iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003935

Ensembl Protein ID

ENSAPLP00000015299.1

UniProt Accession

U3J722; U3J722_ANAPL

Genbank Protein ID

ENSAPLP00000015299

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01087241

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000015383.1	ENSAPLT00000016094.1	ENSAPLP00000015299.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.40e-122	406.6	1243	1575

Active Site

Position(s)	Description	Evidence
1543	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1243 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1328
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1329 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1411
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1412 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1498
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1499 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1575
           **************************************************************************985 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

DKSAEEMASS AREHLLFVRR RNPQLRYTLS PENLQSLASQ GTMAENMNLQ RANSDTDLVT 60
SDSRSSLTAS MYEYTLGQSQ NLIIFWDIKE EVDPTDWIGL YHIDENSPAN FWDSKNRGVT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACAAAAGTG CAGAAGAGAT GGCCAGTTCA GCGCGAGAAC ATCTGCTTTT TGTGCGACGT 60
CGCAACCCAC AGCTCCGGTA TACTCTGAGC CCAGAGAATC TGCAGAGTTT GGCATCTCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	86.22	0.00e+00	2686.00
IUUC-Aca-004558	Anolis carolinensis	86.14	0.00e+00	2715.00
IUUC-Ame-010893	Astyanax mexicanus	88.52	0.00e+00	1310.00
IUUC-Bta-013093	Bos taurus	94.97	0.00e+00	1566.00
IUUC-Cja-019651	Callithrix jacchus	85.36	0.00e+00	2563.00
IUUC-Cfa-021232	Canis familiaris	97.99	0.00e+00	1618.00
IUUC-Cpo-021770	Cavia porcellus	83.48	0.00e+00	2610.00
IUUC-Csa-023970	Chlorocebus sabaeus	86.20	0.00e+00	2672.00
IUUC-Cho-024512	Choloepus hoffmanni	78.92	0.00e+00	2381.00
IUUC-Csv-026127	Ciona savignyi	66.67	1.00e-155	542.00
IUUC-Dre-028275	Danio rerio	85.51	0.00e+00	1492.00
IUUC-Dno-029963	Dasypus novemcinctus	85.17	0.00e+00	2526.00
IUUC-Dor-030282	Dipodomys ordii	76.83	0.00e+00	1684.00
IUUC-Dme-032217	Drosophila melanogaster	71.54	0.00e+00	655.00
IUUC-Ete-033132	Echinops telfairi	81.66	0.00e+00	1244.00
IUUC-Eca-033978	Equus caballus	86.13	0.00e+00	2665.00
IUUC-Eeu-035278	Erinaceus europaeus	58.51	0.00e+00	1083.00
IUUC-Fca-036157	Felis catus	86.39	0.00e+00	2670.00
IUUC-Fal-037110	Ficedula albicollis	92.26	0.00e+00	2578.00
IUUC-Gmo-039291	Gadus morhua	80.06	0.00e+00	1020.00
IUUC-Gga-040821	Gallus gallus	97.51	0.00e+00	3045.00
IUUC-Gac-042181	Gasterosteus aculeatus	83.59	0.00e+00	1437.00
IUUC-Ggo-044862	Gorilla gorilla	86.10	0.00e+00	2565.00
IUUC-Hsa-046219	Homo sapiens	86.20	0.00e+00	2711.00
IUUC-Lch-050526	Latimeria chalumnae	79.38	0.00e+00	2475.00
IUUC-Loc-052648	Lepisosteus oculatus	85.73	0.00e+00	1537.00
IUUC-Laf-054005	Loxodonta africana	86.29	0.00e+00	2708.00
IUUC-Mcc-055314	Macaca mulatta	86.08	0.00e+00	2665.00
IUUC-Meu-056356	Macropus eugenii	64.01	0.00e+00	1007.00
IUUC-Mga-060074	Meleagris gallopavo	96.68	0.00e+00	2921.00
IUUC-Mmr-061526	Microcebus murinus	86.01	0.00e+00	2683.00
IUUC-Mdo-063017	Monodelphis domestica	87.32	0.00e+00	2664.00
IUUC-Mmu-064165	Mus musculus	84.74	0.00e+00	2630.00
IUUC-Mpu-065835	Mustela putorius furo	94.27	0.00e+00	1553.00
IUUC-Mlu-067709	Myotis lucifugus	82.87	0.00e+00	2558.00
IUUC-Nle-069308	Nomascus leucogenys	86.14	0.00e+00	2681.00
IUUC-Opr-070330	Ochotona princeps	73.35	0.00e+00	2154.00
IUUC-Ont-071345	Oreochromis niloticus	87.47	0.00e+00	1452.00
IUUC-Ocu-074775	Oryctolagus cuniculus	84.68	0.00e+00	2387.00
IUUC-Ola-087225	Oryzias latipes	64.05	0.00e+00	1863.00
IUUC-Oga-088177	Otolemur garnettii	84.21	0.00e+00	2595.00
IUUC-Oar-089452	Ovis aries	85.82	0.00e+00	2689.00
IUUC-Ptr-090806	Pan troglodytes	86.39	0.00e+00	2692.00
IUUC-Pan-091838	Papio anubis	86.03	0.00e+00	2552.00
IUUC-Psi-094090	Pelodiscus sinensis	90.04	0.00e+00	2807.00
IUUC-Pfo-096520	Poecilia formosa	68.19	0.00e+00	1531.00
IUUC-Pab-098405	Pongo abelii	86.27	0.00e+00	2683.00
IUUC-Pca-100441	Procavia capensis	79.32	0.00e+00	2032.00
IUUC-Pva-102324	Pteropus vampyrus	97.49	0.00e+00	1610.00
IUUC-Rno-105943	Rattus norvegicus	84.92	0.00e+00	2690.00
IUUC-Sha-106985	Sarcophilus harrisii	83.79	0.00e+00	2235.00
IUUC-Sar-113505	Sorex araneus	94.09	0.00e+00	1525.00
IUUC-Ssc-115439	Sus scrofa	80.16	0.00e+00	1681.00
IUUC-Tgu-117078	Taeniopygia guttata	93.52	0.00e+00	2809.00
IUUC-Tru-118671	Takifugu rubripes	84.75	0.00e+00	1461.00
IUUC-Tni-120619	Tetraodon nigroviridis	86.94	0.00e+00	1431.00
IUUC-Tbe-127975	Tupaia belangeri	82.03	0.00e+00	2169.00
IUUC-Ttr-128469	Tursiops truncatus	80.63	0.00e+00	2407.00
IUUC-Vpa-130498	Vicugna pacos	76.47	0.00e+00	2216.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence