iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059699

UUCD1 version

UUC-MeG-00159

Ensembl Protein ID

ENSMGAP00000002933.2

UniProt Accession

G1MW43; G1MW43_MELGA

Protein Name

E3 ubiquitin-protein ligase RNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168

Gene Name

RNF168

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000003252.2	ENSMGAT00000003623.2	ENSMGAP00000002933.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.70e-06	27.6	16	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C iC+e f + p++lpC+H+++ +C+         +++ +  CP Cr
   Q: 16   CQICMEIFVE-PVTLPCNHTICNSCFqLT------VENASLCCPFCR 55
           9********9.9**************444......5**********8 PP

Organism

Meleagris gallopavo

Functional Description
(View)

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Protein Sequence
(Fasta)

MSKKSEAPLS LDDCLCQICM EIFVEPVTLP CNHTICNSCF QLTVENASLC CPFCRRRVSS 60
WARYNARRNT LINWELWEKI QKKYPKECER RINGQDLEEL VFVPHPQHQL SKPGELRQEY 120

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Nucleotide Sequence
(Fasta)

ATGTCAAAGA AATCGGAGGC TCCCCTTTCC TTAGATGACT GCCTCTGCCA GATCTGCATG 60
GAGATCTTTG TGGAGCCCGT GACGCTGCCG TGCAACCATA CCATCTGTAA TTCTTGTTTC 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034725--RNF168
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0031491--F:nucleosome binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0035518--P:histone H2A monoubiquitination
GO:0036351--P:histone H2A-K13 ubiquitination
GO:0036352--P:histone H2A-K15 ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000755	Aegilops tauschii	35.53	9.00e-10	57.80
IUUC-Aml-001573	Ailuropoda melanoleuca	41.39	7.00e-84	304.00
IUUC-Atr-002992	Amborella trichopoda	36.47	1.00e-09	57.00
IUUC-Apl-003963	Anas platyrhynchos	77.67	0.00e+00	679.00
IUUC-Aca-004420	Anolis carolinensis	47.22	6.00e-88	317.00
IUUC-Ath-007019	Arabidopsis thaliana	37.18	1.00e-08	55.50
IUUC-Ame-011521	Astyanax mexicanus	55.80	5.00e-44	171.00
IUUC-Bta-013002	Bos taurus	40.00	7.00e-75	274.00
IUUC-Cja-019945	Callithrix jacchus	39.83	3.00e-77	282.00
IUUC-Cfa-020533	Canis familiaris	38.74	2.00e-77	283.00
IUUC-Cpo-021643	Cavia porcellus	36.44	2.00e-54	206.00
IUUC-Csa-023638	Chlorocebus sabaeus	41.89	2.00e-77	283.00
IUUC-Cho-024319	Choloepus hoffmanni	40.30	2.00e-74	272.00
IUUC-Cin-025679	Ciona intestinalis	36.36	1.00e-22	99.80
IUUC-Csv-026052	Ciona savignyi	34.72	3.00e-23	101.00
IUUC-Dre-028519	Danio rerio	54.17	4.00e-40	158.00
IUUC-Dno-029294	Dasypus novemcinctus	39.90	3.00e-79	288.00
IUUC-Ete-032714	Echinops telfairi	63.25	1.00e-40	160.00
IUUC-Eca-033343	Equus caballus	43.98	3.00e-80	291.00
IUUC-Fca-036251	Felis catus	41.92	2.00e-81	296.00
IUUC-Fal-037048	Ficedula albicollis	66.55	7.00e-179	619.00
IUUC-Gmo-039400	Gadus morhua	49.58	9.00e-36	141.00
IUUC-Gga-040444	Gallus gallus	88.02	0.00e+00	968.00
IUUC-Gac-041735	Gasterosteus aculeatus	48.89	8.00e-41	159.00
IUUC-Gma-044332	Glycine max	36.25	2.00e-11	63.20
IUUC-Ggo-044940	Gorilla gorilla	32.09	6.00e-28	118.00
IUUC-Hsa-046424	Homo sapiens	39.77	6.00e-75	274.00
IUUC-Itr-048965	Ictidomys tridecemlineatus	41.56	2.00e-69	256.00
IUUC-Lch-050649	Latimeria chalumnae	40.08	1.00e-60	226.00
IUUC-Loc-051847	Lepisosteus oculatus	38.76	1.00e-52	200.00
IUUC-Laf-053938	Loxodonta africana	40.63	5.00e-81	294.00
IUUC-Mcc-055360	Macaca mulatta	39.93	5.00e-74	271.00
IUUC-Meu-056684	Macropus eugenii	40.07	5.00e-70	258.00
IUUC-Mtr-058007	Medicago truncatula	36.84	7.00e-11	61.20
IUUC-Mmr-060779	Microcebus murinus	41.03	2.00e-83	303.00
IUUC-Mdo-062225	Monodelphis domestica	43.10	1.00e-79	290.00
IUUC-Mmu-064239	Mus musculus	38.29	7.00e-64	237.00
IUUC-Mpu-066141	Mustela putorius furo	43.51	4.00e-92	331.00
IUUC-Mlu-067945	Myotis lucifugus	43.10	2.00e-76	279.00
IUUC-Nle-069769	Nomascus leucogenys	49.82	8.00e-52	197.00
IUUC-Opr-070905	Ochotona princeps	34.50	9.00e-49	187.00
IUUC-Ont-071477	Oreochromis niloticus	52.38	7.00e-39	154.00
IUUC-Oan-073587	Ornithorhynchus anatinus	69.29	1.00e-50	191.00
IUUC-Ocu-073832	Oryctolagus cuniculus	39.09	5.00e-68	251.00
IUUC-Obr-076219	Oryza brachyantha	35.53	1.00e-09	56.60
IUUC-Ogl-077658	Oryza glaberrima	36.84	1.00e-09	57.00
IUUC-Oin-079383	Oryza indica	36.84	1.00e-09	57.40
IUUC-Ome-081482	Oryza meridionalis	36.84	1.00e-09	57.40
IUUC-Oni-083025	Oryza nivara	36.84	1.00e-09	57.40
IUUC-Opu-083547	Oryza punctata	36.11	4.00e-09	55.50
IUUC-Osa-085978	Oryza sativa	36.84	1.00e-09	57.40
IUUC-Ola-086478	Oryzias latipes	53.60	1.00e-37	147.00
IUUC-Oga-088318	Otolemur garnettii	40.54	3.00e-75	275.00
IUUC-Oar-089647	Ovis aries	39.12	4.00e-75	275.00
IUUC-Ptr-090516	Pan troglodytes	39.77	2.00e-76	279.00
IUUC-Pan-092302	Papio anubis	39.26	7.00e-71	261.00
IUUC-Psi-093604	Pelodiscus sinensis	52.36	4.00e-129	454.00
IUUC-Pfo-096441	Poecilia formosa	55.71	1.00e-45	176.00
IUUC-Pab-097729	Pongo abelii	39.56	3.00e-73	269.00
IUUC-Pca-100552	Procavia capensis	68.00	2.00e-40	159.00
IUUC-Pva-102780	Pteropus vampyrus	38.91	1.00e-72	266.00
IUUC-Rno-105461	Rattus norvegicus	39.24	3.00e-74	272.00
IUUC-Sha-106809	Sarcophilus harrisii	43.70	2.00e-79	289.00
IUUC-Sly-111317	Solanum lycopersicum	40.79	9.00e-13	67.40
IUUC-Stu-112446	Solanum tuberosum	37.80	2.00e-12	66.20
IUUC-Sar-113579	Sorex araneus	40.45	5.00e-63	234.00
IUUC-Sbi-113834	Sorghum bicolor	38.16	2.00e-10	59.70
IUUC-Tgu-117187	Taeniopygia guttata	88.08	2.00e-85	307.00
IUUC-Tru-118182	Takifugu rubripes	53.15	9.00e-37	147.00
IUUC-Tni-120205	Tetraodon nigroviridis	56.52	5.00e-46	177.00
IUUC-Tca-121416	Theobroma cacao	36.25	4.00e-11	62.00
IUUC-Tvi-122557	Trichoderma virens	39.19	1.00e-05	44.30
IUUC-Tae-123092	Triticum aestivum	35.53	1.00e-09	57.80
IUUC-Tur-126688	Triticum urartu	34.21	8.00e-10	57.40
IUUC-Tbe-127622	Tupaia belangeri	42.06	6.00e-85	307.00
IUUC-Ttr-128988	Tursiops truncatus	39.77	3.00e-75	275.00
IUUC-Vpa-130302	Vicugna pacos	65.08	1.00e-46	180.00
IUUC-Vvi-131424	Vitis vinifera	35.53	4.00e-09	55.10
IUUC-Xtr-132196	Xenopus tropicalis	37.42	4.00e-67	248.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence