iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132956

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Histone deacetylase

Genbank Nucleotide ID

AAMC01007518

Gene Name

hdac4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000004880.3	ENSXETT00000010592.2	ENSXETP00000010592.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	80.04	0.00e+00	1466.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
793	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Xenopus tropicalis

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

LNSQTSADGI SGLDQPVDLL TQTRAKHMPS TVDVSAALPL QVAPSALPMD LRLDPQYTIS 60
AQEPGGREQQ LQQELLALKQ KQQIQRQLLI AEFQRQHEQL SRQHEAQLHE HIKQQQELLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAATTCAC AGACATCAGA AAAGGGTTTA GGAAAGGACA AATCTTTTAA TTAATGGGGC 60
TTGCTAATTT GTTAGAAAAA ACCCCAGTTG GCATAAAAGC TAACTTTTGT ACTGGGGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0004407--F:histone deacetylase activity
GO:0046872--F:metal ion binding
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0001755--P:neural crest cell migration
GO:0090299--P:regulation of neural crest formation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	79.74	0.00e+00	1463.00
IUUC-Apl-003250	Anas platyrhynchos	78.73	0.00e+00	1401.00
IUUC-Aca-004668	Anolis carolinensis	75.65	0.00e+00	1454.00
IUUC-Bta-013215	Bos taurus	79.94	0.00e+00	1467.00
IUUC-Cja-019816	Callithrix jacchus	79.94	0.00e+00	1489.00
IUUC-Cfa-020861	Canis familiaris	79.96	0.00e+00	1452.00
IUUC-Cpo-021562	Cavia porcellus	79.10	0.00e+00	1483.00
IUUC-Csa-023612	Chlorocebus sabaeus	79.66	0.00e+00	1467.00
IUUC-Cin-025614	Ciona intestinalis	38.46	2.60e-01	29.30
IUUC-Csv-026359	Ciona savignyi	55.41	6.00e-97	346.00
IUUC-Dre-028284	Danio rerio	71.36	0.00e+00	1222.00
IUUC-Dno-029951	Dasypus novemcinctus	77.98	0.00e+00	1338.00
IUUC-Dor-030362	Dipodomys ordii	70.01	0.00e+00	1213.00
IUUC-Dme-031766	Drosophila melanogaster	58.72	5.00e-164	572.00
IUUC-Fca-036187	Felis catus	81.69	0.00e+00	1461.00
IUUC-Gmo-038473	Gadus morhua	73.80	0.00e+00	724.00
IUUC-Gga-040501	Gallus gallus	80.65	0.00e+00	1467.00
IUUC-Gac-042335	Gasterosteus aculeatus	66.70	0.00e+00	1189.00
IUUC-Ggo-045380	Gorilla gorilla	79.76	0.00e+00	1457.00
IUUC-Hsa-046925	Homo sapiens	79.94	0.00e+00	1487.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	80.29	0.00e+00	1429.00
IUUC-Lch-050325	Latimeria chalumnae	78.67	0.00e+00	1397.00
IUUC-Loc-052231	Lepisosteus oculatus	76.20	0.00e+00	1327.00
IUUC-Laf-054490	Loxodonta africana	75.12	0.00e+00	1405.00
IUUC-Mcc-055265	Macaca mulatta	79.34	0.00e+00	1486.00
IUUC-Meu-056676	Macropus eugenii	79.73	0.00e+00	693.00
IUUC-Mmr-061633	Microcebus murinus	73.23	0.00e+00	1293.00
IUUC-Mmu-063089	Mus musculus	79.78	0.00e+00	1428.00
IUUC-Mpu-065887	Mustela putorius furo	80.04	0.00e+00	1476.00
IUUC-Mlu-067470	Myotis lucifugus	81.60	0.00e+00	1474.00
IUUC-Nle-069099	Nomascus leucogenys	75.93	0.00e+00	922.00
IUUC-Ont-071613	Oreochromis niloticus	63.62	0.00e+00	1181.00
IUUC-Oan-073275	Ornithorhynchus anatinus	82.12	0.00e+00	1474.00
IUUC-Ola-087031	Oryzias latipes	63.72	0.00e+00	1141.00
IUUC-Oga-088201	Otolemur garnettii	72.84	0.00e+00	1281.00
IUUC-Oar-089997	Ovis aries	73.10	0.00e+00	1199.00
IUUC-Ptr-091116	Pan troglodytes	80.22	0.00e+00	1503.00
IUUC-Pan-092132	Papio anubis	82.03	0.00e+00	1012.00
IUUC-Psi-093734	Pelodiscus sinensis	80.06	0.00e+00	1405.00
IUUC-Pma-094347	Petromyzon marinus	69.92	0.00e+00	695.00
IUUC-Pfo-096293	Poecilia formosa	67.62	0.00e+00	1140.00
IUUC-Pab-098491	Pongo abelii	77.23	0.00e+00	1401.00
IUUC-Pca-101004	Procavia capensis	69.77	0.00e+00	737.00
IUUC-Pva-102961	Pteropus vampyrus	59.80	0.00e+00	702.00
IUUC-Rno-105005	Rattus norvegicus	79.96	0.00e+00	1406.00
IUUC-Sha-107646	Sarcophilus harrisii	59.87	0.00e+00	868.00
IUUC-Ssc-115428	Sus scrofa	81.04	0.00e+00	1424.00
IUUC-Tgu-116776	Taeniopygia guttata	80.75	0.00e+00	1450.00
IUUC-Tru-118180	Takifugu rubripes	67.91	0.00e+00	1191.00
IUUC-Tsy-119468	Tarsius syrichta	74.80	0.00e+00	637.00
IUUC-Tni-120196	Tetraodon nigroviridis	66.33	0.00e+00	1189.00
IUUC-Ttr-128360	Tursiops truncatus	74.84	0.00e+00	869.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence