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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064360
Ensembl Protein ID ENSMUSP00000052619.6
UniProt Accession Q9JK83; A2ANX8; Q8R3J8; PAR6B_MOUSE
Genbank Protein ID AAF71528.1; CAM17536.1; EDL06536.1; AAH25147.1
Protein Name Partitioning defective 6 homolog beta
Genbank Nucleotide ID AF252291; AL831766; CH466551; BC025147
Gene Name Pard6b; Par6b
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000044641.7 ENSMUST00000052125.6 ENSMUSP00000052619.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBaseTRANSFACRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UDP/UFD/PB1 3.60e-22 79.5 16 96
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UFD/PB1
   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliqkk 84
           t++vk+++++e+r+f+l+++kpgkfe+++ +++++++++n +v ++Y+D +GDl+++++D++++kavs   ++++llr++iqkk
   Q: 16   TMEVKSKFGAEFRRFSLERSKPGKFEEFYGLLQHVHKIPNVDVLVGYADIHGDLLPINNDDNYHKAVS---TANPLLRIFIQKK 96
           589*****************************************************************...9**********86 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
 Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Protein Sequence
(Fasta)
MNRGHRHGAS SGCLGTMEVK SKFGAEFRRF SLERSKPGKF EEFYGLLQHV HKIPNVDVLV 60
GYADIHGDLL PINNDDNYHK AVSTANPLLR IFIQKKEEAD YSAFGTDTLI RKKNMLSNVL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064360|ULD,PB1|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGGAGGCTG CGGCGGCTGT AGGGCTGTGC TCCGCCCTCT CCTCACCGCC GCGGCCGCCG 60
CCGCCCCCGA GCCTCGCTGG GAGGGACCGG TGTCCCCGCC TGCTGCACTG GCAGTCCGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064360|ULD,PB1|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0796--Tight junction
Interpro

IPR000270--PB1_dom
IPR001478--PDZ
PROSITE

PS51745--PB1
PS50106--PDZ
Pfam

PF00564--PB1
PF00595--PDZ
SMART

SM00666--PB1
SM00228--PDZ
Gene Ontology

GO:0045177--C:apical part of cell
GO:0016324--C:apical plasma membrane
GO:0005923--C:bicellular tight junction
GO:0005938--C:cell cortex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0006461--P:protein complex assembly
KEGG mmu:58220
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000216 Aegilops tauschii 29.09 4.60e-02 31.20
IUUC-Aml-002050 Ailuropoda melanoleuca 91.40 3.00e-180 624.00
IUUC-Apl-003829 Anas platyrhynchos 80.21 4.00e-153 534.00
IUUC-Aca-004451 Anolis carolinensis 78.57 2.00e-124 438.00
IUUC-Ame-011428 Astyanax mexicanus 81.10 2.00e-120 425.00
IUUC-Bta-013165 Bos taurus 83.91 2.00e-171 595.00
IUUC-Cja-018719 Callithrix jacchus 90.59 0.00e+00 640.00
IUUC-Cfa-020802 Canis familiaris 77.21 2.00e-140 491.00
IUUC-Cpo-021864 Cavia porcellus 90.57 2.00e-166 578.00
IUUC-Csa-023766 Chlorocebus sabaeus 91.13 0.00e+00 629.00
IUUC-Cho-024608 Choloepus hoffmanni 87.10 6.00e-176 610.00
IUUC-Dre-028158 Danio rerio 62.50 3.00e-118 418.00
IUUC-Dno-030052 Dasypus novemcinctus 89.78 1.00e-177 615.00
IUUC-Dor-030924 Dipodomys ordii 87.90 2.00e-173 601.00
IUUC-Ete-032876 Echinops telfairi 76.08 5.00e-139 487.00
IUUC-Eca-033894 Equus caballus 90.00 2.00e-168 584.00
IUUC-Eeu-034442 Erinaceus europaeus 83.60 2.00e-159 555.00
IUUC-Fca-035602 Felis catus 91.43 1.00e-167 582.00
IUUC-Fal-037422 Ficedula albicollis 83.14 3.00e-141 494.00
IUUC-Gga-040289 Gallus gallus 83.29 3.00e-154 537.00
IUUC-Gac-041720 Gasterosteus aculeatus 84.94 8.00e-117 413.00
IUUC-Ggo-045502 Gorilla gorilla 91.40 0.00e+00 632.00
IUUC-Hsa-046189 Homo sapiens 91.40 0.00e+00 632.00
IUUC-Itr-048930 Ictidomys tridecemlineatus 91.43 1.00e-170 592.00
IUUC-Kpa-049339 Komagataella pastoris 32.08 1.60e+00 28.10
IUUC-Lch-050235 Latimeria chalumnae 74.47 1.00e-142 499.00
IUUC-Loc-052534 Lepisosteus oculatus 70.00 4.00e-133 468.00
IUUC-Laf-053439 Loxodonta africana 87.10 1.00e-179 622.00
IUUC-Mcc-054945 Macaca mulatta 89.81 8.00e-178 616.00
IUUC-Meu-056703 Macropus eugenii 85.14 1.00e-157 548.00
IUUC-Mor-057134 Magnaporthe oryzae 32.93 8.90e-02 30.80
IUUC-Mga-059330 Meleagris gallopavo 81.59 1.00e-142 499.00
IUUC-Mmr-060844 Microcebus murinus 91.17 3.00e-169 587.00
IUUC-Mdo-062120 Monodelphis domestica 86.02 6.00e-172 596.00
IUUC-Mpu-066914 Mustela putorius furo 91.14 9.00e-166 576.00
IUUC-Mlu-067135 Myotis lucifugus 90.29 2.00e-167 581.00
IUUC-Nle-069266 Nomascus leucogenys 91.67 0.00e+00 632.00
IUUC-Ont-071750 Oreochromis niloticus 82.24 1.00e-123 436.00
IUUC-Oan-073082 Ornithorhynchus anatinus 87.29 4.00e-164 570.00
IUUC-Ocu-074563 Oryctolagus cuniculus 88.74 2.00e-172 598.00
IUUC-Ola-086459 Oryzias latipes 60.84 2.00e-122 432.00
IUUC-Oga-089180 Otolemur garnettii 91.40 0.00e+00 630.00
IUUC-Oar-089284 Ovis aries 85.44 6.00e-157 546.00
IUUC-Ptr-090918 Pan troglodytes 91.40 0.00e+00 627.00
IUUC-Pan-092624 Papio anubis 91.13 0.00e+00 629.00
IUUC-Psi-093544 Pelodiscus sinensis 79.41 1.00e-152 532.00
IUUC-Pfo-097463 Poecilia formosa 81.50 7.00e-119 420.00
IUUC-Pab-097846 Pongo abelii 91.40 0.00e+00 632.00
IUUC-Pva-103173 Pteropus vampyrus 89.25 8.00e-180 622.00
IUUC-Rno-105169 Rattus norvegicus 95.97 0.00e+00 656.00
IUUC-Sha-106608 Sarcophilus harrisii 86.29 2.00e-171 595.00
IUUC-Ssc-115788 Sus scrofa 91.94 0.00e+00 645.00
IUUC-Tgu-117327 Taeniopygia guttata 79.84 1.00e-148 519.00
IUUC-Tru-117906 Takifugu rubripes 78.12 7.00e-115 407.00
IUUC-Tsy-119156 Tarsius syrichta 88.00 7.00e-166 576.00
IUUC-Tbe-127604 Tupaia belangeri 88.86 9.00e-162 562.00
IUUC-Ttr-128716 Tursiops truncatus 91.13 0.00e+00 627.00
IUUC-Vpa-130278 Vicugna pacos 91.67 0.00e+00 630.00
IUUC-Xtr-132550 Xenopus tropicalis 75.07 6.00e-138 483.00
IUUC-Xma-133768 Xiphophorus maculatus 81.85 1.00e-121 429.00
Created Date 25-Jun-2017

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