 165.00
IUUC-Dre-136453 Danio rerio 59.95 5.00e-132 464.00
IUUC-Dno-136457 Dasypus novemcinctus 88.16 0.00e+00 682.00
IUUC-Dor-136462 Dipodomys ordii 74.18 0.00e+00 1081.00
IUUC-Dme-136465 Drosophila melanogaster 30.58 9.00e-30 124.00
IUUC-Ete-136468 Echinops telfairi 55.82 3.00e-128 452.00
IUUC-Eca-136472 Equus caballus 82.20 0.00e+00 1204.00
IUUC-Fca-136478 Felis catus 81.75 0.00e+00 1179.00
IUUC-Fal-136482 Ficedula albicollis 52.56 0.00e+00 699.00
IUUC-Gmo-136487 Gadus morhua 54.15 4.00e-103 368.00
IUUC-Gga-136492 Gallus gallus 64.61 3.00e-171 595.00
IUUC-Gac-136496 Gasterosteus aculeatus 57.22 1.00e-119 424.00
IUUC-Gma-136501 Glycine max 33.13 1.00e-41 164.00
IUUC-Ggo-136503 Gorilla gorilla 98.42 0.00e+00 1392.00
IUUC-Itr-136511 Ictidomys tridecemlineatus 87.42 4.00e-83 300.00
IUUC-Lch-136514 Latimeria chalumnae 74.37 3.00e-91 327.00
IUUC-Loc-136522 Lepisosteus oculatus 47.64 0.00e+00 647.00
IUUC-Laf-136526 Loxodonta africana 34.55 3.00e-50 192.00
IUUC-Mcc-136531 Macaca mulatta 95.51 0.00e+00 1347.00
IUUC-Meu-136535 Macropus eugenii 69.51 1.00e-138 487.00
IUUC-Mtr-136540 Medicago truncatula 32.96 3.00e-43 169.00
IUUC-Mla-136541 Melampsora laricipopulina 35.48 9.30e-02 30.80
IUUC-Mga-136544 Meleagris gallopavo 71.88 2.00e-144 506.00
IUUC-Mmr-136548 Microcebus murinus 84.55 0.00e+00 1264.00
IUUC-Mdo-136552 Monodelphis domestica 54.84 0.00e+00 757.00
IUUC-Mmu-136556 Mus musculus 73.79 0.00e+00 1045.00
IUUC-Mac-136559 Musa acuminata 34.13 7.00e-39 155.00
IUUC-Mpu-136562 Mustela putorius furo 81.68 0.00e+00 1233.00
IUUC-Mlu-136566 Myotis lucifugus 76.89 0.00e+00 1097.00
IUUC-Ncr-136570 Neurospora crassa 30.00 2.00e-01 31.60
IUUC-Nle-136573 Nomascus leucogenys 96.51 0.00e+00 1423.00
IUUC-Opr-136577 Ochotona princeps 69.57 0.00e+00 993.00
IUUC-Ont-136580 Oreochromis niloticus 40.00 2.00e-140 493.00
IUUC-Oan-136583 Ornithorhynchus anatinus 66.33 1.00e-149 523.00
IUUC-Ocu-136586 Oryctolagus cuniculus 76.11 0.00e+00 1073.00
IUUC-Oga-136615 Otolemur garnettii 84.16 0.00e+00 1258.00
IUUC-Oar-136620 Ovis aries 35.18 3.00e-52 199.00
IUUC-Ptr-136624 Pan troglodytes 98.68 0.00e+00 1466.00
IUUC-Pan-136628 Papio anubis 95.64 0.00e+00 1348.00
IUUC-Psi-136632 Pelodiscus sinensis 56.13 0.00e+00 781.00
IUUC-Ppa-136638 Physcomitrella patens 36.09 2.00e-42 167.00
IUUC-Pfo-136642 Poecilia formosa 52.15 5.00e-119 422.00
IUUC-Pab-136646 Pongo abelii 96.96 0.00e+00 1414.00
IUUC-Pca-136653 Procavia capensis 71.07 0.00e+00 636.00
IUUC-Pva-136660 Pteropus vampyrus 74.80 0.00e+00 1093.00
IUUC-Rno-136666 Rattus norvegicus 74.05 0.00e+00 1049.00
IUUC-Sce-136669 Saccharomyces cerevisiae 47.06 2.80e-02 33.50
IUUC-Sha-136672 Sarcophilus harrisii 49.39 8.00e-135 474.00
IUUC-Smo-136678 Selaginella moellendorffii 34.96 2.00e-45 177.00
IUUC-Sar-136686 Sorex araneus 63.53 0.00e+00 904.00
IUUC-Ssc-136692 Sus scrofa 67.76 0.00e+00 814.00
IUUC-Tgu-136695 Taeniopygia guttata 70.26 4.00e-165 574.00
IUUC-Tru-136699 Takifugu rubripes 58.15 1.00e-120 427.00
IUUC-Tsy-136702 Tarsius syrichta 62.22 0.00e+00 760.00
IUUC-Tni-136707 Tetraodon nigroviridis 51.61 8.00e-108 384.00
IUUC-Tbe-136720 Tupaia belangeri 70.68 4.00e-128 452.00
IUUC-Ttr-136723 Tursiops truncatus 78.18 0.00e+00 1044.00
IUUC-Vpa-136730 Vicugna pacos 69.68 3.00e-147 515.00
IUUC-Xtr-136735 Xenopus tropicalis 61.14 1.00e-136 480.00
Created Date 25-Jun-2017

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