iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-060040

Ensembl Protein ID

ENSMGAP00000017366.1

UniProt Accession

G3UP76; G3UP76_MELGA

Protein Name

Tyrosine-protein kinase

Gene Name

CSK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000002394.2	ENSMGAT00000002649.1	ENSMGAP00000001978.1
ENSMGAG00000002394.2	ENSMGAT00000020922.1	ENSMGAP00000017366.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.40e-10	40.7	9	63

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            +++ y++ ++ + +L + kGdv++++   ++d +W k+ k+  g++G++P+n+v+k
   Q: 9    ECIAKYNFHGTAEQDLPFSKGDVLTIV-AVTKDPNWYKA-KNKVGREGIIPANYVQK 63
           68999**********************.***********.6**************87 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

QAVWPSGTEC IAKYNFHGTA EQDLPFSKGD VLTIVAVTKD PNWYKAKNKV GREGIIPANY 60
VQKREGVKAG IKLSLMPWFH GKITREQAER LLYPPETGLF LVRESTNYPG DYTLCVSCEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCAGGGA TGCAGGTAAG GTGCCGTGAG CCCTGCGCTC CCCTGCTGCT CGGTGTCAGG 60
GTGGGTGGGA GATGCTCTGA CCCACCTCTC GTATCCTCCC CCCTTCCTTT TACTCCCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0008285--P:negative regulation of cell proliferation
GO:0042997--P:negative regulation of Golgi to plasma membrane protein transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004391	Anolis carolinensis	93.05	0.00e+00	863.00
IUUC-Cin-025513	Ciona intestinalis	53.91	3.00e-142	497.00
IUUC-Csv-025899	Ciona savignyi	50.31	7.00e-133	466.00
IUUC-Fal-037215	Ficedula albicollis	97.53	0.00e+00	903.00
IUUC-Gmo-039103	Gadus morhua	83.30	0.00e+00	782.00
IUUC-Gga-040506	Gallus gallus	97.76	0.00e+00	903.00
IUUC-Loc-052586	Lepisosteus oculatus	87.67	0.00e+00	822.00
IUUC-Meu-056387	Macropus eugenii	93.50	0.00e+00	863.00
IUUC-Mdo-061871	Monodelphis domestica	93.50	0.00e+00	863.00
IUUC-Ont-072457	Oreochromis niloticus	82.77	0.00e+00	775.00
IUUC-Ola-087105	Oryzias latipes	81.67	0.00e+00	771.00
IUUC-Oga-087928	Otolemur garnettii	91.48	0.00e+00	844.00
IUUC-Pfo-096126	Poecilia formosa	81.94	0.00e+00	772.00
IUUC-Sha-106987	Sarcophilus harrisii	93.95	0.00e+00	868.00
IUUC-Tru-118712	Takifugu rubripes	80.87	0.00e+00	761.00
IUUC-Tni-119856	Tetraodon nigroviridis	80.95	0.00e+00	761.00
IUUC-Xtr-132763	Xenopus tropicalis	83.45	0.00e+00	778.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence