iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/UBZ	UBZ	18239685

Classification

Family	E-value	Score	Start	End
UBD/ZnF/UBZ	9.50e-19	68.3	780	806

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/UBZ

   S: 2    lvCPvCqkm....vdqtdfeeHlDeCl 24
           +vCP+C+++    +dq++fe+H+++++
   Q: 780  KVCPMCSEQfppdYDQQGFERHVQTHF 806
           79************************8 PP

Organism

Mus musculus

Functional Description
(View)

Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).

Protein Sequence
(Fasta)

MTSFQEVQLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHSKDWV GIFKVGWSTA 60
RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCGGAAG TGACGCACCG CCGGCTCTCC GCTTAGAGAA GGTGTAGCCG GTCTACGCTG 60
AGAGGCAGTG GTGGTGGCCG CGGAGGTTCG GGGCGCGGCG TAGCGTGCGG GGCGGAGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR012852--CALCOCO1-like
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF07888--CALCOCO1

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0019900--F:kinase binding
GO:0046872--F:metal ion binding
GO:0043130--F:ubiquitin binding
GO:0006915--P:apoptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity

KEGG

mmu:52440

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001679	Ailuropoda melanoleuca	87.06	0.00e+00	1422.00
IUUC-Apl-003483	Anas platyrhynchos	69.63	0.00e+00	983.00
IUUC-Aca-004388	Anolis carolinensis	66.34	0.00e+00	1017.00
IUUC-Ame-011597	Astyanax mexicanus	52.44	0.00e+00	737.00
IUUC-Bta-013302	Bos taurus	85.84	0.00e+00	1392.00
IUUC-Cja-019115	Callithrix jacchus	87.39	0.00e+00	1420.00
IUUC-Cfa-020964	Canis familiaris	87.32	0.00e+00	1423.00
IUUC-Cpo-021321	Cavia porcellus	85.05	0.00e+00	1370.00
IUUC-Csa-023834	Chlorocebus sabaeus	83.70	0.00e+00	1350.00
IUUC-Cho-024833	Choloepus hoffmanni	70.38	0.00e+00	1055.00
IUUC-Cin-025652	Ciona intestinalis	46.15	1.00e-32	132.00
IUUC-Csv-026309	Ciona savignyi	34.34	2.00e-38	153.00
IUUC-Dre-028589	Danio rerio	51.45	0.00e+00	703.00
IUUC-Dno-030000	Dasypus novemcinctus	85.84	0.00e+00	1382.00
IUUC-Dor-030372	Dipodomys ordii	75.36	0.00e+00	844.00
IUUC-Ete-032476	Echinops telfairi	64.72	0.00e+00	746.00
IUUC-Eca-033369	Equus caballus	87.18	0.00e+00	1384.00
IUUC-Eeu-034551	Erinaceus europaeus	82.65	0.00e+00	917.00
IUUC-Fca-036201	Felis catus	85.84	0.00e+00	1396.00
IUUC-Fal-036858	Ficedula albicollis	69.46	0.00e+00	1130.00
IUUC-Fox-038033	Fusarium oxysporum	26.50	1.70e-02	35.40
IUUC-Gmo-038559	Gadus morhua	50.18	0.00e+00	692.00
IUUC-Gga-040410	Gallus gallus	70.15	0.00e+00	1117.00
IUUC-Gac-041455	Gasterosteus aculeatus	48.56	0.00e+00	694.00
IUUC-Ggo-044630	Gorilla gorilla	82.76	0.00e+00	1340.00
IUUC-Hsa-046382	Homo sapiens	84.44	0.00e+00	1368.00
IUUC-Itr-048080	Ictidomys tridecemlineatus	89.96	0.00e+00	912.00
IUUC-Lch-050570	Latimeria chalumnae	58.47	0.00e+00	887.00
IUUC-Loc-052138	Lepisosteus oculatus	53.08	0.00e+00	780.00
IUUC-Laf-053961	Loxodonta africana	85.37	0.00e+00	1399.00
IUUC-Mcc-055567	Macaca mulatta	87.25	0.00e+00	1428.00
IUUC-Meu-056498	Macropus eugenii	57.47	2.00e-124	439.00
IUUC-Mga-059976	Meleagris gallopavo	70.53	0.00e+00	1096.00
IUUC-Mmr-061120	Microcebus murinus	86.01	0.00e+00	1407.00
IUUC-Mdo-062786	Monodelphis domestica	73.98	0.00e+00	1155.00
IUUC-Mpu-065955	Mustela putorius furo	84.86	0.00e+00	1217.00
IUUC-Mlu-067346	Myotis lucifugus	83.88	0.00e+00	1367.00
IUUC-Nle-070020	Nomascus leucogenys	85.17	0.00e+00	1380.00
IUUC-Opr-070912	Ochotona princeps	87.41	0.00e+00	920.00
IUUC-Ont-072077	Oreochromis niloticus	49.76	0.00e+00	674.00
IUUC-Oan-072766	Ornithorhynchus anatinus	74.97	0.00e+00	1189.00
IUUC-Ocu-073890	Oryctolagus cuniculus	87.06	0.00e+00	1370.00
IUUC-Oba-075310	Oryza barthii	35.56	3.00e-02	34.70
IUUC-Ogl-077852	Oryza glaberrima	35.56	5.00e-03	35.00
IUUC-Ogu-079005	Oryza glumaepatula	35.56	5.00e-03	35.40
IUUC-Oni-082860	Oryza nivara	35.56	5.50e-02	34.30
IUUC-Ola-086797	Oryzias latipes	48.64	0.00e+00	687.00
IUUC-Oga-088654	Otolemur garnettii	85.96	0.00e+00	1367.00
IUUC-Oar-089818	Ovis aries	85.47	0.00e+00	1375.00
IUUC-Ptr-091003	Pan troglodytes	84.07	0.00e+00	1363.00
IUUC-Pan-092314	Papio anubis	87.25	0.00e+00	1426.00
IUUC-Psi-093572	Pelodiscus sinensis	71.97	0.00e+00	1109.00
IUUC-Pma-094507	Petromyzon marinus	64.29	3.00e-52	197.00
IUUC-Pfo-097213	Poecilia formosa	49.94	0.00e+00	706.00
IUUC-Pab-097686	Pongo abelii	83.46	0.00e+00	1345.00
IUUC-Pca-100726	Procavia capensis	60.65	1.00e-99	357.00
IUUC-Pva-102509	Pteropus vampyrus	66.95	0.00e+00	973.00
IUUC-Pgr-103264	Puccinia graminis	27.27	9.00e-03	33.10
IUUC-Rno-105535	Rattus norvegicus	93.37	0.00e+00	1496.00
IUUC-Sha-107520	Sarcophilus harrisii	71.62	0.00e+00	1118.00
IUUC-Sja-107809	Schizosaccharomyces japonicus	36.84	1.00e-01	31.60
IUUC-Stu-112806	Solanum tuberosum	32.73	5.20e-02	31.60
IUUC-Sar-113699	Sorex araneus	80.71	0.00e+00	1284.00
IUUC-Sbi-114114	Sorghum bicolor	27.32	4.00e-04	39.70
IUUC-Ssc-115399	Sus scrofa	83.11	1.00e-152	532.00
IUUC-Tgu-116486	Taeniopygia guttata	69.54	0.00e+00	1127.00
IUUC-Tru-118050	Takifugu rubripes	48.39	0.00e+00	666.00
IUUC-Tsy-118822	Tarsius syrichta	83.88	0.00e+00	1392.00
IUUC-Tni-120117	Tetraodon nigroviridis	47.02	0.00e+00	677.00
IUUC-Tvi-122468	Trichoderma virens	25.97	1.80e-02	35.80
IUUC-Tbe-127368	Tupaia belangeri	68.74	8.00e-139	487.00
IUUC-Ttr-128751	Tursiops truncatus	79.25	0.00e+00	853.00
IUUC-Vpa-130362	Vicugna pacos	80.33	0.00e+00	1040.00
IUUC-Vvi-131054	Vitis vinifera	26.26	5.00e-04	40.80
IUUC-Xtr-132419	Xenopus tropicalis	59.52	0.00e+00	885.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence