iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-097840

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01126997

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000006272.2	ENSPPYT00000007404.2	ENSPPYP00000007109.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-102	343.5	524	848

Active Site

Position(s)	Description	Evidence
817	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++l +a++++ +ld+
   Q: 524  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVL-LAIYNNCILDV 606
           689******************************************998888876.88888....789*******999.9********** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 607  HFP-MVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 692
           **7.68*******************************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 693  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQ 781
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 782  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 848
           *****************...8888866666**************************************97 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MKRAAAKHLI ERYYHQLTEG CGNEACTNEF CASCPTFLRM DNNAAAIKAL ELYKINAKLC 60
DPHPSKKGAS SAYLENSKGA PNNSCSEIKM NKKGARIDFK DVTYLTEEKV YEILELRRER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCCAGCAGG TTTATTTTTT GTTTTGCAAG CCAGCTCTGC CTCCTTACAG TATGACATCT 60
GATGCTGGAG GGTCGCACTT TCAAAAATGA GTCAGCTGGT ACATGGGGTT ATCATCAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	97.54	0.00e+00	1583.00
IUUC-Atr-003144	Amborella trichopoda	45.58	2.00e-92	332.00
IUUC-Apl-003742	Anas platyrhynchos	91.39	0.00e+00	1541.00
IUUC-Aca-004873	Anolis carolinensis	91.65	0.00e+00	1553.00
IUUC-Ame-011166	Astyanax mexicanus	84.73	0.00e+00	1423.00
IUUC-Bta-013286	Bos taurus	96.73	0.00e+00	1526.00
IUUC-Cja-019707	Callithrix jacchus	96.24	0.00e+00	1605.00
IUUC-Cfa-020154	Canis familiaris	95.90	0.00e+00	1573.00
IUUC-Cpo-021292	Cavia porcellus	96.96	0.00e+00	1571.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	47.17	4.00e-80	291.00
IUUC-Csa-023378	Chlorocebus sabaeus	96.24	0.00e+00	1608.00
IUUC-Cho-025059	Choloepus hoffmanni	93.11	0.00e+00	1483.00
IUUC-Cin-025643	Ciona intestinalis	44.43	0.00e+00	697.00
IUUC-Csv-026282	Ciona savignyi	44.99	0.00e+00	661.00
IUUC-Cme-027151	Cyanidioschyzon merolae	43.79	1.00e-97	351.00
IUUC-Dre-027901	Danio rerio	84.25	0.00e+00	1407.00
IUUC-Dno-029320	Dasypus novemcinctus	97.08	0.00e+00	1569.00
IUUC-Dor-030756	Dipodomys ordii	94.50	0.00e+00	728.00
IUUC-Dme-032035	Drosophila melanogaster	42.68	3.00e-161	562.00
IUUC-Eca-033843	Equus caballus	97.42	0.00e+00	1551.00
IUUC-Eeu-035109	Erinaceus europaeus	95.65	0.00e+00	1532.00
IUUC-Fca-036344	Felis catus	95.79	0.00e+00	1568.00
IUUC-Fal-036747	Ficedula albicollis	91.39	0.00e+00	1542.00
IUUC-Gmo-038840	Gadus morhua	63.08	0.00e+00	1081.00
IUUC-Gga-040399	Gallus gallus	91.27	0.00e+00	1540.00
IUUC-Gac-041933	Gasterosteus aculeatus	84.60	0.00e+00	1348.00
IUUC-Ggo-044804	Gorilla gorilla	96.48	0.00e+00	1608.00
IUUC-Hsa-045727	Homo sapiens	96.48	0.00e+00	1608.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	93.79	0.00e+00	1488.00
IUUC-Lch-050197	Latimeria chalumnae	88.32	0.00e+00	1504.00
IUUC-Loc-052743	Lepisosteus oculatus	88.36	0.00e+00	1481.00
IUUC-Lma-053245	Leptosphaeria maculans	33.87	4.00e-55	210.00
IUUC-Laf-053615	Loxodonta africana	96.48	0.00e+00	1569.00
IUUC-Mcc-054934	Macaca mulatta	96.24	0.00e+00	1607.00
IUUC-Meu-056061	Macropus eugenii	89.55	0.00e+00	1397.00
IUUC-Mga-059271	Meleagris gallopavo	91.26	0.00e+00	1536.00
IUUC-Mmr-061288	Microcebus murinus	98.36	0.00e+00	1600.00
IUUC-Mdo-062975	Monodelphis domestica	95.33	0.00e+00	1547.00
IUUC-Mmu-063674	Mus musculus	92.61	0.00e+00	1527.00
IUUC-Mpu-066568	Mustela putorius furo	97.78	0.00e+00	1589.00
IUUC-Mlu-067522	Myotis lucifugus	87.11	0.00e+00	1443.00
IUUC-Nle-069505	Nomascus leucogenys	96.48	0.00e+00	1608.00
IUUC-Opr-070570	Ochotona princeps	89.07	0.00e+00	1436.00
IUUC-Ont-071527	Oreochromis niloticus	83.90	0.00e+00	1432.00
IUUC-Oan-073446	Ornithorhynchus anatinus	90.48	0.00e+00	1014.00
IUUC-Ocu-074922	Oryctolagus cuniculus	95.24	0.00e+00	1575.00
IUUC-Ola-086996	Oryzias latipes	85.09	0.00e+00	1436.00
IUUC-Oga-088261	Otolemur garnettii	98.24	0.00e+00	1600.00
IUUC-Oar-090024	Ovis aries	96.73	0.00e+00	1526.00
IUUC-Ptr-090455	Pan troglodytes	96.48	0.00e+00	1608.00
IUUC-Pan-092509	Papio anubis	95.81	0.00e+00	1446.00
IUUC-Psi-092974	Pelodiscus sinensis	91.49	0.00e+00	1510.00
IUUC-Pma-094643	Petromyzon marinus	69.75	0.00e+00	1233.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.32	4.00e-55	210.00
IUUC-Pfo-096905	Poecilia formosa	83.76	0.00e+00	1422.00
IUUC-Pca-100869	Procavia capensis	96.14	0.00e+00	1560.00
IUUC-Pva-103040	Pteropus vampyrus	96.43	0.00e+00	654.00
IUUC-Rno-105453	Rattus norvegicus	92.72	0.00e+00	1531.00
IUUC-Sha-107651	Sarcophilus harrisii	95.33	0.00e+00	1547.00
IUUC-Smo-108858	Selaginella moellendorffii	49.17	5.00e-112	398.00
IUUC-Sar-113293	Sorex araneus	96.73	0.00e+00	1566.00
IUUC-Ssc-115979	Sus scrofa	96.84	0.00e+00	1568.00
IUUC-Tgu-116901	Taeniopygia guttata	91.39	0.00e+00	1541.00
IUUC-Tru-118368	Takifugu rubripes	85.71	0.00e+00	1420.00
IUUC-Tsy-119516	Tarsius syrichta	94.24	0.00e+00	1489.00
IUUC-Tni-120143	Tetraodon nigroviridis	83.51	0.00e+00	1417.00
IUUC-Tbe-127484	Tupaia belangeri	91.81	0.00e+00	1079.00
IUUC-Ttr-129078	Tursiops truncatus	96.61	0.00e+00	1541.00
IUUC-Vpa-130312	Vicugna pacos	85.50	0.00e+00	1323.00
IUUC-Xtr-132881	Xenopus tropicalis	89.14	0.00e+00	1509.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence