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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045664
Ensembl Protein ID ENSP00000334314.4
UniProt Accession O00423; Q86U15; Q8N536; Q8N5C4; Q8WWL6; EMAL1_HUMAN
Genbank Protein ID AAB57824.1; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; CAD12600.2; AAH32541.1; AAH33043.1; CAD62313.1
Protein Name Echinoderm microtubule-associated protein-like 1
Genbank Nucleotide ID U97018; AJ420603; AJ428183; AJ428184; AJ428185; AJ428189; AJ428191; AJ428193; AJ428195; AJ428197; AJ496645; AJ496644; AJ428200; AJ428199; AJ428198; AJ428196; AJ428194; AJ428192; AJ428190; AJ428188; AJ428187; AJ428186; BC032541; BC033043; BX247979
Gene Name EML1; EMAP1; EMAPL; EMAPL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000066629.16 ENST00000554479.5 ENSP00000451346.1
ENSG00000066629.16 ENST00000555145.5 ENSP00000452160.1
ENSG00000066629.16 ENST00000262233.10 ENSP00000262233.6
ENSG00000066629.16 ENST00000334192.8 ENSP00000334314.4
ENSG00000066629.16 ENST00000555096.5 ENSP00000451269.1
ENSG00000066629.16 ENST00000553720.5 ENSP00000452292.1
ENSG00000066629.16 ENST00000556947.1 ENSP00000451805.1
ENSG00000066629.16 ENST00000557741.1 ENSP00000452063.1
ENSG00000066629.16 ENST00000554553.5 ENSP00000451706.1
ENSG00000066629.16 ENST00000554386.1 ENSP00000452474.1
ENSG00000066629.16 ENST00000557313.5 ENSP00000451288.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.00e-16 62.0 346 379
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 5    svtclaf...sd.tllvs..GsdDgtikvWDlrt 32
            vtc+af   ++ t l++   s+D+++ vWD+ +
   Q: 346  AVTCIAFsksNGgTNLCAvdDSNDHVLSVWDWQK 379
           59*******7556555555899*********865 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.
 Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.
Protein Sequence
(Fasta)
MEDGFSSYSS LYDTSSLLQF CNDDSASAAS SMEVTDRIAS LEQRVQMQED DIQLLKSALA 60
DVVRRLNITE EQQAVLNRKG PTKARPLMQT LPLRTTVNNG TVLPKKPTGS LPSPSGVRKE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045664|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGTGGCCAGG CCGGCCGGGG CGGGACGCTG CCTGGGGCTG GACGCGGAGG AGCCCCAAGC 60
CCTGCTGGGT GGGTGACAGC CGCTGAGGCT CTGAGTGACC CTGCAGGCTG GTGGCCAGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045664|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0887--Epilepsy
KW-0451--Lissencephaly
KW-0991--Mental retardation
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR005108--HELP
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF03451--HELP
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:1990023--C:mitotic spindle midzone
GO:0097431--C:mitotic spindle pole
GO:0048471--C:perinuclear region of cytoplasm
GO:0005509--F:calcium ion binding
GO:0008017--F:microtubule binding
GO:0015631--F:tubulin binding
GO:0007420--P:brain development
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0000226--P:microtubule cytoskeleton organization
GO:0007052--P:mitotic spindle organization
GO:0007405--P:neuroblast proliferation
KEGG hsa:2009
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002077 Ailuropoda melanoleuca 94.08 0.00e+00 1513.00
IUUC-Apl-004179 Anas platyrhynchos 90.76 0.00e+00 1449.00
IUUC-Aca-004993 Anolis carolinensis 87.66 0.00e+00 1421.00
IUUC-Ame-011332 Astyanax mexicanus 75.54 0.00e+00 1302.00
IUUC-Bta-013419 Bos taurus 81.55 0.00e+00 1270.00
IUUC-Cel-018623 Caenorhabditis elegans 29.02 8.00e-83 301.00
IUUC-Cja-018976 Callithrix jacchus 99.01 0.00e+00 1585.00
IUUC-Cfa-021276 Canis familiaris 92.46 0.00e+00 1486.00
IUUC-Csa-023355 Chlorocebus sabaeus 99.25 0.00e+00 1570.00
IUUC-Cin-025784 Ciona intestinalis 56.16 0.00e+00 754.00
IUUC-Dre-028728 Danio rerio 76.51 0.00e+00 1296.00
IUUC-Dno-029055 Dasypus novemcinctus 93.15 0.00e+00 1544.00
IUUC-Dor-030628 Dipodomys ordii 95.20 0.00e+00 1515.00
IUUC-Dme-032093 Drosophila melanogaster 38.00 6.00e-121 429.00
IUUC-Ete-032845 Echinops telfairi 95.02 0.00e+00 812.00
IUUC-Eca-034266 Equus caballus 93.30 0.00e+00 1545.00
IUUC-Fca-035446 Felis catus 93.65 0.00e+00 1472.00
IUUC-Fal-036734 Ficedula albicollis 91.11 0.00e+00 1494.00
IUUC-Gmo-038689 Gadus morhua 73.63 0.00e+00 1266.00
IUUC-Gga-040934 Gallus gallus 92.88 0.00e+00 1127.00
IUUC-Gac-042476 Gasterosteus aculeatus 75.33 0.00e+00 1276.00
IUUC-Ggo-044828 Gorilla gorilla 99.51 0.00e+00 1625.00
IUUC-Lch-050508 Latimeria chalumnae 83.24 0.00e+00 1403.00
IUUC-Loc-052823 Lepisosteus oculatus 80.66 0.00e+00 1348.00
IUUC-Laf-054164 Loxodonta africana 88.47 0.00e+00 1393.00
IUUC-Mcc-055810 Macaca mulatta 96.84 0.00e+00 1555.00
IUUC-Mga-059405 Meleagris gallopavo 87.63 0.00e+00 1433.00
IUUC-Mmr-061144 Microcebus murinus 94.15 0.00e+00 1499.00
IUUC-Mdo-062834 Monodelphis domestica 89.25 0.00e+00 1483.00
IUUC-Mmu-063955 Mus musculus 93.88 0.00e+00 1504.00
IUUC-Mpu-066240 Mustela putorius furo 93.65 0.00e+00 1454.00
IUUC-Mlu-067847 Myotis lucifugus 92.15 0.00e+00 1081.00
IUUC-Nle-069783 Nomascus leucogenys 97.06 0.00e+00 1563.00
IUUC-Opr-070409 Ochotona princeps 86.81 0.00e+00 1350.00
IUUC-Ont-072468 Oreochromis niloticus 75.86 0.00e+00 1287.00
IUUC-Oan-073315 Ornithorhynchus anatinus 92.90 0.00e+00 1476.00
IUUC-Ocu-074604 Oryctolagus cuniculus 91.94 0.00e+00 1224.00
IUUC-Ola-086734 Oryzias latipes 74.28 0.00e+00 1259.00
IUUC-Oga-089105 Otolemur garnettii 97.24 0.00e+00 1548.00
IUUC-Oar-090057 Ovis aries 93.83 0.00e+00 1521.00
IUUC-Ptr-091138 Pan troglodytes 99.76 0.00e+00 1644.00
IUUC-Pan-092691 Papio anubis 92.15 0.00e+00 1454.00
IUUC-Psi-093076 Pelodiscus sinensis 91.59 0.00e+00 1488.00
IUUC-Pma-094555 Petromyzon marinus 57.97 0.00e+00 832.00
IUUC-Pfo-096794 Poecilia formosa 75.12 0.00e+00 1239.00
IUUC-Pab-097787 Pongo abelii 97.32 0.00e+00 1596.00
IUUC-Pva-102676 Pteropus vampyrus 93.60 0.00e+00 1476.00
IUUC-Rno-105971 Rattus norvegicus 83.94 0.00e+00 1274.00
IUUC-Sha-107530 Sarcophilus harrisii 91.10 0.00e+00 1460.00
IUUC-Ssc-116169 Sus scrofa 81.72 0.00e+00 1034.00
IUUC-Tgu-117046 Taeniopygia guttata 90.42 0.00e+00 1428.00
IUUC-Tru-118596 Takifugu rubripes 71.31 0.00e+00 1225.00
IUUC-Tsy-119142 Tarsius syrichta 93.20 0.00e+00 1116.00
IUUC-Tni-120377 Tetraodon nigroviridis 75.00 0.00e+00 1271.00
IUUC-Tbe-127916 Tupaia belangeri 73.21 0.00e+00 1071.00
IUUC-Ttr-129042 Tursiops truncatus 95.94 0.00e+00 1568.00
IUUC-Xtr-132117 Xenopus tropicalis 80.55 0.00e+00 1330.00
Created Date 25-Jun-2017

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