iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011166

Ensembl Protein ID

ENSAMXP00000013316.1

UniProt Accession

W5L0F4; W5L0F4_ASTMX

Genbank Protein ID

ENSAMXP00000013316

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01087402

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000012931.1	ENSAMXT00000013316.1	ENSAMXP00000013316.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.60e-107	357.6	531	857

Active Site

Position(s)	Description	Evidence
826	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e++  F+++G++lg+a++++ +ld+
   Q: 531  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ENEGQFTLIGIVLGLAIYNNCILDV 614
           689******************************************998888876.89888....6899********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p ly+slke++e+ e ++ee  + +tf++s++  +g+   ++Lk+gG++ipVt eN++e+v l++
   Q: 615  HFPMVVYRKLMGKKGTFRDLADSHPVLYQSLKELLEY-EGNVEED-MMITFQISQTDlFGNPLMYDLKEGGDKIPVTSENRKEFVALYA 701
           *************************************.6678775.9999996554449****************************** PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           ey l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggy++d + i+ Fwe++++f +e+++ fLq
   Q: 702  EYMLNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYSRDCRIIKDFWETVHSFGQEQKRLFLQ 790
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d drlP+s+TCfn+L LPeYs+ke+l+e+Ll Ai+++kgF++
   Q: 791  FTTGTDRAPVGGLGKLK---MIIAKNGPDsDRLPTSHTCFNVLLLPEYSTKEKLRERLLKAITYAKGFGM 857
           *****************...8888877777**************************************97 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MKRAAAKHLI ERYYHQLTEG CGNEACTNEA CGSSPGFRRM DNNAAAIKAL ELYKNNAKLC 60
DPHPSKKGAS SAFPENSAKG AHNFSACSNG KMNHKDLPPS REDFRDLNYL TEEKVYEILA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGGCTGAA CATCGATGGT TTGTTGGTGG TTCCCGGTGC ATCTTGGGAT ACGGACGGTG 60
TTTGCCTCAG CTAACTAGCT ATCAAGATGG CCGAGAATGT TTGGTTGAGG AGCTGGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	86.70	0.00e+00	1439.00
IUUC-Atr-003144	Amborella trichopoda	44.32	4.00e-93	335.00
IUUC-Apl-003742	Anas platyrhynchos	86.98	0.00e+00	1453.00
IUUC-Aca-004873	Anolis carolinensis	86.23	0.00e+00	1455.00
IUUC-Ago-007908	Ashbya gossypii	35.10	1.00e-67	251.00
IUUC-Acl-008288	Aspergillus clavatus	37.69	1.00e-79	291.00
IUUC-Afl-008402	Aspergillus flavus	38.51	4.00e-75	275.00
IUUC-Afu-008762	Aspergillus fumigatus	37.69	3.00e-81	297.00
IUUC-Ani-009176	Aspergillus nidulans	38.70	3.00e-81	296.00
IUUC-Ang-009791	Aspergillus niger	37.17	1.00e-76	281.00
IUUC-Aor-009921	Aspergillus oryzae	38.73	9.00e-76	278.00
IUUC-Ate-010295	Aspergillus terreus	38.02	6.00e-83	302.00
IUUC-Bgr-011981	Blumeria graminis	39.10	1.00e-81	298.00
IUUC-Bta-013286	Bos taurus	86.25	0.00e+00	1412.00
IUUC-Bci-013697	Botrytis cinerea	36.38	3.00e-71	263.00
IUUC-Cja-019707	Callithrix jacchus	87.06	0.00e+00	1438.00
IUUC-Cfa-020154	Canis familiaris	86.36	0.00e+00	1438.00
IUUC-Cpo-021292	Cavia porcellus	85.76	0.00e+00	1419.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	50.00	1.00e-82	299.00
IUUC-Csa-023378	Chlorocebus sabaeus	86.83	0.00e+00	1436.00
IUUC-Cho-025059	Choloepus hoffmanni	82.75	0.00e+00	1357.00
IUUC-Cin-025643	Ciona intestinalis	43.57	0.00e+00	698.00
IUUC-Csv-026282	Ciona savignyi	44.61	0.00e+00	655.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	37.64	4.00e-80	293.00
IUUC-Cme-027151	Cyanidioschyzon merolae	43.34	9.00e-99	355.00
IUUC-Dre-027901	Danio rerio	94.76	0.00e+00	1589.00
IUUC-Dno-029320	Dasypus novemcinctus	86.13	0.00e+00	1436.00
IUUC-Dor-030756	Dipodomys ordii	92.56	0.00e+00	641.00
IUUC-Dme-032035	Drosophila melanogaster	49.59	3.00e-163	569.00
IUUC-Eca-033843	Equus caballus	86.00	0.00e+00	1410.00
IUUC-Eeu-035109	Erinaceus europaeus	85.18	0.00e+00	1394.00
IUUC-Fca-036344	Felis catus	86.36	0.00e+00	1442.00
IUUC-Fal-036747	Ficedula albicollis	86.86	0.00e+00	1452.00
IUUC-Fox-037941	Fusarium oxysporum	38.51	4.00e-89	323.00
IUUC-Fso-038388	Fusarium solani	40.40	9.00e-90	325.00
IUUC-Gmo-038840	Gadus morhua	64.75	0.00e+00	1109.00
IUUC-Gga-040399	Gallus gallus	86.98	0.00e+00	1453.00
IUUC-Gac-041933	Gasterosteus aculeatus	87.08	0.00e+00	1403.00
IUUC-Ggo-044804	Gorilla gorilla	86.95	0.00e+00	1437.00
IUUC-Hsa-045727	Homo sapiens	86.95	0.00e+00	1437.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	82.85	0.00e+00	1343.00
IUUC-Lch-050197	Latimeria chalumnae	85.66	0.00e+00	1439.00
IUUC-Loc-052743	Lepisosteus oculatus	88.60	0.00e+00	1480.00
IUUC-Lma-053245	Leptosphaeria maculans	35.54	4.00e-56	213.00
IUUC-Laf-053615	Loxodonta africana	86.23	0.00e+00	1445.00
IUUC-Mcc-054934	Macaca mulatta	86.83	0.00e+00	1434.00
IUUC-Meu-056061	Macropus eugenii	88.56	0.00e+00	1263.00
IUUC-Mor-057045	Magnaporthe oryzae	37.00	3.00e-81	297.00
IUUC-Mla-059187	Melampsora laricipopulina	37.64	3.00e-68	252.00
IUUC-Mga-059271	Meleagris gallopavo	86.85	0.00e+00	1447.00
IUUC-Mmr-061288	Microcebus murinus	86.83	0.00e+00	1438.00
IUUC-Mdo-062975	Monodelphis domestica	87.18	0.00e+00	1461.00
IUUC-Mmu-063674	Mus musculus	85.43	0.00e+00	1397.00
IUUC-Mpu-066568	Mustela putorius furo	86.71	0.00e+00	1445.00
IUUC-Mlu-067522	Myotis lucifugus	82.29	0.00e+00	1357.00
IUUC-Nfi-068439	Neosartorya fischeri	37.47	1.00e-80	295.00
IUUC-Nle-069505	Nomascus leucogenys	86.95	0.00e+00	1437.00
IUUC-Opr-070570	Ochotona princeps	79.70	0.00e+00	1307.00
IUUC-Ont-071527	Oreochromis niloticus	85.56	0.00e+00	1482.00
IUUC-Oan-073446	Ornithorhynchus anatinus	81.72	0.00e+00	915.00
IUUC-Ocu-074922	Oryctolagus cuniculus	85.65	0.00e+00	1430.00
IUUC-Ola-086996	Oryzias latipes	85.96	0.00e+00	1453.00
IUUC-Oga-088261	Otolemur garnettii	86.58	0.00e+00	1437.00
IUUC-Oar-090024	Ovis aries	86.25	0.00e+00	1412.00
IUUC-Ptr-090455	Pan troglodytes	86.95	0.00e+00	1437.00
IUUC-Pan-092509	Papio anubis	86.36	0.00e+00	1287.00
IUUC-Psi-092974	Pelodiscus sinensis	86.96	0.00e+00	1429.00
IUUC-Pma-094643	Petromyzon marinus	71.49	0.00e+00	1243.00
IUUC-Pno-094886	Phaeosphaeria nodorum	36.10	2.00e-58	221.00
IUUC-Pfo-096905	Poecilia formosa	86.13	0.00e+00	1464.00
IUUC-Pab-097840	Pongo abelii	84.38	0.00e+00	1395.00
IUUC-Pca-100869	Procavia capensis	85.43	0.00e+00	1427.00
IUUC-Pva-103040	Pteropus vampyrus	91.37	0.00e+00	635.00
IUUC-Pgr-103315	Puccinia graminis	37.23	8.00e-75	275.00
IUUC-Ptt-103736	Puccinia triticina	37.86	1.00e-75	278.00
IUUC-Rno-105453	Rattus norvegicus	85.31	0.00e+00	1398.00
IUUC-Sce-106306	Saccharomyces cerevisiae	36.36	6.00e-65	242.00
IUUC-Sha-107651	Sarcophilus harrisii	87.18	0.00e+00	1462.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	36.60	3.00e-76	280.00
IUUC-Smo-108858	Selaginella moellendorffii	49.65	2.00e-115	409.00
IUUC-Sar-113293	Sorex araneus	86.60	0.00e+00	1437.00
IUUC-Ssc-115979	Sus scrofa	86.35	0.00e+00	1432.00
IUUC-Tgu-116901	Taeniopygia guttata	86.86	0.00e+00	1451.00
IUUC-Tru-118368	Takifugu rubripes	87.53	0.00e+00	1469.00
IUUC-Tsy-119516	Tarsius syrichta	82.85	0.00e+00	1329.00
IUUC-Tni-120143	Tetraodon nigroviridis	87.18	0.00e+00	1469.00
IUUC-Tre-122108	Trichoderma reesei	40.48	2.00e-78	288.00
IUUC-Tvi-122644	Trichoderma virens	38.27	2.00e-78	288.00
IUUC-Tbe-127484	Tupaia belangeri	80.41	0.00e+00	960.00
IUUC-Ttr-129078	Tursiops truncatus	86.13	0.00e+00	1425.00
IUUC-Vda-129969	Verticillium dahliae	38.19	3.00e-84	307.00
IUUC-Vpa-130312	Vicugna pacos	78.70	0.00e+00	1206.00
IUUC-Xtr-132881	Xenopus tropicalis	86.13	0.00e+00	1444.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence