iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-022001

Ensembl Protein ID

ENSCPOP00000010792.2

UniProt Accession

H0VKG4; H0VKG4_CAVPO

Genbank Protein ID

ENSCPOP00000010792

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02056488

Gene Name

TSG101

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000011994.3	ENSCPOT00000012110.2	ENSCPOP00000010792.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UEV	1.90e-45	154.2	2	146
UBD/UBC-like/UBD_UEV	1.80e-68	228.8	2	145

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UEV

   S: 1    avseselkvvvpr......nfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtv. 82
           avses+lk++v++      ++r+++++++ +k+l+++++sy+++Dg++++l++ltgtI++p+r+++ ++I +++l++ ++YP++PP++ 
   Q: 2    AVSESQLKKMVSKykyrdlTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNT-YNI-PICLWLLDTYPYNPPICf 88
           799***************************************************************.***.****************** PP
   S: 83   ...rfsskinmaevndsnGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPp 140
              ++s++i++ +++d+nG++   +lp+L++Wk+++s+++ l+q++++++++e++++++P+
   Q: 89   vkpTSSMTIKTGKHVDANGKI---YLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPT 146
           *********************...************************************5 PP

UBD/UBC-like/UBD_UEV

   S: 1    AvsesslkkvpskykdkrltvrellnliesykslkpktasfvlnDgesreLlrltGtipvpergitynipiilwlletYPekPPfvsvk 89
           Avses+lkk++skyk+++ltvre++n+i+ yk+lkp+++s+v+nDg+sreL++ltGtipvp+rg+tynipi+lwll+tYP++PP+++vk
   Q: 2    AVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVK 90
           89*************************************************************************************** PP
   S: 90   ekidmntikssnehvdpnGkialpvLhkWknpasnlvelvqelivllskeppklsrp 146
           ++++m tik++ +hvd+nGki+lp+Lh+Wk+p+s+l+ l+q++iv++++epp++srp
   Q: 91   PTSSM-TIKTG-KHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRP 145
           *****.*****.*******************************************98 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MAVSESQLKK MVSKYKYRDL TVRETVNVIT LYKDLKPVLD SYVFNDGSSR ELMNLTGTIP 60
VPYRGNTYNI PICLWLLDTY PYNPPICFVK PTSSMTIKTG KHVDANGKIY LPYLHEWKHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGTGT CGGAGAGCCA GCTCAAGAAG ATGGTGTCTA AGGTGAGGCT GCGACCTGCT 60
CGCCGTCCCG CGGGCGCCCA CCGCTCCCTT CCGCGCCTTC CCTCGCCGGC CCGGCCCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR017916--SB_dom
IPR016135--UBQ-conjugating_enzyme/RWD
IPR008883--UEV_N

PROSITE

PS51312--SB
PS51322--UEV

Pfam

PF05743--UEV
PF09454--Vps23_core

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0000813--C:ESCRT I complex
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0005730--C:nucleolus
GO:0005886--C:plasma membrane
GO:0003714--F:transcription corepressor activity
GO:0046790--F:virion binding
GO:0007050--P:cell cycle arrest
GO:0006464--P:cellular protein modification process
GO:1990182--P:exosomal secretion
GO:0030216--P:keratinocyte differentiation
GO:0008285--P:negative regulation of cell proliferation
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:1903543--P:positive regulation of exosomal secretion
GO:2000397--P:positive regulation of ubiquitin-dependent endocytosis
GO:1903774--P:positive regulation of viral budding via host ESCRT complex
GO:1902188--P:positive regulation of viral release from host cell
GO:0015031--P:protein transport
GO:0001558--P:regulation of cell growth
GO:1903551--P:regulation of extracellular exosome assembly
GO:0043405--P:regulation of MAP kinase activity
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0046755--P:viral budding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001072	Aegilops tauschii	38.02	6.00e-21	95.10
IUUC-Aml-002415	Ailuropoda melanoleuca	98.21	0.00e+00	738.00
IUUC-Atr-002875	Amborella trichopoda	29.51	2.00e-36	146.00
IUUC-Apl-003473	Anas platyrhynchos	88.78	0.00e+00	684.00
IUUC-Aca-004573	Anolis carolinensis	90.82	0.00e+00	676.00
IUUC-Aly-006164	Arabidopsis lyrata	44.12	5.00e-22	98.60
IUUC-Ath-006575	Arabidopsis thaliana	44.12	4.00e-22	99.00
IUUC-Ago-007755	Ashbya gossypii	25.00	1.00e-05	44.30
IUUC-Acl-008218	Aspergillus clavatus	38.76	2.00e-25	110.00
IUUC-Afl-008597	Aspergillus flavus	39.10	3.00e-25	110.00
IUUC-Afu-009017	Aspergillus fumigatus	37.98	3.00e-23	103.00
IUUC-Ani-009468	Aspergillus nidulans	38.64	4.00e-21	96.30
IUUC-Ang-009755	Aspergillus niger	36.51	2.00e-22	100.00
IUUC-Aor-010072	Aspergillus oryzae	37.59	2.00e-25	110.00
IUUC-Ate-010400	Aspergillus terreus	37.98	9.00e-25	108.00
IUUC-Ame-011620	Astyanax mexicanus	80.26	0.00e+00	644.00
IUUC-Bgr-012136	Blumeria graminis	35.77	7.00e-24	105.00
IUUC-Bta-012557	Bos taurus	98.47	0.00e+00	728.00
IUUC-Bci-013881	Botrytis cinerea	37.41	3.00e-26	113.00
IUUC-Bdi-014325	Brachypodium distachyon	32.11	2.00e-14	73.60
IUUC-Bol-016308	Brassica oleracea	41.60	8.00e-27	115.00
IUUC-Bra-017442	Brassica rapa	42.37	2.00e-24	106.00
IUUC-Cel-018697	Caenorhabditis elegans	48.84	3.00e-37	149.00
IUUC-Cja-018963	Callithrix jacchus	91.33	0.00e+00	721.00
IUUC-Cfa-020472	Canis familiaris	98.21	0.00e+00	734.00
IUUC-Cre-022918	Chlamydomonas reinhardtii	30.11	8.00e-32	131.00
IUUC-Csa-023959	Chlorocebus sabaeus	98.98	0.00e+00	707.00
IUUC-Cho-024389	Choloepus hoffmanni	56.36	2.00e-38	153.00
IUUC-Cin-025688	Ciona intestinalis	44.53	4.00e-99	354.00
IUUC-Cne-026904	Cryptococcus neoformans	30.07	2.00e-14	74.30
IUUC-Cme-027280	Cyanidioschyzon merolae	39.09	9.00e-18	84.30
IUUC-Dre-027913	Danio rerio	80.51	1.00e-176	612.00
IUUC-Dno-029672	Dasypus novemcinctus	97.95	0.00e+00	746.00
IUUC-Dor-030175	Dipodomys ordii	98.00	2.00e-94	338.00
IUUC-Dse-031375	Dothistroma septosporum	32.85	4.00e-23	102.00
IUUC-Dme-031736	Drosophila melanogaster	49.28	3.00e-97	348.00
IUUC-Ete-032343	Echinops telfairi	93.09	0.00e+00	702.00
IUUC-Eca-033926	Equus caballus	98.47	0.00e+00	733.00
IUUC-Eeu-034940	Erinaceus europaeus	90.79	0.00e+00	724.00
IUUC-Fca-035491	Felis catus	97.95	0.00e+00	719.00
IUUC-Fal-037508	Ficedula albicollis	91.33	0.00e+00	680.00
IUUC-Fox-037937	Fusarium oxysporum	32.31	3.00e-21	96.70
IUUC-Fso-038091	Fusarium solani	36.03	5.00e-25	108.00
IUUC-Gmo-039427	Gadus morhua	78.21	2.00e-172	598.00
IUUC-Ggr-039724	Gaeumannomyces graminis	37.31	4.00e-25	109.00
IUUC-Gga-040998	Gallus gallus	88.75	0.00e+00	701.00
IUUC-Gac-041356	Gasterosteus aculeatus	80.72	0.00e+00	640.00
IUUC-Gma-044361	Glycine max	39.68	4.00e-25	108.00
IUUC-Ggo-044967	Gorilla gorilla	98.98	0.00e+00	707.00
IUUC-Hsa-046686	Homo sapiens	98.98	0.00e+00	707.00
IUUC-Hvu-047430	Hordeum vulgare	38.02	5.00e-21	95.50
IUUC-Itr-047929	Ictidomys tridecemlineatus	99.11	7.00e-111	392.00
IUUC-Kpa-049287	Komagataella pastoris	30.86	8.00e-16	78.20
IUUC-Lch-050597	Latimeria chalumnae	86.73	0.00e+00	679.00
IUUC-Lpe-051090	Leersia perrieri	38.02	2.00e-20	93.60
IUUC-Loc-052399	Lepisosteus oculatus	81.07	1.00e-178	619.00
IUUC-Lma-053249	Leptosphaeria maculans	29.82	9.00e-14	71.60
IUUC-Laf-053766	Loxodonta africana	99.23	0.00e+00	741.00
IUUC-Mcc-055641	Macaca mulatta	98.98	0.00e+00	707.00
IUUC-Meu-055919	Macropus eugenii	90.80	2.00e-171	594.00
IUUC-Mor-056970	Magnaporthe oryzae	38.46	5.00e-24	105.00
IUUC-Mpo-057345	Magnaporthe poae	36.92	8.00e-23	101.00
IUUC-Mtr-058436	Medicago truncatula	38.10	8.00e-26	111.00
IUUC-Mla-059037	Melampsora laricipopulina	35.86	1.00e-25	111.00
IUUC-Mga-059263	Meleagris gallopavo	88.05	0.00e+00	674.00
IUUC-Mvi-060463	Microbotryum violaceum	29.56	2.00e-17	84.30
IUUC-Mmr-060915	Microcebus murinus	98.98	0.00e+00	736.00
IUUC-Mdo-062449	Monodelphis domestica	94.88	0.00e+00	697.00
IUUC-Mmu-063151	Mus musculus	95.65	0.00e+00	709.00
IUUC-Mac-065581	Musa acuminata	36.43	6.00e-22	98.20
IUUC-Mpu-066621	Mustela putorius furo	98.21	0.00e+00	738.00
IUUC-Mlu-067336	Myotis lucifugus	98.72	0.00e+00	717.00
IUUC-Nfi-068530	Neosartorya fischeri	38.76	2.00e-23	103.00
IUUC-Ncr-068785	Neurospora crassa	36.03	1.00e-24	107.00
IUUC-Nle-069972	Nomascus leucogenys	98.98	0.00e+00	707.00
IUUC-Opr-071150	Ochotona princeps	69.31	4.00e-125	441.00
IUUC-Ont-071366	Oreochromis niloticus	82.05	0.00e+00	640.00
IUUC-Oan-073290	Ornithorhynchus anatinus	93.91	2.00e-105	374.00
IUUC-Ocu-074351	Oryctolagus cuniculus	99.23	0.00e+00	739.00
IUUC-Oba-075338	Oryza barthii	37.14	1.00e-11	63.50
IUUC-Obr-076135	Oryza brachyantha	26.43	1.00e-28	120.00
IUUC-Ogl-077182	Oryza glaberrima	36.84	3.00e-17	82.80
IUUC-Ogu-078281	Oryza glumaepatula	37.19	2.00e-20	93.20
IUUC-Oin-079068	Oryza indica	36.28	6.00e-17	82.00
IUUC-Olo-080460	Oryza longistaminata	35.80	1.00e-08	52.80
IUUC-Ome-081781	Oryza meridionalis	25.54	5.00e-18	85.50
IUUC-Oni-082517	Oryza nivara	26.56	1.00e-20	94.40
IUUC-Opu-084101	Oryza punctata	36.84	2.00e-17	83.20
IUUC-Oru-084556	Oryza rufipogon	36.84	3.00e-17	82.80
IUUC-Osa-086264	Oryza sativa	36.84	3.00e-17	82.80
IUUC-Ola-087252	Oryzias latipes	93.29	3.00e-69	253.00
IUUC-Olu-087610	Ostreococcus lucimarinus	26.98	1.00e-13	70.50
IUUC-Oga-088304	Otolemur garnettii	98.47	0.00e+00	734.00
IUUC-Oar-089734	Ovis aries	98.47	0.00e+00	728.00
IUUC-Ptr-091476	Pan troglodytes	98.98	0.00e+00	707.00
IUUC-Pan-092341	Papio anubis	98.98	0.00e+00	707.00
IUUC-Psi-093470	Pelodiscus sinensis	93.51	0.00e+00	678.00
IUUC-Pma-094143	Petromyzon marinus	64.36	7.00e-134	469.00
IUUC-Pno-095069	Phaeosphaeria nodorum	31.93	2.00e-14	73.90
IUUC-Ppa-095933	Physcomitrella patens	29.40	5.00e-36	145.00
IUUC-Pfo-096321	Poecilia formosa	80.26	1.00e-175	609.00
IUUC-Pab-098527	Pongo abelii	98.87	0.00e+00	628.00
IUUC-Pop-099323	Populus trichocarpa	27.93	7.00e-37	147.00
IUUC-Pca-101044	Procavia capensis	80.31	2.00e-160	558.00
IUUC-Ppe-101458	Prunus persica	41.67	5.00e-27	115.00
IUUC-Pva-103014	Pteropus vampyrus	88.24	9.00e-175	605.00
IUUC-Pgr-103615	Puccinia graminis	36.09	2.00e-20	94.40
IUUC-Ptt-103826	Puccinia triticina	40.20	2.00e-16	80.50
IUUC-Pte-104171	Pyrenophora teres	35.29	1.00e-21	97.80
IUUC-Pyt-104433	Pyrenophora triticirepentis	33.01	2.00e-10	60.50
IUUC-Rno-105957	Rattus norvegicus	94.63	0.00e+00	702.00
IUUC-Sce-106262	Saccharomyces cerevisiae	26.12	2.00e-10	60.10
IUUC-Sha-107607	Sarcophilus harrisii	95.70	2.00e-176	610.00
IUUC-Spo-108175	Schizosaccharomyces pombe	30.56	1.20e-02	34.70
IUUC-Ssl-108672	Sclerotinia sclerotiorum	35.29	3.00e-25	110.00
IUUC-Smo-108973	Selaginella moellendorffii	39.47	5.00e-21	95.10
IUUC-Sly-111373	Solanum lycopersicum	36.51	1.00e-23	104.00
IUUC-Stu-112844	Solanum tuberosum	35.71	7.00e-23	101.00
IUUC-Sar-113653	Sorex araneus	85.60	2.00e-177	614.00
IUUC-Sbi-114390	Sorghum bicolor	35.54	3.00e-20	92.80
IUUC-Sre-115200	Sporisorium reilianum	37.50	3.00e-24	106.00
IUUC-Ssc-115888	Sus scrofa	99.12	2.00e-113	400.00
IUUC-Tgu-117506	Taeniopygia guttata	84.63	0.00e+00	688.00
IUUC-Tru-118063	Takifugu rubripes	79.28	4.00e-172	597.00
IUUC-Tsy-118851	Tarsius syrichta	75.00	2.00e-146	511.00
IUUC-Tni-120010	Tetraodon nigroviridis	79.08	1.00e-170	592.00
IUUC-Tca-121182	Theobroma cacao	38.89	3.00e-22	99.80
IUUC-Tre-122040	Trichoderma reesei	36.15	7.00e-22	98.60
IUUC-Tvi-122660	Trichoderma virens	39.71	7.00e-26	111.00
IUUC-Tae-124561	Triticum aestivum	38.02	6.00e-21	95.10
IUUC-Tur-126651	Triticum urartu	38.02	1.00e-20	94.00
IUUC-Tme-127184	Tuber melanosporum	47.32	8.00e-26	111.00
IUUC-Tbe-127894	Tupaia belangeri	83.00	3.00e-90	324.00
IUUC-Ttr-128264	Tursiops truncatus	89.51	0.00e+00	711.00
IUUC-Uma-129407	Ustilago maydis	36.18	1.00e-24	108.00
IUUC-Vda-130002	Verticillium dahliae	29.73	8.00e-16	78.60
IUUC-Vpa-130156	Vicugna pacos	97.50	3.00e-99	355.00
IUUC-Vvi-131062	Vitis vinifera	29.30	6.00e-32	131.00
IUUC-Xtr-132332	Xenopus tropicalis	81.68	4.00e-64	236.00
IUUC-Xma-133186	Xiphophorus maculatus	77.94	3.00e-176	610.00
IUUC-Yli-134500	Yarrowia lipolytica	33.55	9.00e-13	67.80
IUUC-Zma-135391	Zea mays	36.13	5.00e-20	92.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence