iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000003571.2	ENSCJAT00000007007.2	ENSCJAP00000006637.2
ENSCJAG00000003571.2	ENSCJAT00000061718.1	ENSCJAP00000049663.1
ENSCJAG00000003571.2	ENSCJAT00000006946.2	ENSCJAP00000006580.2
ENSCJAG00000003571.2	ENSCJAT00000006965.1	ENSCJAP00000006599.1
ENSCJAG00000003571.2	ENSCJAT00000010751.2	ENSCJAP00000010173.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-114	384.2	597	1314

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 597  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 683
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 684  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 768
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 769  FLYLPVPLPQKQKVLPVfyfarephskpvkflvsiskenstasevldslsqsvhvkpenlrlaeviknrfqrvflpshsldtvspsd 855
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 856  mllcfellspelakervvvlevqqrpqvpsvpiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypf 942
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 943  lvsvpasrltyarlaqllegyarysvsvfqppfqpgrmalesqspgcttllstgsleagdserdpiqppelqlvtpvadgdtgplrv 1029
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1030 wtapdrgpvpstsgissdmlasgpievgslpaservsrpeaavpgyqhpsealnahtpqffiykidssnreqrledkgdtplelgdd 1116
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1117 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1203
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wll 308
           i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W l
   Q: 1204 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPNYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRL 1287
           ************8886.**********9**********99888..9**************************544445566777*** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYkrr 338
           fdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1288 FDDSTVTTVDESQVVT---RYAYVLFYRRR 1314
           ****************...********996 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MSGGASATGP RRGPPGLEDA SSKKKQKDGA NQESKDGDPR KETGSRYVTQ AGLELLASGD 60
PSASASCAAG ITGSHHRTRL FFPSSSGSAS TPREEQTKAG ACETLDLFAT PPTELLLDWR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCGACCTGA CGCCGGAACC GGAACGGAGA GCGGGTTGCC AGGGCCCGAA GAGGGCTGGC 60
TGCGGCGGTC TCGCTCGGTG AGTGGAGCAG GCTGCAACTC GCCGGCTTGG CCGCAGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	89.54	0.00e+00	2275.00
IUUC-Apl-003368	Anas platyrhynchos	67.20	0.00e+00	1706.00
IUUC-Aca-004267	Anolis carolinensis	68.47	0.00e+00	1609.00
IUUC-Ame-010970	Astyanax mexicanus	70.55	0.00e+00	1337.00
IUUC-Bta-012905	Bos taurus	87.89	0.00e+00	2264.00
IUUC-Cel-018257	Caenorhabditis elegans	43.00	1.00e-91	331.00
IUUC-Cfa-021004	Canis familiaris	89.08	0.00e+00	2268.00
IUUC-Cpo-021529	Cavia porcellus	85.42	0.00e+00	2298.00
IUUC-Csa-024035	Chlorocebus sabaeus	94.95	0.00e+00	2327.00
IUUC-Cho-025036	Choloepus hoffmanni	79.09	0.00e+00	1209.00
IUUC-Cin-025451	Ciona intestinalis	42.89	2.00e-85	310.00
IUUC-Csv-025931	Ciona savignyi	36.01	2.00e-109	389.00
IUUC-Dre-028556	Danio rerio	67.75	0.00e+00	1313.00
IUUC-Dno-029240	Dasypus novemcinctus	88.70	0.00e+00	2092.00
IUUC-Dor-030495	Dipodomys ordii	94.83	0.00e+00	1248.00
IUUC-Ete-032741	Echinops telfairi	91.83	0.00e+00	1850.00
IUUC-Eca-033661	Equus caballus	89.07	0.00e+00	2355.00
IUUC-Eeu-034648	Erinaceus europaeus	91.05	0.00e+00	806.00
IUUC-Fca-035646	Felis catus	88.64	0.00e+00	2243.00
IUUC-Fal-037094	Ficedula albicollis	67.83	0.00e+00	1719.00
IUUC-Gmo-038869	Gadus morhua	72.27	0.00e+00	848.00
IUUC-Gga-041170	Gallus gallus	66.06	0.00e+00	1676.00
IUUC-Gac-041901	Gasterosteus aculeatus	66.73	0.00e+00	1315.00
IUUC-Ggo-044708	Gorilla gorilla	96.34	0.00e+00	2599.00
IUUC-Hsa-046791	Homo sapiens	97.40	0.00e+00	2101.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	88.17	0.00e+00	2324.00
IUUC-Lch-050456	Latimeria chalumnae	51.05	0.00e+00	1183.00
IUUC-Loc-052861	Lepisosteus oculatus	61.80	0.00e+00	1126.00
IUUC-Laf-053788	Loxodonta africana	87.12	0.00e+00	2266.00
IUUC-Mcc-055693	Macaca mulatta	94.99	0.00e+00	2503.00
IUUC-Meu-055921	Macropus eugenii	79.01	0.00e+00	1517.00
IUUC-Mga-059879	Meleagris gallopavo	65.21	0.00e+00	1736.00
IUUC-Mmr-060802	Microcebus murinus	90.79	0.00e+00	2435.00
IUUC-Mdo-061856	Monodelphis domestica	82.41	0.00e+00	1616.00
IUUC-Mmu-063874	Mus musculus	86.57	0.00e+00	2316.00
IUUC-Mpu-066166	Mustela putorius furo	88.97	0.00e+00	2248.00
IUUC-Nle-070161	Nomascus leucogenys	96.26	0.00e+00	2642.00
IUUC-Opr-071015	Ochotona princeps	92.64	0.00e+00	1915.00
IUUC-Ont-072308	Oreochromis niloticus	69.98	0.00e+00	1365.00
IUUC-Oan-072723	Ornithorhynchus anatinus	64.86	0.00e+00	1568.00
IUUC-Ocu-073938	Oryctolagus cuniculus	89.91	0.00e+00	2268.00
IUUC-Ola-086375	Oryzias latipes	61.41	0.00e+00	1381.00
IUUC-Oga-088297	Otolemur garnettii	90.23	0.00e+00	2352.00
IUUC-Oar-089675	Ovis aries	81.52	0.00e+00	1983.00
IUUC-Ptr-091621	Pan troglodytes	97.22	0.00e+00	2099.00
IUUC-Pan-092118	Papio anubis	93.73	0.00e+00	2443.00
IUUC-Pma-094154	Petromyzon marinus	52.26	3.00e-115	409.00
IUUC-Pfo-097246	Poecilia formosa	60.02	0.00e+00	1414.00
IUUC-Pab-098551	Pongo abelii	96.77	0.00e+00	2080.00
IUUC-Pca-100158	Procavia capensis	83.31	0.00e+00	2231.00
IUUC-Pva-103160	Pteropus vampyrus	88.39	0.00e+00	2301.00
IUUC-Rno-105355	Rattus norvegicus	86.81	0.00e+00	2334.00
IUUC-Sha-107057	Sarcophilus harrisii	72.77	0.00e+00	1816.00
IUUC-Sar-113011	Sorex araneus	90.49	0.00e+00	1499.00
IUUC-Ssc-115761	Sus scrofa	88.80	0.00e+00	2296.00
IUUC-Tgu-116956	Taeniopygia guttata	63.06	0.00e+00	825.00
IUUC-Tru-118739	Takifugu rubripes	69.56	0.00e+00	1352.00
IUUC-Tsy-118827	Tarsius syrichta	80.94	0.00e+00	1241.00
IUUC-Tni-119921	Tetraodon nigroviridis	60.21	0.00e+00	1386.00
IUUC-Tbe-128017	Tupaia belangeri	92.03	0.00e+00	1968.00
IUUC-Ttr-128869	Tursiops truncatus	87.61	0.00e+00	2291.00
IUUC-Vpa-130427	Vicugna pacos	95.09	0.00e+00	922.00
IUUC-Xtr-132734	Xenopus tropicalis	61.77	0.00e+00	1562.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence