iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108078

Ensembl Protein ID

SPCC320.13c.1:pep

UniProt Accession

O59790; ARK1_SCHPO

Genbank Protein ID

CAD88263.1

Protein Name

Serine/threonine-protein kinase ark1; Aurora-related kinase 1

Genbank Nucleotide ID

CU329672

Gene Name

ark1; sex1; SPCC320.13c; SPCC330.16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPCC320.13c	SPCC320.13c.1	SPCC320.13c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	61.09	8.00e-100	361.00	IUUC-Hsa-046968

Active Site

Position(s)	Description	Evidence
212	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10027}

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Required for the spindle checkpoint attachment response during spindle formation, kinetochore microtubule interactions and chromosome segregation during anaphase. Ark1 activity depends upon cut17 function and phosphorylation. Ark1 with bir1 is required for full-scale association with kinetochores and formation of a complex with mad3. Ark1 is also required for phosphorylation of histone H3 that accompanies chromosome condensation and condensin recruitment to mitotic chromatin. Ark1 with pic1 is required for the execution of cytokinesis.

Protein Sequence
(Fasta)

MSDSKLADSL NCLSVSTPST TANPGRQQLL RLAVSNQRQV NNVSLANGKE NKRTSNSKFN 60
SSLRKIEEPI AGVPSSAGPQ WREFHIGMFE IGKPLGKGKF GRVYLAKEKK TGFIVALKTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCAAAAGCC AACATCAGCG TTTTTTTACG AAATAATGTC AGATTCAAAG TTGGCAGATT 60
CTTTGAATTG CCTTTCTGTG TCAACTCCAT CAACCACAGC TAATCCTGGG AGACAACAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR030616--Aur
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0032133--C:chromosome passenger complex
GO:0000775--C:chromosome, centromeric region
GO:0000939--C:condensed chromosome inner kinetochore
GO:0000777--C:condensed chromosome kinetochore
GO:0000778--C:condensed nuclear chromosome kinetochore
GO:0005737--C:cytoplasm
GO:0072687--C:meiotic spindle
GO:1990385--C:meiotic spindle midzone
GO:1990023--C:mitotic spindle midzone
GO:0005876--C:spindle microtubule
GO:0005524--F:ATP binding
GO:0035174--F:histone serine kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0051316--P:attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation
GO:0090699--P:correction of merotelic kinetochore attachment, meiosis I
GO:0098783--P:correction of merotelic kinetochore attachment, mitotic
GO:2000775--P:histone H3-S10 phosphorylation involved in chromosome condensation
GO:0033316--P:meiotic spindle assembly checkpoint
GO:0007076--P:mitotic chromosome condensation
GO:0000281--P:mitotic cytokinesis
GO:1990758--P:mitotic sister chromatid biorientation
GO:0000070--P:mitotic sister chromatid segregation
GO:0007094--P:mitotic spindle assembly checkpoint
GO:0007052--P:mitotic spindle organization
GO:0034501--P:protein localization to kinetochore
GO:0034503--P:protein localization to nucleolar rDNA repeats
GO:0000320--P:re-entry into mitotic cell cycle
GO:0032465--P:regulation of cytokinesis

KEGG

spo:SPCC320.13c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000930	Aegilops tauschii	60.22	3.00e-95	339.00
IUUC-Aml-001426	Ailuropoda melanoleuca	63.85	6.00e-103	365.00
IUUC-Atr-002453	Amborella trichopoda	60.90	3.00e-94	335.00
IUUC-Apl-003626	Anas platyrhynchos	62.69	7.00e-102	362.00
IUUC-Aca-004602	Anolis carolinensis	62.55	5.00e-100	355.00
IUUC-Aly-005878	Arabidopsis lyrata	60.77	3.00e-94	335.00
IUUC-Ath-007117	Arabidopsis thaliana	61.39	5.00e-94	335.00
IUUC-Acl-008199	Aspergillus clavatus	58.13	2.00e-111	393.00
IUUC-Afl-008419	Aspergillus flavus	58.89	2.00e-111	393.00
IUUC-Afu-008751	Aspergillus fumigatus	61.14	3.00e-110	389.00
IUUC-Ani-009181	Aspergillus nidulans	60.68	1.00e-116	410.00
IUUC-Ang-009787	Aspergillus niger	58.89	8.00e-113	398.00
IUUC-Aor-009980	Aspergillus oryzae	58.89	2.00e-111	393.00
IUUC-Ate-010286	Aspergillus terreus	59.94	1.00e-112	397.00
IUUC-Ame-010849	Astyanax mexicanus	61.02	2.00e-95	340.00
IUUC-Bgr-012110	Blumeria graminis	56.18	2.00e-109	387.00
IUUC-Bta-013474	Bos taurus	60.58	1.00e-102	364.00
IUUC-Bci-013756	Botrytis cinerea	57.43	1.00e-115	407.00
IUUC-Bdi-014257	Brachypodium distachyon	62.93	6.00e-96	341.00
IUUC-Bol-016310	Brassica oleracea	60.62	2.00e-93	333.00
IUUC-Bra-017438	Brassica rapa	58.24	4.00e-94	335.00
IUUC-Cel-018157	Caenorhabditis elegans	56.20	2.00e-89	320.00
IUUC-Cja-019282	Callithrix jacchus	60.73	1.00e-101	361.00
IUUC-Cfa-020162	Canis familiaris	63.46	8.00e-103	365.00
IUUC-Cpo-021764	Cavia porcellus	59.51	9.00e-102	361.00
IUUC-Cre-022827	Chlamydomonas reinhardtii	62.31	3.00e-98	349.00
IUUC-Csa-023694	Chlorocebus sabaeus	61.09	7.00e-102	361.00
IUUC-Cho-024350	Choloepus hoffmanni	63.78	6.00e-75	271.00
IUUC-Cin-025542	Ciona intestinalis	63.10	4.00e-97	345.00
IUUC-Csv-025873	Ciona savignyi	58.01	3.00e-98	349.00
IUUC-Cgl-026632	Colletotrichum gloeosporioides	66.16	2.00e-102	363.00
IUUC-Cne-026928	Cryptococcus neoformans	71.60	5.00e-115	405.00
IUUC-Cme-027336	Cyanidioschyzon merolae	63.43	4.00e-105	372.00
IUUC-Dre-028198	Danio rerio	62.60	2.00e-98	350.00
IUUC-Dno-029928	Dasypus novemcinctus	63.08	3.00e-101	359.00
IUUC-Dor-030238	Dipodomys ordii	54.71	1.00e-86	311.00
IUUC-Dse-031266	Dothistroma septosporum	70.63	2.00e-114	403.00
IUUC-Dme-032007	Drosophila melanogaster	57.59	1.00e-85	308.00
IUUC-Ete-032911	Echinops telfairi	46.99	1.00e-61	228.00
IUUC-Eca-033749	Equus caballus	63.85	4.00e-103	365.00
IUUC-Eeu-035170	Erinaceus europaeus	61.69	5.00e-96	342.00
IUUC-Fca-035498	Felis catus	61.96	4.00e-104	369.00
IUUC-Fal-037397	Ficedula albicollis	60.87	3.00e-101	360.00
IUUC-Fox-037747	Fusarium oxysporum	58.94	1.00e-112	397.00
IUUC-Fso-038429	Fusarium solani	62.46	5.00e-109	385.00
IUUC-Gmo-039378	Gadus morhua	62.11	4.00e-98	349.00
IUUC-Ggr-039939	Gaeumannomyces graminis	68.80	7.00e-112	395.00
IUUC-Gga-040187	Gallus gallus	61.92	1.00e-99	354.00
IUUC-Gac-042223	Gasterosteus aculeatus	58.97	4.00e-98	349.00
IUUC-Gma-042870	Glycine max	58.52	4.00e-86	308.00
IUUC-Ggo-045617	Gorilla gorilla	61.09	6.00e-102	362.00
IUUC-Hsa-046968	Homo sapiens	61.09	9.00e-102	361.00
IUUC-Hvu-047072	Hordeum vulgare	53.31	2.00e-75	273.00
IUUC-Itr-048233	Ictidomys tridecemlineatus	50.00	2.00e-74	270.00
IUUC-Kpa-049093	Komagataella pastoris	62.36	2.00e-90	323.00
IUUC-Lch-050346	Latimeria chalumnae	54.52	1.00e-102	364.00
IUUC-Lpe-051466	Leersia perrieri	62.93	3.00e-95	338.00
IUUC-Lma-053006	Leptosphaeria maculans	60.40	4.00e-112	395.00
IUUC-Laf-053422	Loxodonta africana	63.08	2.00e-100	357.00
IUUC-Mcc-055245	Macaca mulatta	61.09	1.00e-101	360.00
IUUC-Mor-056952	Magnaporthe oryzae	67.27	1.00e-110	390.00
IUUC-Mpo-057605	Magnaporthe poae	67.64	8.00e-112	394.00
IUUC-Mtr-057726	Medicago truncatula	59.56	5.00e-92	328.00
IUUC-Mla-059174	Melampsora laricipopulina	69.29	2.00e-114	403.00
IUUC-Mga-059562	Meleagris gallopavo	58.59	7.00e-78	282.00
IUUC-Mvi-060305	Microbotryum violaceum	69.23	1.00e-110	391.00
IUUC-Mmr-061588	Microcebus murinus	63.08	1.00e-101	361.00
IUUC-Mdo-061914	Monodelphis domestica	63.85	1.00e-103	367.00
IUUC-Mmu-063288	Mus musculus	55.74	8.00e-101	358.00
IUUC-Mac-064969	Musa acuminata	59.12	4.00e-95	338.00
IUUC-Mpu-066855	Mustela putorius furo	63.85	3.00e-103	366.00
IUUC-Mlu-068046	Myotis lucifugus	63.85	1.00e-102	364.00
IUUC-Nfi-068527	Neosartorya fischeri	60.65	3.00e-111	392.00
IUUC-Ncr-068678	Neurospora crassa	68.54	2.00e-108	384.00
IUUC-Nle-069848	Nomascus leucogenys	61.09	2.00e-101	360.00
IUUC-Opr-070589	Ochotona princeps	63.08	1.00e-100	357.00
IUUC-Ont-071733	Oreochromis niloticus	61.25	7.00e-94	335.00
IUUC-Oan-073399	Ornithorhynchus anatinus	63.08	7.00e-102	361.00
IUUC-Ocu-074063	Oryctolagus cuniculus	61.39	3.00e-99	353.00
IUUC-Oba-075264	Oryza barthii	62.55	3.00e-94	335.00
IUUC-Obr-076048	Oryza brachyantha	63.32	3.00e-96	342.00
IUUC-Ogl-077637	Oryza glaberrima	58.82	1.00e-95	340.00
IUUC-Ogu-078830	Oryza glumaepatula	62.93	9.00e-95	337.00
IUUC-Oin-079150	Oryza indica	62.93	7.00e-95	337.00
IUUC-Olo-080398	Oryza longistaminata	53.25	7.00e-75	271.00
IUUC-Ome-081544	Oryza meridionalis	53.53	6.00e-85	305.00
IUUC-Oni-082250	Oryza nivara	62.93	7.00e-95	337.00
IUUC-Opu-083638	Oryza punctata	62.93	1.00e-94	337.00
IUUC-Oru-084981	Oryza rufipogon	62.93	5.00e-95	338.00
IUUC-Osa-085961	Oryza sativa	62.93	5.00e-95	338.00
IUUC-Olu-087880	Ostreococcus lucimarinus	64.48	7.00e-101	358.00
IUUC-Oga-088891	Otolemur garnettii	62.93	2.00e-101	360.00
IUUC-Oar-090021	Ovis aries	60.58	5.00e-102	362.00
IUUC-Ptr-091458	Pan troglodytes	61.09	8.00e-102	361.00
IUUC-Pan-092546	Papio anubis	60.73	2.00e-101	360.00
IUUC-Psi-093280	Pelodiscus sinensis	52.29	7.00e-101	358.00
IUUC-Pma-094298	Petromyzon marinus	64.09	2.00e-94	336.00
IUUC-Pno-094847	Phaeosphaeria nodorum	59.27	4.00e-106	375.00
IUUC-Ppa-095855	Physcomitrella patens	60.29	7.00e-97	344.00
IUUC-Pfo-096428	Poecilia formosa	60.89	5.00e-93	332.00
IUUC-Pab-098696	Pongo abelii	60.73	1.00e-100	357.00
IUUC-Pop-099405	Populus trichocarpa	59.04	1.00e-93	334.00
IUUC-Pca-100740	Procavia capensis	63.08	1.00e-101	361.00
IUUC-Ppe-101854	Prunus persica	60.46	1.00e-93	334.00
IUUC-Pva-103212	Pteropus vampyrus	64.62	2.00e-103	367.00
IUUC-Pgr-103474	Puccinia graminis	68.32	1.00e-110	390.00
IUUC-Ptt-103933	Puccinia triticina	52.38	1.00e-75	274.00
IUUC-Pte-104089	Pyrenophora teres	59.49	1.00e-108	384.00
IUUC-Pyt-104555	Pyrenophora triticirepentis	59.21	3.00e-108	383.00
IUUC-Rno-105057	Rattus norvegicus	55.52	1.00e-100	357.00
IUUC-Sha-107137	Sarcophilus harrisii	63.85	4.00e-104	369.00
IUUC-Sja-107767	Schizosaccharomyces japonicus	76.50	3.00e-157	545.00
IUUC-Smo-109288	Selaginella moellendorffii	59.04	2.00e-94	336.00
IUUC-Sit-110246	Setaria italica	63.32	3.00e-96	342.00
IUUC-Sly-111379	Solanum lycopersicum	61.39	1.00e-92	330.00
IUUC-Stu-112777	Solanum tuberosum	60.62	3.00e-93	332.00
IUUC-Sar-113569	Sorex araneus	29.26	2.00e-30	126.00
IUUC-Sbi-114325	Sorghum bicolor	63.71	5.00e-96	342.00
IUUC-Sre-115203	Sporisorium reilianum	59.29	2.00e-90	323.00
IUUC-Ssc-115361	Sus scrofa	52.87	4.00e-103	366.00
IUUC-Tgu-116967	Taeniopygia guttata	64.82	3.00e-100	356.00
IUUC-Tru-117570	Takifugu rubripes	60.53	7.00e-99	352.00
IUUC-Tsy-119280	Tarsius syrichta	63.78	3.00e-77	280.00
IUUC-Tni-120721	Tetraodon nigroviridis	61.72	2.00e-97	347.00
IUUC-Tca-121494	Theobroma cacao	61.07	2.00e-94	336.00
IUUC-Tre-121869	Trichoderma reesei	68.91	6.00e-111	391.00
IUUC-Tvi-122510	Trichoderma virens	67.38	2.00e-111	393.00
IUUC-Tae-123071	Triticum aestivum	60.22	3.00e-95	339.00
IUUC-Tur-126240	Triticum urartu	59.85	1.00e-94	337.00
IUUC-Tme-126921	Tuber melanosporum	62.12	3.00e-117	412.00
IUUC-Tbe-127872	Tupaia belangeri	58.46	7.00e-90	322.00
IUUC-Ttr-129134	Tursiops truncatus	63.85	3.00e-103	366.00
IUUC-Uma-129412	Ustilago maydis	60.00	3.00e-89	320.00
IUUC-Vda-130003	Verticillium dahliae	58.33	3.00e-114	402.00
IUUC-Vvi-131272	Vitis vinifera	58.01	3.00e-94	335.00
IUUC-Xtr-132019	Xenopus tropicalis	56.95	2.00e-101	360.00
IUUC-Xma-134203	Xiphophorus maculatus	62.20	9.00e-98	348.00
IUUC-Yli-134503	Yarrowia lipolytica	58.89	1.00e-105	374.00
IUUC-Zma-135232	Zea mays	63.71	2.00e-96	342.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence