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Tag Content
UUCD2 ID IUUC-Gga-040612
UUCD1 version UUC-GaG-00339
Ensembl Protein ID ENSGALP00000048171.1
UniProt Accession Q5ZLD3; KLH13_CHICK
Genbank Protein ID CAG31460.1
Protein Name Kelch-like protein 13
Genbank Nucleotide ID AJ719801
Gene Name KLHL13; RCJMB04_6k12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000005982.5 ENSGALT00000009621.5 ENSGALP00000009607.5
ENSGALG00000005982.5 ENSGALT00000061100.1 ENSGALP00000048171.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 6.70e-16 58.8 68 136
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.10e-08 34.3 169 200
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvg..geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+lv g  +e+f++h++++a++S++F+a+f+++++e++   ++++++v    ++ +++F+Yt kl++n
   Q: 68   CDVTLVPGdgDEVFPVHRAMMASASDYFKAMFTGGMKEQD-LMCIKLHGVNKIGLKKIIDFIYTAKLSLN 136
           8******999*****************************9.**************************987 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           leNc+++ r+A++y+++++ +++++filk+F+
   Q: 169  LENCVEVGRIANTYNLTEVDKYVNNFILKNFP 200
           79*****************************6 PP
   
Organism Gallus gallus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity).
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity).
Protein Sequence
(Fasta)
HFWRGNLFTS LVEEEDPHMK VSLGSSDMGV SAHLQSSKTG TTRFFTSNTH SSVVLQGFDQ 60
LRVEGLLCDV TLVPGDGDEV FPVHRAMMAS ASDYFKAMFT GGMKEQDLMC IKLHGVNKIG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Gga-040612|E3,BTB_3-box|Gallus gallus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGGCCAGGC GGCGGGCGCG GGGCCGCGCT CGGTACTTAG GGAGCGCTCC GGAGCGGGGC 60
CCGCGGTCGC GGCTCGCAGG TGAGTGAGGG GCGTGTGGAG GGGGCCGGGC TGCTGTGTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Gga-040612|E3,BTB_3-box|Gallus gallus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0030496--C:midbody
GO:0000910--P:cytokinesis
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination
KEGG gga:422226
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001184 Ailuropoda melanoleuca 92.63 0.00e+00 1147.00
IUUC-Apl-003784 Anas platyrhynchos 99.68 0.00e+00 1272.00
IUUC-Aca-005013 Anolis carolinensis 98.56 0.00e+00 1257.00
IUUC-Ame-011461 Astyanax mexicanus 91.88 0.00e+00 1190.00
IUUC-Bta-013439 Bos taurus 95.43 0.00e+00 1208.00
IUUC-Cja-019972 Callithrix jacchus 92.31 0.00e+00 1144.00
IUUC-Cfa-021230 Canis familiaris 93.09 0.00e+00 1147.00
IUUC-Cpo-022428 Cavia porcellus 92.15 0.00e+00 1142.00
IUUC-Csa-023027 Chlorocebus sabaeus 92.47 0.00e+00 1144.00
IUUC-Cho-024873 Choloepus hoffmanni 95.60 0.00e+00 1214.00
IUUC-Cin-025654 Ciona intestinalis 64.96 0.00e+00 816.00
IUUC-Csv-026204 Ciona savignyi 67.08 0.00e+00 805.00
IUUC-Dre-028137 Danio rerio 91.41 0.00e+00 1182.00
IUUC-Dno-029077 Dasypus novemcinctus 93.77 0.00e+00 1125.00
IUUC-Dor-030975 Dipodomys ordii 92.15 0.00e+00 1166.00
IUUC-Ete-032431 Echinops telfairi 92.74 0.00e+00 1173.00
IUUC-Eca-033771 Equus caballus 92.63 0.00e+00 1145.00
IUUC-Fca-036060 Felis catus 92.63 0.00e+00 1147.00
IUUC-Fal-037167 Ficedula albicollis 94.14 0.00e+00 995.00
IUUC-Gmo-039422 Gadus morhua 85.55 0.00e+00 1078.00
IUUC-Gac-042629 Gasterosteus aculeatus 92.31 0.00e+00 1190.00
IUUC-Ggo-045388 Gorilla gorilla 92.47 0.00e+00 1144.00
IUUC-Hsa-046683 Homo sapiens 95.76 0.00e+00 1213.00
IUUC-Itr-048813 Ictidomys tridecemlineatus 95.60 0.00e+00 1212.00
IUUC-Lch-050402 Latimeria chalumnae 94.87 0.00e+00 1225.00
IUUC-Loc-052719 Lepisosteus oculatus 94.24 0.00e+00 1254.00
IUUC-Laf-054306 Loxodonta africana 92.31 0.00e+00 1142.00
IUUC-Mcc-055150 Macaca mulatta 92.77 0.00e+00 1147.00
IUUC-Meu-056474 Macropus eugenii 92.33 0.00e+00 1169.00
IUUC-Mor-057229 Magnaporthe oryzae 36.23 3.00e-07 48.50
IUUC-Mga-060174 Meleagris gallopavo 99.68 0.00e+00 1276.00
IUUC-Mmr-061476 Microcebus murinus 93.09 0.00e+00 1149.00
IUUC-Mdo-061869 Monodelphis domestica 91.98 0.00e+00 1219.00
IUUC-Mmu-063519 Mus musculus 95.60 0.00e+00 1212.00
IUUC-Mpu-065703 Mustela putorius furo 95.60 0.00e+00 1212.00
IUUC-Mlu-067082 Myotis lucifugus 95.11 0.00e+00 1202.00
IUUC-Nle-069858 Nomascus leucogenys 92.77 0.00e+00 1145.00
IUUC-Opr-070825 Ochotona princeps 95.74 0.00e+00 1205.00
IUUC-Ont-071620 Oreochromis niloticus 92.93 0.00e+00 1197.00
IUUC-Oan-073694 Ornithorhynchus anatinus 88.59 0.00e+00 1048.00
IUUC-Ocu-074027 Oryctolagus cuniculus 96.08 0.00e+00 1217.00
IUUC-Ola-086565 Oryzias latipes 93.09 0.00e+00 1201.00
IUUC-Oga-088341 Otolemur garnettii 94.44 0.00e+00 1219.00
IUUC-Oar-090227 Ovis aries 92.79 0.00e+00 1147.00
IUUC-Ptr-091283 Pan troglodytes 96.70 0.00e+00 1087.00
IUUC-Pan-092417 Papio anubis 92.47 0.00e+00 1144.00
IUUC-Psi-094003 Pelodiscus sinensis 99.20 0.00e+00 1267.00
IUUC-Pma-094341 Petromyzon marinus 71.45 0.00e+00 812.00
IUUC-Pfo-096698 Poecilia formosa 88.82 0.00e+00 1164.00
IUUC-Pab-098052 Pongo abelii 95.76 0.00e+00 1213.00
IUUC-Pca-100332 Procavia capensis 87.34 0.00e+00 1088.00
IUUC-Pva-102590 Pteropus vampyrus 92.47 0.00e+00 1134.00
IUUC-Rno-105991 Rattus norvegicus 95.60 0.00e+00 1211.00
IUUC-Sha-107055 Sarcophilus harrisii 92.31 0.00e+00 1191.00
IUUC-Sar-113034 Sorex araneus 87.82 0.00e+00 1093.00
IUUC-Ssc-116052 Sus scrofa 96.08 0.00e+00 1217.00
IUUC-Tgu-117014 Taeniopygia guttata 99.04 0.00e+00 1271.00
IUUC-Tru-117586 Takifugu rubripes 92.19 0.00e+00 1197.00
IUUC-Tsy-119119 Tarsius syrichta 95.92 0.00e+00 1213.00
IUUC-Tni-119722 Tetraodon nigroviridis 90.72 0.00e+00 1162.00
IUUC-Tbe-127718 Tupaia belangeri 79.30 0.00e+00 913.00
IUUC-Ttr-128192 Tursiops truncatus 95.76 0.00e+00 1213.00
IUUC-Vpa-130727 Vicugna pacos 95.76 0.00e+00 1213.00
IUUC-Xtr-132681 Xenopus tropicalis 95.83 0.00e+00 1238.00
Created Date 25-Jun-2017

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