iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062073

UUCD1 version

UUC-MoD-01120

Ensembl Protein ID

ENSMODP00000016059.2

UniProt Accession

F7DCJ7; F7DCJ7_MONDO

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000012836.3	ENSMODT00000016356.2	ENSMODP00000016059.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.30e-98	329.1	260	665

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp....................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+             l+++++                                       
   Q: 260  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldlceteeL----LAKTANgkaqmsgklangspadesarndriepcnrqdlptglngg 344
           7******************************999744432....33333366678899999999999999999**************** PP
   S: 43   ...............kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpke 116
                          ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         
   Q: 345  ssinrsleliqpkepSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLDKVQQEL--------- 424
           **999999999999999999************************************************************......... PP
   S: 117  eeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesft 195
           e+e+++++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft
   Q: 425  ESEGTKRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCITCNYKSNTIEPFWDLSLEFPERYHCIEKglipfnqtecMLTEMLAKFT 513
           6788899999999***************************************************998779******************* PP
   S: 196  keeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqk 273
           ++e leg+  y c++c+++++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++ ++ 
   Q: 514  ETEALEGRI-YACDQCNSRRRksspkplvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQVLTMEPYCCRDTLSSL 600
           ******965.*******999999999999999***********************997.8889********************887765 PP
   S: 274  e..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           +  +  Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 601  DkeTFAYDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQ 665
           434899*************************9999********************...********98 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWHCMQCN TTESVWACLK CSHVACGRYI EEHAFKHFEE 60
TRHPLAMEVN DLYVFCYLCE DYVLNDNPEG DLKLLRSTLS AIRSQKQDLS VRSGRMLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAGAT GCAAACATGT AGGGCGGTTA CGACTCGCCC AGGACCATTC TATCTTGAAT 60
CCTCAGAAGT GGCACTGCAT GCAGTGTAAT ACCACAGAGT CTGTCTGGGC ATGTCTGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mdo:100030401

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003658	Anas platyrhynchos	88.81	0.00e+00	1225.00
IUUC-Aca-005278	Anolis carolinensis	87.95	0.00e+00	1236.00
IUUC-Bta-012911	Bos taurus	79.66	0.00e+00	1028.00
IUUC-Cja-019171	Callithrix jacchus	81.90	0.00e+00	1077.00
IUUC-Cfa-020408	Canis familiaris	81.03	0.00e+00	1049.00
IUUC-Cpo-022233	Cavia porcellus	75.11	0.00e+00	983.00
IUUC-Csa-024272	Chlorocebus sabaeus	80.72	0.00e+00	863.00
IUUC-Cho-025051	Choloepus hoffmanni	84.09	3.00e-175	608.00
IUUC-Dno-029856	Dasypus novemcinctus	82.50	0.00e+00	1084.00
IUUC-Eca-033851	Equus caballus	76.58	0.00e+00	937.00
IUUC-Fal-037290	Ficedula albicollis	83.07	0.00e+00	1048.00
IUUC-Gmo-039249	Gadus morhua	78.30	2.00e-149	523.00
IUUC-Gga-040383	Gallus gallus	86.76	0.00e+00	911.00
IUUC-Gac-042595	Gasterosteus aculeatus	62.50	0.00e+00	806.00
IUUC-Ggo-044979	Gorilla gorilla	82.90	0.00e+00	1083.00
IUUC-Hsa-046743	Homo sapiens	82.90	0.00e+00	1080.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	82.35	0.00e+00	1082.00
IUUC-Lch-050294	Latimeria chalumnae	82.01	0.00e+00	1056.00
IUUC-Loc-051961	Lepisosteus oculatus	73.39	0.00e+00	692.00
IUUC-Mcc-055048	Macaca mulatta	82.61	0.00e+00	1079.00
IUUC-Meu-055971	Macropus eugenii	82.00	0.00e+00	682.00
IUUC-Mga-059720	Meleagris gallopavo	89.52	0.00e+00	904.00
IUUC-Mmu-064095	Mus musculus	79.91	0.00e+00	1059.00
IUUC-Mlu-067090	Myotis lucifugus	79.34	0.00e+00	1036.00
IUUC-Nle-069486	Nomascus leucogenys	82.61	0.00e+00	1078.00
IUUC-Opr-070563	Ochotona princeps	79.86	0.00e+00	1053.00
IUUC-Ocu-074851	Oryctolagus cuniculus	79.45	0.00e+00	838.00
IUUC-Ola-086413	Oryzias latipes	60.52	0.00e+00	772.00
IUUC-Oga-088862	Otolemur garnettii	81.86	0.00e+00	1070.00
IUUC-Ptr-091525	Pan troglodytes	82.52	0.00e+00	971.00
IUUC-Pan-092363	Papio anubis	83.16	0.00e+00	1046.00
IUUC-Psi-093353	Pelodiscus sinensis	90.83	0.00e+00	1247.00
IUUC-Pma-094155	Petromyzon marinus	58.92	2.00e-83	302.00
IUUC-Pfo-096413	Poecilia formosa	64.09	0.00e+00	826.00
IUUC-Pab-098592	Pongo abelii	80.20	0.00e+00	857.00
IUUC-Pca-100449	Procavia capensis	81.52	0.00e+00	1056.00
IUUC-Pva-102868	Pteropus vampyrus	80.49	0.00e+00	1041.00
IUUC-Rno-105190	Rattus norvegicus	79.05	0.00e+00	1053.00
IUUC-Sha-107337	Sarcophilus harrisii	97.54	0.00e+00	1348.00
IUUC-Sar-113561	Sorex araneus	91.02	9.00e-90	323.00
IUUC-Ssc-115735	Sus scrofa	80.49	0.00e+00	1039.00
IUUC-Tgu-117025	Taeniopygia guttata	77.89	0.00e+00	965.00
IUUC-Tru-117585	Takifugu rubripes	63.11	0.00e+00	790.00
IUUC-Tsy-118814	Tarsius syrichta	81.64	0.00e+00	1062.00
IUUC-Tni-120600	Tetraodon nigroviridis	62.37	0.00e+00	760.00
IUUC-Xtr-132090	Xenopus tropicalis	73.59	0.00e+00	999.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence