iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003815

Ensembl Protein ID

ENSAPLP00000001396.1

UniProt Accession

R0LRX2; R0LRX2_ANAPL

Genbank Protein ID

EOB08474.1

Protein Name

Suppressor of cytokine signaling 5

Genbank Nucleotide ID

ADON01006215

Gene Name

SOCS5; Anapl_08358

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000001971.1	ENSAPLT00000001969.1	ENSAPLP00000001396.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	7.80e-16	57.4	475	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 5    wllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            l r+ p+SLq++CR +I+rc++++++   d LPLP++L+d+L++++y+
   Q: 475  SLNRTFPFSLQYICRAVICRCTTYDGI---DDLPLPSMLQDFLKEYHYK 520
           577899*********************...****************985 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MDKVGKMWNN FKYRCQNLFS HEGGSQNENV VVNTSSCSSA KDKAIQITGV AQQQPSSPLR 60
ENIALQLGLS PSKNSARRNQ NCVTEIPQIV EISIEKENDS CITTGARLAR RDSYSRHAPW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAAAG TGGGAAAGAT GTGGAACAAT TTCAAATACA GGTGCCAGAA TCTCTTCAGT 60
CATGAAGGTG GAAGCCAAAA TGAAAATGTG GTTGTGAACA CCAGTAGTTG CTCATCTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005622--C:intracellular
GO:0071404--P:cellular response to low-density lipoprotein particle stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0050728--P:negative regulation of inflammatory response
GO:0032715--P:negative regulation of interleukin-6 production
GO:0071638--P:negative regulation of monocyte chemotactic protein-1 production
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045627--P:positive regulation of T-helper 1 cell differentiation
GO:0097699--P:vascular endothelial cell response to fluid shear stress

KEGG

apla:101798051

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000371	Aegilops tauschii	32.65	9.50e-02	29.60
IUUC-Aca-004504	Anolis carolinensis	86.01	0.00e+00	877.00
IUUC-Ame-010677	Astyanax mexicanus	63.76	0.00e+00	639.00
IUUC-Bta-012338	Bos taurus	91.42	0.00e+00	986.00
IUUC-Cja-019828	Callithrix jacchus	91.42	0.00e+00	967.00
IUUC-Cfa-020369	Canis familiaris	90.67	0.00e+00	985.00
IUUC-Cpo-021397	Cavia porcellus	89.55	0.00e+00	994.00
IUUC-Csa-023856	Chlorocebus sabaeus	91.23	0.00e+00	985.00
IUUC-Dre-028262	Danio rerio	62.94	1.00e-170	592.00
IUUC-Dno-029019	Dasypus novemcinctus	91.23	0.00e+00	1009.00
IUUC-Dme-031965	Drosophila melanogaster	67.44	7.00e-70	258.00
IUUC-Eca-033867	Equus caballus	90.11	0.00e+00	1001.00
IUUC-Fca-035806	Felis catus	91.04	0.00e+00	981.00
IUUC-Fal-037117	Ficedula albicollis	96.83	0.00e+00	1055.00
IUUC-Gmo-039066	Gadus morhua	83.49	2.00e-107	382.00
IUUC-Gga-040876	Gallus gallus	97.76	0.00e+00	1046.00
IUUC-Gac-042149	Gasterosteus aculeatus	66.30	0.00e+00	640.00
IUUC-Ggo-045169	Gorilla gorilla	90.49	0.00e+00	978.00
IUUC-Hsa-045805	Homo sapiens	91.60	0.00e+00	988.00
IUUC-Hvu-047122	Hordeum vulgare	39.02	1.00e-02	33.50
IUUC-Itr-049048	Ictidomys tridecemlineatus	90.86	0.00e+00	1005.00
IUUC-Lch-049686	Latimeria chalumnae	80.89	0.00e+00	858.00
IUUC-Lpe-051639	Leersia perrieri	29.23	2.10e-01	30.40
IUUC-Loc-051745	Lepisosteus oculatus	73.32	0.00e+00	724.00
IUUC-Laf-054124	Loxodonta africana	89.76	0.00e+00	988.00
IUUC-Mcc-055175	Macaca mulatta	91.23	0.00e+00	985.00
IUUC-Meu-056557	Macropus eugenii	90.54	0.00e+00	996.00
IUUC-Mga-059214	Meleagris gallopavo	97.01	0.00e+00	1070.00
IUUC-Mmr-060613	Microcebus murinus	76.31	0.00e+00	765.00
IUUC-Mdo-062788	Monodelphis domestica	90.91	0.00e+00	965.00
IUUC-Mmu-064333	Mus musculus	90.11	0.00e+00	975.00
IUUC-Mpu-066048	Mustela putorius furo	91.60	0.00e+00	988.00
IUUC-Mlu-067430	Myotis lucifugus	91.23	0.00e+00	965.00
IUUC-Nle-069086	Nomascus leucogenys	91.23	0.00e+00	1009.00
IUUC-Opr-070312	Ochotona princeps	87.31	0.00e+00	938.00
IUUC-Ont-072299	Oreochromis niloticus	64.84	0.00e+00	644.00
IUUC-Ocu-074123	Oryctolagus cuniculus	86.38	0.00e+00	926.00
IUUC-Ola-086934	Oryzias latipes	68.02	0.00e+00	665.00
IUUC-Oga-088535	Otolemur garnettii	91.42	0.00e+00	1013.00
IUUC-Oar-089875	Ovis aries	91.04	0.00e+00	987.00
IUUC-Ptr-090541	Pan troglodytes	91.60	0.00e+00	988.00
IUUC-Pan-092416	Papio anubis	91.23	0.00e+00	985.00
IUUC-Psi-092960	Pelodiscus sinensis	90.30	0.00e+00	995.00
IUUC-Pma-094222	Petromyzon marinus	50.99	6.00e-138	483.00
IUUC-Pfo-096930	Poecilia formosa	64.66	0.00e+00	657.00
IUUC-Pab-098659	Pongo abelii	91.42	0.00e+00	987.00
IUUC-Pop-098820	Populus trichocarpa	41.18	1.20e-01	30.80
IUUC-Pca-100222	Procavia capensis	88.08	0.00e+00	971.00
IUUC-Pva-102387	Pteropus vampyrus	91.04	0.00e+00	983.00
IUUC-Rno-105698	Rattus norvegicus	90.30	0.00e+00	975.00
IUUC-Sha-107234	Sarcophilus harrisii	89.24	0.00e+00	960.00
IUUC-Sar-113698	Sorex araneus	84.89	0.00e+00	877.00
IUUC-Ssc-115985	Sus scrofa	90.49	0.00e+00	1001.00
IUUC-Tgu-116676	Taeniopygia guttata	96.64	0.00e+00	1060.00
IUUC-Tru-118441	Takifugu rubripes	59.85	1.00e-152	532.00
IUUC-Tsy-119163	Tarsius syrichta	85.63	0.00e+00	938.00
IUUC-Tni-120436	Tetraodon nigroviridis	66.11	0.00e+00	641.00
IUUC-Tae-124846	Triticum aestivum	32.65	1.60e-01	28.90
IUUC-Tbe-127353	Tupaia belangeri	91.42	0.00e+00	986.00
IUUC-Ttr-128907	Tursiops truncatus	91.60	0.00e+00	969.00
IUUC-Vpa-130140	Vicugna pacos	91.60	0.00e+00	989.00
IUUC-Xtr-132817	Xenopus tropicalis	79.70	0.00e+00	868.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence