iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120151

UUCD1 version

UUC-TeN-00738

Ensembl Protein ID

ENSTNIP00000011595.1

UniProt Accession

H3CTL1; H3CTL1_TETNG

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000008747.1	ENSTNIT00000011782.1	ENSTNIP00000011595.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.70e-134	446.3	585	918

Active Site

Position(s)	Description	Evidence
887	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++++++d+
   Q: 585  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHSKFIDT 672
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl l+dle++dpe+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lkp+G+n+ Vt+eNkeeY++l++e
   Q: 673  GFSLPFYKRMLNKKLILKDLESIDPEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKITSHDLKPDGANVLVTEENKEEYISLMAE 758
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++ q++af +Gfnev+pl++l++F+e+ele+++cG++e+d++d++++t y++ yt++s++i+wFw+ ++e+++e r +++qFv
   Q: 759  WRFSRGVEGQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRH-YTRNSKQIIWFWQLVKEVDNEVRLRLMQFV 846
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+     p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s e+lkekLl+Aieet+gF++
   Q: 847  TGTCRLPLGGFAELMgrsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSFEQLKEKLLFAIEETEGFGQ 918
           **********************************************************************96 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

MAAAPSRGES CQNHRGTSQL HALVSCAKIK RKKSLFGTTV FVEVTAEGES RRTTKSHSCS 60
NPKWEERLTL NVTSRTQLDF KVWSHHTLKA DVLLGKASLD LSQSLEQHQR KLENVKEVLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGCGG CCCCGTCTCG AGGCGAGTCC TGCCAGAACC ACAGAGGGAC ATCACAGCTC 60
CACGCCCTGG GTGAGTTTAC GGTGCTTTCG TGCACGTGCT TGCTCATCTG GGCTGTCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	70.00	0.00e+00	1288.00
IUUC-Apl-003310	Anas platyrhynchos	71.87	0.00e+00	1322.00
IUUC-Aca-005388	Anolis carolinensis	70.25	0.00e+00	1271.00
IUUC-Ago-007742	Ashbya gossypii	46.60	5.00e-155	541.00
IUUC-Bta-012857	Bos taurus	70.88	0.00e+00	1292.00
IUUC-Cel-018299	Caenorhabditis elegans	66.96	0.00e+00	825.00
IUUC-Cja-019448	Callithrix jacchus	70.71	0.00e+00	1308.00
IUUC-Cfa-020728	Canis familiaris	70.53	0.00e+00	1308.00
IUUC-Cpo-021635	Cavia porcellus	68.65	0.00e+00	1288.00
IUUC-Csa-023805	Chlorocebus sabaeus	91.20	0.00e+00	1116.00
IUUC-Cin-025212	Ciona intestinalis	72.93	0.00e+00	899.00
IUUC-Csv-026256	Ciona savignyi	72.37	0.00e+00	894.00
IUUC-Cne-026849	Cryptococcus neoformans	46.52	7.00e-151	527.00
IUUC-Dre-028245	Danio rerio	77.23	0.00e+00	1264.00
IUUC-Dno-029618	Dasypus novemcinctus	70.11	0.00e+00	1286.00
IUUC-Dme-032041	Drosophila melanogaster	69.87	0.00e+00	886.00
IUUC-Ete-032779	Echinops telfairi	89.10	0.00e+00	1048.00
IUUC-Eca-033313	Equus caballus	69.22	0.00e+00	1274.00
IUUC-Eeu-035259	Erinaceus europaeus	63.48	0.00e+00	1125.00
IUUC-Fca-035420	Felis catus	70.71	0.00e+00	1301.00
IUUC-Fal-037335	Ficedula albicollis	71.28	0.00e+00	1317.00
IUUC-Gmo-039172	Gadus morhua	90.32	0.00e+00	1083.00
IUUC-Gga-040246	Gallus gallus	71.17	0.00e+00	1315.00
IUUC-Gac-042211	Gasterosteus aculeatus	97.77	0.00e+00	1217.00
IUUC-Ggo-045001	Gorilla gorilla	71.67	0.00e+00	1172.00
IUUC-Hsa-046544	Homo sapiens	69.97	0.00e+00	1300.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	71.13	0.00e+00	1281.00
IUUC-Lch-050398	Latimeria chalumnae	92.81	0.00e+00	1154.00
IUUC-Loc-052116	Lepisosteus oculatus	75.69	0.00e+00	1362.00
IUUC-Laf-053551	Loxodonta africana	70.35	0.00e+00	1283.00
IUUC-Mga-059986	Meleagris gallopavo	71.60	0.00e+00	1319.00
IUUC-Mmr-060945	Microcebus murinus	67.87	0.00e+00	1236.00
IUUC-Mdo-063024	Monodelphis domestica	90.64	0.00e+00	1074.00
IUUC-Mmu-063202	Mus musculus	71.34	0.00e+00	1288.00
IUUC-Mpu-065773	Mustela putorius furo	70.35	0.00e+00	1303.00
IUUC-Nle-069188	Nomascus leucogenys	70.50	0.00e+00	1308.00
IUUC-Opr-070965	Ochotona princeps	91.13	0.00e+00	1103.00
IUUC-Ont-072226	Oreochromis niloticus	97.79	0.00e+00	1229.00
IUUC-Oan-073497	Ornithorhynchus anatinus	71.46	0.00e+00	1307.00
IUUC-Ocu-073891	Oryctolagus cuniculus	67.31	0.00e+00	1196.00
IUUC-Ola-087438	Oryzias latipes	96.43	0.00e+00	1210.00
IUUC-Oga-087922	Otolemur garnettii	70.43	0.00e+00	1294.00
IUUC-Oar-089317	Ovis aries	70.93	0.00e+00	1297.00
IUUC-Ptr-090484	Pan troglodytes	69.86	0.00e+00	1300.00
IUUC-Pan-092117	Papio anubis	69.97	0.00e+00	1298.00
IUUC-Psi-093338	Pelodiscus sinensis	72.10	0.00e+00	1331.00
IUUC-Pma-094279	Petromyzon marinus	72.17	0.00e+00	822.00
IUUC-Pfo-096171	Poecilia formosa	97.28	0.00e+00	1221.00
IUUC-Pab-098654	Pongo abelii	88.93	0.00e+00	1074.00
IUUC-Pva-102811	Pteropus vampyrus	91.67	0.00e+00	1117.00
IUUC-Rno-106125	Rattus norvegicus	69.58	0.00e+00	1280.00
IUUC-Sha-107243	Sarcophilus harrisii	90.65	0.00e+00	1126.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	48.77	3.00e-153	535.00
IUUC-Sre-114929	Sporisorium reilianum	45.69	9.00e-148	517.00
IUUC-Ssc-115368	Sus scrofa	70.21	0.00e+00	1276.00
IUUC-Tgu-117079	Taeniopygia guttata	71.96	0.00e+00	1316.00
IUUC-Tru-118062	Takifugu rubripes	84.08	0.00e+00	1545.00
IUUC-Tsy-119507	Tarsius syrichta	66.56	0.00e+00	1187.00
IUUC-Tre-122203	Trichoderma reesei	44.66	1.00e-145	509.00
IUUC-Vda-129753	Verticillium dahliae	45.08	4.00e-148	518.00
IUUC-Xtr-132877	Xenopus tropicalis	65.38	0.00e+00	1118.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence