iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108226

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase 8; Deubiquitinating enzyme 8; Ubiquitin thioesterase 8; Ubiquitin-specific-processing protease 8

Genbank Nucleotide ID

CU329670

Gene Name

ubp8; SPAC13A11.04c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC13A11.04c	SPAC13A11.04c.1	SPAC13A11.04c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.80e-70	234.8	146	434

Active Site

Position(s)	Description	Evidence
154	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
395	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeq 89
           G++Nlg+tC+m  +LQ++++ p +r+l+++ ++ +++     ++ +++++++ ++f++++  k+k++ + p+++l+ ++k+++++ gy+q
   Q: 146  GIQNLGATCFMSVILQSILHNPLVRNLFFSGFHTSTD----CKRPTCMTCAIDDMFSSIYnsKNKSTFYGPTAVLNLMWKLSKSLCGYSQ 231
           9*****************************4444444....56779*************9888888899********************* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           qD +Ef+ +lldq+++e                           + +  +++i+++F g+lk+ ++cl+c+++ +  +p +d+sl++++ 
   Q: 232  QDGHEFFVYLLDQMHTES-----------------------GGGTSMPCTCPIHRIFSGSLKNVVTCLDCKKERVAVDPLMDISLDINEP 298
           *****************9.......................4578999***************************************977 PP
   S: 180  eetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspe 269
           +      lq cLe f+++e+++    y+c +c +k  a k+l ++klP++++++LkRf+ ++   +++ki+k+v++p  L ++ ++ +++
   Q: 299  T------LQGCLERFVSKEKVQ----YSCHSCGSKN-AIKQLVFDKLPPTICMQLKRFEQNNF-AMSTKIDKQVSYPAFLRMR-YNFNQD 375
           6......9*************9....******9877.*********************88777.7778**************9.666633 PP
   S: 270  ekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
                ++ Y+L++vv+H+G+l+ GHY+ay +  +++W+l+dD+++ evke+evl+   s+aY+lfY++
   Q: 376  -----DVDYQLYSVVCHKGTLDTGHYIAYTYY-QNQWFLLDDTTIVEVKESEVLN---SQAYLLFYHE 434
           .....899************************.999*******************...********87 PP

Organism

Schizosaccharomyces pombe

Protein Sequence
(Fasta)

MPGDVEGCQH LKLKPADVEN YQKICTQIFS CHFVPRRCST CKRINKRSIR CLSCHSVGCL 60
WGHHGEEHAM EHTHMIGVDV KNGHTYCFGC QDYVYQTELE TLRFKIKNIK AWQSDHKRLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATGGCTCTT AACGCTGTAC ACCGCATCCT TAATTGCCCA AATTTAAGCA AAGAGAAATA 60
ATGTTCTTTT GCCAGAATAG CGAGTTCGTC TATTGTTGTC GTTTCACCCT GCATCGAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000124--C:SAGA complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0016573--P:histone acetylation
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0016579--P:protein deubiquitination
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

spo:SPAC13A11.04c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	29.53	1.00e-37	149.00
IUUC-Aml-002084	Ailuropoda melanoleuca	33.12	9.00e-61	225.00
IUUC-Atr-002653	Amborella trichopoda	31.17	6.00e-60	223.00
IUUC-Apl-003433	Anas platyrhynchos	32.64	4.00e-60	223.00
IUUC-Aca-005347	Anolis carolinensis	30.64	9.00e-59	219.00
IUUC-Aly-006565	Arabidopsis lyrata	30.31	6.00e-50	189.00
IUUC-Ath-007536	Arabidopsis thaliana	30.53	4.00e-50	190.00
IUUC-Ago-007811	Ashbya gossypii	32.57	1.00e-59	221.00
IUUC-Acl-008124	Aspergillus clavatus	36.84	7.00e-72	262.00
IUUC-Afl-008464	Aspergillus flavus	36.13	4.00e-63	233.00
IUUC-Afu-008912	Aspergillus fumigatus	35.08	4.00e-67	246.00
IUUC-Ani-009168	Aspergillus nidulans	35.63	3.00e-66	243.00
IUUC-Ang-009694	Aspergillus niger	31.58	7.00e-68	249.00
IUUC-Aor-010035	Aspergillus oryzae	37.05	7.00e-44	168.00
IUUC-Ate-010382	Aspergillus terreus	35.86	2.00e-64	237.00
IUUC-Ame-011253	Astyanax mexicanus	31.42	9.00e-53	199.00
IUUC-Bgr-012150	Blumeria graminis	31.64	3.00e-56	210.00
IUUC-Bta-013303	Bos taurus	31.12	2.00e-61	227.00
IUUC-Bci-013604	Botrytis cinerea	32.79	4.00e-70	256.00
IUUC-Bdi-014171	Brachypodium distachyon	27.99	3.00e-48	184.00
IUUC-Bol-016509	Brassica oleracea	31.75	9.00e-54	202.00
IUUC-Bra-016962	Brassica rapa	30.93	4.00e-52	197.00
IUUC-Cja-019283	Callithrix jacchus	32.40	7.00e-56	209.00
IUUC-Cfa-020956	Canis familiaris	32.32	2.00e-61	228.00
IUUC-Cpo-022354	Cavia porcellus	30.92	2.00e-60	224.00
IUUC-Csa-023145	Chlorocebus sabaeus	31.51	2.00e-61	228.00
IUUC-Cho-024863	Choloepus hoffmanni	31.10	1.00e-24	105.00
IUUC-Cin-025109	Ciona intestinalis	29.10	7.00e-36	142.00
IUUC-Csv-026214	Ciona savignyi	32.37	1.00e-57	215.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	31.86	1.00e-60	225.00
IUUC-Cne-027085	Cryptococcus neoformans	30.06	8.00e-52	196.00
IUUC-Dre-027433	Danio rerio	33.19	3.00e-61	226.00
IUUC-Dno-030095	Dasypus novemcinctus	32.91	6.00e-61	226.00
IUUC-Dse-031415	Dothistroma septosporum	34.13	3.00e-70	257.00
IUUC-Dme-032074	Drosophila melanogaster	29.61	7.00e-51	192.00
IUUC-Ete-032611	Echinops telfairi	27.53	2.00e-32	131.00
IUUC-Eca-033736	Equus caballus	32.26	4.00e-61	226.00
IUUC-Eeu-035268	Erinaceus europaeus	27.14	2.00e-30	125.00
IUUC-Fca-035861	Felis catus	32.48	2.00e-61	227.00
IUUC-Fal-037645	Ficedula albicollis	32.91	8.00e-60	222.00
IUUC-Fox-038046	Fusarium oxysporum	32.86	3.00e-59	221.00
IUUC-Fso-038321	Fusarium solani	32.19	1.00e-55	208.00
IUUC-Gmo-039598	Gadus morhua	27.93	5.00e-36	143.00
IUUC-Ggr-040044	Gaeumannomyces graminis	30.06	2.00e-56	211.00
IUUC-Gga-040624	Gallus gallus	31.70	4.00e-61	226.00
IUUC-Gac-042197	Gasterosteus aculeatus	31.08	1.00e-58	218.00
IUUC-Gma-043933	Glycine max	30.54	3.00e-55	207.00
IUUC-Ggo-044409	Gorilla gorilla	31.51	8.00e-62	229.00
IUUC-Hsa-046521	Homo sapiens	31.51	9.00e-62	229.00
IUUC-Hvu-047739	Hordeum vulgare	30.19	3.00e-45	173.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	31.31	2.00e-61	227.00
IUUC-Kpa-049135	Komagataella pastoris	37.56	9.00e-75	272.00
IUUC-Lch-050537	Latimeria chalumnae	32.29	8.00e-62	229.00
IUUC-Lpe-050969	Leersia perrieri	28.95	1.00e-44	172.00
IUUC-Loc-052765	Lepisosteus oculatus	29.40	4.00e-48	183.00
IUUC-Lma-053105	Leptosphaeria maculans	33.66	1.00e-67	248.00
IUUC-Laf-053571	Loxodonta africana	32.48	2.00e-61	228.00
IUUC-Mcc-055166	Macaca mulatta	31.51	2.00e-61	228.00
IUUC-Mor-057103	Magnaporthe oryzae	31.47	3.00e-59	221.00
IUUC-Mpo-057621	Magnaporthe poae	30.83	2.00e-60	224.00
IUUC-Mtr-057894	Medicago truncatula	31.29	3.00e-58	218.00
IUUC-Mla-059185	Melampsora laricipopulina	28.97	2.00e-38	150.00
IUUC-Mga-059709	Meleagris gallopavo	32.64	4.00e-60	223.00
IUUC-Mvi-060530	Microbotryum violaceum	34.75	9.00e-54	202.00
IUUC-Mmr-060988	Microcebus murinus	31.31	6.00e-62	229.00
IUUC-Mdo-063065	Monodelphis domestica	32.49	3.00e-62	230.00
IUUC-Mmu-063829	Mus musculus	31.12	3.00e-61	227.00
IUUC-Mac-065419	Musa acuminata	29.81	1.00e-53	201.00
IUUC-Mpu-066433	Mustela putorius furo	33.12	1.00e-60	225.00
IUUC-Mlu-067330	Myotis lucifugus	33.55	2.00e-60	224.00
IUUC-Nfi-068423	Neosartorya fischeri	35.57	4.00e-66	243.00
IUUC-Ncr-068809	Neurospora crassa	30.43	1.00e-59	222.00
IUUC-Nle-069859	Nomascus leucogenys	31.03	4.00e-56	210.00
IUUC-Opr-070469	Ochotona princeps	31.90	5.00e-31	126.00
IUUC-Ont-071961	Oreochromis niloticus	31.51	9.00e-59	219.00
IUUC-Oan-073565	Ornithorhynchus anatinus	30.69	9.00e-56	209.00
IUUC-Ocu-074951	Oryctolagus cuniculus	32.48	1.00e-59	221.00
IUUC-Oba-075688	Oryza barthii	30.24	4.00e-45	173.00
IUUC-Obr-076652	Oryza brachyantha	29.71	1.00e-45	174.00
IUUC-Ogl-077910	Oryza glaberrima	27.42	7.00e-46	176.00
IUUC-Ogu-078479	Oryza glumaepatula	27.42	7.00e-46	176.00
IUUC-Oin-079697	Oryza indica	30.24	6.00e-45	173.00
IUUC-Olo-080811	Oryza longistaminata	29.02	1.00e-29	121.00
IUUC-Ome-081706	Oryza meridionalis	27.42	2.00e-45	175.00
IUUC-Oni-083070	Oryza nivara	27.42	7.00e-46	176.00
IUUC-Opu-083605	Oryza punctata	28.57	9.00e-39	152.00
IUUC-Oru-084522	Oryza rufipogon	27.42	7.00e-46	176.00
IUUC-Osa-085351	Oryza sativa	29.79	3.00e-45	174.00
IUUC-Ola-086743	Oryzias latipes	35.49	4.00e-51	193.00
IUUC-Olu-087695	Ostreococcus lucimarinus	31.63	3.00e-40	156.00
IUUC-Oga-089131	Otolemur garnettii	31.43	6.00e-61	226.00
IUUC-Oar-089610	Ovis aries	32.52	1.00e-61	228.00
IUUC-Ptr-090783	Pan troglodytes	32.48	6.00e-61	226.00
IUUC-Pan-092927	Papio anubis	31.51	1.00e-61	228.00
IUUC-Psi-093670	Pelodiscus sinensis	32.64	4.00e-60	223.00
IUUC-Pma-094323	Petromyzon marinus	29.89	1.00e-46	178.00
IUUC-Pno-095141	Phaeosphaeria nodorum	34.78	3.00e-66	243.00
IUUC-Ppa-095413	Physcomitrella patens	32.01	7.00e-51	193.00
IUUC-Pfo-096473	Poecilia formosa	32.09	1.00e-61	228.00
IUUC-Pab-097612	Pongo abelii	31.51	9.00e-62	229.00
IUUC-Pop-099893	Populus trichocarpa	32.40	4.00e-55	207.00
IUUC-Pca-100329	Procavia capensis	32.70	3.00e-60	223.00
IUUC-Ppe-101583	Prunus persica	31.49	4.00e-50	190.00
IUUC-Pva-102721	Pteropus vampyrus	32.53	3.00e-57	214.00
IUUC-Pgr-103657	Puccinia graminis	24.80	2.00e-34	138.00
IUUC-Pte-104340	Pyrenophora teres	32.60	8.00e-61	225.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	33.90	6.00e-68	249.00
IUUC-Rno-105247	Rattus norvegicus	31.12	3.00e-61	227.00
IUUC-Sce-106247	Saccharomyces cerevisiae	33.26	2.00e-58	218.00
IUUC-Sha-107429	Sarcophilus harrisii	27.29	2.00e-32	131.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	51.72	4.00e-134	469.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	31.32	6.00e-67	246.00
IUUC-Smo-109310	Selaginella moellendorffii	29.40	3.00e-56	210.00
IUUC-Sit-109716	Setaria italica	28.63	3.00e-48	184.00
IUUC-Sly-111077	Solanum lycopersicum	31.85	3.00e-55	207.00
IUUC-Stu-112203	Solanum tuberosum	34.32	2.00e-52	197.00
IUUC-Sar-113174	Sorex araneus	31.17	8.00e-50	189.00
IUUC-Sbi-114205	Sorghum bicolor	27.91	4.00e-48	183.00
IUUC-Sre-115195	Sporisorium reilianum	24.55	1.00e-45	176.00
IUUC-Ssc-115315	Sus scrofa	32.43	4.00e-60	223.00
IUUC-Tgu-116938	Taeniopygia guttata	33.33	2.00e-61	228.00
IUUC-Tru-118304	Takifugu rubripes	31.81	3.00e-63	233.00
IUUC-Tsy-119413	Tarsius syrichta	31.72	4.00e-58	217.00
IUUC-Tni-120119	Tetraodon nigroviridis	31.90	3.00e-61	227.00
IUUC-Tca-121154	Theobroma cacao	30.37	2.00e-60	224.00
IUUC-Tre-122139	Trichoderma reesei	33.25	5.00e-60	223.00
IUUC-Tvi-122599	Trichoderma virens	33.33	8.00e-62	229.00
IUUC-Tae-125608	Triticum aestivum	28.26	1.00e-53	202.00
IUUC-Tme-127115	Tuber melanosporum	36.89	4.00e-80	290.00
IUUC-Tbe-127423	Tupaia belangeri	31.32	1.00e-24	105.00
IUUC-Ttr-129006	Tursiops truncatus	32.61	2.00e-58	218.00
IUUC-Uma-129455	Ustilago maydis	30.04	1.00e-28	119.00
IUUC-Vda-129829	Verticillium dahliae	32.99	7.00e-36	142.00
IUUC-Vvi-131477	Vitis vinifera	29.98	5.00e-50	190.00
IUUC-Xtr-132444	Xenopus tropicalis	31.49	5.00e-61	226.00
IUUC-Xma-133514	Xiphophorus maculatus	32.29	4.00e-62	229.00
IUUC-Yli-134357	Yarrowia lipolytica	31.14	3.00e-54	204.00
IUUC-Zma-134945	Zea mays	27.27	3.00e-46	177.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence