iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-117809

Ensembl Protein ID

ENSTRUP00000041393.1

UniProt Accession

H2UWR5; H2UWR5_TAKRU

Protein Name

Uncharacterized protein

Gene Name

eml2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000016192.1	ENSTRUT00000041537.1	ENSTRUP00000041393.1
ENSTRUG00000016192.1	ENSTRUT00000041538.1	ENSTRUP00000041394.1
ENSTRUG00000016192.1	ENSTRUT00000041539.1	ENSTRUP00000041395.1
ENSTRUG00000016192.1	ENSTRUT00000041540.1	ENSTRUP00000041396.1
ENSTRUG00000016192.1	ENSTRUT00000041541.1	ENSTRUP00000041397.1
ENSTRUG00000016192.1	ENSTRUT00000041542.1	ENSTRUP00000041398.1
ENSTRUG00000016192.1	ENSTRUT00000041543.1	ENSTRUP00000041399.1
ENSTRUG00000016192.1	ENSTRUT00000041544.1	ENSTRUP00000041400.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.80e-25	88.1	545	581
UBD/Beta-Prp	1.60e-42	147.0	544	725

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gHtd+ ++l+  ++   +v++s D+++++WD+ ++ +
   Q: 545  GHTDELWGLDIhPSmEQFVTCSQDKQVHLWDTNSHQP 581
           8***********7779***************877665 PP

UBD/Beta-Prp

   S: 49   sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghd 137
           +                                          gh+d+++ l+++ps + +v+ s+d+ +++wd+++ q l    +  +
   Q: 544  Y------------------------------------------GHTDELWGLDIHPSMEQFVTCSQDKQVHLWDTNSHQPLW--SKTIE 588
           3..........................................677777777777777777777777777777777777774..55555 PP
   S: 138  gvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlq....tgecvrtlnght 222
           +  +c+ +hp+g +++ G+  +   + d  t +l+   t   ++ +  ++++++g++l+  s+d+ v ++ +     + + v +++gh+
   Q: 589  DPGRCAGFHPSGAVIAVGTMTGRWLVLDADTHDLVSMHTD-GDEIISNVKYSPDGNFLAVSSHDNFVYIYAVTengrKYSRVGKCTGHS 676
           5777777777777777777777777777777777776665.566666677777777777777777777777766444334477777777 PP
   S: 223  dnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisva 271
           ++++ v+ s+++ +l++ s D  i +W   s++ ++++   ++  ++ +
   Q: 677  SFITHVDWSKDSRYLITNSGDYEILFWEAASSKHVTNMDTVRNVEWATS 725
           7777777777777777777777777776666555555555555555544 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MSERVASCGS LYDSTNLLLQ YCNNDDTVSA SSNMDMEDRV SHLEQKLQLQ EDEIQLLKSA 60
LADALRRLGY CEEQAQGMHP GGAGRRPLAA AAPAQPTKVR QLLQALPSRP VSNGYVQQKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTGAAA GGGTGGCTTC GTGTGGGAGC CTGTACGACA GCACCAACCT GCTGCTCCAG 60
TACTGCAACA ACGGTGAGCA TGTTCCACCA CCAATAATAA TTACAACAAC AATGTAATCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR005108--HELP
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03451--HELP
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0015630--C:microtubule cytoskeleton
GO:0008017--F:microtubule binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002155	Ailuropoda melanoleuca	63.09	0.00e+00	988.00
IUUC-Aca-005316	Anolis carolinensis	64.66	0.00e+00	1007.00
IUUC-Ame-011647	Astyanax mexicanus	77.22	0.00e+00	1236.00
IUUC-Bta-013267	Bos taurus	61.50	0.00e+00	1007.00
IUUC-Cel-018623	Caenorhabditis elegans	32.59	4.00e-89	322.00
IUUC-Cfa-020267	Canis familiaris	62.71	0.00e+00	1009.00
IUUC-Cin-025784	Ciona intestinalis	54.39	0.00e+00	716.00
IUUC-Dre-028734	Danio rerio	78.32	0.00e+00	1272.00
IUUC-Dno-028961	Dasypus novemcinctus	61.90	0.00e+00	968.00
IUUC-Dme-032093	Drosophila melanogaster	36.47	2.00e-117	417.00
IUUC-Eca-033785	Equus caballus	62.45	0.00e+00	1006.00
IUUC-Eeu-035302	Erinaceus europaeus	67.75	2.00e-156	546.00
IUUC-Fca-036170	Felis catus	61.55	0.00e+00	978.00
IUUC-Gmo-039389	Gadus morhua	79.95	0.00e+00	1153.00
IUUC-Gac-042643	Gasterosteus aculeatus	83.13	0.00e+00	1346.00
IUUC-Hsa-046141	Homo sapiens	63.37	0.00e+00	1016.00
IUUC-Itr-048788	Ictidomys tridecemlineatus	62.20	0.00e+00	995.00
IUUC-Loc-052518	Lepisosteus oculatus	72.69	0.00e+00	1143.00
IUUC-Meu-056664	Macropus eugenii	66.61	0.00e+00	923.00
IUUC-Mmr-060853	Microcebus murinus	63.55	0.00e+00	1011.00
IUUC-Mmu-063860	Mus musculus	63.16	0.00e+00	1016.00
IUUC-Mpu-066043	Mustela putorius furo	63.20	0.00e+00	1006.00
IUUC-Ont-071258	Oreochromis niloticus	88.44	0.00e+00	1389.00
IUUC-Ola-086616	Oryzias latipes	80.36	0.00e+00	1191.00
IUUC-Pan-092082	Papio anubis	62.95	0.00e+00	1013.00
IUUC-Pma-094555	Petromyzon marinus	56.20	0.00e+00	782.00
IUUC-Pfo-096717	Poecilia formosa	85.61	0.00e+00	1388.00
IUUC-Pca-101070	Procavia capensis	58.81	0.00e+00	802.00
IUUC-Rno-105074	Rattus norvegicus	67.81	0.00e+00	948.00
IUUC-Tni-120815	Tetraodon nigroviridis	95.12	0.00e+00	1549.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence