iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Csv-026273

UUCD1 version

UUC-CiS-00457

Ensembl Protein ID

ENSCSAVP00000002267.1

UniProt Accession

H2YAB9; H2YAB9_CIOSA

Protein Name

Ubiquitin thioesterase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000001327.1	ENSCSAVT00000002305.1	ENSCSAVP00000002267.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	5.00e-29	101.4	79	266

Active Site

Position(s)	Description	Evidence
85	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
261		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 3    ilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           ++kt+gDGnC++rA++++                                                          l ++f d+ ls+
   Q: 79   VRKTRGDGNCFFRAFGFGylevmlhnkkdyskfqenangtfkklmslnypaftvedffenfmslvnsigekttleeLTQSFVDEGLSN 166
           799*************************************************************************8888888888** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeekl 119
           ++v++Lr+ +s  lq ++df+++fi+ ++ + efc+ +vep+ + +++ihi+aL  +L  ++ v ++d++       l+++ fpe+  
   Q: 167  YFVVYLRLIASCQLQIDADFYQNFIDSGKSVVEFCKTEVEPMYQeSDHIHIIALTSALGASVRVAYMDRGG----EQLIFHDFPEDC- 249
           ******************************************988*************************6....599*********. PP
   S: 120  kkpivLlYrsgHYdaLv 136
           ++ + LlY++gHYd+L+
   Q: 250  EPTLHLLYKPGHYDILY 266
           ****************8 PP

Organism

Ciona savignyi

Protein Sequence
(Fasta)

MAEHNSNKQN DQEYLSAMPN QEFDQAVTTM QNNIQTEIAA SSALVGRKEE ISRLKAEYSD 60
DDSPYQQKIK ELCKLYSHVR KTRGDGNCFF RAFGFGYLEV MLHNKKDYSK FQENANGTFK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCAAGCACA AAACTATACA AATTGCTTCC AGCTTTATCT TACTAATAAC GTAAACTAAA 60
CAAAAAGATT ACGCACTGAA ATGGCCGAAC ACAACTCAAA TAAACAAAAT GACCAGGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	49.80	3.00e-69	253.00
IUUC-Apl-003233	Anas platyrhynchos	32.81	4.00e-07	44.30
IUUC-Aca-004648	Anolis carolinensis	49.22	1.00e-66	244.00
IUUC-Aly-005710	Arabidopsis lyrata	40.77	5.00e-49	186.00
IUUC-Ath-007112	Arabidopsis thaliana	39.57	2.00e-49	187.00
IUUC-Afl-008439	Aspergillus flavus	31.58	2.00e-07	47.40
IUUC-Ame-010740	Astyanax mexicanus	49.80	8.00e-69	251.00
IUUC-Bta-013533	Bos taurus	49.80	3.00e-69	253.00
IUUC-Bol-016100	Brassica oleracea	36.73	2.00e-48	184.00
IUUC-Bra-017705	Brassica rapa	35.69	3.00e-45	173.00
IUUC-Cel-018295	Caenorhabditis elegans	34.90	6.00e-42	162.00
IUUC-Cja-019190	Callithrix jacchus	49.80	4.00e-69	253.00
IUUC-Cfa-020430	Canis familiaris	49.80	4.00e-69	252.00
IUUC-Cpo-022355	Cavia porcellus	49.80	2.00e-69	253.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	37.86	1.00e-46	178.00
IUUC-Csa-023286	Chlorocebus sabaeus	48.03	6.00e-67	245.00
IUUC-Cho-024411	Choloepus hoffmanni	33.83	4.00e-18	82.80
IUUC-Cin-025507	Ciona intestinalis	78.82	3.00e-95	339.00
IUUC-Cgl-026767	Colletotrichum gloeosporioides	26.74	1.00e+00	26.90
IUUC-Dre-027843	Danio rerio	51.84	3.00e-72	263.00
IUUC-Dno-029165	Dasypus novemcinctus	49.75	3.00e-56	209.00
IUUC-Dor-030943	Dipodomys ordii	49.80	2.00e-69	253.00
IUUC-Dme-031922	Drosophila melanogaster	48.61	5.00e-66	242.00
IUUC-Ete-032296	Echinops telfairi	48.10	2.00e-40	157.00
IUUC-Eca-033695	Equus caballus	49.80	9.00e-70	254.00
IUUC-Eeu-034775	Erinaceus europaeus	40.59	1.00e-42	164.00
IUUC-Fca-036441	Felis catus	48.43	2.00e-69	253.00
IUUC-Gmo-038908	Gadus morhua	47.57	5.00e-67	245.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.23	2.00e-26	112.00
IUUC-Gga-040460	Gallus gallus	47.35	2.00e-64	236.00
IUUC-Gac-042417	Gasterosteus aculeatus	51.02	4.00e-69	252.00
IUUC-Gma-043712	Glycine max	39.85	1.00e-49	187.00
IUUC-Ggo-045023	Gorilla gorilla	37.72	4.00e-43	166.00
IUUC-Hsa-046766	Homo sapiens	49.80	2.00e-69	253.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	49.80	2.00e-69	253.00
IUUC-Lch-050602	Latimeria chalumnae	46.12	4.00e-61	226.00
IUUC-Loc-052003	Lepisosteus oculatus	34.98	1.00e-36	144.00
IUUC-Laf-053705	Loxodonta africana	49.80	2.00e-69	253.00
IUUC-Mcc-055745	Macaca mulatta	46.39	7.00e-66	242.00
IUUC-Meu-056569	Macropus eugenii	43.27	6.00e-57	212.00
IUUC-Mtr-057712	Medicago truncatula	39.43	2.00e-43	167.00
IUUC-Mvi-060358	Microbotryum violaceum	28.48	6.00e-15	73.20
IUUC-Mmr-061123	Microcebus murinus	47.34	3.00e-55	207.00
IUUC-Mdo-062613	Monodelphis domestica	46.51	7.00e-55	205.00
IUUC-Mmu-063658	Mus musculus	49.80	2.00e-69	253.00
IUUC-Mac-065274	Musa acuminata	34.92	2.00e-32	131.00
IUUC-Mpu-066172	Mustela putorius furo	49.80	2.00e-69	253.00
IUUC-Mlu-066966	Myotis lucifugus	49.80	4.00e-69	252.00
IUUC-Nle-069673	Nomascus leucogenys	40.10	5.00e-43	165.00
IUUC-Opr-070761	Ochotona princeps	29.93	4.00e-17	79.00
IUUC-Ont-071901	Oreochromis niloticus	49.80	1.00e-67	248.00
IUUC-Oan-072922	Ornithorhynchus anatinus	39.46	1.00e-43	168.00
IUUC-Ocu-074643	Oryctolagus cuniculus	40.59	1.00e-43	167.00
IUUC-Olo-080607	Oryza longistaminata	27.12	7.20e-01	26.90
IUUC-Oni-082026	Oryza nivara	29.03	2.00e-13	68.90
IUUC-Oru-084761	Oryza rufipogon	29.03	2.00e-13	68.90
IUUC-Ola-087331	Oryzias latipes	49.15	1.00e-45	174.00
IUUC-Oga-088064	Otolemur garnettii	49.80	2.00e-69	253.00
IUUC-Oar-089251	Ovis aries	49.80	4.00e-69	252.00
IUUC-Ptr-091430	Pan troglodytes	49.80	4.00e-69	253.00
IUUC-Pan-091969	Papio anubis	40.10	5.00e-43	165.00
IUUC-Psi-093823	Pelodiscus sinensis	49.19	1.00e-65	240.00
IUUC-Pma-094366	Petromyzon marinus	51.54	1.00e-67	248.00
IUUC-Pfo-096734	Poecilia formosa	47.76	2.00e-59	220.00
IUUC-Pab-097919	Pongo abelii	47.34	5.00e-55	206.00
IUUC-Pop-099401	Populus trichocarpa	38.67	2.00e-44	170.00
IUUC-Pca-100252	Procavia capensis	41.67	6.00e-14	69.30
IUUC-Ppe-101977	Prunus persica	37.72	2.00e-49	187.00
IUUC-Pva-102499	Pteropus vampyrus	49.80	2.00e-69	253.00
IUUC-Rno-105233	Rattus norvegicus	49.80	2.00e-69	253.00
IUUC-Sha-107081	Sarcophilus harrisii	49.80	2.00e-69	254.00
IUUC-Sly-111640	Solanum lycopersicum	39.34	1.00e-46	177.00
IUUC-Sar-113295	Sorex araneus	41.09	2.00e-42	163.00
IUUC-Ssc-116202	Sus scrofa	49.80	2.00e-69	253.00
IUUC-Tru-117664	Takifugu rubripes	46.67	4.00e-66	242.00
IUUC-Tsy-119334	Tarsius syrichta	25.00	8.80e-02	28.10
IUUC-Tni-120440	Tetraodon nigroviridis	38.26	2.00e-36	143.00
IUUC-Tca-121467	Theobroma cacao	37.87	3.00e-47	180.00
IUUC-Tbe-128116	Tupaia belangeri	48.73	2.00e-41	160.00
IUUC-Ttr-128622	Tursiops truncatus	49.80	1.00e-69	254.00
IUUC-Uma-129443	Ustilago maydis	31.53	3.00e-23	100.00
IUUC-Vvi-131389	Vitis vinifera	37.50	2.00e-46	177.00
IUUC-Xtr-131951	Xenopus tropicalis	36.62	4.00e-37	146.00
IUUC-Xma-134191	Xiphophorus maculatus	48.98	5.00e-61	225.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence