iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040527

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

AC147443

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000015813.5	ENSGALT00000025494.5	ENSGALP00000025448.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.30e-84	283.3	192	816

Active Site

Position(s)	Description	Evidence
201	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
752	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.........kkkeklneenp...........kepkgellkslqklfeelwkskkkavs 69
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e                 + +            ++ g+l+ +++++++e++++k+++v+
   Q: 192  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEakmpdttvkI-------D-SpelsmepqlvkLDQPGPLTLAMHQFLTEMQETKRGVVT 272
           5******************************7644333331.......2.13555555666688889********************** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkk.....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq 153
           p+el+++++k+a +f+gy+qqD+qE+l++lld+++ e  +       +  +++ ++++++ +++++e++kkk  ks+++++F+g+l+s+
   Q: 273  PKELFAQVCKKAIRFKGYQQQDSQELLRYLLDGMRAEEIQrisvgILKALTDSDKQNEEELRKKIKEYEKKKGIKSFVDRIFGGELTST 361
           **********************************98775557776555555555666666677779*********************** PP
   S: 154  ikclecdnvssreepfldlslpvpgkeetkke......................................................... 185
           i+c+ec++vs  +e+fldlslpv ++++ k++                                                         
   Q: 362  IMCEECRTVSLVHESFLDLSLPVLDDQKIKNTnernvkkikgreseeeeedknndyyikqrdeppgtskhlqkkakkqakkqaksqrrq 450
           ***************************988889******************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 451  qklqgkvlqltdicateesekdvvcdqegeaeinseisdvkqeeessndckddyltqndlniqgsstdvqsmhestgkpeqekestanl 539
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 540  ptedldspvefvnglddlslkdedeenedeeglatdfsklhlsanaesdinvlddlqtapaktceiltedaemafctlanredlnpeeg 628
           ***************************************************************************************** PP
   S: 186  slqdcLesftkeeelegenkyycekckkkqe..............aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLd 260
           s+++cL +ft++e+l ++nk+ c+ c++++               a+k++ ++  P++L+lhLkRf  ++++ + +k+n++++fp+ +d
   Q: 629  SIHQCLYQFTRNEKLSENNKLLCDICTQRRYgpkntknekhvytnAKKQMLISLAPPILTLHLKRF--QQAGFNLRKVNRHIKFPEVID 715
           ***************************777778888888888888*********************..9999***************** PP
   S: 261  lspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVtevkeeev 322
           l+pfct ++++++e   k+ Y+L++vv HsG+++sGHY+ay+k                          kg+W++++D++V++v+ ++v
   Q: 716  LAPFCTVKCKNVAEgntKVLYSLYGVVEHSGTMRSGHYTAYAKMrnmnnhlsdlilqgqppqaletepIKGQWFHISDTHVQAVSTSKV 804
           *******99999888889**************************9999999999999999988888888******************** PP
   S: 323  leetgstaYvlfYkr 337
           l+   s+aY+lfY+r
   Q: 805  LS---SQAYLLFYER 816
           **...********98 PP

Organism

Gallus gallus

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT AQADESMDIV EPVCKHIRKG LEQSHLKKAL LNVEWHVCQD CKADNKTQEK 60
SEEETDESPS IWLCLKCGHR GCGRNSQEQH ALKHYTTPRS DPHCLVLSLD NWSVWCYICD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCACTGTTG TGTGTGAAGA AAATCATAGG CTACAAATAT GGGAAAGAAA CGGACCAAAG 60
GCAAAACTGC ACAGGCTGAT GAGTCTATGG ATATAGTGGG TATGTTTCTT CTGAGAAGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

gga:418485

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	27.95	3.00e-27	117.00
IUUC-Aml-001931	Ailuropoda melanoleuca	62.28	0.00e+00	911.00
IUUC-Atr-003015	Amborella trichopoda	30.22	2.00e-36	147.00
IUUC-Apl-004145	Anas platyrhynchos	85.08	0.00e+00	1253.00
IUUC-Aca-004314	Anolis carolinensis	62.96	0.00e+00	928.00
IUUC-Aly-006422	Arabidopsis lyrata	28.00	2.00e-29	124.00
IUUC-Ath-006732	Arabidopsis thaliana	30.86	1.00e-32	135.00
IUUC-Ame-011659	Astyanax mexicanus	47.78	4.00e-107	382.00
IUUC-Bta-013362	Bos taurus	62.60	0.00e+00	919.00
IUUC-Bdi-014624	Brachypodium distachyon	27.60	1.00e-28	121.00
IUUC-Bol-015941	Brassica oleracea	29.01	5.00e-34	139.00
IUUC-Bra-016751	Brassica rapa	28.30	1.00e-31	132.00
IUUC-Cja-019177	Callithrix jacchus	63.37	0.00e+00	935.00
IUUC-Cfa-020051	Canis familiaris	63.03	0.00e+00	927.00
IUUC-Cpo-021886	Cavia porcellus	58.85	0.00e+00	898.00
IUUC-Csa-024103	Chlorocebus sabaeus	62.90	0.00e+00	929.00
IUUC-Cho-024315	Choloepus hoffmanni	58.87	3.00e-76	279.00
IUUC-Cin-025775	Ciona intestinalis	49.65	2.00e-39	154.00
IUUC-Csv-026075	Ciona savignyi	47.72	5.00e-53	202.00
IUUC-Dre-028388	Danio rerio	53.81	1.00e-113	404.00
IUUC-Dno-029409	Dasypus novemcinctus	62.89	0.00e+00	942.00
IUUC-Dor-030443	Dipodomys ordii	55.15	2.00e-123	436.00
IUUC-Ete-032807	Echinops telfairi	62.68	3.00e-140	492.00
IUUC-Eca-033479	Equus caballus	63.75	0.00e+00	949.00
IUUC-Eeu-034835	Erinaceus europaeus	56.59	1.00e-105	377.00
IUUC-Fca-036320	Felis catus	62.67	0.00e+00	932.00
IUUC-Fal-037029	Ficedula albicollis	77.51	0.00e+00	1138.00
IUUC-Gmo-039480	Gadus morhua	50.48	3.00e-107	382.00
IUUC-Gac-042343	Gasterosteus aculeatus	50.93	1.00e-108	387.00
IUUC-Gma-044402	Glycine max	29.77	6.00e-35	142.00
IUUC-Ggo-045598	Gorilla gorilla	62.56	0.00e+00	926.00
IUUC-Hsa-046598	Homo sapiens	62.89	0.00e+00	927.00
IUUC-Hvu-047146	Hordeum vulgare	35.42	2.00e-26	114.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	63.75	0.00e+00	934.00
IUUC-Lch-050536	Latimeria chalumnae	50.06	0.00e+00	702.00
IUUC-Lpe-050703	Leersia perrieri	27.90	5.00e-29	123.00
IUUC-Loc-051814	Lepisosteus oculatus	55.88	5.00e-121	428.00
IUUC-Laf-053732	Loxodonta africana	63.04	0.00e+00	926.00
IUUC-Mcc-054661	Macaca mulatta	63.02	0.00e+00	929.00
IUUC-Meu-055967	Macropus eugenii	65.14	6.00e-135	474.00
IUUC-Mtr-057945	Medicago truncatula	31.21	8.00e-33	135.00
IUUC-Mga-059551	Meleagris gallopavo	94.42	0.00e+00	1403.00
IUUC-Mvi-060391	Microbotryum violaceum	31.75	7.00e-18	86.30
IUUC-Mmr-061747	Microcebus murinus	63.19	0.00e+00	909.00
IUUC-Mdo-062220	Monodelphis domestica	62.36	0.00e+00	891.00
IUUC-Mmu-063582	Mus musculus	60.57	0.00e+00	882.00
IUUC-Mac-064941	Musa acuminata	30.14	1.00e-62	234.00
IUUC-Mpu-066339	Mustela putorius furo	62.18	0.00e+00	922.00
IUUC-Mlu-067511	Myotis lucifugus	61.21	0.00e+00	896.00
IUUC-Nle-069252	Nomascus leucogenys	63.02	0.00e+00	929.00
IUUC-Opr-070969	Ochotona princeps	61.27	0.00e+00	876.00
IUUC-Ont-071786	Oreochromis niloticus	52.17	5.00e-113	401.00
IUUC-Ocu-074704	Oryctolagus cuniculus	62.62	0.00e+00	923.00
IUUC-Oba-075094	Oryza barthii	28.48	7.00e-27	116.00
IUUC-Obr-076743	Oryza brachyantha	26.96	6.00e-28	119.00
IUUC-Ogl-077739	Oryza glaberrima	28.48	6.00e-27	116.00
IUUC-Ogu-078851	Oryza glumaepatula	28.48	7.00e-27	116.00
IUUC-Oin-079402	Oryza indica	28.48	8.00e-27	115.00
IUUC-Olo-080431	Oryza longistaminata	28.48	6.00e-27	116.00
IUUC-Ome-081580	Oryza meridionalis	28.97	5.00e-27	116.00
IUUC-Oni-082644	Oryza nivara	28.48	8.00e-27	115.00
IUUC-Opu-083452	Oryza punctata	28.21	1.00e-26	115.00
IUUC-Oru-084546	Oryza rufipogon	28.48	8.00e-27	115.00
IUUC-Osa-085858	Oryza sativa	28.48	7.00e-27	116.00
IUUC-Ola-086795	Oryzias latipes	48.32	9.00e-107	380.00
IUUC-Oga-088713	Otolemur garnettii	62.90	0.00e+00	932.00
IUUC-Oar-089887	Ovis aries	62.75	0.00e+00	924.00
IUUC-Ptr-091670	Pan troglodytes	63.23	0.00e+00	927.00
IUUC-Pan-092293	Papio anubis	63.02	0.00e+00	929.00
IUUC-Psi-093101	Pelodiscus sinensis	68.15	0.00e+00	1012.00
IUUC-Ppa-095622	Physcomitrella patens	29.17	6.00e-34	139.00
IUUC-Pfo-097202	Poecilia formosa	50.22	4.00e-115	408.00
IUUC-Pab-098773	Pongo abelii	63.72	0.00e+00	681.00
IUUC-Pop-099136	Populus trichocarpa	30.31	1.00e-41	164.00
IUUC-Pca-101069	Procavia capensis	55.50	1.00e-106	380.00
IUUC-Ppe-101794	Prunus persica	31.61	7.00e-37	149.00
IUUC-Pva-103092	Pteropus vampyrus	53.94	2.00e-104	373.00
IUUC-Rno-105237	Rattus norvegicus	60.34	0.00e+00	882.00
IUUC-Sha-106889	Sarcophilus harrisii	62.40	0.00e+00	904.00
IUUC-Ssl-108648	Sclerotinia sclerotiorum	27.84	5.00e-11	62.80
IUUC-Sit-110283	Setaria italica	30.53	2.00e-27	118.00
IUUC-Sly-111491	Solanum lycopersicum	29.27	6.00e-35	142.00
IUUC-Stu-112820	Solanum tuberosum	30.91	2.00e-38	154.00
IUUC-Sar-113530	Sorex araneus	60.99	0.00e+00	902.00
IUUC-Sbi-113785	Sorghum bicolor	35.67	2.00e-23	104.00
IUUC-Ssc-116091	Sus scrofa	63.21	0.00e+00	931.00
IUUC-Tgu-117478	Taeniopygia guttata	75.49	0.00e+00	1098.00
IUUC-Tru-118640	Takifugu rubripes	52.36	1.00e-115	410.00
IUUC-Tsy-119042	Tarsius syrichta	52.04	7.00e-157	547.00
IUUC-Tni-120015	Tetraodon nigroviridis	51.70	1.00e-110	394.00
IUUC-Tca-121701	Theobroma cacao	30.59	8.00e-39	155.00
IUUC-Tae-125351	Triticum aestivum	29.06	5.00e-27	116.00
IUUC-Tur-126788	Triticum urartu	35.42	2.00e-25	110.00
IUUC-Tbe-127309	Tupaia belangeri	58.49	4.00e-102	365.00
IUUC-Ttr-128271	Tursiops truncatus	61.62	0.00e+00	905.00
IUUC-Vpa-130674	Vicugna pacos	61.55	0.00e+00	835.00
IUUC-Xtr-131869	Xenopus tropicalis	52.73	0.00e+00	775.00
IUUC-Xma-134195	Xiphophorus maculatus	51.10	2.00e-115	409.00
IUUC-Zma-135157	Zea mays	29.25	7.00e-25	109.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence