iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059917

UUCD1 version

UUC-MeG-00530

Ensembl Protein ID

ENSMGAP00000012185.1

UniProt Accession

G1NGG7; G1NGG7_MELGA

Protein Name

Uncharacterized protein

Gene Name

UBR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000011594.1	ENSMGAT00000013072.1	ENSMGAP00000012185.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/N-recognin/N-domain	2.20e-38	130.0	227	303
E3 activity/RING/RING	2.00e-07	31.2	1105	1209
E3 activity/N-recognin/UBR-box	1.80e-29	101.8	97	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy+vLfNDE+Hsy++viyslq+Al +e+ ea++++t+idkeGRravkaG ya c+eak+ei+++se+++q pL+Vev
   Q: 227  YYCVLFNDEHHSYDHVIYSLQRALGCELGEAQLHTTAIDKEGRRAVKAGHYASCQEAKEEIKRHSENVSQRPLHVEV 303
           9**************************************************************************97 PP

E3 activity/RING/RING

   S: 1    CaiCledf...............kd..............................gplvlpCgHvfhadClqkw............. 29
           C++C+e+                ++                              g+++++CgHv+ha C+qk+             
   Q: 1105 CILCQEEQevklesaamvlsacvQKstaltqnrsrilelsgdtvdplfmhpdlpcGTHTGSCGHVMHAACWQKYfeamqlnfrqrlh 1191
           77885555444433333333333003333333333333333344444444333337999***************************9 PP
   S: 30   .pglknssskefrCPlCr 46
             +  +++++e +CPlC+
   Q: 1192 vEQIFDLENGEYLCPLCK 1209
           99999999*********7 PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCg+vfk get+y+Cr+C+vd+t+vlC++Cf++++H++H+yk++ s+gggfCdCGdteAw+ g+ C k++
   Q: 97   QLCGKVFKGGETTYSCRDCAVDPTCVLCMDCFQNSIHRNHRYKMHSSTGGGFCDCGDTEAWKAGPVCTKHE 167
           68******************************************************************996 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

VLIEDFKGTE VAVVGTEIQS AGLLLLQWCD ERFDFQATFL QCLAKHVPNI YSAEMDPLLE 60
KQEEMVQAAI FYPLECYLFG EDPDTFLEKL QQSGISQLCG KVFKGGETTY SCRDCAVDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTAATAG AAGACTTCAA GGGAACAGAG GTTGCTGTGG TGGGTACTGA AATACAATCA 60
GCAGGGAAGT TTTAGGGAAA TGGTGCTTTC TGGGGATTTA TTGTGCACAG AACTGACTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000502--C:proteasome complex
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0032007--P:negative regulation of TOR signaling
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001354	Ailuropoda melanoleuca	77.21	0.00e+00	2731.00
IUUC-Apl-004160	Anas platyrhynchos	94.81	0.00e+00	3286.00
IUUC-Aca-004982	Anolis carolinensis	77.64	0.00e+00	2731.00
IUUC-Ate-010550	Aspergillus terreus	23.25	2.00e-42	168.00
IUUC-Ame-011231	Astyanax mexicanus	58.74	0.00e+00	1936.00
IUUC-Bgr-011999	Blumeria graminis	23.45	6.00e-50	193.00
IUUC-Bta-012347	Bos taurus	77.08	0.00e+00	2731.00
IUUC-Bci-013834	Botrytis cinerea	23.82	2.00e-48	189.00
IUUC-Cja-018911	Callithrix jacchus	74.86	0.00e+00	2610.00
IUUC-Cfa-020991	Canis familiaris	78.18	0.00e+00	2758.00
IUUC-Cpo-021448	Cavia porcellus	76.40	0.00e+00	2681.00
IUUC-Cre-022930	Chlamydomonas reinhardtii	46.15	3.20e-02	30.00
IUUC-Csa-024255	Chlorocebus sabaeus	76.59	0.00e+00	2229.00
IUUC-Cho-024550	Choloepus hoffmanni	59.89	0.00e+00	1974.00
IUUC-Dno-029427	Dasypus novemcinctus	76.58	0.00e+00	2634.00
IUUC-Dor-031073	Dipodomys ordii	68.64	0.00e+00	1188.00
IUUC-Dme-031910	Drosophila melanogaster	32.48	0.00e+00	748.00
IUUC-Ete-032318	Echinops telfairi	63.23	0.00e+00	1015.00
IUUC-Eca-033348	Equus caballus	78.60	0.00e+00	2586.00
IUUC-Eeu-034664	Erinaceus europaeus	70.50	0.00e+00	2476.00
IUUC-Fal-037333	Ficedula albicollis	94.42	0.00e+00	3228.00
IUUC-Gmo-039363	Gadus morhua	56.63	0.00e+00	1668.00
IUUC-Gga-040486	Gallus gallus	98.18	0.00e+00	3331.00
IUUC-Gac-041985	Gasterosteus aculeatus	58.70	0.00e+00	1773.00
IUUC-Gma-043622	Glycine max	23.64	5.00e-28	120.00
IUUC-Ggo-044704	Gorilla gorilla	71.70	0.00e+00	2096.00
IUUC-Hsa-046753	Homo sapiens	77.49	0.00e+00	2746.00
IUUC-Itr-048410	Ictidomys tridecemlineatus	77.66	0.00e+00	2722.00
IUUC-Lch-049904	Latimeria chalumnae	63.66	0.00e+00	2147.00
IUUC-Lpe-051516	Leersia perrieri	25.99	3.00e-30	128.00
IUUC-Loc-052624	Lepisosteus oculatus	61.79	0.00e+00	2052.00
IUUC-Laf-053857	Loxodonta africana	75.83	0.00e+00	2651.00
IUUC-Mcc-054873	Macaca mulatta	77.26	0.00e+00	2699.00
IUUC-Meu-056858	Macropus eugenii	63.40	0.00e+00	961.00
IUUC-Mmr-061128	Microcebus murinus	74.02	0.00e+00	2549.00
IUUC-Mdo-062306	Monodelphis domestica	78.74	0.00e+00	2700.00
IUUC-Mmu-063389	Mus musculus	76.81	0.00e+00	2716.00
IUUC-Mpu-065983	Mustela putorius furo	78.01	0.00e+00	2775.00
IUUC-Mlu-068013	Myotis lucifugus	75.36	0.00e+00	2662.00
IUUC-Nle-070031	Nomascus leucogenys	77.55	0.00e+00	2752.00
IUUC-Opr-070551	Ochotona princeps	62.67	0.00e+00	899.00
IUUC-Ont-072035	Oreochromis niloticus	58.82	0.00e+00	1986.00
IUUC-Ocu-074930	Oryctolagus cuniculus	74.31	0.00e+00	2583.00
IUUC-Obr-076117	Oryza brachyantha	25.92	3.00e-29	125.00
IUUC-Ogl-077571	Oryza glaberrima	25.38	7.00e-29	123.00
IUUC-Ome-081738	Oryza meridionalis	24.50	4.00e-14	74.30
IUUC-Osa-085336	Oryza sativa	25.67	7.00e-29	122.00
IUUC-Ola-086683	Oryzias latipes	58.21	0.00e+00	1940.00
IUUC-Oga-088017	Otolemur garnettii	75.55	0.00e+00	2619.00
IUUC-Oar-089557	Ovis aries	76.57	0.00e+00	2727.00
IUUC-Ptr-091366	Pan troglodytes	76.64	0.00e+00	2717.00
IUUC-Pan-092184	Papio anubis	77.32	0.00e+00	2700.00
IUUC-Psi-093720	Pelodiscus sinensis	85.62	0.00e+00	2895.00
IUUC-Pma-094152	Petromyzon marinus	40.58	1.00e-153	536.00
IUUC-Pfo-097124	Poecilia formosa	58.48	0.00e+00	1975.00
IUUC-Pab-098586	Pongo abelii	77.32	0.00e+00	2741.00
IUUC-Pop-099496	Populus trichocarpa	24.20	5.00e-28	120.00
IUUC-Pca-100673	Procavia capensis	67.08	0.00e+00	1528.00
IUUC-Pva-102724	Pteropus vampyrus	71.97	0.00e+00	2493.00
IUUC-Pte-104174	Pyrenophora teres	23.42	3.00e-45	177.00
IUUC-Pyt-104431	Pyrenophora triticirepentis	23.15	8.00e-45	176.00
IUUC-Rno-105474	Rattus norvegicus	75.04	0.00e+00	1971.00
IUUC-Sha-106993	Sarcophilus harrisii	77.88	0.00e+00	2752.00
IUUC-Sit-110716	Setaria italica	25.30	1.00e-29	126.00
IUUC-Sar-113447	Sorex araneus	74.34	0.00e+00	1791.00
IUUC-Sre-115045	Sporisorium reilianum	26.10	4.00e-46	181.00
IUUC-Ssc-115768	Sus scrofa	75.54	0.00e+00	2467.00
IUUC-Tgu-116949	Taeniopygia guttata	86.74	0.00e+00	2910.00
IUUC-Tru-117782	Takifugu rubripes	58.14	0.00e+00	1939.00
IUUC-Tsy-119177	Tarsius syrichta	69.47	0.00e+00	1866.00
IUUC-Tni-120884	Tetraodon nigroviridis	54.22	0.00e+00	1761.00
IUUC-Tae-125358	Triticum aestivum	25.81	3.00e-27	118.00
IUUC-Tbe-128088	Tupaia belangeri	67.70	0.00e+00	1048.00
IUUC-Ttr-129062	Tursiops truncatus	72.61	0.00e+00	2518.00
IUUC-Uma-129344	Ustilago maydis	27.78	3.00e-51	197.00
IUUC-Vpa-130578	Vicugna pacos	70.59	0.00e+00	2420.00
IUUC-Xtr-132244	Xenopus tropicalis	62.33	0.00e+00	2130.00
IUUC-Xma-134112	Xiphophorus maculatus	59.01	0.00e+00	1977.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence