iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	19172179; 15208641; 11864566

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.0003	21.2	79	125

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 100  aglldrlpeeilveilklldkeellraarvcrrwqelas..qkalwk 144
           + + +rlp+++l +i+++l+ ++l +a ++c++w+++ s  ++ +w+
   Q: 79   EVSASRLPLKVLNQIFQYLPLKDLRSAMLTCHSWNNALSmeDSDIWQ 125
           457899*****************************877744566665 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons (PubMed:15208641, PubMed:23665919). Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles (PubMed:23665919). By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing (PubMed:23665919). May stabilize synapse formation by promoting the down-regulation of scd-2 (PubMed:15208641). Regulates axon termination in PLM and ALM neurons (PubMed:21968191).

Protein Sequence
(Fasta)

MAENDGETIV PDEQCNLTAS TPMKSSGLEQ VESPKERKTS MVECDDEGNP SSGTPDESPK 60
QLTPHSIPPR RRRSPRRPEV SASRLPLKVL NQIFQYLPLK DLRSAMLTCH SWNNALSMED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGCGAATGA CAAGACTGTG GTGAGCTGGT TAATCGAGAA GTATGGCTGA AAACGACGGG 60
GAAACGATTG TTCCAGACGA ACAGTGCAAT TTGACGGCCT CAACGCCTAT GAAAAGTAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1185--Reference proteome
KW-0770--Synapse
KW-0833--Ubl conjugation pathway

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001810--F-box_dom
IPR003877--SPRY_dom

PROSITE

PS50188--B302_SPRY
PS50181--FBOX

Pfam

PF00646--F-box
PF00622--SPRY

SMART

SM00256--FBOX
SM00449--SPRY

Gene Ontology

GO:0030054--C:cell junction
GO:0043005--C:neuron projection
GO:0045202--C:synapse
GO:0043066--P:negative regulation of apoptotic process
GO:0030517--P:negative regulation of axon extension
GO:0048681--P:negative regulation of axon regeneration
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0010629--P:negative regulation of gene expression
GO:0051965--P:positive regulation of synapse assembly
GO:0016567--P:protein ubiquitination
GO:0010212--P:response to ionizing radiation

KEGG

cel:CELE_C26E6.5

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001815	Ailuropoda melanoleuca	55.20	2.00e-78	283.00
IUUC-Apl-003739	Anas platyrhynchos	65.08	3.00e-47	179.00
IUUC-Aca-005393	Anolis carolinensis	54.40	5.00e-74	269.00
IUUC-Aly-005820	Arabidopsis lyrata	46.88	3.00e-04	39.30
IUUC-Ath-007265	Arabidopsis thaliana	50.00	6.00e-04	37.40
IUUC-Ame-011341	Astyanax mexicanus	55.42	4.00e-80	289.00
IUUC-Bta-013136	Bos taurus	55.20	3.00e-78	283.00
IUUC-Bdi-014875	Brachypodium distachyon	28.12	7.00e-04	36.60
IUUC-Bol-016020	Brassica oleracea	24.34	2.00e-03	35.80
IUUC-Bra-017133	Brassica rapa	38.64	5.00e-04	37.40
IUUC-Cja-019860	Callithrix jacchus	55.60	4.00e-79	286.00
IUUC-Cfa-020372	Canis familiaris	54.40	1.00e-76	278.00
IUUC-Cpo-022254	Cavia porcellus	55.60	4.00e-79	286.00
IUUC-Cre-022608	Chlamydomonas reinhardtii	23.64	3.50e-02	33.10
IUUC-Csa-023427	Chlorocebus sabaeus	55.16	3.00e-79	286.00
IUUC-Cho-024723	Choloepus hoffmanni	55.56	1.00e-54	203.00
IUUC-Cin-025644	Ciona intestinalis	51.59	2.00e-74	270.00
IUUC-Csv-025822	Ciona savignyi	51.59	2.00e-73	267.00
IUUC-Cgl-026382	Colletotrichum gloeosporioides	33.33	4.00e-03	34.30
IUUC-Dre-028352	Danio rerio	57.03	3.00e-81	293.00
IUUC-Dno-029763	Dasypus novemcinctus	55.60	8.00e-79	285.00
IUUC-Dor-030984	Dipodomys ordii	55.60	8.00e-79	285.00
IUUC-Dme-032049	Drosophila melanogaster	56.56	2.00e-80	290.00
IUUC-Eca-034006	Equus caballus	57.48	2.00e-70	257.00
IUUC-Eeu-035294	Erinaceus europaeus	61.67	6.00e-65	238.00
IUUC-Fca-035599	Felis catus	55.60	4.00e-79	286.00
IUUC-Fal-037304	Ficedula albicollis	54.92	1.00e-73	268.00
IUUC-Fox-037691	Fusarium oxysporum	27.37	2.00e-02	32.70
IUUC-Gmo-038969	Gadus morhua	54.98	4.00e-79	286.00
IUUC-Gga-040625	Gallus gallus	61.68	3.00e-37	145.00
IUUC-Gac-041926	Gasterosteus aculeatus	55.42	2.00e-80	290.00
IUUC-Ggo-045114	Gorilla gorilla	55.79	1.00e-73	268.00
IUUC-Hsa-046619	Homo sapiens	55.60	4.00e-79	286.00
IUUC-Itr-049037	Ictidomys tridecemlineatus	55.60	8.00e-79	285.00
IUUC-Lch-049702	Latimeria chalumnae	54.33	2.00e-78	284.00
IUUC-Loc-052199	Lepisosteus oculatus	55.60	6.00e-79	286.00
IUUC-Laf-054069	Loxodonta africana	55.60	1.00e-78	285.00
IUUC-Mcc-055362	Macaca mulatta	55.60	4.00e-79	286.00
IUUC-Meu-056400	Macropus eugenii	53.44	1.00e-55	207.00
IUUC-Mtr-057709	Medicago truncatula	22.94	7.00e-03	33.50
IUUC-Mga-059682	Meleagris gallopavo	55.13	1.00e-70	257.00
IUUC-Mmr-061545	Microcebus murinus	55.60	5.00e-79	286.00
IUUC-Mdo-063044	Monodelphis domestica	55.60	6.00e-79	285.00
IUUC-Mmu-063211	Mus musculus	55.60	8.00e-79	285.00
IUUC-Mpu-065969	Mustela putorius furo	54.94	4.00e-79	286.00
IUUC-Mlu-067484	Myotis lucifugus	57.01	1.00e-68	251.00
IUUC-Nfi-068324	Neosartorya fischeri	29.87	2.30e-02	32.30
IUUC-Nle-069299	Nomascus leucogenys	55.60	4.00e-79	286.00
IUUC-Ont-071824	Oreochromis niloticus	55.82	4.00e-80	289.00
IUUC-Ocu-074917	Oryctolagus cuniculus	55.51	5.00e-77	279.00
IUUC-Ome-081296	Oryza meridionalis	29.41	2.00e-03	33.90
IUUC-Ola-087014	Oryzias latipes	56.22	4.00e-80	289.00
IUUC-Oga-089176	Otolemur garnettii	55.20	9.00e-79	285.00
IUUC-Oar-089517	Ovis aries	54.69	7.00e-74	268.00
IUUC-Ptr-091318	Pan troglodytes	61.67	3.00e-65	239.00
IUUC-Pan-092627	Papio anubis	55.60	4.00e-79	286.00
IUUC-Psi-093937	Pelodiscus sinensis	61.67	6.00e-65	238.00
IUUC-Pno-094795	Phaeosphaeria nodorum	34.62	1.00e-01	30.80
IUUC-Ppa-095362	Physcomitrella patens	25.00	8.00e-04	36.20
IUUC-Pfo-097200	Poecilia formosa	56.38	3.00e-78	283.00
IUUC-Pva-102717	Pteropus vampyrus	55.60	1.00e-78	285.00
IUUC-Rno-105956	Rattus norvegicus	55.65	9.00e-71	258.00
IUUC-Sha-107117	Sarcophilus harrisii	61.67	3.00e-65	239.00
IUUC-Sja-107898	Schizosaccharomyces japonicus	42.86	2.60e-01	29.60
IUUC-Sar-113757	Sorex araneus	61.67	6.00e-65	238.00
IUUC-Sbi-114203	Sorghum bicolor	26.37	1.10e-02	33.50
IUUC-Tgu-117169	Taeniopygia guttata	61.88	2.00e-66	243.00
IUUC-Tru-118146	Takifugu rubripes	55.82	3.00e-79	286.00
IUUC-Tni-120858	Tetraodon nigroviridis	55.82	2.00e-78	284.00
IUUC-Tca-121081	Theobroma cacao	37.78	1.10e-02	35.00
IUUC-Tbe-128110	Tupaia belangeri	52.77	1.00e-65	241.00
IUUC-Ttr-128569	Tursiops truncatus	55.60	4.00e-79	286.00
IUUC-Vda-129902	Verticillium dahliae	37.74	2.80e-02	32.30
IUUC-Vpa-130507	Vicugna pacos	55.60	4.00e-79	286.00
IUUC-Xtr-132793	Xenopus tropicalis	54.55	3.00e-78	283.00
IUUC-Xma-133910	Xiphophorus maculatus	56.38	3.00e-78	283.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence