iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120600

UUCD1 version

UUC-TeN-01143

Ensembl Protein ID

ENSTNIP00000017674.1

UniProt Accession

H3DAY2; H3DAY2_TETNG

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000014646.1	ENSTNIT00000017897.1	ENSTNIP00000017674.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-98	330.6	259	661

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenp........................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+    +++e l+++n+                                           
   Q: 259  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldlcETEELLAKSNHpqgvkgaalsnagpplsgcslgrlgnlpagkkesapppaqape 347
           7******************************99975555555555578888888999******************99999999999999 PP
   S: 43   ..........kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeee 121
                     + ++ +l+ +l++lf+ +w+++++ vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         ++e++
   Q: 348  lvqakasrcsTRQQMSLCYELHTLFRVMWSGRWSLVSPFAMLHSVWNLIPAFRGYDQQDAQEFLCELLDKVQQEL---------DTEGS 427
           999999999888888************************************************************.........78899 PP
   S: 122  dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke......slqdcLesftkeeelegen 204
           +++    ++++k  k+  ++++++F+gql sq++cl+c+++s++ epf+dlsl++p++ ++ k       +l+++L++ft+ e leg n
   Q: 428  KRRIVIPISKRKLSKQVLKVLNTIFHGQLLSQVTCLSCKHKSNTVEPFWDLSLEFPERYHSVKAahqrscTLTEMLSKFTEMEALEG-N 515
           99999999************************************************99987766999999****************9.7 PP
   S: 205  kyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeL 280
            y c++c++k++           a k+l + +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++ +  + +   ++Y+L
   Q: 516  IYACNHCNRKRRksshkplvlseACKQLLIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVAFDQVLNIKPYCCTGSGHSVHrgGYTYDL 603
           7*******9999999999**999***********************997.8889*****************9995554433679***** PP
   S: 281  iavvvHsG.slssGHYvayvknekgk..WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           +avv+H+G +++sGHY+ay++n++g+  W++++Ds+ ++++ eev++   ++aY+lfY++r
   Q: 604  SAVVMHHGkGFGSGHYTAYCYNTEGGgfWVHCNDSEMKVCSVEEVCN---TQAYILFYTQR 661
           **********************99999********************...********985 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

MDRCKHVGRL RLGHDHSILN PQKWRCVDCS TTDSLWACLK CSHVACGRFM EEHSLKHFQE 60
SQHPLAMEVR ELDVFCFACG DYVLNDNAEG DLKLLRGALS TVRSPGTRSL RSSTGGDCTP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATCGCT GTAAGCACGT GGGACGCCTG CGCCTGGGCC ACGACCACTC CATCCTCAAC 60
CCGCAGAAAT GGCGCTGCGT GGACTGCAGC ACCACCGACT CGCTGTGGGC CTGCCTCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003658	Anas platyrhynchos	63.72	0.00e+00	812.00
IUUC-Aca-005278	Anolis carolinensis	64.20	0.00e+00	813.00
IUUC-Ame-011403	Astyanax mexicanus	71.56	0.00e+00	834.00
IUUC-Bta-012911	Bos taurus	68.40	6.00e-165	574.00
IUUC-Cja-019171	Callithrix jacchus	62.03	0.00e+00	774.00
IUUC-Cpo-022233	Cavia porcellus	70.84	3.00e-167	581.00
IUUC-Cho-025051	Choloepus hoffmanni	62.53	6.00e-124	437.00
IUUC-Cin-025587	Ciona intestinalis	46.52	9.00e-104	371.00
IUUC-Dre-027577	Danio rerio	71.51	0.00e+00	856.00
IUUC-Eca-033851	Equus caballus	56.60	0.00e+00	692.00
IUUC-Fal-037290	Ficedula albicollis	65.04	0.00e+00	758.00
IUUC-Gmo-039249	Gadus morhua	90.22	5.00e-169	587.00
IUUC-Gac-042595	Gasterosteus aculeatus	83.92	0.00e+00	1070.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	59.77	0.00e+00	761.00
IUUC-Lch-050294	Latimeria chalumnae	64.91	0.00e+00	773.00
IUUC-Loc-051961	Lepisosteus oculatus	75.81	0.00e+00	669.00
IUUC-Meu-055971	Macropus eugenii	50.52	6.00e-105	374.00
IUUC-Mdo-062073	Monodelphis domestica	63.13	0.00e+00	810.00
IUUC-Mmu-064095	Mus musculus	62.48	0.00e+00	773.00
IUUC-Mlu-067090	Myotis lucifugus	69.21	7.00e-167	580.00
IUUC-Opr-070563	Ochotona princeps	59.13	0.00e+00	756.00
IUUC-Ont-072103	Oreochromis niloticus	84.26	0.00e+00	1092.00
IUUC-Ola-086413	Oryzias latipes	76.78	0.00e+00	972.00
IUUC-Oga-088862	Otolemur garnettii	60.49	0.00e+00	765.00
IUUC-Psi-093353	Pelodiscus sinensis	64.25	0.00e+00	816.00
IUUC-Pfo-096413	Poecilia formosa	85.59	0.00e+00	1092.00
IUUC-Pva-102868	Pteropus vampyrus	69.78	3.00e-168	585.00
IUUC-Rno-105190	Rattus norvegicus	61.79	0.00e+00	776.00
IUUC-Sha-107337	Sarcophilus harrisii	62.99	0.00e+00	808.00
IUUC-Sar-113561	Sorex araneus	80.43	3.00e-64	238.00
IUUC-Ssc-115727	Sus scrofa	69.51	1.00e-163	569.00
IUUC-Tgu-117025	Taeniopygia guttata	59.88	0.00e+00	682.00
IUUC-Tru-117585	Takifugu rubripes	88.38	0.00e+00	1120.00
IUUC-Tsy-118814	Tarsius syrichta	59.91	0.00e+00	762.00
IUUC-Xtr-132090	Xenopus tropicalis	64.49	0.00e+00	800.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence