iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-098301

Ensembl Protein ID

ENSPPYP00000010151.2

UniProt Accession

H2NVZ4; H2NVZ4_PONAB

Genbank Protein ID

ENSPPYP00000010151

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ABGA01080925

Gene Name

YES1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000009043.2	ENSPPYT00000010555.2	ENSPPYP00000010151.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.20e-15	54.8	38	93

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++++L++kkG+  ++i  ++++++W+++ + ++gk+G +P+n+v+ ++
   Q: 38   FVALYDYEARTTEDLSFKKGERFQII--NNTEGDWWEARSIATGKNGYIPSNYVAPAD 93
           789***********************..8999**********************9875 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MTPFGGSSGV TPFGGASSSF SVVPSSYPAG LTGGVTIFVA LYDYEARTTE DLSFKKGERF 60
QIINNTEGDW WEARSIATGK NGYIPSNYVA PADSIQAEEW YFGKMGRKDA ERLLLNPGNQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTGATAAT GGGCTGCATT AAAAGTAAAG AAAACAAAAA GTCCAGCCAT TAAATACAGA 60
CCTGAAAATA CTCCAGAGCC TGTCAGTACA AGTGTGAGCC ATTATGGAGC AGAACCCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0015758--P:glucose transport
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002374	Ailuropoda melanoleuca	99.79	0.00e+00	969.00
IUUC-Apl-004032	Anas platyrhynchos	96.29	0.00e+00	963.00
IUUC-Aca-004255	Anolis carolinensis	95.67	0.00e+00	964.00
IUUC-Ame-010954	Astyanax mexicanus	91.19	0.00e+00	924.00
IUUC-Bta-013503	Bos taurus	99.79	0.00e+00	966.00
IUUC-Cja-019694	Callithrix jacchus	99.18	0.00e+00	964.00
IUUC-Cfa-020402	Canis familiaris	100.00	0.00e+00	973.00
IUUC-Cpo-022506	Cavia porcellus	99.38	0.00e+00	966.00
IUUC-Csa-023713	Chlorocebus sabaeus	100.00	0.00e+00	971.00
IUUC-Csv-026029	Ciona savignyi	72.20	1.00e-180	625.00
IUUC-Dre-027978	Danio rerio	90.37	0.00e+00	899.00
IUUC-Dno-029897	Dasypus novemcinctus	98.33	0.00e+00	838.00
IUUC-Dor-030202	Dipodomys ordii	98.01	0.00e+00	928.00
IUUC-Eca-034157	Equus caballus	99.38	0.00e+00	966.00
IUUC-Eeu-034950	Erinaceus europaeus	98.52	9.00e-162	562.00
IUUC-Fca-036233	Felis catus	99.79	0.00e+00	1015.00
IUUC-Fal-037461	Ficedula albicollis	96.29	0.00e+00	965.00
IUUC-Gmo-038929	Gadus morhua	92.38	0.00e+00	865.00
IUUC-Gga-041107	Gallus gallus	96.08	0.00e+00	962.00
IUUC-Gac-042321	Gasterosteus aculeatus	90.16	0.00e+00	901.00
IUUC-Hsa-047010	Homo sapiens	99.79	0.00e+00	971.00
IUUC-Lch-050239	Latimeria chalumnae	94.02	0.00e+00	952.00
IUUC-Lpe-051166	Leersia perrieri	34.74	2.00e-23	104.00
IUUC-Loc-052314	Lepisosteus oculatus	91.41	0.00e+00	879.00
IUUC-Laf-053517	Loxodonta africana	99.78	0.00e+00	954.00
IUUC-Mcc-055626	Macaca mulatta	100.00	0.00e+00	971.00
IUUC-Mga-059310	Meleagris gallopavo	96.08	0.00e+00	962.00
IUUC-Mmr-061652	Microcebus murinus	99.18	0.00e+00	969.00
IUUC-Mdo-062963	Monodelphis domestica	95.88	0.00e+00	959.00
IUUC-Mmu-064128	Mus musculus	98.97	0.00e+00	985.00
IUUC-Mpu-065906	Mustela putorius furo	100.00	0.00e+00	973.00
IUUC-Mlu-067035	Myotis lucifugus	98.98	0.00e+00	963.00
IUUC-Nle-069041	Nomascus leucogenys	95.26	0.00e+00	911.00
IUUC-Opr-070299	Ochotona princeps	90.10	0.00e+00	860.00
IUUC-Ont-072127	Oreochromis niloticus	94.22	0.00e+00	895.00
IUUC-Oan-072997	Ornithorhynchus anatinus	97.58	0.00e+00	930.00
IUUC-Ocu-074171	Oryctolagus cuniculus	99.59	0.00e+00	974.00
IUUC-Oba-075994	Oryza barthii	34.27	3.00e-21	97.10
IUUC-Ogl-077331	Oryza glaberrima	34.74	2.00e-23	104.00
IUUC-Olo-080286	Oryza longistaminata	34.74	1.00e-23	105.00
IUUC-Ome-081400	Oryza meridionalis	34.74	1.00e-23	105.00
IUUC-Oru-084741	Oryza rufipogon	35.47	1.00e-23	105.00
IUUC-Ola-086619	Oryzias latipes	89.53	0.00e+00	909.00
IUUC-Oga-087957	Otolemur garnettii	98.76	0.00e+00	958.00
IUUC-Oar-089670	Ovis aries	99.17	0.00e+00	995.00
IUUC-Ptr-091352	Pan troglodytes	99.79	0.00e+00	971.00
IUUC-Pan-092202	Papio anubis	100.00	0.00e+00	971.00
IUUC-Psi-093310	Pelodiscus sinensis	96.08	0.00e+00	962.00
IUUC-Pma-094232	Petromyzon marinus	87.90	0.00e+00	860.00
IUUC-Pfo-096137	Poecilia formosa	90.14	0.00e+00	908.00
IUUC-Pva-102592	Pteropus vampyrus	95.67	0.00e+00	915.00
IUUC-Rno-105544	Rattus norvegicus	99.38	0.00e+00	968.00
IUUC-Sar-113364	Sorex araneus	95.42	0.00e+00	912.00
IUUC-Tgu-117380	Taeniopygia guttata	96.29	0.00e+00	965.00
IUUC-Tru-117594	Takifugu rubripes	89.73	0.00e+00	910.00
IUUC-Tni-120433	Tetraodon nigroviridis	89.96	0.00e+00	896.00
IUUC-Ttr-128893	Tursiops truncatus	99.59	0.00e+00	968.00
IUUC-Vpa-130060	Vicugna pacos	99.79	0.00e+00	974.00
IUUC-Xtr-132322	Xenopus tropicalis	94.85	0.00e+00	956.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence