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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106154
UUCD1 version UUC-SaC-00106
Ensembl Protein ID YKR017C
UniProt Accession P36113; D6VX82; HEL1_YEAST
Genbank Protein ID CAA82089.1; DAA09172.1
Protein Name E3 ubiquitin-protein ligase HEL1; Histone E3 ligase 1; RING-type E3 ubiquitin transferase HEL1
Genbank Nucleotide ID Z28242; BK006944
Gene Name HEL1; YKR017C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YKR017C YKR017C YKR017C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 30.95 2.00e-63 240.00 IUUC-Cel-018521
E3 activity/RBR 30.63 6.00e-63 239.00 IUUC-Hsa-045718
E3 activity/RING/RING 30.12 1.00e-50 196.00 IUUC-Ots-000040
Active Site
Position(s) Description Evidence
354 N/A {ECO:0000250|UniProtKB:Q9Y4X5}
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.
 Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.
Protein Sequence
(Fasta)
MSSGTENDQF YSFDESDSSS IELYESHNTS EFTIHGLVFP KLISVTSQDS EFDINEDEDG 60
VDTIYEGMLD APLTKNNKRI LCEGSVPNLS YECLTTKGIF ERMLQRVDHL QPIFAIPSAD 120
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Protein Fasta Sequence


>IUUC-Sce-106154|E3,RING;E3,RBR|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGTAGTG GTACCGAAAA TGATCAATTT TATAGTTTTG ATGAAAGTGA TTCCAGCTCT 60
ATTGAACTTT ATGAATCTCA CAATACATCT GAATTTACTA TACATGGACT AGTTTTCCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106154|E3,RING;E3,RBR|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF01485--IBR
PF00097--zf-C3HC4
SMART

SM00647--IBR
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0036205--P:histone catabolic process
GO:0016574--P:histone ubiquitination
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG sce:YKR017C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000970 Aegilops tauschii 27.93 8.00e-42 162.00
IUUC-Aml-001385 Ailuropoda melanoleuca 30.63 7.00e-61 226.00
IUUC-Atr-002495 Amborella trichopoda 29.02 5.00e-42 163.00
IUUC-Apl-004184 Anas platyrhynchos 31.09 3.00e-57 213.00
IUUC-Aca-004976 Anolis carolinensis 31.03 2.00e-57 214.00
IUUC-Aly-005665 Arabidopsis lyrata 27.84 4.00e-43 167.00
IUUC-Ath-006859 Arabidopsis thaliana 27.15 1.00e-48 185.00
IUUC-Ago-007926 Ashbya gossypii 45.59 5.00e-127 446.00
IUUC-Acl-008252 Aspergillus clavatus 33.54 2.00e-79 288.00
IUUC-Afl-008468 Aspergillus flavus 35.44 2.00e-78 284.00
IUUC-Afu-009062 Aspergillus fumigatus 34.62 3.00e-80 290.00
IUUC-Ani-009219 Aspergillus nidulans 34.05 2.00e-77 280.00
IUUC-Ang-009538 Aspergillus niger 34.36 2.00e-75 274.00
IUUC-Aor-010009 Aspergillus oryzae 35.57 4.00e-78 283.00
IUUC-Ate-010497 Aspergillus terreus 33.48 4.00e-74 270.00
IUUC-Ame-011264 Astyanax mexicanus 30.63 5.00e-65 239.00
IUUC-Bgr-012016 Blumeria graminis 33.62 8.00e-76 275.00
IUUC-Bta-013518 Bos taurus 30.63 6.00e-61 226.00
IUUC-Bci-013819 Botrytis cinerea 34.00 4.00e-77 280.00
IUUC-Bdi-014096 Brachypodium distachyon 29.21 2.00e-49 188.00
IUUC-Bol-016087 Brassica oleracea 28.03 9.00e-48 182.00
IUUC-Bra-017944 Brassica rapa 27.21 4.00e-44 170.00
IUUC-Cel-018521 Caenorhabditis elegans 30.95 8.00e-59 219.00
IUUC-Cja-019728 Callithrix jacchus 28.23 2.00e-47 181.00
IUUC-Cfa-020812 Canis familiaris 30.63 3.00e-59 220.00
IUUC-Cpo-021627 Cavia porcellus 30.63 6.00e-61 226.00
IUUC-Cre-022815 Chlamydomonas reinhardtii 29.33 4.00e-46 176.00
IUUC-Csa-023034 Chlorocebus sabaeus 31.09 2.00e-57 214.00
IUUC-Cho-024444 Choloepus hoffmanni 31.22 3.00e-59 220.00
IUUC-Cin-025135 Ciona intestinalis 30.02 2.00e-58 218.00
IUUC-Csv-026243 Ciona savignyi 31.42 8.00e-58 216.00
IUUC-Cgl-026434 Colletotrichum gloeosporioides 33.91 9.00e-80 288.00
IUUC-Cne-026861 Cryptococcus neoformans 32.97 1.00e-71 261.00
IUUC-Dre-027785 Danio rerio 30.63 8.00e-65 239.00
IUUC-Dno-029205 Dasypus novemcinctus 30.63 6.00e-61 226.00
IUUC-Dor-030769 Dipodomys ordii 26.76 6.00e-41 159.00
IUUC-Dse-031171 Dothistroma septosporum 33.97 4.00e-78 283.00
IUUC-Dme-031903 Drosophila melanogaster 30.87 1.00e-61 228.00
IUUC-Ete-032355 Echinops telfairi 29.09 9.00e-40 155.00
IUUC-Eca-033431 Equus caballus 30.34 4.00e-58 216.00
IUUC-Eeu-035230 Erinaceus europaeus 43.79 2.00e-32 130.00
IUUC-Fca-035882 Felis catus 34.41 1.00e-51 195.00
IUUC-Fal-037068 Ficedula albicollis 30.34 4.00e-58 216.00
IUUC-Fox-037790 Fusarium oxysporum 42.47 1.00e-58 217.00
IUUC-Fso-038125 Fusarium solani 35.39 2.00e-83 300.00
IUUC-Gmo-038703 Gadus morhua 30.85 1.00e-64 238.00
IUUC-Ggr-039722 Gaeumannomyces graminis 32.62 7.00e-75 272.00
IUUC-Gga-040319 Gallus gallus 32.17 1.00e-47 181.00
IUUC-Gac-041708 Gasterosteus aculeatus 30.63 8.00e-65 239.00
IUUC-Gma-042954 Glycine max 28.03 4.00e-50 190.00
IUUC-Ggo-045178 Gorilla gorilla 30.63 6.00e-61 226.00
IUUC-Hsa-045718 Homo sapiens 30.63 6.00e-61 226.00
IUUC-Hvu-047322 Hordeum vulgare 28.31 4.00e-48 183.00
IUUC-Itr-048934 Ictidomys tridecemlineatus 36.21 1.00e-46 177.00
IUUC-Kpa-049350 Komagataella pastoris 34.48 6.00e-86 309.00
IUUC-Lch-049584 Latimeria chalumnae 29.13 2.00e-47 181.00
IUUC-Lpe-051080 Leersia perrieri 28.76 3.00e-49 187.00
IUUC-Loc-052442 Lepisosteus oculatus 30.42 7.00e-65 239.00
IUUC-Lma-053253 Leptosphaeria maculans 34.85 3.00e-77 280.00
IUUC-Laf-054351 Loxodonta africana 31.09 3.00e-57 213.00
IUUC-Mcc-054670 Macaca mulatta 28.88 6.00e-56 209.00
IUUC-Meu-056332 Macropus eugenii 32.59 1.00e-44 172.00
IUUC-Mor-057179 Magnaporthe oryzae 33.48 4.00e-76 276.00
IUUC-Mpo-057553 Magnaporthe poae 32.83 4.00e-75 273.00
IUUC-Mtr-058263 Medicago truncatula 28.86 9.00e-49 186.00
IUUC-Mla-058889 Melampsora laricipopulina 29.21 3.00e-51 194.00
IUUC-Mga-059385 Meleagris gallopavo 31.09 2.00e-57 214.00
IUUC-Mvi-060517 Microbotryum violaceum 31.22 1.00e-71 261.00
IUUC-Mmr-061439 Microcebus murinus 29.76 1.00e-52 198.00
IUUC-Mdo-062890 Monodelphis domestica 30.63 6.00e-61 226.00
IUUC-Mmu-063433 Mus musculus 30.63 6.00e-61 226.00
IUUC-Mac-065341 Musa acuminata 29.02 8.00e-49 186.00
IUUC-Mpu-066288 Mustela putorius furo 30.63 7.00e-61 226.00
IUUC-Mlu-067187 Myotis lucifugus 30.92 4.00e-61 226.00
IUUC-Nfi-068339 Neosartorya fischeri 34.72 5.00e-80 289.00
IUUC-Ncr-068947 Neurospora crassa 35.12 1.00e-72 265.00
IUUC-Nle-069263 Nomascus leucogenys 30.63 6.00e-61 226.00
IUUC-Opr-070518 Ochotona princeps 27.95 3.00e-46 177.00
IUUC-Ont-072309 Oreochromis niloticus 30.85 3.00e-64 237.00
IUUC-Oan-073731 Ornithorhynchus anatinus 32.88 8.00e-53 198.00
IUUC-Ocu-074000 Oryctolagus cuniculus 31.09 2.00e-57 214.00
IUUC-Oba-075918 Oryza barthii 27.76 4.00e-41 160.00
IUUC-Obr-076705 Oryza brachyantha 28.82 1.00e-47 182.00
IUUC-Ogl-077640 Oryza glaberrima 28.12 4.00e-48 184.00
IUUC-Ogu-079025 Oryza glumaepatula 28.50 9.00e-47 179.00
IUUC-Oin-079448 Oryza indica 28.12 2.00e-48 184.00
IUUC-Olo-080626 Oryza longistaminata 30.82 1.00e-37 149.00
IUUC-Ome-081470 Oryza meridionalis 28.12 4.00e-48 184.00
IUUC-Oni-082202 Oryza nivara 27.63 1.00e-45 175.00
IUUC-Opu-084059 Oryza punctata 28.57 3.00e-47 181.00
IUUC-Oru-084181 Oryza rufipogon 28.50 8.00e-47 179.00
IUUC-Osa-086069 Oryza sativa 28.50 4.00e-47 180.00
IUUC-Ola-086792 Oryzias latipes 30.85 3.00e-64 236.00
IUUC-Olu-087826 Ostreococcus lucimarinus 25.92 3.00e-31 127.00
IUUC-Oga-088706 Otolemur garnettii 30.63 6.00e-61 226.00
IUUC-Oar-089354 Ovis aries 30.63 7.00e-61 226.00
IUUC-Ptr-091287 Pan troglodytes 30.63 6.00e-61 226.00
IUUC-Pan-091701 Papio anubis 31.09 3.00e-57 214.00
IUUC-Psi-093814 Pelodiscus sinensis 31.11 1.00e-57 214.00
IUUC-Pma-094243 Petromyzon marinus 27.04 3.00e-40 158.00
IUUC-Pno-095124 Phaeosphaeria nodorum 29.45 1.00e-53 201.00
IUUC-Ppa-095554 Physcomitrella patens 28.05 1.00e-47 182.00
IUUC-Pfo-096449 Poecilia formosa 30.85 3.00e-64 237.00
IUUC-Pab-098132 Pongo abelii 30.63 6.00e-61 226.00
IUUC-Pop-099139 Populus trichocarpa 28.63 1.00e-48 185.00
IUUC-Pca-100303 Procavia capensis 35.86 5.00e-46 176.00
IUUC-Ppe-101451 Prunus persica 27.93 4.00e-43 167.00
IUUC-Pva-102457 Pteropus vampyrus 30.63 6.00e-61 226.00
IUUC-Pgr-103443 Puccinia graminis 30.21 2.00e-65 241.00
IUUC-Ptt-103795 Puccinia triticina 29.83 6.00e-55 206.00
IUUC-Pte-104022 Pyrenophora teres 34.38 2.00e-73 268.00
IUUC-Pyt-104643 Pyrenophora triticirepentis 35.71 5.00e-80 289.00
IUUC-Rno-106083 Rattus norvegicus 30.63 6.00e-61 226.00
IUUC-Sha-106765 Sarcophilus harrisii 31.08 2.00e-59 220.00
IUUC-Sja-107977 Schizosaccharomyces japonicus 33.33 1.00e-70 258.00
IUUC-Spo-108222 Schizosaccharomyces pombe 34.98 5.00e-79 286.00
IUUC-Ssl-108406 Sclerotinia sclerotiorum 24.21 1.00e-06 45.80
IUUC-Smo-109424 Selaginella moellendorffii 28.57 1.00e-48 185.00
IUUC-Sit-110645 Setaria italica 28.44 1.00e-47 182.00
IUUC-Sly-111226 Solanum lycopersicum 29.61 3.00e-49 187.00
IUUC-Stu-112533 Solanum tuberosum 29.28 6.00e-47 179.00
IUUC-Sar-113023 Sorex araneus 30.86 3.00e-55 207.00
IUUC-Sbi-114839 Sorghum bicolor 27.79 7.00e-48 182.00
IUUC-Sre-115120 Sporisorium reilianum 35.36 4.00e-80 290.00
IUUC-Ssc-115362 Sus scrofa 28.17 9.00e-47 179.00
IUUC-Tgu-117273 Taeniopygia guttata 31.09 2.00e-57 214.00
IUUC-Tru-118338 Takifugu rubripes 31.89 3.00e-64 237.00
IUUC-Tsy-119096 Tarsius syrichta 28.87 8.00e-45 172.00
IUUC-Tni-120238 Tetraodon nigroviridis 30.85 1.00e-63 235.00
IUUC-Tca-121539 Theobroma cacao 27.79 3.00e-46 177.00
IUUC-Tre-121902 Trichoderma reesei 35.05 1.00e-81 295.00
IUUC-Tvi-122474 Trichoderma virens 34.21 6.00e-80 289.00
IUUC-Tae-123545 Triticum aestivum 28.86 6.00e-49 186.00
IUUC-Tur-126320 Triticum urartu 26.65 7.00e-29 119.00
IUUC-Tme-127089 Tuber melanosporum 36.09 1.00e-80 291.00
IUUC-Tbe-127647 Tupaia belangeri 28.15 1.00e-25 110.00
IUUC-Ttr-128315 Tursiops truncatus 27.95 7.00e-47 179.00
IUUC-Uma-129487 Ustilago maydis 34.35 2.00e-78 284.00
IUUC-Vda-129939 Verticillium dahliae 33.75 1.00e-79 288.00
IUUC-Vpa-130259 Vicugna pacos 30.26 2.00e-58 217.00
IUUC-Vvi-131543 Vitis vinifera 27.79 3.00e-47 181.00
IUUC-Xtr-132219 Xenopus tropicalis 30.70 2.00e-60 224.00
IUUC-Xma-133423 Xiphophorus maculatus 30.85 3.00e-64 237.00
IUUC-Yli-134622 Yarrowia lipolytica 32.10 1.00e-67 248.00
IUUC-Zma-134901 Zea mays 27.79 3.00e-48 184.00
Created Date 25-Jun-2017

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