iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046140

UUCD1 version

UUC-HoS-00157

Ensembl Protein ID

ENSP00000464087.1

UniProt Accession

Q63HN8; C9JCP4; D6RI12; F8WKS1; Q658P6; Q69YK7; Q6MZR1; Q8IWF4; Q8IZX1; Q8IZX2; Q8N406; Q8TEU0; Q9H6C9; Q9H6H9; Q9H6P3; Q9H8A9; Q9HCF4; Q9HCL8; RN213_HUMAN

Genbank Protein ID

BAK53191.1; CAH10615.1; CAH56308.1; CAE45967.1; CAH56189.1; AAH32220.1; AAH36891.1; AAH40341.1; AAN63520.1; AAN63521.1; BAB13380.1; BAB13444.1; BAB14708.1; BAB15212.1; BAB15280.1; BAB15330.1; BAB84856.1

Protein Name

E3 ubiquitin-protein ligase RNF213; ALK lymphoma oligomerization partner on chromosome 17; Mysterin; RING finger protein 213; RING-type E3 ubiquitin transferase RNF213

Genbank Nucleotide ID

AB537889; AL832920; AL833201; BX640932; BX647946; AC123764; BC036891; BC040341; AF397204; AF397205; AB046774; AB046838; AK023871; AK025676; AK025914; AK026038; AK074030

Gene Name

RNF213; ALO17; C17orf27; KIAA1554; KIAA1618; MYSTR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000173821.19	ENST00000508628.6	ENSP00000425956.2
ENSG00000173821.19	ENST00000582970.5	ENSP00000464087.1
ENSG00000173821.19	ENST00000319921.4	ENSP00000324392.4
ENSG00000173821.19	ENST00000573038.1	ENSP00000460462.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	21799892

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00019	23.5	3997	4035

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C+iCl d kd p++lpC Hv ++ Cl +w     ++s + +CP+C
   Q: 3997 CSICLGDAKD-PVCLPCDHVHCLRCLRAW-----FASEQMICPYC 4035
           **********.777***************.....9********** PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase involved in angiogenesis (PubMed:21799892, PubMed:26278786, PubMed:26766444, PubMed:26126547). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity (PubMed:24658080, PubMed:26126547).

Protein Sequence
(Fasta)

MECPSCQHVS KEETPKFCSQ CGERLPPAAP IADSENNNST MASASEGEME CGQELKEEGG 60
PCLFPGSDSW QENPEEPCSK ASWTVQESKK KKRKKKKKGN KSASSELASL PLSPASPCHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACAGCGCGC GGCAGGCGGC GAGCTCGGGG GCCGCAGGTG CGAGCGGGCC TGGAGAGTCT 60
CCCGGGGCGG GGAGCGGGCT AGGATACAGT GGGCCCCGCG GGCCGGCGGG CCGGGTCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0037--Angiogenesis
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003593--AAA+_ATPase
IPR027417--P-loop_NTPase
IPR031248--RNF213
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF00097--zf-C3HC4

SMART

SM00382--AAA
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0016887--F:ATPase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001525--P:angiogenesis
GO:2000051--P:negative regulation of non-canonical Wnt signaling pathway
GO:0051865--P:protein autoubiquitination
GO:0051260--P:protein homooligomerization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0002040--P:sprouting angiogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:57674

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004090	Anas platyrhynchos	55.27	0.00e+00	4677.00
IUUC-Ame-010883	Astyanax mexicanus	48.07	0.00e+00	3850.00
IUUC-Cja-019209	Callithrix jacchus	86.11	0.00e+00	5749.00
IUUC-Cfa-020058	Canis familiaris	69.12	0.00e+00	6254.00
IUUC-Cpo-022285	Cavia porcellus	71.29	0.00e+00	3981.00
IUUC-Csa-023613	Chlorocebus sabaeus	89.04	0.00e+00	9020.00
IUUC-Cho-024453	Choloepus hoffmanni	79.51	0.00e+00	2877.00
IUUC-Cin-025584	Ciona intestinalis	31.91	0.00e+00	1443.00
IUUC-Csv-026161	Ciona savignyi	21.60	2.00e-25	111.00
IUUC-Dre-027864	Danio rerio	45.79	0.00e+00	4192.00
IUUC-Dno-029563	Dasypus novemcinctus	66.26	0.00e+00	3862.00
IUUC-Dor-030748	Dipodomys ordii	73.32	0.00e+00	2355.00
IUUC-Eca-034252	Equus caballus	73.50	0.00e+00	7064.00
IUUC-Eeu-035087	Erinaceus europaeus	74.96	0.00e+00	2058.00
IUUC-Fca-036042	Felis catus	73.70	0.00e+00	1719.00
IUUC-Fal-037402	Ficedula albicollis	53.36	0.00e+00	4949.00
IUUC-Gmo-039713	Gadus morhua	48.76	0.00e+00	3745.00
IUUC-Gga-040437	Gallus gallus	56.25	0.00e+00	3612.00
IUUC-Gac-042182	Gasterosteus aculeatus	40.16	0.00e+00	2524.00
IUUC-Ggo-045212	Gorilla gorilla	98.29	0.00e+00	6573.00
IUUC-Itr-048748	Ictidomys tridecemlineatus	75.63	0.00e+00	5027.00
IUUC-Lch-050262	Latimeria chalumnae	50.33	0.00e+00	4472.00
IUUC-Loc-052115	Lepisosteus oculatus	47.82	0.00e+00	4518.00
IUUC-Laf-054258	Loxodonta africana	55.48	0.00e+00	1459.00
IUUC-Mcc-055793	Macaca mulatta	86.25	0.00e+00	8856.00
IUUC-Meu-055905	Macropus eugenii	61.93	0.00e+00	1247.00
IUUC-Mdo-062190	Monodelphis domestica	60.26	0.00e+00	6167.00
IUUC-Mmu-063486	Mus musculus	66.19	0.00e+00	6821.00
IUUC-Mpu-065783	Mustela putorius furo	66.56	0.00e+00	6786.00
IUUC-Mlu-067959	Myotis lucifugus	70.24	0.00e+00	4608.00
IUUC-Nle-069617	Nomascus leucogenys	91.83	0.00e+00	6711.00
IUUC-Opr-071117	Ochotona princeps	73.42	0.00e+00	2354.00
IUUC-Ont-072667	Oreochromis niloticus	46.67	0.00e+00	4319.00
IUUC-Ocu-074421	Oryctolagus cuniculus	67.81	0.00e+00	1638.00
IUUC-Ola-086411	Oryzias latipes	49.98	0.00e+00	3984.00
IUUC-Oga-088090	Otolemur garnettii	77.18	0.00e+00	5145.00
IUUC-Oar-089763	Ovis aries	69.84	0.00e+00	7171.00
IUUC-Pan-091737	Papio anubis	88.03	0.00e+00	9134.00
IUUC-Psi-093008	Pelodiscus sinensis	58.70	0.00e+00	5080.00
IUUC-Pma-094477	Petromyzon marinus	40.46	0.00e+00	2184.00
IUUC-Pfo-096327	Poecilia formosa	52.71	0.00e+00	3580.00
IUUC-Pab-098316	Pongo abelii	93.86	0.00e+00	5283.00
IUUC-Pca-101059	Procavia capensis	79.21	0.00e+00	2270.00
IUUC-Pva-102703	Pteropus vampyrus	70.06	0.00e+00	3650.00
IUUC-Rno-105537	Rattus norvegicus	65.14	0.00e+00	6706.00
IUUC-Sha-106990	Sarcophilus harrisii	69.91	0.00e+00	4636.00
IUUC-Tgu-116501	Taeniopygia guttata	57.29	0.00e+00	814.00
IUUC-Tru-118139	Takifugu rubripes	34.44	0.00e+00	1057.00
IUUC-Tsy-118810	Tarsius syrichta	79.03	0.00e+00	2462.00
IUUC-Tni-119963	Tetraodon nigroviridis	49.01	0.00e+00	3910.00
IUUC-Tbe-127986	Tupaia belangeri	72.65	0.00e+00	1144.00
IUUC-Uma-129532	Ustilago maydis	37.68	7.00e-05	42.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence