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Tag Content
UUCD2 ID IUUC-Oan-073032
UUCD1 version UUC-OrA-00225
Ensembl Protein ID ENSOANP00000022251.1
UniProt Accession F6VN71; F6VN71_ORNAN
Genbank Protein ID ENSOANP00000022251
Protein Name Uncharacterized protein
Genbank Nucleotide ID AAPN01246581
Gene Name NEDD4L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOANG00000014105.3 ENSOANT00000022255.2 ENSOANP00000022251.1
ENSOANG00000014105.3 ENSOANT00000022254.3 ENSOANP00000022250.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 4.50e-99 332.2 542 840
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 542  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 630
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 631  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 714
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq.. 266
           +r+ +++++q++af eGf+e++p +l+++F+e+elell+cG  ++dv+d+++++ yk+gy +++p+iqwFw+v+ +         L   
   Q: 715  WRFVNRVQKQMNAFLEGFTELLPTDLIKIFDENELELLMCGLGDVDVNDWRQHAIYKNGYCPNHPVIQWFWKVIIQYRTVPPLLYLPfs 803
           *************************************************************************9777777666666611 PP
   S: 267  .FvTgs.srlPlgGfaelkprlfvirkdasddrlPssnT 303
            F++   s +    + +  p+lf+i++++s+++lP+++T
   Q: 804  sFMWAAfSFVS--HLGSNGPQLFTIEQWGSPEKLPRAHT 840
           14443313333..34444499*****************9 PP
   
Organism Ornithorhynchus anatinus
Protein Sequence
(Fasta)
TRDDFLGQVD VPLNHLPTED PTMERPYTFK DFLLRPRSHK SRVKGFLRLK MAYMPKNGGQ 60
DEENNEQREE LEHGWEVVDS NDSASQHQEE LPPPPLPPGW EEKVDNLGRT YYVNHNNRTT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Oan-073032|E3,HECT|Ornithorhynchus anatinus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGCTGGCCCA GGATGAAAAC TTAACTCTAT TTCTCTGTTT TACAGACGAG AGACGACTTC 60
TTGGGGCAGG TGGACGTGCC TCTTAATCAT CTACCGGTAA GAGAAGTTCT GTGTCTCAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Oan-073032|E3,HECT|Ornithorhynchus anatinus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001314 Ailuropoda melanoleuca 90.62 0.00e+00 1409.00
IUUC-Apl-003893 Anas platyrhynchos 91.45 0.00e+00 1460.00
IUUC-Aca-004744 Anolis carolinensis 87.78 0.00e+00 1394.00
IUUC-Ame-010810 Astyanax mexicanus 66.55 0.00e+00 998.00
IUUC-Bta-012679 Bos taurus 92.42 0.00e+00 1447.00
IUUC-Cja-018732 Callithrix jacchus 93.01 0.00e+00 1488.00
IUUC-Cfa-021226 Canis familiaris 92.76 0.00e+00 1469.00
IUUC-Cpo-021671 Cavia porcellus 90.97 0.00e+00 1425.00
IUUC-Csa-023344 Chlorocebus sabaeus 90.93 0.00e+00 1474.00
IUUC-Cho-024832 Choloepus hoffmanni 91.19 0.00e+00 670.00
IUUC-Dre-027770 Danio rerio 74.68 0.00e+00 1142.00
IUUC-Dno-029466 Dasypus novemcinctus 92.87 0.00e+00 1491.00
IUUC-Dor-030138 Dipodomys ordii 88.48 0.00e+00 1366.00
IUUC-Ete-033145 Echinops telfairi 83.19 0.00e+00 1130.00
IUUC-Eca-033445 Equus caballus 92.99 0.00e+00 1434.00
IUUC-Eeu-035247 Erinaceus europaeus 85.15 0.00e+00 1254.00
IUUC-Fca-035489 Felis catus 90.92 0.00e+00 1408.00
IUUC-Fal-037604 Ficedula albicollis 87.46 0.00e+00 1419.00
IUUC-Gmo-039674 Gadus morhua 72.45 0.00e+00 1103.00
IUUC-Gga-040703 Gallus gallus 90.50 0.00e+00 1447.00
IUUC-Gac-042020 Gasterosteus aculeatus 76.20 0.00e+00 1142.00
IUUC-Ggo-045332 Gorilla gorilla 91.09 0.00e+00 1455.00
IUUC-Hsa-045968 Homo sapiens 92.99 0.00e+00 1486.00
IUUC-Lch-050443 Latimeria chalumnae 83.79 0.00e+00 1309.00
IUUC-Loc-052662 Lepisosteus oculatus 77.56 0.00e+00 1184.00
IUUC-Lma-052980 Leptosphaeria maculans 45.82 1.00e-86 313.00
IUUC-Laf-053850 Loxodonta africana 91.09 0.00e+00 1457.00
IUUC-Mcc-055821 Macaca mulatta 92.87 0.00e+00 1484.00
IUUC-Meu-056712 Macropus eugenii 84.38 0.00e+00 714.00
IUUC-Mga-059264 Meleagris gallopavo 72.89 0.00e+00 1014.00
IUUC-Mmr-060798 Microcebus murinus 88.52 0.00e+00 1365.00
IUUC-Mdo-062173 Monodelphis domestica 91.87 0.00e+00 1501.00
IUUC-Mmu-064136 Mus musculus 92.29 0.00e+00 1453.00
IUUC-Mpu-066765 Mustela putorius furo 92.52 0.00e+00 1456.00
IUUC-Mlu-067565 Myotis lucifugus 91.01 0.00e+00 1424.00
IUUC-Nle-069070 Nomascus leucogenys 89.32 0.00e+00 1399.00
IUUC-Opr-071044 Ochotona princeps 90.34 0.00e+00 1045.00
IUUC-Ont-072044 Oreochromis niloticus 74.49 0.00e+00 1179.00
IUUC-Ocu-074160 Oryctolagus cuniculus 89.68 0.00e+00 1401.00
IUUC-Ola-087467 Oryzias latipes 75.67 0.00e+00 1159.00
IUUC-Oga-088460 Otolemur garnettii 88.37 0.00e+00 1419.00
IUUC-Oar-090198 Ovis aries 92.16 0.00e+00 1444.00
IUUC-Ptr-090939 Pan troglodytes 92.99 0.00e+00 1486.00
IUUC-Pan-092284 Papio anubis 92.87 0.00e+00 1483.00
IUUC-Psi-093645 Pelodiscus sinensis 91.45 0.00e+00 1453.00
IUUC-Pfo-096768 Poecilia formosa 85.27 0.00e+00 825.00
IUUC-Pab-098088 Pongo abelii 92.99 0.00e+00 1486.00
IUUC-Pca-100714 Procavia capensis 73.84 0.00e+00 1123.00
IUUC-Pva-102354 Pteropus vampyrus 90.50 0.00e+00 1410.00
IUUC-Rno-105318 Rattus norvegicus 92.29 0.00e+00 1451.00
IUUC-Sha-107482 Sarcophilus harrisii 93.51 0.00e+00 1493.00
IUUC-Sar-113394 Sorex araneus 100.00 3.00e-129 455.00
IUUC-Ssc-115950 Sus scrofa 66.35 0.00e+00 1032.00
IUUC-Tgu-117130 Taeniopygia guttata 90.38 0.00e+00 1450.00
IUUC-Tru-118610 Takifugu rubripes 75.41 0.00e+00 1178.00
IUUC-Tsy-119492 Tarsius syrichta 90.62 0.00e+00 1446.00
IUUC-Tni-120113 Tetraodon nigroviridis 69.78 0.00e+00 1110.00
IUUC-Tbe-127441 Tupaia belangeri 90.91 0.00e+00 714.00
IUUC-Ttr-128235 Tursiops truncatus 82.41 0.00e+00 1244.00
IUUC-Vpa-130544 Vicugna pacos 75.97 0.00e+00 761.00
IUUC-Xtr-132859 Xenopus tropicalis 86.24 0.00e+00 1379.00
Created Date 25-Jun-2017

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