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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046682
UUCD1 version UUC-HoS-00818
Ensembl Protein ID ENSP00000237281.3
UniProt Accession Q8TB52; Q9BXZ7; FBX30_HUMAN
Genbank Protein ID AAH24326.3; AAK30299.1
Protein Name F-box only protein 30
Genbank Nucleotide ID AL356599; AF248640
Gene Name FBXO30; FBX30
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000118496.4 ENST00000237281.4 ENSP00000237281.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 24076600
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.63 11.7 609 647
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 99   daglldrlpeeilveilklldkeellraarvcrrwqela 137
           ++++l++lp e+l++i ++ld+ +l+++++v++ ++ ++
   Q: 609  HNDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVC 647
           6778999**************************999654 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.
 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.
Protein Sequence
(Fasta)
MEEELQHSHC VNCVSRRCMT RPEPGISCDL IGCPLVCGAV FHSCKADEHR LLCPFERVPC 60
LNSDFGCPFT MARNKVAEHL EMCPASVVCC TMEWNRWPVS YADRKSYENL SRDVDEVAQL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046682|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAAAGGCGG CGGCCCGGCT GGGGAAGAGG GGCGGAGGAG GCGGTTCGGA CGGCTGTGTG 60
GGGTACGGAG CGTCGCCGGG ACAGAGCGGA GCAGCTGGGC ACGGCGTCCA GGGCAGCTAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046682|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001810--F-box_dom
IPR031890--Fbxo30/Fbxo40
IPR008974--TRAF-like
IPR013083--Znf_RING/FYVE/PHD
IPR001293--Znf_TRAF
PROSITE

PS50181--FBOX
PS50145--ZF_TRAF
Pfam

PF15966--F-box_4
PF15965--zf-TRAF_2
Gene Ontology

GO:0005829--C:cytosol
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000209--P:protein polyubiquitination
KEGG hsa:84085
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001191 Ailuropoda melanoleuca 92.51 0.00e+00 1447.00
IUUC-Apl-003279 Anas platyrhynchos 75.76 0.00e+00 1162.00
IUUC-Aca-004293 Anolis carolinensis 71.83 0.00e+00 1092.00
IUUC-Ani-009450 Aspergillus nidulans 38.46 1.00e-02 34.70
IUUC-Ame-011141 Astyanax mexicanus 59.79 0.00e+00 828.00
IUUC-Bta-013004 Bos taurus 90.51 0.00e+00 1401.00
IUUC-Cel-018506 Caenorhabditis elegans 30.71 7.00e-11 62.00
IUUC-Cja-019129 Callithrix jacchus 95.45 0.00e+00 1483.00
IUUC-Cfa-020617 Canis familiaris 91.84 0.00e+00 1419.00
IUUC-Cpo-021712 Cavia porcellus 90.51 0.00e+00 1397.00
IUUC-Cre-022576 Chlamydomonas reinhardtii 52.38 6.00e-04 39.30
IUUC-Csa-023463 Chlorocebus sabaeus 98.12 0.00e+00 1519.00
IUUC-Cho-024287 Choloepus hoffmanni 84.32 0.00e+00 1298.00
IUUC-Dre-028739 Danio rerio 60.26 0.00e+00 816.00
IUUC-Dno-029454 Dasypus novemcinctus 88.24 0.00e+00 1352.00
IUUC-Dor-031145 Dipodomys ordii 91.04 0.00e+00 1420.00
IUUC-Ete-033085 Echinops telfairi 88.69 0.00e+00 1243.00
IUUC-Eca-034171 Equus caballus 93.18 0.00e+00 1459.00
IUUC-Eeu-034630 Erinaceus europaeus 84.27 0.00e+00 1321.00
IUUC-Fca-035665 Felis catus 91.71 0.00e+00 1412.00
IUUC-Fal-036615 Ficedula albicollis 73.16 0.00e+00 1127.00
IUUC-Gmo-039277 Gadus morhua 59.11 0.00e+00 854.00
IUUC-Gga-040427 Gallus gallus 75.26 0.00e+00 1153.00
IUUC-Gac-041803 Gasterosteus aculeatus 58.50 0.00e+00 840.00
IUUC-Ggo-044649 Gorilla gorilla 99.87 0.00e+00 1548.00
IUUC-Itr-048787 Ictidomys tridecemlineatus 92.11 0.00e+00 1438.00
IUUC-Kpa-049358 Komagataella pastoris 42.50 5.90e-01 29.30
IUUC-Lch-049910 Latimeria chalumnae 66.71 0.00e+00 1005.00
IUUC-Loc-052516 Lepisosteus oculatus 64.22 0.00e+00 955.00
IUUC-Laf-054464 Loxodonta africana 89.71 0.00e+00 1346.00
IUUC-Mcc-054771 Macaca mulatta 98.39 0.00e+00 1525.00
IUUC-Meu-056672 Macropus eugenii 94.12 8.00e-157 547.00
IUUC-Mga-059844 Meleagris gallopavo 75.53 0.00e+00 1145.00
IUUC-Mmr-060619 Microcebus murinus 92.91 0.00e+00 1461.00
IUUC-Mdo-062500 Monodelphis domestica 80.46 0.00e+00 1193.00
IUUC-Mmu-064149 Mus musculus 87.58 0.00e+00 1361.00
IUUC-Mpu-066049 Mustela putorius furo 92.78 0.00e+00 1429.00
IUUC-Mlu-067541 Myotis lucifugus 93.18 0.00e+00 1426.00
IUUC-Nle-069653 Nomascus leucogenys 98.93 0.00e+00 1535.00
IUUC-Opr-070824 Ochotona princeps 83.69 0.00e+00 1277.00
IUUC-Ont-072617 Oreochromis niloticus 60.51 0.00e+00 855.00
IUUC-Oan-073691 Ornithorhynchus anatinus 78.93 0.00e+00 1158.00
IUUC-Ocu-074793 Oryctolagus cuniculus 90.91 0.00e+00 1380.00
IUUC-Ola-087112 Oryzias latipes 47.12 2.00e-176 613.00
IUUC-Oga-088620 Otolemur garnettii 92.25 0.00e+00 1445.00
IUUC-Oar-090411 Ovis aries 90.78 0.00e+00 1380.00
IUUC-Ptr-091121 Pan troglodytes 99.73 0.00e+00 1547.00
IUUC-Pan-092257 Papio anubis 98.26 0.00e+00 1525.00
IUUC-Psi-094017 Pelodiscus sinensis 74.50 0.00e+00 1014.00
IUUC-Pma-094673 Petromyzon marinus 49.49 2.00e-81 296.00
IUUC-Pfo-096058 Poecilia formosa 73.30 5.00e-163 568.00
IUUC-Pab-098470 Pongo abelii 93.96 0.00e+00 1438.00
IUUC-Pop-099374 Populus trichocarpa 37.78 4.50e-02 33.10
IUUC-Pca-100432 Procavia capensis 89.26 0.00e+00 1363.00
IUUC-Ppe-101323 Prunus persica 42.86 8.00e-03 34.30
IUUC-Pva-103197 Pteropus vampyrus 92.51 0.00e+00 1447.00
IUUC-Rno-106018 Rattus norvegicus 87.05 0.00e+00 1347.00
IUUC-Sha-106714 Sarcophilus harrisii 81.12 0.00e+00 1211.00
IUUC-Smo-109422 Selaginella moellendorffii 28.95 8.10e-02 32.30
IUUC-Sar-113544 Sorex araneus 88.24 0.00e+00 1350.00
IUUC-Ssc-115836 Sus scrofa 92.38 0.00e+00 1416.00
IUUC-Tgu-116548 Taeniopygia guttata 75.00 0.00e+00 1137.00
IUUC-Tru-118572 Takifugu rubripes 79.59 2.00e-163 569.00
IUUC-Tsy-119478 Tarsius syrichta 91.98 0.00e+00 1422.00
IUUC-Tni-120227 Tetraodon nigroviridis 46.59 3.00e-170 592.00
IUUC-Tbe-127566 Tupaia belangeri 91.28 0.00e+00 1113.00
IUUC-Vpa-130509 Vicugna pacos 91.58 0.00e+00 1414.00
IUUC-Xtr-132254 Xenopus tropicalis 64.25 0.00e+00 969.00
Created Date 25-Jun-2017

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