iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000033623.13	ENSMUST00000112597.7	ENSMUSP00000108216.1
ENSMUSG00000033623.13	ENSMUST00000046975.11	ENSMUSP00000041790.5
ENSMUSG00000033623.13	ENSMUST00000138264.7	ENSMUSP00000142465.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.00e-06	28.4	17	56
ULD/UDP/UFD/RAWUL	6.10e-27	95.1	154	235

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C   + d + v+ C H+f+++Cl k+         + +CP+Cr
   Q: 17   CRLCSGYLIDATTVTECLHTFCRSCLVKY------LEENNTCPTCR 56
           9***9999999999***************......9*********8 PP

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsklkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwk.kegpLvLqYr 86
           +s++Le+ +s+k ++   lk+k++rcsa++tV hlkkf+a+kl+lss +e+d+lc++e+L++++tL+++ ++++w+ k++pL+L+Yr
   Q: 154  VSICLEC-NSSKLRG---LKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFV-VVTRWRfKKAPLLLHYR 235
           69*****.9999***...***************************************************.******99********9 PP

Organism

Mus musculus

Functional Description
(View)

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).

Protein Sequence
(Fasta)

MLTRKIKLWD INAHITCRLC SGYLIDATTV TECLHTFCRS CLVKYLEENN TCPTCRIVIH 60
QSHPLQYIGH DRTMQDIVYK LVPGLQEAEM RKQREFYHKL GMEVPGDIKG EACSAKQHLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTCGTTTGC GAGGTGGGAG CTGAGCCACA CACTGCGCAT GCTCCAGCCG CGGCGCCCCC 60
GACTCCGCAC TCGGCTGGGT TCGGGCATTT CCGCCTCTTT GTTTTAAACT CTGCACGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0008270--F:zinc ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:69587

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002400	Ailuropoda melanoleuca	96.69	6.00e-139	486.00
IUUC-Apl-004072	Anas platyrhynchos	95.38	1.00e-95	342.00
IUUC-Aca-004484	Anolis carolinensis	95.87	1.00e-137	482.00
IUUC-Aly-005422	Arabidopsis lyrata	40.00	1.00e-12	67.80
IUUC-Ath-007274	Arabidopsis thaliana	40.48	2.00e-12	66.60
IUUC-Ame-011838	Astyanax mexicanus	91.32	1.00e-129	455.00
IUUC-Bta-012853	Bos taurus	80.58	1.00e-113	402.00
IUUC-Bdi-015045	Brachypodium distachyon	44.44	1.00e-12	68.20
IUUC-Bra-017953	Brassica rapa	34.78	5.00e-09	55.80
IUUC-Cel-018403	Caenorhabditis elegans	32.78	6.00e-35	142.00
IUUC-Cja-019195	Callithrix jacchus	81.89	2.00e-119	421.00
IUUC-Cfa-021121	Canis familiaris	97.52	3.00e-140	491.00
IUUC-Cpo-021904	Cavia porcellus	98.76	1.00e-142	498.00
IUUC-Csa-024029	Chlorocebus sabaeus	97.52	3.00e-139	487.00
IUUC-Cin-025711	Ciona intestinalis	49.78	1.00e-55	209.00
IUUC-Csv-026354	Ciona savignyi	49.59	9.00e-60	223.00
IUUC-Dno-029902	Dasypus novemcinctus	96.28	6.00e-138	482.00
IUUC-Dor-030528	Dipodomys ordii	89.81	2.00e-112	398.00
IUUC-Dme-032006	Drosophila melanogaster	56.43	5.00e-77	280.00
IUUC-Eca-033585	Equus caballus	97.93	5.00e-140	489.00
IUUC-Fca-035514	Felis catus	98.35	6.00e-141	492.00
IUUC-Fal-036909	Ficedula albicollis	96.28	4.00e-138	483.00
IUUC-Gmo-039424	Gadus morhua	72.61	1.00e-95	342.00
IUUC-Gga-040513	Gallus gallus	96.69	5.00e-139	486.00
IUUC-Gac-041417	Gasterosteus aculeatus	73.25	6.00e-93	333.00
IUUC-Ggo-044870	Gorilla gorilla	97.52	3.00e-139	487.00
IUUC-Hsa-046308	Homo sapiens	97.52	3.00e-139	487.00
IUUC-Hvu-047653	Hordeum vulgare	43.66	5.00e-11	62.80
IUUC-Itr-048221	Ictidomys tridecemlineatus	97.10	3.00e-140	490.00
IUUC-Lpe-051152	Leersia perrieri	47.89	1.00e-11	64.70
IUUC-Loc-052499	Lepisosteus oculatus	92.24	9.00e-133	465.00
IUUC-Laf-053480	Loxodonta africana	98.35	9.00e-141	492.00
IUUC-Mcc-054829	Macaca mulatta	97.52	3.00e-139	487.00
IUUC-Meu-056337	Macropus eugenii	76.96	1.00e-92	332.00
IUUC-Mtr-057854	Medicago truncatula	41.98	4.00e-11	62.80
IUUC-Mga-059490	Meleagris gallopavo	93.72	7.00e-114	402.00
IUUC-Mmr-061326	Microcebus murinus	96.28	6.00e-139	486.00
IUUC-Mdo-062485	Monodelphis domestica	97.12	2.00e-138	484.00
IUUC-Mpu-066589	Mustela putorius furo	98.35	3.00e-141	493.00
IUUC-Nle-069442	Nomascus leucogenys	97.52	3.00e-139	487.00
IUUC-Opr-070753	Ochotona princeps	73.14	4.00e-94	337.00
IUUC-Ont-072514	Oreochromis niloticus	90.46	3.00e-130	457.00
IUUC-Oan-073034	Ornithorhynchus anatinus	83.71	2.00e-125	441.00
IUUC-Ocu-074720	Oryctolagus cuniculus	97.93	2.00e-140	491.00
IUUC-Oba-075690	Oryza barthii	45.07	9.00e-12	64.70
IUUC-Obr-076192	Oryza brachyantha	45.07	7.00e-12	65.10
IUUC-Ogl-077513	Oryza glaberrima	45.07	1.00e-11	65.10
IUUC-Ogu-078755	Oryza glumaepatula	45.07	1.00e-11	65.10
IUUC-Oin-079944	Oryza indica	46.48	3.00e-11	63.20
IUUC-Oni-082107	Oryza nivara	25.40	3.00e-11	62.40
IUUC-Opu-083871	Oryza punctata	45.07	7.00e-12	65.10
IUUC-Oru-084965	Oryza rufipogon	45.07	1.00e-11	65.10
IUUC-Osa-086282	Oryza sativa	45.07	6.00e-12	65.50
IUUC-Ola-087347	Oryzias latipes	89.63	1.00e-128	452.00
IUUC-Oga-088901	Otolemur garnettii	96.28	6.00e-139	486.00
IUUC-Ptr-090761	Pan troglodytes	97.52	1.00e-137	481.00
IUUC-Pan-092617	Papio anubis	97.52	3.00e-139	487.00
IUUC-Psi-093117	Pelodiscus sinensis	96.71	7.00e-138	482.00
IUUC-Pfo-096724	Poecilia formosa	90.87	1.00e-130	458.00
IUUC-Pab-097921	Pongo abelii	97.11	3.00e-137	480.00
IUUC-Pca-100156	Procavia capensis	98.24	4.00e-132	463.00
IUUC-Pva-102841	Pteropus vampyrus	97.50	9.00e-115	405.00
IUUC-Ptt-103843	Puccinia triticina	40.38	8.00e-06	44.70
IUUC-Rno-105088	Rattus norvegicus	100.00	7.00e-144	502.00
IUUC-Sha-107034	Sarcophilus harrisii	97.53	4.00e-139	486.00
IUUC-Sit-110108	Setaria italica	43.66	4.00e-11	62.80
IUUC-Sar-113067	Sorex araneus	100.00	2.00e-49	188.00
IUUC-Ssc-115483	Sus scrofa	95.50	2.00e-112	397.00
IUUC-Tgu-116929	Taeniopygia guttata	96.28	4.00e-138	483.00
IUUC-Tca-121638	Theobroma cacao	40.74	3.00e-11	63.20
IUUC-Tbe-127854	Tupaia belangeri	79.75	2.00e-101	361.00
IUUC-Ttr-128958	Tursiops truncatus	91.32	2.00e-129	454.00
IUUC-Vvi-131533	Vitis vinifera	40.74	8.00e-11	61.60
IUUC-Xtr-131955	Xenopus tropicalis	87.40	1.00e-123	435.00
IUUC-Xma-133504	Xiphophorus maculatus	90.87	1.00e-130	458.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence