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Tag Content
UUCD2 ID IUUC-Cfa-020957
UUCD1 version UUC-CaF-00987
Ensembl Protein ID ENSCAFP00000009548.3
UniProt Accession E2R0W7; E2R0W7_CANLF
Genbank Protein ID ENSCAFP00000009548
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID AAEX03009951
Gene Name USP44
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000006375.4 ENSCAFT00000010298.4 ENSCAFP00000009548.3
ENSCAFG00000006375.4 ENSCAFT00000010306.2 ENSCAFP00000009555.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 4.50e-97 325.6 272 676
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenp.................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+                     +                                    
   Q: 272  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnrwlavtaG---------Dktrspykhppitdavyqmnecqekdtcsalsrhpsl 351
           7******************************877766655552.........0234445555777788888888888889999999999 PP
   S: 43   ......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk 109
                                 +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el  
   Q: 352  slglsggasksrnmeliqpresSSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQHEL-- 438
           999999998888888888877666777************************************************************.. PP
   S: 110  eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcL 191
                  e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +        ++++L
   Q: 439  -------ETTGTRLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKdtasqpcLVTEML 520
           .......7788888999999************************************************877776667777777****** PP
   S: 192  esftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspe 269
           ++ft++e leg+  y c++c+ k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++
   Q: 521  AKFTETEALEGKI-YVCDHCNTKRRrfssksvvlteAQKQLMICHLPQVLRLHLKRFRWSGR-NNREKIGVHVGFEEILNMEPYCCRES 607
           **********965.*******999999999999999***********************998.7778********************99 PP
   S: 270  ekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
            k+ +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 608  LKSLRpeCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 676
           88876779***************************9999********************...********98 PP
   
Organism Canis familiaris
Protein Sequence
(Fasta)
MLTMDKCKHI GQLQLAQDHS ILNPQKWHCV DCNTTESIWA CLSCSHVACG RYIEEHALKH 60
FQESSHPVAL EVNEMYVFCY LCDDYVLNDN ATGDLKLLRN MLSAIKSQNY QCTTRSGRVL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cfa-020957|DUB,USP|Canis familiaris
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTTAACAA TGGATAAGTG CAAACATATT GGGCAGTTGC AGCTTGCTCA AGACCATTCC 60
ATCCTCAACC CTCAGAAGTG GCATTGTGTG GACTGCAATA CAACTGAGTC AATTTGGGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cfa-020957|DUB,USP|Canis familiaris
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG cfa:475430
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001220 Ailuropoda melanoleuca 96.34 0.00e+00 1389.00
IUUC-Apl-003673 Anas platyrhynchos 74.89 0.00e+00 1048.00
IUUC-Aca-004434 Anolis carolinensis 71.37 0.00e+00 1034.00
IUUC-Ame-010986 Astyanax mexicanus 72.66 0.00e+00 627.00
IUUC-Bta-012774 Bos taurus 89.73 0.00e+00 1289.00
IUUC-Cja-019619 Callithrix jacchus 89.34 0.00e+00 1277.00
IUUC-Csa-023177 Chlorocebus sabaeus 89.06 0.00e+00 1276.00
IUUC-Cho-024877 Choloepus hoffmanni 88.45 0.00e+00 842.00
IUUC-Cin-025587 Ciona intestinalis 48.39 8.00e-108 385.00
IUUC-Csv-025814 Ciona savignyi 45.28 2.00e-154 539.00
IUUC-Dre-027878 Danio rerio 70.91 6.00e-179 620.00
IUUC-Dno-029832 Dasypus novemcinctus 91.14 0.00e+00 1325.00
IUUC-Ete-032627 Echinops telfairi 86.26 0.00e+00 1244.00
IUUC-Eca-033863 Equus caballus 85.47 0.00e+00 1224.00
IUUC-Eeu-035225 Erinaceus europaeus 84.83 0.00e+00 1204.00
IUUC-Fca-036288 Felis catus 94.94 0.00e+00 1376.00
IUUC-Fal-037207 Ficedula albicollis 74.47 0.00e+00 1009.00
IUUC-Gga-040457 Gallus gallus 74.23 0.00e+00 1013.00
IUUC-Gac-042595 Gasterosteus aculeatus 53.64 0.00e+00 706.00
IUUC-Ggo-044926 Gorilla gorilla 89.34 0.00e+00 1273.00
IUUC-Hsa-046079 Homo sapiens 88.92 0.00e+00 1269.00
IUUC-Itr-048737 Ictidomys tridecemlineatus 91.01 0.00e+00 1293.00
IUUC-Lch-050260 Latimeria chalumnae 67.98 0.00e+00 934.00
IUUC-Loc-051981 Lepisosteus oculatus 76.51 0.00e+00 669.00
IUUC-Laf-054491 Loxodonta africana 89.40 0.00e+00 1223.00
IUUC-Mcc-055694 Macaca mulatta 88.92 0.00e+00 1271.00
IUUC-Mga-059523 Meleagris gallopavo 74.33 0.00e+00 1032.00
IUUC-Mmr-060885 Microcebus murinus 92.01 0.00e+00 1308.00
IUUC-Mdo-063018 Monodelphis domestica 78.90 0.00e+00 1110.00
IUUC-Mmu-064012 Mus musculus 79.78 0.00e+00 1092.00
IUUC-Mpu-066207 Mustela putorius furo 94.37 0.00e+00 1390.00
IUUC-Mlu-066929 Myotis lucifugus 88.55 0.00e+00 1211.00
IUUC-Nle-069313 Nomascus leucogenys 79.20 0.00e+00 1094.00
IUUC-Opr-070375 Ochotona princeps 80.81 0.00e+00 1114.00
IUUC-Ont-071637 Oreochromis niloticus 67.90 4.00e-177 614.00
IUUC-Oan-073030 Ornithorhynchus anatinus 77.80 0.00e+00 842.00
IUUC-Ocu-074836 Oryctolagus cuniculus 86.34 0.00e+00 1221.00
IUUC-Oga-088367 Otolemur garnettii 92.29 0.00e+00 1296.00
IUUC-Oar-089953 Ovis aries 91.57 0.00e+00 1335.00
IUUC-Ptr-090980 Pan troglodytes 88.92 0.00e+00 1271.00
IUUC-Pan-092748 Papio anubis 89.61 0.00e+00 1285.00
IUUC-Pab-098514 Pongo abelii 89.06 0.00e+00 1272.00
IUUC-Pva-102984 Pteropus vampyrus 91.56 0.00e+00 1290.00
IUUC-Rno-106019 Rattus norvegicus 80.28 0.00e+00 1135.00
IUUC-Sha-106965 Sarcophilus harrisii 77.67 0.00e+00 1104.00
IUUC-Ssc-115299 Sus scrofa 92.69 0.00e+00 1350.00
IUUC-Tgu-117160 Taeniopygia guttata 74.56 0.00e+00 1010.00
IUUC-Tru-118156 Takifugu rubripes 60.14 0.00e+00 837.00
IUUC-Tni-119733 Tetraodon nigroviridis 60.54 0.00e+00 845.00
IUUC-Tbe-128084 Tupaia belangeri 85.39 0.00e+00 1231.00
IUUC-Ttr-128928 Tursiops truncatus 93.67 0.00e+00 1353.00
IUUC-Vpa-130706 Vicugna pacos 92.41 0.00e+00 1337.00
IUUC-Xtr-132061 Xenopus tropicalis 70.80 0.00e+00 936.00
Created Date 25-Jun-2017

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